DICER_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DICER_HUMAN
• UniProt AC: Q9UPY3
• Protein Name: Endoribonuclease Dicer
• Gene Name: DICER1
• Organism: Homo sapiens (Human).
• Sequence Length: 1922
• Subcellular Localization: Cytoplasm .
• Protein Description: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes..
• Protein Sequence: MKSPALQPLSMAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELSYQIRGDFSRNGKRTVFLVNSANQVAQQVSAVRTHSDLKVGEYSNLEVNASWTKERWNQEFTKHQVLIMTCYVALNVLKNGYLSLSDINLLVFDECHLAILDHPYREIMKLCENCPSCPRILGLTASILNGKCDPEELEEKIQKLEKILKSNAETATDLVVLDRYTSQPCEIVVDCGPFTDRSGLYERLLMELEEALNFINDCNISVHSKERDSTLISKQILSDCRAVLVVLGPWCADKVAGMMVRELQKYIKHEQEELHRKFLLFTDTFLRKIHALCEEHFSPASLDLKFVTPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDDEDEEIEEKEKPETNFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRNKQMEAEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYIMLADTDKIKSFEEDLKTYKAIEKILRNKCSKSVDTGETDIDPVMDDDDVFPPYVLRPDDGGPRVTINTAIGHINRYCARLPSDPFTHLAPKCRTRELPDGTFYSTLYLPINSPLRASIVGPPMSCVRLAERVVALICCEKLHKIGELDDHLMPVGKETVKYEEELDLHDEEETSVPGRPGSTKRRQCYPKAIPECLRDSYPRPDQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFMLSLQMLELITRLHQYIFSHILRLEKPALEFKPTDADSAYCVLPLNVVNDSSTLDIDFKFMEDIEKSEARIGIPSTKYTKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRAQTASDAGVGVRSLPADFRYPNLDFGWKKSIDSKSFISISNSSSAENDNYCKHSTIVPENAAHQGANRTSSLENHDQMSVNCRTLLSESPGKLHVEVSADLTAINGLSYNQNLANGSYDLANRDFCQGNQLNYYKQEIPVQPTTSYSIQNLYSYENQPQPSDECTLLSNKYLDGNANKSTSDGSPVMAVMPGTTDTIQVLKGRMDSEQSPSIGYSSRTLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKHAITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSIFDPPVNWLPPGYVVNQDKSNTDKWEKDEMTKDCMLANGKLDEDYEEEDEEEESLMWRAPKEEADYEDDFLEYDQEHIRFIDNMLMGSGAFVKKISLSPFSTTDSAYEWKMPKKSSLGSMPFSSDFEDFDYSSWDAMCYLDPSKAVEEDDFVVGFWNPSEENCGVDTGKQSISYDLHTEQCIADKSIADCVEALLGCYLTSCGERAAQLFLCSLGLKVLPVIKRTDREKALCPTRENFNSQQKNLSVSCAAASVASSRSSVLKDSEYGCLKIPPRCMFDHPDADKTLNHLISGFENFEKKINYRFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVQFQLEKNEMQGMDSELRRSEEDEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLETVWQVYYPMMRPLIEKFSANVPRSPVRELLEMEPETAKFSPAERTYDGKVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSLKANQPQVPNS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Phosphorylation	AIHDNIYTPRKYQVE HHCCCCCCCCHHHHH	16.90	24719451
57	Ubiquitination	ELLEAALDHNTIVCL HHHHHHHCCCEEEEE	28.41	24816145
82	Phosphorylation	VLLTKELSYQIRGDF EEECCCCCEEECCCC	18.98	26852163
83	Phosphorylation	LLTKELSYQIRGDFS EECCCCCEEECCCCC	22.15	26852163
102	Phosphorylation	RTVFLVNSANQVAQQ EEEEEECCHHHHHHH	22.55	18785766
