| UniProt ID | SAMC_HUMAN | |
|---|---|---|
| UniProt AC | Q70HW3 | |
| Protein Name | S-adenosylmethionine mitochondrial carrier protein | |
| Gene Name | SLC25A26 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 274 | |
| Subcellular Localization |
Mitochondrion inner membrane Multi-pass membrane protein . |
|
| Protein Description | Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria.. | |
| Protein Sequence | MDRPGFVAALVAGGVAGVSVDLILFPLDTIKTRLQSPQGFSKAGGFHGIYAGVPSAAIGSFPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQRAQVSASTRTFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKALWSWRQDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRITLAKAGSSTADGNVLSVLHGVWRSQGLAGLFAGVFPRMAAISLGGFIFLGAYDRTHSLLLEVGRKSP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 25 (in isoform 2) | Ubiquitination | - | 4.47 | 21906983 | |
| 25 (in isoform 3) | Ubiquitination | - | 4.47 | 21906983 | |
| 113 | Ubiquitination | RVPSEVVKQRAQVSA ECCHHHHHHHHCCCC | 38.96 | 2190698 | |
| 113 | Ubiquitination | RVPSEVVKQRAQVSA ECCHHHHHHHHCCCC | 38.96 | - | |
| 113 (in isoform 1) | Ubiquitination | - | 38.96 | 21906983 | |
| 124 | Phosphorylation | QVSASTRTFQIFSNI CCCCCHHHHHHHHHH | 21.71 | 27732954 | |
| 129 | Phosphorylation | TRTFQIFSNILYEEG HHHHHHHHHHHHHHH | 25.29 | 27732954 | |
| 133 | Phosphorylation | QIFSNILYEEGIQGL HHHHHHHHHHHCHHH | 14.24 | 27732954 | |
| 141 | Phosphorylation | EEGIQGLYRGYKSTV HHHCHHHHCCCCCCC | 14.60 | 27732954 | |
| 147 | Phosphorylation | LYRGYKSTVLREIPF HHCCCCCCCHHHCCC | 21.29 | 24719451 | |
| 231 | Phosphorylation | VLHGVWRSQGLAGLF HHHHHHHHCCHHHHH | 16.94 | - | |
| 262 | Phosphorylation | FLGAYDRTHSLLLEV EECCCCCCCCHHHHC | 16.96 | 24114839 | |
| 264 | Phosphorylation | GAYDRTHSLLLEVGR CCCCCCCCHHHHCCC | 21.79 | 21964256 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SAMC_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SAMC_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SAMC_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MARH5_HUMAN | MARCH5 | physical | 26813789 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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