ZBT43_HUMAN - dbPTM
ZBT43_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZBT43_HUMAN
UniProt AC O43298
Protein Name Zinc finger and BTB domain-containing protein 43
Gene Name ZBTB43
Organism Homo sapiens (Human).
Sequence Length 467
Subcellular Localization Nucleus .
Protein Description May be involved in transcriptional regulation..
Protein Sequence MEPGTNSFRVEFPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRVFENILLSSYTGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVLEGNPTVLCQKLNHGSDHQSPSSSSYNGLVESFELGSGGHTDFPKAQELRDGENEEESTKDELSSQLTEHEYLPSNSSTEHDRLSTEMASQDGEEGASDSAEFHYTRPMYSKPSIMAHKRWIHVKPERLEQACEGMDVHATYDEHQVTESINTVQTEHTVQPSGVEEDFHIGEKKVEAEFDEQADESNYDEQVDFYGSSMEEFSGERSDGNLIGHRQEAALAAGYSENIEMVTGIKEEASHLGFSATDKLYPCQCGKSFTHKSQRDRHMSMHLGLRPYGCGVCGKKFKMKHHLVGHMKIHTGIKPYECNICAKRFMWRDSFHRHVTSCTKSYEAAKAEQNTTEAN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MEPGTNSF
-------CCCCCCCE		14.6622814378
22UbiquitinationFSSTILQKLNQQRQQ
CHHHHHHHHHHHHHC		46.06-
65UbiquitinationFCDQVLLKNSRRIVL
CHHHHHHCCCCEEEC		49.03-
128PhosphorylationEVLEGNPTVLCQKLN
HHHCCCCEEEEEECC		30.0630622161
138PhosphorylationCQKLNHGSDHQSPSS
EEECCCCCCCCCCCC		25.1130108239
142PhosphorylationNHGSDHQSPSSSSYN
CCCCCCCCCCCCCCC		24.2730108239
144PhosphorylationGSDHQSPSSSSYNGL
CCCCCCCCCCCCCCC		48.3630108239
145PhosphorylationSDHQSPSSSSYNGLV
CCCCCCCCCCCCCCE		27.0430108239
146PhosphorylationDHQSPSSSSYNGLVE
CCCCCCCCCCCCCEE		40.9730108239
147PhosphorylationHQSPSSSSYNGLVES
CCCCCCCCCCCCEEE		25.2730108239
148PhosphorylationQSPSSSSYNGLVESF
CCCCCCCCCCCEEEE		18.3930108239
154PhosphorylationSYNGLVESFELGSGG
CCCCCEEEEECCCCC		19.2827080861
180PhosphorylationDGENEEESTKDELSS
CCCCCCCCCHHHHHH		44.00-
182SumoylationENEEESTKDELSSQL
CCCCCCCHHHHHHHH		59.4928112733
182SumoylationENEEESTKDELSSQL
CCCCCCCHHHHHHHH		59.49-
186PhosphorylationESTKDELSSQLTEHE
CCCHHHHHHHHHCCC		17.62-
200PhosphorylationEYLPSNSSTEHDRLS
CCCCCCCCCHHHHHH		41.9025627689
207PhosphorylationSTEHDRLSTEMASQD
CCHHHHHHHHHHHCC		24.1824275569
212PhosphorylationRLSTEMASQDGEEGA
HHHHHHHHCCCCCCC		27.7427251275
227PhosphorylationSDSAEFHYTRPMYSK
CCCCEEEECCCCCCC		15.1224275569
228PhosphorylationDSAEFHYTRPMYSKP
CCCEEEECCCCCCCC		21.5224275569
232PhosphorylationFHYTRPMYSKPSIMA
EEECCCCCCCCCCCC		19.0724275569
233PhosphorylationHYTRPMYSKPSIMAH
EECCCCCCCCCCCCC		31.6624719451
236PhosphorylationRPMYSKPSIMAHKRW
CCCCCCCCCCCCCCE		28.8224275569
241SumoylationKPSIMAHKRWIHVKP
CCCCCCCCCEEECCH		39.6328112733
247AcetylationHKRWIHVKPERLEQA
CCCEEECCHHHHHHH		27.3119608861
247SumoylationHKRWIHVKPERLEQA
CCCEEECCHHHHHHH		27.3128112733
247SumoylationHKRWIHVKPERLEQA
CCCEEECCHHHHHHH		27.31-
297SumoylationDFHIGEKKVEAEFDE
CEEECCCEEEEECHH		40.7928112733
358SumoylationIEMVTGIKEEASHLG
CEEECCCHHHHHHCC		51.3428112733
362PhosphorylationTGIKEEASHLGFSAT
CCCHHHHHHCCCCCC		23.6430622161
367PhosphorylationEASHLGFSATDKLYP
HHHHCCCCCCCCCEE		28.5830622161
369PhosphorylationSHLGFSATDKLYPCQ
HHCCCCCCCCCEECC		32.2530622161
423PhosphorylationVGHMKIHTGIKPYEC
HCCEEECCCCCCCCC		44.0425159151
442PhosphorylationKRFMWRDSFHRHVTS
HHHHHHHHHHHHHHH		17.8723312004
458SumoylationTKSYEAAKAEQNTTE
CHHHHHHHHHHHCCC		60.5528112733
458SumoylationTKSYEAAKAEQNTTE
CHHHHHHHHHHHCCC		60.55-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZBT43_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZBT43_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZBT43_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ZN417_HUMANZNF417physical
16189514
ELOA2_HUMANTCEB3Bphysical
16189514
LMO3_HUMANLMO3physical
16189514
MCM10_HUMANMCM10physical
16189514
LNX1_HUMANLNX1physical
16189514
ZBT43_HUMANZBTB43physical
25416956
DIP2A_HUMANDIP2Aphysical
25416956
AEN_HUMANAENphysical
25416956
F161A_HUMANFAM161Aphysical
25416956
SYT6_HUMANSYT6physical
25416956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZBT43_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-247, AND MASS SPECTROMETRY.

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