238	Phosphorylation	KSNAETATDLVVLDR HCCCCCCCCEEEEEC	36.97	-
248	Ubiquitination	VVLDRYTSQPCEIVV EEEECCCCCCCEEEE	24.16	-
363	Ubiquitination	HALCEEHFSPASLDL HHHHHHCCCCCCCCC	12.08	-
364	Ubiquitination	ALCEEHFSPASLDLK HHHHHCCCCCCCCCC	22.82	-
397	Phosphorylation	YERQQFESVEWYNNR CCHHCCCCEEECCCC	26.99	28985074
409	Phosphorylation	NNRNQDNYVSWSDSE CCCCCCCCCCCCCCC	12.26	23090842
411	Phosphorylation	RNQDNYVSWSDSEDD CCCCCCCCCCCCCCC	15.53	30576142
413	Phosphorylation	QDNYVSWSDSEDDDE CCCCCCCCCCCCCCC	24.61	28348404
415	Phosphorylation	NYVSWSDSEDDDEDE CCCCCCCCCCCCCHH	37.09	28348404
415	Ubiquitination	NYVSWSDSEDDDEDE CCCCCCCCCCCCCHH	37.09	24816145
452	Phosphorylation	IIFVERRYTAVVLNR EEEECHHHHHHHHHH	12.79	-
466	Ubiquitination	RLIKEAGKQDPELAY HHHHHHCCCCHHHEE	59.58	29967540
475	Phosphorylation	DPELAYISSNFITGH CHHHEEEECCCCCCC	13.42	25332170
480	Phosphorylation	YISSNFITGHGIGKN EEECCCCCCCCCCCC	20.98	25332170
550	Ubiquitination	YRSYVQSKGRARAPI HHHHHHCCCCCCCCC	35.01	24816145
570	Ubiquitination	LADTDKIKSFEEDLK EECHHHHCCHHHHHH	55.63	29967540
571	Phosphorylation	ADTDKIKSFEEDLKT ECHHHHCCHHHHHHH	41.17	23898821
577	Ubiquitination	KSFEEDLKTYKAIEK CCHHHHHHHHHHHHH	63.23	29967540
584	Acetylation	KTYKAIEKILRNKCS HHHHHHHHHHHCCCC	40.71	25953088
643	Phosphorylation	RYCARLPSDPFTHLA HHHHCCCCCCCCCCC	63.61	30108239
647	Phosphorylation	RLPSDPFTHLAPKCR CCCCCCCCCCCCCCC	22.74	29978859
652	Ubiquitination	PFTHLAPKCRTRELP CCCCCCCCCCCCCCC	30.64	-
654	Phosphorylation	THLAPKCRTRELPDG CCCCCCCCCCCCCCC	42.83	15592455
664	Phosphorylation	ELPDGTFYSTLYLPI CCCCCCEEEEEEEEC	10.69	22817900
668	Phosphorylation	GTFYSTLYLPINSPL CCEEEEEEEECCCCC	15.55	-
819	Phosphorylation	QIPHFPVYTRSGEVT CCCCCCCEECCCEEE	9.18	19835603
820	Phosphorylation	IPHFPVYTRSGEVTI CCCCCCEECCCEEEE	20.70	19835603
822	Phosphorylation	HFPVYTRSGEVTISI CCCCEECCCEEEEEE	31.35	28122231
828	Phosphorylation	RSGEVTISIELKKSG CCCEEEEEEEEECCC	10.72	19835603
847	Phosphorylation	LQMLELITRLHQYIF HHHHHHHHHHHHHHH	39.54	23532336
869	Ubiquitination	KPALEFKPTDADSAY CCCCCCCCCCCCCCE	40.61	24816145
911	Phosphorylation	EARIGIPSTKYTKET HCCCCCCCCCCCCCC	35.29	26074081
912	Phosphorylation	ARIGIPSTKYTKETP CCCCCCCCCCCCCCC	23.79	26074081
914	Phosphorylation	IGIPSTKYTKETPFV CCCCCCCCCCCCCEE	24.11	26074081
915	Phosphorylation	GIPSTKYTKETPFVF CCCCCCCCCCCCEEE	24.78	26074081
946	Phosphorylation	FDQPHRFYVADVYTD CCCCCCEEEEEEECC	8.49	23403867
951	Phosphorylation	RFYVADVYTDLTPLS CEEEEEEECCCCCHH	8.62	23403867
952	Phosphorylation	FYVADVYTDLTPLSK EEEEEEECCCCCHHH	25.12	23403867
955	Phosphorylation	ADVYTDLTPLSKFPS EEEECCCCCHHHCCC	25.62	23403867
958	Phosphorylation	YTDLTPLSKFPSPEY ECCCCCHHHCCCCCH	33.19	23403867
