MAP1B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAP1B_HUMAN
• UniProt AC: P46821
• Protein Name: Microtubule-associated protein 1B
• Gene Name: MAP1B
• Organism: Homo sapiens (Human).
• Sequence Length: 2468
• Subcellular Localization: Cytoplasm, cytoskeleton . Cytoplasm . Cell junction, synapse. Cell projection, dendritic spine. Colocalizes with DAPK1 in the microtubules and cortical actin fibers..
• Protein Description: Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing..
• Protein Sequence: MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRAIGNIELGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVPGQKILHHRSDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFIEIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEMEGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNMLINGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNSDWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVGNTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQWTGTNKDKAEFILPNGQEVDLPISYLTSVSSLIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLSPKSDISPLTPRESSPLYSPTFSDSTSAVKEKTATCHSSSSPPIDAASAEPYGFRASVLFDTMQHHLALNRDLSTPGLEKDSGGKTPGDFSYAYQKPEETTRSPDEEDYDYESYEKTTRTSDVGGYYYEKIERTTKSPSDSGYSYETIGKTTKTPEDGDYSYEIIEKTTRTPEEGGYSYDISEKTTSPPEVSGYSYEKTERSRRLLDDISNGYDDSEDGGHTLGDPSYSYETTEKITSFPESEGYSYETSTKTTRTPDTSTYCYETAEKITRTPQASTYSYETSDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKSSAVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGNDPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLASSSTVVMQDESFPACKIEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATVVVEAT ------CCEEEEEEC	22.02	21406692
3	Phosphorylation	-----MATVVVEATE -----CCEEEEEECC	26.20	21406692
9	Phosphorylation	ATVVVEATEPEPSGS CEEEEEECCCCCCCC	38.27	30108239
14	Phosphorylation	EATEPEPSGSIANPA EECCCCCCCCCCCCC	43.44	24043423
16	Phosphorylation	TEPEPSGSIANPAAS CCCCCCCCCCCCCCC	23.90	30206219
23	Phosphorylation	SIANPAASTSPSLSH CCCCCCCCCCCCHHH	31.37	21955146
24	Phosphorylation	IANPAASTSPSLSHR CCCCCCCCCCCHHHH	39.67	21955146
25	Phosphorylation	ANPAASTSPSLSHRF CCCCCCCCCCHHHHH	15.25	28355574
27	Phosphorylation	PAASTSPSLSHRFLD CCCCCCCCHHHHHHC	42.12	21955146
29	Phosphorylation	ASTSPSLSHRFLDSK CCCCCCHHHHHHCCC	19.56	21955146
35	Phosphorylation	LSHRFLDSKFYLLVV HHHHHHCCCEEEEEE	27.15	29514088
84	Phosphorylation	QELKLFVSRHSARFS HHHHHHHHHHCCCCC	19.55	29514088
87	Phosphorylation	KLFVSRHSARFSPEV HHHHHHHCCCCCCCC	21.74	29514088
91	Phosphorylation	SRHSARFSPEVPGQK HHHCCCCCCCCCCCE	18.01	23403867
