PIWL3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PIWL3_HUMAN
• UniProt AC: Q7Z3Z3
• Protein Name: Piwi-like protein 3
• Gene Name: PIWIL3
• Organism: Homo sapiens (Human).
• Sequence Length: 882
• Subcellular Localization: Cytoplasm . Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
• Protein Description: May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity)..
• Protein Sequence: MPGRARTRARGRARRRESYQQEAPGGPRAPGSATTQEPPQLQSTPRPLQEEVPVVRPLQPRAARGGAGGGAQSQGVKEPGPEAGLHTAPLQERRIGGVFQDLVVNTRQDMKHVKDSKTGSEGTVVQLLANHFRVISRPQWVAYKYNVDYKPDIEDGNLRTILLDQHRRKFGERHIFDGNSLLLSRPLKERRVEWLSTTKDKNIVKITVEFSKELTPTSPDCLRYYNILFRRTFKLLDFEQVGRNYYTKKKAIQLYRHGTSLEIWLGYVTSVLQYENSITLCADVSHKLLRIETAYDFIKRTSAQAQTGNIREEVTNKLIGSIVLTKYNNKTYRVDDIDWKQNPEDTFNKSDGSKITYIDYYRQQHKEIVTVKKQPLLVSQGRWKKGLTGTQREPILLIPQLCHMTGLTDEICKDYSIVKELAKHTRLSPRRRHHTLKEFINTLQDNKKVRELLQLWDLKFDTNFLSVPGRVLKNANIVQGRRMVKANSQGDWSREIRELPLLNAMPLHSWLILYSRSSHREAMSLKGHLQSVTAPMGITMKPAEMIEVDGDANSYIDTLRKYTRPTLQMGMSCLLVFKVICILPNDDKRRYDSIKRYLCTKCPIPSQCVVKKTLEKVQARTIVTKIAQQMNCKMGGALWKVETDVQRTMFVGIDCFHDIVNRQKSIAGFVASTNAELTKWYSQCVIQKTGEELVKELEICLKAALDVWCKNESSMPHSVIVYRDGVGDGQLQALLDHEAKKMSTYLKTISPNNFTLAFIVVKKRINTRFFLKHGSNFQNPPPGTVIDVELTRNEWYDFFIVSQSVQDGTVTPTHYNVIYDTIGLSPDTVQRLTYCLCHMYYNLPGIIRVPAPCHYAHKLAYLVGQSIHQEPNRSLSTRLFYL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
111	Acetylation	VNTRQDMKHVKDSKT ECCHHHHHCCCCCCC	54.24	7987831
307	Phosphorylation	RTSAQAQTGNIREEV HHCHHHCCCCCCHHH	34.90	26546556
325	Phosphorylation	LIGSIVLTKYNNKTY HCCEEEEEEECCEEE	22.16	24505115
515	Phosphorylation	HSWLILYSRSSHREA CHHHHEECCCCHHHH	23.42	24719451
526	Acetylation	HREAMSLKGHLQSVT HHHHHHHHHHHCCCC	36.66	7429659
600	Phosphorylation	SIKRYLCTKCPIPSQ HHHHHHHCCCCCCHH	32.84	22210691
633	Acetylation	IAQQMNCKMGGALWK HHHHCCCCCCCEEEE	35.26	7671003
672	Phosphorylation	SIAGFVASTNAELTK CHHHHHHCCCHHHHH	19.52	-
743	Phosphorylation	DHEAKKMSTYLKTIS HHHHHHHHHHHHHCC	23.84	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PIWL3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PIWL3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PIWL3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PIWL3_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.