| UniProt ID | CACO2_HUMAN | |
|---|---|---|
| UniProt AC | Q13137 | |
| Protein Name | Calcium-binding and coiled-coil domain-containing protein 2 | |
| Gene Name | CALCOCO2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 446 | |
| Subcellular Localization |
Cytoplasm, perinuclear region . Cytoplasm, cytoskeleton . Cytoplasmic vesicle, autophagosome membrane Peripheral membrane protein . According to PubMed:7540613, localizes to nuclear dots. According to PubMed:9230084 and PubMed:12869526, it is not a |
|
| Protein Description | Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy. [PubMed: 22246324 Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation] | |
| Protein Sequence | MEETIKDPPTSAVLLDHCHFSQVIFNSVEKFYIPGGDVTCHYTFTQHFIPRRKDWIGIFRVGWKTTREYYTFMWVTLPIDLNNKSAKQQEVQFKAYYLPKDDEYYQFCYVDEDGVVRGASIPFQFRPENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLSYMGLDFNSLPYQVPTSDEGGARQNPGLAYGNPYSGIQESSSPSPLSIKKCPICKADDICDHTLEQQQMQPLCFNCPICDKIFPATEKQIFEDHVFCHSL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MEETIKDPPTS ----CCCCCCCCCCC | 21.74 | 28122231 | |
| 10 | Phosphorylation | ETIKDPPTSAVLLDH CCCCCCCCCHHHCCC | 34.40 | 28122231 | |
| 11 | Phosphorylation | TIKDPPTSAVLLDHC CCCCCCCCHHHCCCC | 23.35 | 28122231 | |
| 12 | Ubiquitination | IKDPPTSAVLLDHCH CCCCCCCHHHCCCCC | 9.84 | 22817900 | |
| 15 | Ubiquitination | PPTSAVLLDHCHFSQ CCCCHHHCCCCCHHH | 3.21 | 22817900 | |
| 22 | Ubiquitination | LDHCHFSQVIFNSVE CCCCCHHHHHHCCCE | 31.23 | 27667366 | |
| 39 | Phosphorylation | YIPGGDVTCHYTFTQ EECCCCEEEEEEEEE | 9.78 | - | |
| 84 | Ubiquitination | LPIDLNNKSAKQQEV EEEECCCCCHHCCEE | 51.20 | 22817900 | |
| 87 | Ubiquitination | DLNNKSAKQQEVQFK ECCCCCHHCCEEEEE | 60.65 | 21906983 | |
| 88 | Ubiquitination | LNNKSAKQQEVQFKA CCCCCHHCCEEEEEE | 44.37 | 32015554 | |
| 94 | Ubiquitination | KQQEVQFKAYYLPKD HCCEEEEEEEECCCC | 20.56 | 27667366 | |
| 96 | Phosphorylation | QEVQFKAYYLPKDDE CEEEEEEEECCCCCC | 13.21 | - | |
| 96 | Ubiquitination | QEVQFKAYYLPKDDE CEEEEEEEECCCCCC | 13.21 | 32015554 | |
| 104 | Phosphorylation | YLPKDDEYYQFCYVD ECCCCCCCEEEEEEC | 15.01 | 22817900 | |
| 105 | Phosphorylation | LPKDDEYYQFCYVDE CCCCCCCEEEEEECC | 7.96 | 22817900 | |
| 105 | Ubiquitination | LPKDDEYYQFCYVDE CCCCCCCEEEEEECC | 7.96 | 22817900 | |
| 108 | Ubiquitination | DDEYYQFCYVDEDGV CCCCEEEEEECCCCC | 1.59 | 22817900 | |
| 111 | Ubiquitination | YYQFCYVDEDGVVRG CEEEEEECCCCCEEC | 23.07 | 22817900 | |