129	Phosphorylation	TEVRLMITDAARHKL CHHHHHHHHHHHCCE	12.96	21406692
203	Methylation	WKNSNLDRHNLQDFI CCCCCCCCCCHHHHH	24.62	115482535
259	Ubiquitination	GGFLKLSKPCCYIFP CCCCCCCCCEEEEEC	53.14	-
327	Ubiquitination	INSMLQRKIAELEEE HHHHHHHHHHHHHHH	33.05	-
336	Phosphorylation	AELEEEQSQGSTTNS HHHHHHHHCCCCCCH	39.53	17525332
339	Phosphorylation	EEEQSQGSTTNSDWM HHHHHCCCCCCHHHH	25.15	22617229
340	Phosphorylation	EEQSQGSTTNSDWMK HHHHCCCCCCHHHHH	36.50	21712546
341	Phosphorylation	EQSQGSTTNSDWMKN HHHCCCCCCHHHHHH	34.13	22167270
343	Phosphorylation	SQGSTTNSDWMKNLI HCCCCCCHHHHHHHC	30.47	22167270
346	Sulfoxidation	STTNSDWMKNLISPD CCCCHHHHHHHCCCC	2.18	30846556
351	Phosphorylation	DWMKNLISPDLGVVF HHHHHHCCCCCEEEE	18.61	-
366	Ubiquitination	LNVPENLKNPEPNIK ECCCHHHCCCCCCCC	80.28	-
405	Phosphorylation	LFRSVGNTIDPVILF CCCCCCCCCCCCHHE	22.34	21712546
423	Phosphorylation	GVGKLEMYVLNPVKS CCCEEEEEEECCCCC	7.75	21712546
429	Malonylation	MYVLNPVKSSKEMQY EEEECCCCCHHHHHH	50.71	26320211
436	Phosphorylation	KSSKEMQYFMQQWTG CCHHHHHHHHHHHCC	10.33	30622161
442	Phosphorylation	QYFMQQWTGTNKDKA HHHHHHHCCCCCCCC	29.77	30622161
444	Phosphorylation	FMQQWTGTNKDKAEF HHHHHCCCCCCCCEE	31.55	30622161
504	Ubiquitination	NILEGLEKLKHLDFL CHHHHHHHHCCCHHH	68.80	-
506	2-Hydroxyisobutyrylation	LEGLEKLKHLDFLKQ HHHHHHHCCCHHHCC	53.87	-
506	Acetylation	LEGLEKLKHLDFLKQ HHHHHHHCCCHHHCC	53.87	19608861
517	Phosphorylation	FLKQPLATQKDLTGQ HHCCCCCCCCCCCCC	43.78	-
519	Ubiquitination	KQPLATQKDLTGQVP CCCCCCCCCCCCCCC	50.80	-
522	Phosphorylation	LATQKDLTGQVPTPV CCCCCCCCCCCCCHH	35.38	30266825
527	Phosphorylation	DLTGQVPTPVVKQTK CCCCCCCCHHHCHHH	29.83	30266825
531	Malonylation	QVPTPVVKQTKLKQR CCCCHHHCHHHCCHH	53.11	26320211
531	Ubiquitination	QVPTPVVKQTKLKQR CCCCHHHCHHHCCHH	53.11	21890473
541	Phosphorylation	KLKQRADSRESLKPA HCCHHCCCHHHCCCC	36.64	29255136
544	Phosphorylation	QRADSRESLKPAAKP HHCCCHHHCCCCCCC	40.35	29255136
546	Ubiquitination	ADSRESLKPAAKPLP CCCHHHCCCCCCCCC	41.72	-
554	Phosphorylation	PAAKPLPSKSVRKES CCCCCCCCHHHCCCC	45.29	25219547
561	Phosphorylation	SKSVRKESKEETPEV CHHHCCCCCCCCCCC	48.69	29255136
562	Ubiquitination	KSVRKESKEETPEVT HHHCCCCCCCCCCCC	61.74	-
565	Phosphorylation	RKESKEETPEVTKVN CCCCCCCCCCCCCCC	26.32	24702127
569	Phosphorylation	KEETPEVTKVNHVEK CCCCCCCCCCCCCCC	27.84	22817900
582	Phosphorylation	EKPPKVESKEKVMVK CCCCCCCCCCCEEEE	49.45	27732954
596	Phosphorylation	KKDKPIKTETKPSVT ECCCCCCCCCCCCCC	50.00	23403867
598	Phosphorylation	DKPIKTETKPSVTEK CCCCCCCCCCCCCCC	54.19	23403867
601	Phosphorylation	IKTETKPSVTEKEVP CCCCCCCCCCCCCCC	43.13	23403867
