DUS23_HUMAN - dbPTM
DUS23_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DUS23_HUMAN
UniProt AC Q9BVJ7
Protein Name Dual specificity protein phosphatase 23
Gene Name DUSP23
Organism Homo sapiens (Human).
Sequence Length 150
Subcellular Localization Cytoplasm, cytosol. Nucleus. Mainly cytosolic. Also nuclear.
Protein Description Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14)..
Protein Sequence MGVQPPNFSWVLPGRLAGLALPRLPAHYQFLLDLGVRHLVSLTERGPPHSDSCPGLTLHRLRIPDFCPPAPDQIDRFVQIVDEANARGEAVGVHCALGFGRTGTMLACYLVKERGLAAGDAIAEIRRLRPGSIETYEQEKAVFQFYQRTK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
52PhosphorylationRGPPHSDSCPGLTLH
CCCCCCCCCCCCEEE		25.8127251275
102PhosphorylationCALGFGRTGTMLACY
EECCCCCCHHHHHHH		37.0728857561
104PhosphorylationLGFGRTGTMLACYLV
CCCCCCHHHHHHHHH		14.3828857561
109PhosphorylationTGTMLACYLVKERGL
CHHHHHHHHHHHCCC		14.6629083192
132PhosphorylationIRRLRPGSIETYEQE
HHHHCCCCCCCHHHH		21.6728857561
136PhosphorylationRPGSIETYEQEKAVF
CCCCCCCHHHHHHHH		11.6527642862
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DUS23_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DUS23_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DUS23_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GCM1_HUMANGCM1physical
20855292
DREB_HUMANDBN1physical
21900206
TBA1A_HUMANTUBA1Aphysical
21900206
CC186_HUMANCCDC186physical
21900206
ASM_HUMANSMPD1physical
21900206
KAT5_HUMANKAT5physical
21900206
RUFY2_HUMANRUFY2physical
21900206
CE126_HUMANKIAA1377physical
21900206
ASB13_HUMANASB13physical
21900206
EDRF1_HUMANEDRF1physical
21900206
EED_HUMANEEDphysical
21900206
MTFR1_HUMANMTFR1physical
21900206
RM20_HUMANMRPL20physical
21900206
PRDX4_HUMANPRDX4physical
21900206
TMOD3_HUMANTMOD3physical
21900206
SHC1_HUMANSHC1physical
21900206
ACBP_HUMANDBIphysical
21900206
MKRN1_HUMANMKRN1physical
21900206
ZN746_HUMANZNF746physical
21900206
DNM3B_HUMANDNMT3Bphysical
21900206
KBTB7_HUMANKBTBD7physical
21900206
NIF3L_HUMANNIF3L1physical
25416956
PLK4_HUMANPLK4physical
27880917
RGPA1_HUMANRALGAPA1physical
27880917
DUS23_HUMANDUSP23physical
27432908
RAD50_HUMANRAD50physical
27432908
TMM70_HUMANTMEM70physical
27432908
RAC1_HUMANRAC1physical
27432908
GDS1_HUMANRAP1GDS1physical
27432908
PGRC2_HUMANPGRMC2physical
27432908
AP3S1_HUMANAP3S1physical
27432908
VDAC3_HUMANVDAC3physical
27432908
MTCH2_HUMANMTCH2physical
27432908
SSRA_HUMANSSR1physical
27432908
FOG2_HUMANZFPM2physical
27432908
SAMC_HUMANSLC25A26physical
27432908
TI17B_HUMANTIMM17Bphysical
27432908
PTSS2_HUMANPTDSS2physical
27432908
RAB34_HUMANRAB34physical
27432908
DUS28_HUMANDUSP28physical
27432908
CIRBP_HUMANCIRBPphysical
27432908
RAB28_HUMANRAB28physical
27432908
KAD6_HUMANAK6physical
27432908
NDK3_HUMANNME3physical
27432908
UBC12_HUMANUBE2Mphysical
27432908
KT3K_HUMANFN3KRPphysical
27432908
OTUL_HUMANOTULINphysical
27432908
HDDC2_HUMANHDDC2physical
27432908
SUGP1_HUMANSUGP1physical
28514442
ERIC5_HUMANERICH5physical
28514442
CA131_HUMANC1orf131physical
28514442
RBM27_HUMANRBM27physical
28514442
DNM1L_HUMANDNM1Lphysical
28514442
CTBL1_HUMANCTNNBL1physical
28514442
PRC2A_HUMANPRRC2Aphysical
28514442
AHNK2_HUMANAHNAK2physical
28514442
RED_HUMANIKphysical
28514442
SCYL1_HUMANSCYL1physical
28514442
FACE1_HUMANZMPSTE24physical
28514442
PTPRG_HUMANPTPRGphysical
28514442
ADDB_HUMANADD2physical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DUS23_HUMAN

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Related Literatures of Post-Translational Modification

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