| 115 | Ubiquitination | CYVDEDGVVRGASIP EEECCCCCEECCCCC | 4.03 | 27667366 | |
| 118 | Ubiquitination | DEDGVVRGASIPFQF CCCCCEECCCCCEEC | 16.44 | 27667366 | |
| 120 | Ubiquitination | DGVVRGASIPFQFRP CCCEECCCCCEECCC | 33.35 | 29967540 | |
| 141 | Ubiquitination | LVVTTQGEVEEIEQH EEEEECCCHHHHHHH | 36.62 | 29967540 | |
| 144 | Phosphorylation | TTQGEVEEIEQHNKE EECCCHHHHHHHHHH | 57.93 | 27251275 | |
| 144 (in isoform 2) | Phosphorylation | - | 57.93 | 27251275 | |
| 147 (in isoform 2) | Phosphorylation | - | 51.63 | 27251275 | |
| 153 | Ubiquitination | EQHNKELCKENQELK HHHHHHHHHHCHHHH | 5.65 | 29967540 | |
| 160 | Ubiquitination | CKENQELKDSCISLQ HHHCHHHHHHHHHHH | 47.01 | 32015554 | |
| 165 | Phosphorylation | ELKDSCISLQKQNSD HHHHHHHHHHHHCHH | 29.13 | 24719451 | |
| 168 | Ubiquitination | DSCISLQKQNSDMQA HHHHHHHHHCHHHHH | 57.66 | 32015554 | |
| 170 | Ubiquitination | CISLQKQNSDMQAEL HHHHHHHCHHHHHHH | 47.19 | 33845483 | |
| 171 | Ubiquitination | ISLQKQNSDMQAELQ HHHHHHCHHHHHHHH | 31.78 | 29967540 | |
| 174 | Ubiquitination | QKQNSDMQAELQKKQ HHHCHHHHHHHHHHH | 36.35 | 33845483 | |
| 180 | Ubiquitination | MQAELQKKQEELETL HHHHHHHHHHHHHHH | 50.40 | 29967540 | |
| 181 | Ubiquitination | QAELQKKQEELETLQ HHHHHHHHHHHHHHH | 57.33 | 32015554 | |
| 183 | Ubiquitination | ELQKKQEELETLQSI HHHHHHHHHHHHHHH | 49.79 | 29967540 | |
| 184 | Ubiquitination | LQKKQEELETLQSIN HHHHHHHHHHHHHHH | 6.32 | 32015554 | |
| 189 | Ubiquitination | EELETLQSINKKLEL HHHHHHHHHHHHHHH | 31.10 | 32015554 | |
| 190 | Ubiquitination | ELETLQSINKKLELK HHHHHHHHHHHHHHH | 5.89 | 33845483 | |
| 192 | Ubiquitination | ETLQSINKKLELKVK HHHHHHHHHHHHHHH | 58.00 | 32015554 | |
| 200 | Ubiquitination | KLELKVKEQKDYWET HHHHHHHHHHCHHHH | 66.89 | 33845483 | |
| 201 | Ubiquitination | LELKVKEQKDYWETE HHHHHHHHHCHHHHH | 37.90 | 29967540 | |
| 204 | Phosphorylation | KVKEQKDYWETELLQ HHHHHHCHHHHHHHH | 16.51 | 28796482 | |
| 204 | Ubiquitination | KVKEQKDYWETELLQ HHHHHHCHHHHHHHH | 16.51 | 33845483 | |
| 207 | Phosphorylation | EQKDYWETELLQLKE HHHCHHHHHHHHHHH | 20.14 | 29978859 | |
| 209 | Ubiquitination | KDYWETELLQLKEQN HCHHHHHHHHHHHHH | 4.88 | 33845483 | |
| 213 | Ubiquitination | ETELLQLKEQNQKMS HHHHHHHHHHHHHCC | 44.27 | 29967540 | |
| 216 | Ubiquitination | LLQLKEQNQKMSSEN HHHHHHHHHHCCHHH | 44.52 | 29967540 | |
| 218 | Ubiquitination | QLKEQNQKMSSENEK HHHHHHHHCCHHHHH | 48.58 | 33845483 | |
| 220 | Ubiquitination | KEQNQKMSSENEKMG HHHHHHCCHHHHHHC | 41.35 | 33845483 | |