603	Phosphorylation	TETKPSVTEKEVPSK CCCCCCCCCCCCCCC	45.75	29457462
605	2-Hydroxyisobutyrylation	TKPSVTEKEVPSKEE CCCCCCCCCCCCCCC	55.43	-
609	Phosphorylation	VTEKEVPSKEEPSPV CCCCCCCCCCCCCCH	58.85	22167270
614	Phosphorylation	VPSKEEPSPVKAEVA CCCCCCCCCHHHHHH	45.68	29255136
623	2-Hydroxyisobutyrylation	VKAEVAEKQATDVKP HHHHHHHHHCCCCCC	35.18	-
636	Acetylation	KPKAAKEKTVKKETK CCHHHHHHCCCCCCC	58.89	18530439
643	Acetylation	KTVKKETKVKPEDKK HCCCCCCCCCHHHHH	49.72	18530449
666	2-Hydroxyisobutyrylation	EVAKKEDKTPIKKEE HHCCCCCCCCCCCCC	58.24	-
667	Phosphorylation	VAKKEDKTPIKKEEK HCCCCCCCCCCCCCC	42.44	24719451
685	Acetylation	EEVKKEVKKEIKKEE HHHHHHHHHHHHHHH	45.86	88157
686	Acetylation	EVKKEVKKEIKKEEK HHHHHHHHHHHHHHH	70.60	88161
693	Acetylation	KEIKKEEKKEPKKEV HHHHHHHHCCCCHHH	64.62	88153
694	Acetylation	EIKKEEKKEPKKEVK HHHHHHHCCCCHHHC	80.62	88165
704	Phosphorylation	KKEVKKETPPKEVKK CHHHCCCCCCHHHHH	54.49	30266825
707	Acetylation	VKKETPPKEVKKEVK HCCCCCCHHHHHHHH	76.09	70111
714	Acetylation	KEVKKEVKKEEKKEV HHHHHHHHHHHHHHH	56.40	70115
715	Acetylation	EVKKEVKKEEKKEVK HHHHHHHHHHHHHHH	76.04	70119
719	Acetylation	EVKKEEKKEVKKEEK HHHHHHHHHHHHHHH	71.65	70123
742	Phosphorylation	LPKDAKKSSTPLSEA CCCCHHHCCCCHHHC	38.44	28985074
743	Phosphorylation	PKDAKKSSTPLSEAK CCCHHHCCCCHHHCC	42.81	28857561
744	Phosphorylation	KDAKKSSTPLSEAKK CCHHHCCCCHHHCCC	35.03	22199227
747	Phosphorylation	KKSSTPLSEAKKPAA HHCCCCHHHCCCCHH	36.39	29214152
765	Phosphorylation	KVPKKEESVKKDSVA CCCCCHHHCCCCCCC	40.09	24702127
770	Phosphorylation	EESVKKDSVAAGKPK HHHCCCCCCCCCCCC	23.64	29514088
790	Acetylation	KVIKKEGKAAEAVAA EEEECCCHHHHHHHH	45.58	133083
828	Phosphorylation	KELEAERSLMSSPED HHHHHHHHHCCCHHH	21.67	29255136
831	Phosphorylation	EAERSLMSSPEDLTK HHHHHHCCCHHHHHH	48.29	29255136
832	Phosphorylation	AERSLMSSPEDLTKD HHHHHCCCHHHHHHC	20.53	29255136
837	Phosphorylation	MSSPEDLTKDFEELK CCCHHHHHHCHHHHH	40.67	30266825
851	Phosphorylation	KAEEVDVTKDIKPQL HHHHCCCCCCCHHHH	20.66	29632367
868	2-Hydroxyisobutyrylation	IEDEEKLKETEPVEA HCCHHHHCCCCCCEE	73.91	-
870	Phosphorylation	DEEKLKETEPVEAYV CHHHHCCCCCCEEEE	43.96	26074081
876	Phosphorylation	ETEPVEAYVIQKERE CCCCCEEEEEECEEE	5.65	29978859
885	Phosphorylation	IQKEREVTKGPAESP EECEEEECCCCCCCC	26.07	29116813
891	Phosphorylation	VTKGPAESPDEGITT ECCCCCCCCCCCCCC	39.49	30175587
897	Phosphorylation	ESPDEGITTTEGEGE CCCCCCCCCCCCCCC	38.22	21955146
898	Phosphorylation	SPDEGITTTEGEGEC CCCCCCCCCCCCCCC	22.41	29632367
899	Phosphorylation	PDEGITTTEGEGECE CCCCCCCCCCCCCCC	33.09	29632367