962	Phosphorylation	TPLSKFPSPEYETFA CCHHHCCCCCHHHHH	33.23	-
967	Phosphorylation	FPSPEYETFAEYYKT CCCCCHHHHHHHHHH	27.52	-
972	Ubiquitination	YETFAEYYKTKYNLD HHHHHHHHHHHCCCC	12.04	21890473
974	Phosphorylation	TFAEYYKTKYNLDLT HHHHHHHHHCCCCCC	23.73	26074081
976	Phosphorylation	AEYYKTKYNLDLTNL HHHHHHHCCCCCCCC	26.62	26074081
981	Phosphorylation	TKYNLDLTNLNQPLL HHCCCCCCCCCCCCC	37.01	26074081
993	Phosphorylation	PLLDVDHTSSRLNLL CCCCCCCCHHHHHHC	24.76	26074081
994	Phosphorylation	LLDVDHTSSRLNLLT CCCCCCCHHHHHHCC	15.27	26074081
995	Phosphorylation	LDVDHTSSRLNLLTP CCCCCCHHHHHHCCH	41.78	26074081
1001	Phosphorylation	SSRLNLLTPRHLNQK HHHHHHCCHHHHCCC	22.80	23312004
1006	Phosphorylation	LLTPRHLNQKGKALP HCCHHHHCCCCCCCC	35.08	18669648
1015	Phosphorylation	KGKALPLSSAEKRKA CCCCCCCCHHHHHHH	26.09	30266825
1016	Phosphorylation	GKALPLSSAEKRKAK CCCCCCCHHHHHHHH	48.40	30266825
1023	Ubiquitination	SAEKRKAKWESLQNK HHHHHHHHHHHHHCC	55.30	29967540
1046	Phosphorylation	AIHPIPASLWRKAVC HHCCCCHHHHHHHCH	24.10	24719451
1091	Phosphorylation	SLPADFRYPNLDFGW CCCCCCCCCCCCCCC	9.10	-
1111	Phosphorylation	SKSFISISNSSSAEN CCCCEEECCCCCCCC	24.70	29978859
1113	Phosphorylation	SFISISNSSSAENDN CCEEECCCCCCCCCC	20.91	29978859
1114	Phosphorylation	FISISNSSSAENDNY CEEECCCCCCCCCCC	37.51	29978859
1115	Phosphorylation	ISISNSSSAENDNYC EEECCCCCCCCCCCC	39.15	29978859
1121	Phosphorylation	SSAENDNYCKHSTIV CCCCCCCCCCCCCCC	13.02	29978859
1140	Phosphorylation	AHQGANRTSSLENHD HCCCCCCCHHCCCHH	23.60	28450419
1141	Phosphorylation	HQGANRTSSLENHDQ CCCCCCCHHCCCHHH	29.68	28450419
1142	Phosphorylation	QGANRTSSLENHDQM CCCCCCHHCCCHHHC	38.80	28450419
1149	Sulfoxidation	SLENHDQMSVNCRTL HCCCHHHCCCCHHHH	6.34	21406390
1155	Phosphorylation	QMSVNCRTLLSESPG HCCCCHHHHHCCCCC	33.96	29396449
1158	Phosphorylation	VNCRTLLSESPGKLH CCHHHHHCCCCCCEE	38.86	29396449
1160	Phosphorylation	CRTLLSESPGKLHVE HHHHHCCCCCCEEEE	35.26	19664994
1204	Phosphorylation	CQGNQLNYYKQEIPV CCCCCCCEEECCCCC	22.19	29978859
1205	Phosphorylation	QGNQLNYYKQEIPVQ CCCCCCEEECCCCCC	12.72	29978859
1227	Ubiquitination	QNLYSYENQPQPSDE EECCCCCCCCCCCCC	51.07	24816145
1245	Phosphorylation	LSNKYLDGNANKSTS EECCCCCCCCCCCCC	32.33	18669648
1250	Phosphorylation	LDGNANKSTSDGSPV CCCCCCCCCCCCCCE	32.71	25159151
1251	Phosphorylation	DGNANKSTSDGSPVM CCCCCCCCCCCCCEE	32.23	25159151
1252	Phosphorylation	GNANKSTSDGSPVMA CCCCCCCCCCCCEEE	47.25	25159151
1255	Phosphorylation	NKSTSDGSPVMAVMP CCCCCCCCCEEEECC	21.22	25159151
1264	Phosphorylation	VMAVMPGTTDTIQVL EEEECCCCCCCHHHH	18.67	23663014
1265	Phosphorylation	MAVMPGTTDTIQVLK EEECCCCCCCHHHHC	36.74	23663014