| 225 | Ubiquitination | KMSSENEKMGIRVDQ HCCHHHHHHCHHHHH | 54.75 | 29967540 | |
| 226 | Ubiquitination | MSSENEKMGIRVDQL CCHHHHHHCHHHHHH | 4.38 | 22817900 | |
| 227 | Ubiquitination | SSENEKMGIRVDQLQ CHHHHHHCHHHHHHH | 18.67 | 22053931 | |
| 228 | Phosphorylation | SENEKMGIRVDQLQA HHHHHHCHHHHHHHH | 3.29 | 27642862 | |
| 234 | Ubiquitination | GIRVDQLQAQLSTQE CHHHHHHHHHHHHCH | 22.79 | 29967540 | |
| 237 | Ubiquitination | VDQLQAQLSTQEKEM HHHHHHHHHHCHHHH | 7.20 | 29967540 | |
| 238 | Phosphorylation | DQLQAQLSTQEKEME HHHHHHHHHCHHHHH | 18.90 | 29507054 | |
| 239 | Phosphorylation | QLQAQLSTQEKEMEK HHHHHHHHCHHHHHH | 49.71 | 29978859 | |
| 239 | Ubiquitination | QLQAQLSTQEKEMEK HHHHHHHHCHHHHHH | 49.71 | 33845483 | |
| 240 | Ubiquitination | LQAQLSTQEKEMEKL HHHHHHHCHHHHHHH | 57.28 | 33845483 | |
| 242 | Ubiquitination | AQLSTQEKEMEKLVQ HHHHHCHHHHHHHHH | 53.17 | 21906983 | |
| 246 | Ubiquitination | TQEKEMEKLVQGDQD HCHHHHHHHHHCCHH | 53.28 | 33845483 | |
| 248 | Ubiquitination | EKEMEKLVQGDQDKT HHHHHHHHHCCHHHH | 9.90 | 33845483 | |
| 249 | Ubiquitination | KEMEKLVQGDQDKTE HHHHHHHHCCHHHHH | 61.25 | 29967540 | |
| 256 | Ubiquitination | QGDQDKTEQLEQLKK HCCHHHHHHHHHHHH | 59.93 | 22817900 | |
| 257 | Ubiquitination | GDQDKTEQLEQLKKE CCHHHHHHHHHHHHH | 56.37 | 22053931 | |
| 262 | 2-Hydroxyisobutyrylation | TEQLEQLKKENDHLF HHHHHHHHHHCCCEE | 58.71 | - | |
| 262 | Phosphorylation | TEQLEQLKKENDHLF HHHHHHHHHHCCCEE | 58.71 | 27251275 | |
| 262 | Ubiquitination | TEQLEQLKKENDHLF HHHHHHHHHHCCCEE | 58.71 | 33845483 | |
| 263 | Ubiquitination | EQLEQLKKENDHLFL HHHHHHHHHCCCEEE | 71.05 | 33845483 | |
| 266 | Ubiquitination | EQLKKENDHLFLSLT HHHHHHCCCEEEHHH | 40.74 | 33845483 | |
| 267 | Ubiquitination | QLKKENDHLFLSLTE HHHHHCCCEEEHHHH | 30.02 | 21963094 | |
| 270 | Ubiquitination | KENDHLFLSLTEQRK HHCCCEEEHHHHHHH | 5.29 | 33845483 | |
| 271 | Phosphorylation | ENDHLFLSLTEQRKD HCCCEEEHHHHHHHH | 26.38 | 27251275 | |
| 281 | Ubiquitination | EQRKDQKKLEQTVEQ HHHHHHHHHHHHHHH | 52.18 | 29901268 | |
| 283 | Ubiquitination | RKDQKKLEQTVEQMK HHHHHHHHHHHHHHH | 53.75 | 33845483 | |
| 285 | Phosphorylation | DQKKLEQTVEQMKQN HHHHHHHHHHHHHHH | 19.35 | 29083192 | |
| 286 | Ubiquitination | QKKLEQTVEQMKQNE HHHHHHHHHHHHHHH | 4.87 | 33845483 | |
| 290 | Ubiquitination | EQTVEQMKQNETTAM HHHHHHHHHHHHHHH | 50.06 | 33845483 | |
| 295 | Phosphorylation | QMKQNETTAMKKQQE HHHHHHHHHHHHHHH | 20.69 | 27251275 | |
| 297 | Ubiquitination | KQNETTAMKKQQELM HHHHHHHHHHHHHHH | 5.38 | 21963094 | |