908	Phosphorylation	GEGECEQTPEELEPV CCCCCCCCHHHCCCC	15.46	21955146
936	Phosphorylation	EGAGFEESSETGDYE CCCCCCCCCCCCCHH	26.69	22167270
937	Phosphorylation	GAGFEESSETGDYEE CCCCCCCCCCCCHHH	42.32	22167270
939	Phosphorylation	GFEESSETGDYEEKA CCCCCCCCCCHHHHH	36.98	22167270
942	Phosphorylation	ESSETGDYEEKAETE CCCCCCCHHHHHCCC	27.60	22167270
948	Phosphorylation	DYEEKAETEEAEEPE CHHHHHCCCCCCCCC	43.94	23927012
965	Phosphorylation	GEEHVCVSASKHSPT CCCEEEEECCCCCCC	23.00	23403867
967	Phosphorylation	EHVCVSASKHSPTED CEEEEECCCCCCCCC	24.32	23403867
970	Phosphorylation	CVSASKHSPTEDEES EEECCCCCCCCCHHH	36.93	29255136
972	Phosphorylation	SASKHSPTEDEESAK ECCCCCCCCCHHHHH	60.11	29255136
977	Phosphorylation	SPTEDEESAKAEADA CCCCCHHHHHHHHHH	32.78	28348404
985	Phosphorylation	AKAEADAYIREKRES HHHHHHHHHHHHHHH	10.89	24927040
992	Phosphorylation	YIREKRESVASGDDR HHHHHHHHHHCCCCC	27.32	28355574
995	Phosphorylation	EKRESVASGDDRAEE HHHHHHHCCCCCHHH	40.37	29255136
999	Methylation	SVASGDDRAEEDMDE HHHCCCCCHHHHHHH	48.95	115482543
1016	Phosphorylation	EKGEAEQSEEEADEE HHCHHHHCHHHCCHH	38.18	19664994
1034	Phosphorylation	EDAREEEYEPEKMEA HHHHHHHHCHHHHCH	39.81	29978859
1044	Phosphorylation	EKMEAEDYVMAVVDK HHHCHHHHHHHHHHH	5.43	27642862
1062	Phosphorylation	AGGAEEQYGFLTTPT CCCHHHHCCCEECCC	17.08	18707149
1066	Phosphorylation	EEQYGFLTTPTKQLG HHHCCCEECCCHHCC	28.59	30266825
1067	Phosphorylation	EQYGFLTTPTKQLGA HHCCCEECCCHHCCC	30.98	29255136
1069	Phosphorylation	YGFLTTPTKQLGAQS CCCEECCCHHCCCCC	29.36	29255136
1076	Phosphorylation	TKQLGAQSPGREPAS CHHCCCCCCCCCCCH	28.87	29255136
1083	Phosphorylation	SPGREPASSIHDETL CCCCCCCHHCCCCCC	40.31	27732954
1084	Phosphorylation	PGREPASSIHDETLP CCCCCCHHCCCCCCC	26.50	27732954
1089	Phosphorylation	ASSIHDETLPGGSES CHHCCCCCCCCCCCC	44.29	27732954
1094	Phosphorylation	DETLPGGSESEATAS CCCCCCCCCCCCCCC	43.81	27732954
1096	Phosphorylation	TLPGGSESEATASDE CCCCCCCCCCCCCCC	33.94	27732954
1099	Phosphorylation	GGSESEATASDEENR CCCCCCCCCCCCCCC	23.73	27732954
1101	Phosphorylation	SESEATASDEENRED CCCCCCCCCCCCCCC	41.00	27732954
1128	Phosphorylation	QSTIEISSEPTPMDE EEEEEECCCCCCCCC	53.94	19413330
1143	Sulfoxidation	MSTPRDVMSDETNNE CCCCHHHCCCCCCCC	4.97	30846556
1144	Phosphorylation	STPRDVMSDETNNEE CCCHHHCCCCCCCCC	31.95	22617229
1147	Phosphorylation	RDVMSDETNNEETES HHHCCCCCCCCCCCC	48.62	25867546
1152	Phosphorylation	DETNNEETESPSQEF CCCCCCCCCCCCHHH	35.27	21955146
1154	Phosphorylation	TNNEETESPSQEFVN CCCCCCCCCCHHHHH	36.95	19664994
1156	Phosphorylation	NEETESPSQEFVNIT CCCCCCCCHHHHHHH	52.18	21955146
1161	N-linked_Glycosylation	SPSQEFVNITKYESS CCCHHHHHHHHHCHH	41.34	-