1267	Phosphorylation	VMPGTTDTIQVLKGR ECCCCCCCHHHHCCC	15.95	23663014
1280	Phosphorylation	GRMDSEQSPSIGYSS CCCCCCCCCCCCCCC	19.30	21815630
1282	Phosphorylation	MDSEQSPSIGYSSRT CCCCCCCCCCCCCCC	33.61	24719451
1317	Sulfoxidation	FNLERLEMLGDSFLK CCHHHHHHHHHHHHH	6.32	21406390
1321	Phosphorylation	RLEMLGDSFLKHAIT HHHHHHHHHHHHHHH	30.58	24719451
1329	Phosphorylation	FLKHAITTYLFCTYP HHHHHHHHHHCCCCC	16.47	-
1330	Phosphorylation	LKHAITTYLFCTYPD HHHHHHHHHCCCCCC	6.80	-
1330	Ubiquitination	LKHAITTYLFCTYPD HHHHHHHHHCCCCCC	6.80	21890473
1350	Ubiquitination	LSYMRSKKVSNCNLY HHHHHCCCCCCCCHH	52.74	29967540
1362	Ubiquitination	NLYRLGKKKGLPSRM CHHHCCCCCCCCCCE	50.72	24816145
1373	Ubiquitination	PSRMVVSIFDPPVNW CCCEEEEECCCCCCC	2.83	24816145
1391	Acetylation	GYVVNQDKSNTDKWE CCCCCCCCCCCCCCC	35.52	7367815
1403	Phosphorylation	KWEKDEMTKDCMLAN CCCHHHHHHHHHHHC	22.99	23403867
1417	Phosphorylation	NGKLDEDYEEEDEEE CCCCCCCCCCCCHHH	24.16	27642862
1433	Ubiquitination	SLMWRAPKEEADYED HHHCCCCHHHCCCCC	68.17	29967540
1438	Phosphorylation	APKEEADYEDDFLEY CCHHHCCCCCCCHHH	28.45	28796482
1445	Phosphorylation	YEDDFLEYDQEHIRF CCCCCHHHCHHHHHH	25.69	28796482
1460	Phosphorylation	IDNMLMGSGAFVKKI HHHHHHCCCCEEEEE	17.00	25003641
1465	Ubiquitination	MGSGAFVKKISLSPF HCCCCEEEEEECCCC	37.63	21890473
1465	Ubiquitination	MGSGAFVKKISLSPF HCCCCEEEEEECCCC	37.63	21890473
1466	Ubiquitination	GSGAFVKKISLSPFS CCCCEEEEEECCCCC	32.02	29967540
1468	Phosphorylation	GAFVKKISLSPFSTT CCEEEEEECCCCCCC	31.51	21945579
1470	Phosphorylation	FVKKISLSPFSTTDS EEEEEECCCCCCCCC	19.67	21945579
1473	Phosphorylation	KISLSPFSTTDSAYE EEECCCCCCCCCCCC	33.51	21945579
1474	Phosphorylation	ISLSPFSTTDSAYEW EECCCCCCCCCCCCC	34.69	21945579
1475	Phosphorylation	SLSPFSTTDSAYEWK ECCCCCCCCCCCCCC	27.10	21945579
1477	Phosphorylation	SPFSTTDSAYEWKMP CCCCCCCCCCCCCCC	30.56	21945579
1479	Phosphorylation	FSTTDSAYEWKMPKK CCCCCCCCCCCCCCC	26.69	21945579
1487	Phosphorylation	EWKMPKKSSLGSMPF CCCCCCCCCCCCCCC	36.60	28102081
1488	Phosphorylation	WKMPKKSSLGSMPFS CCCCCCCCCCCCCCC	45.70	28102081
1491	Phosphorylation	PKKSSLGSMPFSSDF CCCCCCCCCCCCCCC	28.68	28102081
1595	Ubiquitination	LKVLPVIKRTDREKA CCHHHEECCCCHHHC	49.86	29967540
1612	Phosphorylation	PTRENFNSQQKNLSV CCCCCCCHHCCCHHH	29.83	24719451
1615	Ubiquitination	ENFNSQQKNLSVSCA CCCCHHCCCHHHHHH	52.82	29967540
1618	Phosphorylation	NSQQKNLSVSCAAAS CHHCCCHHHHHHHHH	22.75	28555341
1625	Phosphorylation	SVSCAAASVASSRSS HHHHHHHHHHHCCHH	17.31	24719451
1628	Phosphorylation	CAAASVASSRSSVLK HHHHHHHHCCHHHCC	24.91	24719451
1639	Phosphorylation	SVLKDSEYGCLKIPP HHCCCCCCCCCCCCC	19.66	27642862
1728	Phosphorylation	YEDPRQHSPGVLTDL HCCCCCCCCCHHHHH	18.27	-
