AAMP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AAMP_HUMAN
• UniProt AC: Q13685
• Protein Name: Angio-associated migratory cell protein
• Gene Name: AAMP
• Organism: Homo sapiens (Human).
• Sequence Length: 434
• Subcellular Localization: Cell membrane. Cytoplasm.
• Protein Description: Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway..
• Protein Sequence: MESESESGAAADTPPLETLSFHGDEEIIEVVELDPGPPDPDDLAQEMEDVDFEEEEEEEGNEEGWVLEPQEGVVGSMEGPDDSEVTFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVFCVQRPDR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	ESGAAADTPPLETLS CCCCCCCCCCCEEEE	23.29	26074081
18	Phosphorylation	ADTPPLETLSFHGDE CCCCCCEEEEECCCC	35.07	26074081
20	Phosphorylation	TPPLETLSFHGDEEI CCCCEEEEECCCCCE	23.71	26074081
115	Ubiquitination	VTGGEDDKAFVWRLS EECCCCCCEEEEEEC	56.92	21890473
202	Ubiquitination	DGNTWMWKVPNGDCK CCCEEEEECCCCCCC	31.54	-
202	Acetylation	DGNTWMWKVPNGDCK CCCEEEEECCCCCCC	31.54	25953088
209	Ubiquitination	KVPNGDCKTFQGPNC ECCCCCCCCCCCCCC	58.05	-
228	Ubiquitination	GRVLPDGKRAVVGYE CEECCCCCEEEEEEC	44.56	-
228	Acetylation	GRVLPDGKRAVVGYE CEECCCCCEEEEEEC	44.56	25953088
240	Methylation	GYEDGTIRIWDLKQG EECCCEEEEEECCCC	24.63	-
245	Ubiquitination	TIRIWDLKQGSPIHV EEEEEECCCCCCEEE	50.57	21890473
245	Malonylation	TIRIWDLKQGSPIHV EEEEEECCCCCCEEE	50.57	33225896
245	Acetylation	TIRIWDLKQGSPIHV EEEEEECCCCCCEEE	50.57	25953088
248	Phosphorylation	IWDLKQGSPIHVLKG EEECCCCCCEEEEEC	20.42	25159151
288	Phosphorylation	DCQAKLVSATTGKVV CCEEEEEECCCCCEE	30.27	22985185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AAMP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AAMP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AAMP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DHYS_HUMAN	DHPS	physical	22863883
HSF1_HUMAN	HSF1	physical	22863883
PDCD4_HUMAN	PDCD4	physical	22863883
PLIN3_HUMAN	PLIN3	physical	22863883
SRP09_HUMAN	SRP9	physical	22863883
VPS52_HUMAN	VPS52	physical	25416956
BHE40_HUMAN	BHLHE40	physical	25416956
AEN_HUMAN	AEN	physical	25416956
RL10_HUMAN	RPL10	physical	26186194
DICER_HUMAN	DICER1	physical	26186194
WNK1_HUMAN	WNK1	physical	26186194
2ABD_HUMAN	PPP2R2D	physical	26186194
PTPRU_HUMAN	PTPRU	physical	26186194
ASAH1_HUMAN	ASAH1	physical	26186194
ACE2_HUMAN	ACE2	physical	26186194
TCF25_HUMAN	TCF25	physical	26186194
INP5K_HUMAN	INPP5K	physical	26186194
CK057_HUMAN	C11orf57	physical	21516116
AEN_HUMAN	AEN	physical	28514442
ASAH1_HUMAN	ASAH1	physical	28514442
PTPRU_HUMAN	PTPRU	physical	28514442
WNK1_HUMAN	WNK1	physical	28514442
RL10_HUMAN	RPL10	physical	28514442
INP5K_HUMAN	INPP5K	physical	28514442
ACE2_HUMAN	ACE2	physical	28514442
MKLN1_HUMAN	MKLN1	physical	27173435
MMAD_HUMAN	MMADHC	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.