| 298 | Acetylation | QNETTAMKKQQELMD HHHHHHHHHHHHHHH | 44.99 | 25953088 | |
| 298 | Ubiquitination | QNETTAMKKQQELMD HHHHHHHHHHHHHHH | 44.99 | 22817900 | |
| 299 | Ubiquitination | NETTAMKKQQELMDE HHHHHHHHHHHHHHC | 44.09 | 21906983 | |
| 302 | Ubiquitination | TAMKKQQELMDENFD HHHHHHHHHHHCCCC | 43.50 | 33845483 | |
| 305 | Ubiquitination | KKQQELMDENFDLSK HHHHHHHHCCCCHHH | 61.38 | 33845483 | |
| 311 | Ubiquitination | MDENFDLSKRLSENE HHCCCCHHHHCCCCH | 19.99 | 33845483 | |
| 312 | Ubiquitination | DENFDLSKRLSENEI HCCCCHHHHCCCCHH | 65.73 | 21906983 | |
| 314 | Ubiquitination | NFDLSKRLSENEIIC CCCHHHHCCCCHHHH | 9.65 | 33845483 | |
| 315 | Phosphorylation | FDLSKRLSENEIICN CCHHHHCCCCHHHHH | 42.27 | 30266825 | |
| 319 | Ubiquitination | KRLSENEIICNALQR HHCCCCHHHHHHHHH | 7.02 | 22817900 | |
| 320 | Ubiquitination | RLSENEIICNALQRQ HCCCCHHHHHHHHHH | 0.90 | 22053931 | |
| 322 | Ubiquitination | SENEIICNALQRQKE CCCHHHHHHHHHHHH | 33.02 | 22817900 | |
| 323 | Ubiquitination | ENEIICNALQRQKER CCHHHHHHHHHHHHH | 10.72 | 23000965 | |
| 324 | Ubiquitination | NEIICNALQRQKERL CHHHHHHHHHHHHHH | 2.41 | 23000965 | |
| 329 | Ubiquitination | NALQRQKERLEGEND HHHHHHHHHHHCCCH | 54.91 | 23000965 | |
| 333 | Ubiquitination | RQKERLEGENDLLKR HHHHHHHCCCHHHHH | 43.53 | 33845483 | |
| 336 | Ubiquitination | ERLEGENDLLKRENS HHHHCCCHHHHHHHH | 49.42 | 33845483 | |
| 339 | Phosphorylation | EGENDLLKRENSRLL HCCCHHHHHHHHHHH | 66.03 | 27251275 | |
| 339 | Ubiquitination | EGENDLLKRENSRLL HCCCHHHHHHHHHHH | 66.03 | 21906983 | |
| 347 | Phosphorylation | RENSRLLSYMGLDFN HHHHHHHHHCCCCCC | 20.05 | 22199227 | |
| 348 | Phosphorylation | ENSRLLSYMGLDFNS HHHHHHHHCCCCCCC | 8.65 | 29523821 | |
| 353 | Ubiquitination | LSYMGLDFNSLPYQV HHHCCCCCCCCCCCC | 8.88 | 23000965 | |
| 354 | Ubiquitination | SYMGLDFNSLPYQVP HHCCCCCCCCCCCCC | 42.16 | 23000965 | |
| 355 | Phosphorylation | YMGLDFNSLPYQVPT HCCCCCCCCCCCCCC | 30.62 | 22199227 | |
| 358 | Phosphorylation | LDFNSLPYQVPTSDE CCCCCCCCCCCCCCC | 27.69 | 29523821 | |
| 359 | Ubiquitination | DFNSLPYQVPTSDEG CCCCCCCCCCCCCCC | 32.54 | 23000965 | |
| 360 | Ubiquitination | FNSLPYQVPTSDEGG CCCCCCCCCCCCCCC | 4.63 | 21963094 | |
| 362 | Ubiquitination | SLPYQVPTSDEGGAR CCCCCCCCCCCCCCC | 50.37 | 32015554 | |
| 363 | Ubiquitination | LPYQVPTSDEGGARQ CCCCCCCCCCCCCCC | 27.82 | 21963094 | |
| 376 | Phosphorylation | RQNPGLAYGNPYSGI CCCCCCCCCCCCCCC | 23.60 | 29978859 | |