1731	Ubiquitination	PRQHSPGVLTDLRSA CCCCCCCHHHHHHHH	6.21	24816145
1792	Phosphorylation	MDSELRRSEEDEEKE CCHHHHCCHHHHHHH	38.61	28985074
1852	Phosphorylation	FSANVPRSPVRELLE HCCCCCCCHHHHHHH	22.98	25159151
1860	Sulfoxidation	PVRELLEMEPETAKF HHHHHHHCCCCCCCC	11.97	21406390
1864	Phosphorylation	LLEMEPETAKFSPAE HHHCCCCCCCCCCCC	45.95	23186163
1866	Ubiquitination	EMEPETAKFSPAERT HCCCCCCCCCCCCCC	54.52	24816145
1868	Phosphorylation	EPETAKFSPAERTYD CCCCCCCCCCCCCCC	23.61	21205968
1901	Acetylation	GRSYRIAKSAAARRA CHHHHHHHHHHHHHH	37.95	25953088
1922	Phosphorylation	NQPQVPNS------- CCCCCCCC-------	35.21	28985074

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DICER_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DICER_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DICER_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AGO1_HUMAN	AGO1	physical	12906857
AGO3_HUMAN	AGO3	physical	12906857
AGO4_HUMAN	AGO4	physical	12906857
PIWL4_HUMAN	PIWIL4	physical	12906857
PIWL3_HUMAN	PIWIL3	physical	12906857
PIWL2_HUMAN	PIWIL2	physical	12906857
AGO2_HUMAN	AGO2	physical	12526743
AGO2_MOUSE	Ago2	physical	12526743
AGO2_HUMAN	AGO2	physical	14749716
PIWL1_HUMAN	PIWIL1	physical	14749716
GEMI4_HUMAN	GEMIN4	physical	23143396
CACO2_HUMAN	CALCOCO2	physical	23143396
TRBP2_HUMAN	TARBP2	physical	15973356
HDA11_HUMAN	HDAC11	physical	23752268
SMN_HUMAN	SMN1	physical	23752268
DDX20_HUMAN	DDX20	physical	23752268
GEMI4_HUMAN	GEMIN4	physical	23752268
DICER_HUMAN	DICER1	physical	23752268
AAKB2_HUMAN	PRKAB2	physical	21988832
LOX5_HUMAN	ALOX5	physical	19022417
AGO1_HUMAN	AGO1	physical	24778252
AGO2_HUMAN	AGO2	physical	24778252
AGO3_HUMAN	AGO3	physical	24778252
MTFR2_HUMAN	MTFR2	physical	24778252
NOG2_HUMAN	GNL2	physical	24778252
NOG1_HUMAN	GTPBP4	physical	24778252
MTFR1_HUMAN	MTFR1	physical	24778252
MYSM1_HUMAN	MYSM1	physical	24778252
NOC3L_HUMAN	NOC3L	physical	24778252
POP1_HUMAN	POP1	physical	24778252
PRKRA_HUMAN	PRKRA	physical	24778252
STAU2_HUMAN	STAU2	physical	24778252
TRBP2_HUMAN	TARBP2	physical	24778252

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 601200: Pleuropulmonary blastoma (PPB)
• 138800: Goiter multinodular 1, with or without Sertoli-Leydig cell tumors (MNG1)
• 180295: Rhabdomyosarcoma, embryonal, 2 (RMSE2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1016, AND MASSSPECTROMETRY.
PubMed: 18669648

"Immunoaffinity profiling of tyrosine phosphorylation in cancercells.";
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.;
Nat. Biotechnol. 23:94-101(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-664, AND MASSSPECTROMETRY.
PubMed: 15592455