| UniProt ID | MARH5_HUMAN | |
|---|---|---|
| UniProt AC | Q9NX47 | |
| Protein Name | E3 ubiquitin-protein ligase MARCH5 | |
| Gene Name | 5-Mar | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 278 | |
| Subcellular Localization |
Mitochondrion outer membrane Multi-pass membrane protein . Endoplasmic reticulum membrane Multi-pass membrane protein . Authors show that the protein can be detected in endoplasmic reticulum (PubMed:14722266). Authors (PubMed:16874301) show its p |
|
| Protein Description | Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1.. | |
| Protein Sequence | MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVHQACLQRWVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYVLDLADRLISKACPFAAAGIMVGSIYWTAVTYGAVTVMQVVGHKEGLDVMERADPLFLLIGLPTIPVMLILGKMIRWEDYVLRLWRKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTIATIVGKLMFSSVNSNLQRTILGGIAFVAIKGAFKVYFKQQQYLRQAHRKILNYPEQEEA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Sulfoxidation | PDQALQQMLDRSCWV CHHHHHHHHHHCCEE | 2.44 | 21406390 | |
| 40 | Ubiquitination | CRCRGSTKWVHQACL CCCCCCHHHHHHHHH | 49.25 | 22505724 | |
| 46 | S-nitrosocysteine | TKWVHQACLQRWVDE HHHHHHHHHHHHHCH | 2.40 | - | |
| 46 | S-nitrosylation | TKWVHQACLQRWVDE HHHHHHHHHHHHHCH | 2.40 | 21278135 | |
| 54 | Ubiquitination | LQRWVDEKQRGNSTA HHHHHCHHHHCCCCC | 40.61 | 21906983 | |
| 164 | Phosphorylation | KMIRWEDYVLRLWRK CHHCHHHHHHHHHHH | 7.00 | - | |
| 179 | Ubiquitination | YSNKLQILNSIFPGI HHCHHHHHHHHCCCC | 2.37 | 22817900 | |
| 183 | Ubiquitination | LQILNSIFPGIGCPV HHHHHHHCCCCCCCC | 4.56 | 21890473 | |
| 194 | Ubiquitination | GCPVPRIPAEANPLA CCCCCCCCCCCCHHH | 25.90 | 22817900 | |
| 238 | O-linked_Glycosylation | VNSNLQRTILGGIAF HCHHHHHHHHHHHHH | 13.95 | 30379171 | |
| 253 | Ubiquitination | VAIKGAFKVYFKQQQ HEECHHHHHHHHHHH | 35.18 | 22817900 | |
| 257 | Ubiquitination | GAFKVYFKQQQYLRQ HHHHHHHHHHHHHHH | 29.52 | 21906983 | |
| 268 | Ubiquitination | YLRQAHRKILNYPEQ HHHHHHHHHHCCHHH | 41.50 | 21906983 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MARH5_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MARH5_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