1161	N-linked_Glycosylation	SPSQEFVNITKYESS CCCHHHHHHHHHCHH	41.34	10899930
1163	Phosphorylation	SQEFVNITKYESSLY CHHHHHHHHHCHHCC	23.52	29632367
1167	Phosphorylation	VNITKYESSLYSQEY HHHHHHCHHCCCCCC	23.66	27732954
1168	Phosphorylation	NITKYESSLYSQEYS HHHHHCHHCCCCCCC	21.27	27732954
1170	Phosphorylation	TKYESSLYSQEYSKP HHHCHHCCCCCCCCC	15.40	25884760
1171	Phosphorylation	KYESSLYSQEYSKPA HHCHHCCCCCCCCCC	23.10	25884760
1174	Phosphorylation	SSLYSQEYSKPADVT HHCCCCCCCCCCCCC	17.85	25884760
1175	Phosphorylation	SLYSQEYSKPADVTP HCCCCCCCCCCCCCC	31.26	26356563
1181	Phosphorylation	YSKPADVTPLNGFSE CCCCCCCCCCCCCCC	23.70	26356563
1187	Phosphorylation	VTPLNGFSEGSKTDA CCCCCCCCCCCCCCC	42.31	20886841
1190	Phosphorylation	LNGFSEGSKTDATDG CCCCCCCCCCCCCCC	28.47	-
1192	Phosphorylation	GFSEGSKTDATDGKD CCCCCCCCCCCCCCC	32.34	23186163
1195	Phosphorylation	EGSKTDATDGKDYNA CCCCCCCCCCCCCCC	48.36	23186163
1200	Phosphorylation	DATDGKDYNASASTI CCCCCCCCCCCCCCC	19.00	23403867
1201	N-linked_Glycosylation	ATDGKDYNASASTIS CCCCCCCCCCCCCCC	37.24	-
1201	N-linked_Glycosylation	ATDGKDYNASASTIS CCCCCCCCCCCCCCC	37.24	10899930
1203	Phosphorylation	DGKDYNASASTISPP CCCCCCCCCCCCCCC	21.08	28102081
1205	Phosphorylation	KDYNASASTISPPSS CCCCCCCCCCCCCCH	24.63	30266825
1206	Phosphorylation	DYNASASTISPPSSM CCCCCCCCCCCCCHH	25.78	30266825
1208	Phosphorylation	NASASTISPPSSMEE CCCCCCCCCCCHHCC	30.74	30266825
1211	Phosphorylation	ASTISPPSSMEEDKF CCCCCCCCHHCCCCC	45.78	30266825
1212	Phosphorylation	STISPPSSMEEDKFS CCCCCCCHHCCCCCC	35.67	30266825
1219	Phosphorylation	SMEEDKFSRSALRDA HHCCCCCCHHHHHHH	30.94	30266825
1221	Phosphorylation	EEDKFSRSALRDAYC CCCCCCHHHHHHHHH	30.38	29214152
1227	Phosphorylation	RSALRDAYCSEVKAS HHHHHHHHHCCCCCC	10.78	-
1229	Phosphorylation	ALRDAYCSEVKASTT HHHHHHHCCCCCCCE	32.52	21712546
1234	Phosphorylation	YCSEVKASTTLDIKD HHCCCCCCCEECCHH	19.06	29514088
1235	Phosphorylation	CSEVKASTTLDIKDS HCCCCCCCEECCHHH	35.92	29514088
1236	O-linked_Glycosylation	SEVKASTTLDIKDSI CCCCCCCEECCHHHH	21.67	23301498
1236	Phosphorylation	SEVKASTTLDIKDSI CCCCCCCEECCHHHH	21.67	23403867
1240	2-Hydroxyisobutyrylation	ASTTLDIKDSISAVS CCCEECCHHHHHCCC	45.12	-
1242	Phosphorylation	TTLDIKDSISAVSSE CEECCHHHHHCCCCC	17.28	22167270
1244	Phosphorylation	LDIKDSISAVSSEKV ECCHHHHHCCCCCCC	26.94	22167270
1247	Phosphorylation	KDSISAVSSEKVSPS HHHHHCCCCCCCCCC	32.28	22167270
1248	Phosphorylation	DSISAVSSEKVSPSK HHHHCCCCCCCCCCC	34.53	29255136
1250	2-Hydroxyisobutyrylation	ISAVSSEKVSPSKSP HHCCCCCCCCCCCCC	50.38	-
