| UniProt ID | AEN_HUMAN | |
|---|---|---|
| UniProt AC | Q8WTP8 | |
| Protein Name | Apoptosis-enhancing nuclease | |
| Gene Name | AEN | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 325 | |
| Subcellular Localization | Nucleus. Nucleus, nucleolus. Localized predomintly in the nucleolus. Translocates from the nucleolus to the nucleoplasm upon apoptosis induction. | |
| Protein Description | Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis.. | |
| Protein Sequence | MVPREAPESAQCLCPSLTIPNAKDVLRKRHKRRSRQHQRFMARKALLQEQGLLSMPPEPGSSPLPTPFGAATATEAASSGKQCLRAGSGSAPCSRRPAPGKASGPLPSKCVAIDCEMVGTGPRGRVSELARCSIVSYHGNVLYDKYIRPEMPIADYRTRWSGITRQHMRKAVPFQVAQKEILKLLKGKVVVGHALHNDFQALKYVHPRSQTRDTTYVPNFLSEPGLHTRARVSLKDLALQLLHKKIQVGQHGHSSVEDATTAMELYRLVEVQWEQQEARSLWTCPEDREPDSSTDMEQYMEDQYWPDDLAHGSRGGAREAQDRRN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 101 (in isoform 1) | Ubiquitination | - | 38.02 | 21906983 | |
| 101 (in isoform 2) | Ubiquitination | - | 38.02 | 21906983 | |
| 101 | Ubiquitination | SRRPAPGKASGPLPS CCCCCCCCCCCCCCC | 38.02 | 21906983 | |
| 108 | Phosphorylation | KASGPLPSKCVAIDC CCCCCCCCCEEEEEC | 46.50 | 24719451 | |
| 109 (in isoform 2) | Ubiquitination | - | 30.68 | - | |
| 109 | Ubiquitination | ASGPLPSKCVAIDCE CCCCCCCCEEEEECE | 30.68 | - | |
| 120 | Phosphorylation | IDCEMVGTGPRGRVS EECEEECCCCCCCHH | 32.38 | 50563817 | |
| 136 | Phosphorylation | LARCSIVSYHGNVLY HHCCEEEEEECCEEE | 15.11 | 28450419 | |
| 137 | Phosphorylation | ARCSIVSYHGNVLYD HCCEEEEEECCEEEE | 11.67 | 28450419 | |
| 143 | Phosphorylation | SYHGNVLYDKYIRPE EEECCEEEECCCCCC | 13.20 | 28450419 | |
| 164 | Phosphorylation | RTRWSGITRQHMRKA CCCCCCCCHHHHHHH | 28.00 | 29449344 | |
| 170 | Ubiquitination | ITRQHMRKAVPFQVA CCHHHHHHHCCHHHH | 46.27 | 29967540 | |
| 204 | Phosphorylation | NDFQALKYVHPRSQT CHHHHHHHCCCCCCC | 12.58 | 22210691 | |
| 209 | Phosphorylation | LKYVHPRSQTRDTTY HHHCCCCCCCCCCCC | 40.11 | 22210691 | |
| 214 | Phosphorylation | PRSQTRDTTYVPNFL CCCCCCCCCCCCCCC | 19.41 | 22210691 | |
| 215 | Phosphorylation | RSQTRDTTYVPNFLS CCCCCCCCCCCCCCC | 27.15 | 22210691 | |
| 235 | Ubiquitination | TRARVSLKDLALQLL CCHHCCHHHHHHHHH | 43.09 | 22817900 | |
| 235 (in isoform 1) | Ubiquitination | - | 43.09 | 21906983 | |
| 235 (in isoform 2) | Ubiquitination | - | 43.09 | 21906983 | |
| 245 | Ubiquitination | ALQLLHKKIQVGQHG HHHHHHHHCCCCCCC | 27.85 | 29967540 | |
| 280 | Phosphorylation | WEQQEARSLWTCPED HHHHHHHHHCCCCCC | 34.99 | 46159971 | |
| 283 | Phosphorylation | QEARSLWTCPEDREP HHHHHHCCCCCCCCC | 24.39 | 46159977 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AEN_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AEN_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AEN_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| GNPTA_HUMAN | GNPTAB | physical | 25416956 | |
| LZTS2_HUMAN | LZTS2 | physical | 25416956 | |
| TRI41_HUMAN | TRIM41 | physical | 25416956 | |
| ADIP_HUMAN | SSX2IP | physical | 25416956 | |
| K1C40_HUMAN | KRT40 | physical | 25416956 | |
| RALYL_HUMAN | RALYL | physical | 25416956 | |
| RBY1F_HUMAN | RBMY1F | physical | 25416956 | |
| KHDR2_HUMAN | KHDRBS2 | physical | 25416956 | |
| KR107_HUMAN | KRTAP10-7 | physical | 25416956 | |
| KR101_HUMAN | KRTAP10-1 | physical | 25416956 | |
| KR108_HUMAN | KRTAP10-8 | physical | 25416956 | |
| KR103_HUMAN | KRTAP10-3 | physical | 25416956 | |
| ZBT8A_HUMAN | ZBTB8A | physical | 25416956 | |
| AAMP_HUMAN | AAMP | physical | 26186194 | |
| PKN1_HUMAN | PKN1 | physical | 28514442 | |
| PPID_HUMAN | PPID | physical | 28514442 | |
| CRIP2_HUMAN | CRIP2 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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