| 379 | Phosphorylation | PGLAYGNPYSGIQES CCCCCCCCCCCCCCC | 21.94 | 27251275 | |
| 380 | Phosphorylation | GLAYGNPYSGIQESS CCCCCCCCCCCCCCC | 24.43 | 29978859 | |
| 381 | Phosphorylation | LAYGNPYSGIQESSS CCCCCCCCCCCCCCC | 30.58 | 29978859 | |
| 382 | Phosphorylation | AYGNPYSGIQESSSP CCCCCCCCCCCCCCC | 21.54 | 27642862 | |
| 386 | Phosphorylation | PYSGIQESSSPSPLS CCCCCCCCCCCCCCC | 21.53 | 26657352 | |
| 387 | Phosphorylation | YSGIQESSSPSPLSI CCCCCCCCCCCCCCC | 45.58 | 25850435 | |
| 388 | Phosphorylation | SGIQESSSPSPLSIK CCCCCCCCCCCCCCC | 38.38 | 25850435 | |
| 390 | Phosphorylation | IQESSSPSPLSIKKC CCCCCCCCCCCCCCC | 40.18 | 29116813 | |
| 392 | Ubiquitination | ESSSPSPLSIKKCPI CCCCCCCCCCCCCCC | 10.96 | 32015554 | |
| 393 | Phosphorylation | SSSPSPLSIKKCPIC CCCCCCCCCCCCCCC | 35.43 | 25850435 | |
| 395 | Acetylation | SPSPLSIKKCPICKA CCCCCCCCCCCCCCH | 44.97 | 25953088 | |
| 395 | Ubiquitination | SPSPLSIKKCPICKA CCCCCCCCCCCCCCH | 44.97 | 23000965 | |
| 396 | Ubiquitination | PSPLSIKKCPICKAD CCCCCCCCCCCCCHH | 43.50 | 23000965 | |
| 401 | Ubiquitination | IKKCPICKADDICDH CCCCCCCCHHHCCCC | 56.42 | 23000965 | |
| 411 | Phosphorylation | DICDHTLEQQQMQPL HCCCCCHHHHHCCCH | 47.72 | 27251275 | |
| 414 | Phosphorylation | DHTLEQQQMQPLCFN CCCHHHHHCCCHHCC | 31.97 | 27251275 | |
| 416 | Ubiquitination | TLEQQQMQPLCFNCP CHHHHHCCCHHCCCC | 24.39 | 23000965 | |
| 417 | Ubiquitination | LEQQQMQPLCFNCPI HHHHHCCCHHCCCCC | 26.25 | 23000965 | |
| 419 | Ubiquitination | QQQMQPLCFNCPICD HHHCCCHHCCCCCCC | 2.68 | 23000965 | |
| 420 | Ubiquitination | QQMQPLCFNCPICDK HHCCCHHCCCCCCCH | 16.18 | 23000965 | |
| 422 | Ubiquitination | MQPLCFNCPICDKIF CCCHHCCCCCCCHHC | 0.90 | 23000965 | |
| 425 | Ubiquitination | LCFNCPICDKIFPAT HHCCCCCCCHHCCCC | 2.35 | 23000965 | |
| 434 | Ubiquitination | KIFPATEKQIFEDHV HHCCCCHHHHHHCCC | 44.32 | 32015554 | |
| 445 | Phosphorylation | EDHVFCHSL------ HCCCCCCCC------ | 36.63 | 30266825 | |
| 455 | Ubiquitination | ---------------- ---------------- | 32015554 | ||
| 458 | Ubiquitination | ------------------- ------------------- | 32015554 | ||
| 469 | Phosphorylation | ------------------------------ ------------------------------ | 27251275 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CACO2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CACO2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CACO2_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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