S2538_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S2538_HUMAN
• UniProt AC: Q96DW6
• Protein Name: Mitochondrial glycine transporter {ECO:0000255|HAMAP-Rule:MF_03064}
• Gene Name: SLC25A38 {ECO:0000255|HAMAP-Rule:MF_03064}
• Organism: Homo sapiens (Human).
• Sequence Length: 304
• Subcellular Localization: Mitochondrion inner membrane ; Multi-pass membrane protein .
• Protein Description: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis..
• Protein Sequence: MIQNSRPSLLQPQDVGDTVETLMLHPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVRTESLLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALESVMLGVGSRSVAGVCMSPITVIKTRYESGKYGYESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLMFYNQTKNIVPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTHMQLYPLKFQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYEEMMAKMGLKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
110	Phosphorylation	IYFGTLYSLKQYFLR CHHHHHHHHHHHHHC	32.00	24719451
179	Phosphorylation	EGHRGLFSGLTATLL CCCCCCCCCHHHHHH	37.63	-
182	Phosphorylation	RGLFSGLTATLLRDA CCCCCCHHHHHHHCC	22.56	-
266	Phosphorylation	VTLIFKDYGLRGFFQ HHHHHHHHCCCHHHC	20.74	-
283	Phosphorylation	IPRALRRTLMAAMAW CCHHHHHHHHHHHHH	17.91	25262027
291	Phosphorylation	LMAAMAWTVYEEMMA HHHHHHHHHHHHHHH	12.04	25262027
293	Phosphorylation	AAMAWTVYEEMMAKM HHHHHHHHHHHHHHC	9.97	25262027

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S2538_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S2538_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S2538_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MFN1_HUMAN	MFN1	physical	26813789
MFN2_HUMAN	MFN2	physical	26813789
MARH5_HUMAN	MARCH5	physical	26813789

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.