DUS26_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DUS26_HUMAN
• UniProt AC: Q9BV47
• Protein Name: Dual specificity protein phosphatase 26
• Gene Name: DUSP26
• Organism: Homo sapiens (Human).
• Sequence Length: 211
• Subcellular Localization: Cytoplasm. Nucleus. Golgi apparatus.
• Protein Description: Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK)..
• Protein Sequence: MCPGNWLWASMTFMARFSRSSSRSPVRTRGTLEEMPTVQHPFLNVFELERLLYTGKTACNHADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSRWRGTPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQPGGKILVHCAVGVSRSATLVLAYLMLYHHLTLVEAIKKVKDHRGIIPNRGFLRQLLALDRRLRQGLEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	PGNWLWASMTFMARF CCCCHHHHHHHHHHH	13.53	24043423
12	Phosphorylation	NWLWASMTFMARFSR CCHHHHHHHHHHHCC	14.04	24043423
18	Phosphorylation	MTFMARFSRSSSRSP HHHHHHHCCCCCCCC	26.21	-
20	Phosphorylation	FMARFSRSSSRSPVR HHHHHCCCCCCCCCC	31.31	26437602
22	Phosphorylation	ARFSRSSSRSPVRTR HHHCCCCCCCCCCCC	37.72	20068231
24	Phosphorylation	FSRSSSRSPVRTRGT HCCCCCCCCCCCCCC	29.69	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DUS26_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DUS26_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DUS26_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NEUL4_HUMAN	NEURL4	physical	27880917
HERC2_HUMAN	HERC2	physical	27880917
PTPRG_HUMAN	PTPRG	physical	27880917
DUS26_HUMAN	DUSP26	physical	27432908
ABTB2_HUMAN	ABTB2	physical	27432908
MRRP1_HUMAN	TRMT10C	physical	27432908
DCTP1_HUMAN	DCTPP1	physical	27432908
DUS23_HUMAN	DUSP23	physical	27432908
UBR2_HUMAN	UBR2	physical	27432908
GID8_HUMAN	GID8	physical	27432908
DOCK7_HUMAN	DOCK7	physical	27432908
WIPI4_HUMAN	WDR45	physical	27432908
ATG2B_HUMAN	ATG2B	physical	27432908
ZNF99_HUMAN	ZNF99	physical	27432908
UBR5_HUMAN	UBR5	physical	27432908
HCD2_HUMAN	HSD17B10	physical	27432908
XPP1_HUMAN	XPNPEP1	physical	27432908
IF5A1_HUMAN	EIF5A	physical	27432908

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.