1252	Phosphorylation	AVSSEKVSPSKSPSL CCCCCCCCCCCCCCC	34.23	29255136
1254	Phosphorylation	SSEKVSPSKSPSLSP CCCCCCCCCCCCCCC	37.95	29255136
1256	Phosphorylation	EKVSPSKSPSLSPSP CCCCCCCCCCCCCCC	24.86	29255136
1258	Phosphorylation	VSPSKSPSLSPSPPS CCCCCCCCCCCCCCC	48.87	29255136
1260	Phosphorylation	PSKSPSLSPSPPSPL CCCCCCCCCCCCCCC	27.89	22167270
1262	Phosphorylation	KSPSLSPSPPSPLEK CCCCCCCCCCCCCCC	46.17	22167270
1265	Phosphorylation	SLSPSPPSPLEKTPL CCCCCCCCCCCCCCC	45.56	19664994
1270	Phosphorylation	PPSPLEKTPLGERSV CCCCCCCCCCCCCEE	17.86	23927012
1276	Phosphorylation	KTPLGERSVNFSLTP CCCCCCCEECEECCC	19.67	22167270
1278	N-linked_Glycosylation	PLGERSVNFSLTPNE CCCCCEECEECCCCE	23.26	-
1278	N-linked_Glycosylation	PLGERSVNFSLTPNE CCCCCEECEECCCCE	23.26	10899930
1280	Phosphorylation	GERSVNFSLTPNEIK CCCEECEECCCCEEE	26.57	30266825
1282	Phosphorylation	RSVNFSLTPNEIKVS CEECEECCCCEEEEC	23.91	19664994
1289	Phosphorylation	TPNEIKVSAEAEVAP CCCEEEECEEEEECC	18.52	30140170
1298	Phosphorylation	EAEVAPVSPEVTQEV EEEECCCCHHHHHHH	17.81	19664994
1302	Phosphorylation	APVSPEVTQEVVEEH CCCCHHHHHHHHHHH	19.83	30266825
1312	Phosphorylation	VVEEHCASPEDKTLE HHHHHCCCCCCCCEE	33.93	19664994
1317	Phosphorylation	CASPEDKTLEVVSPS CCCCCCCCEEEECCC	40.24	21955146
1322	Phosphorylation	DKTLEVVSPSQSVTG CCCEEEECCCHHCCC	24.82	22167270
1324	Phosphorylation	TLEVVSPSQSVTGSA CEEEECCCHHCCCCC	27.81	22167270
1326	Phosphorylation	EVVSPSQSVTGSAGH EEECCCHHCCCCCCC	26.45	22167270
1328	Phosphorylation	VSPSQSVTGSAGHTP ECCCHHCCCCCCCCC	30.57	22167270
1330	Phosphorylation	PSQSVTGSAGHTPYY CCHHCCCCCCCCCCC	23.01	22167270
1334	Phosphorylation	VTGSAGHTPYYQSPT CCCCCCCCCCCCCCC	16.45	22167270
1336	Phosphorylation	GSAGHTPYYQSPTDE CCCCCCCCCCCCCCC	18.45	21955146
1337	Phosphorylation	SAGHTPYYQSPTDEK CCCCCCCCCCCCCCC	12.06	22167270
1339	Phosphorylation	GHTPYYQSPTDEKSS CCCCCCCCCCCCCCC	17.41	22167270
1341	Phosphorylation	TPYYQSPTDEKSSHL CCCCCCCCCCCCCCC	63.14	22167270
1345	Phosphorylation	QSPTDEKSSHLPTEV CCCCCCCCCCCCCCC	22.42	24117733
1346	Phosphorylation	SPTDEKSSHLPTEVI CCCCCCCCCCCCCCC	39.86	24117733
1350	Phosphorylation	EKSSHLPTEVIEKPP CCCCCCCCCCCCCCC	49.60	27732954
1362	Phosphorylation	KPPAVPVSFEFSDAK CCCCCCEEEECCCCC	17.00	29507054
1366	Phosphorylation	VPVSFEFSDAKDENE CCEEEECCCCCCCCC	29.48	22210691
1376	Phosphorylation	KDENERASVSPMDEP CCCCCCCCCCCCCCC	29.37	29255136
1378	Phosphorylation	ENERASVSPMDEPVP CCCCCCCCCCCCCCC	16.41	29255136
1380	Sulfoxidation	ERASVSPMDEPVPDS CCCCCCCCCCCCCCC	7.69	30846556
1387	Phosphorylation	MDEPVPDSESPIEKV CCCCCCCCCCHHHHH	33.63	19664994
1389	Phosphorylation	EPVPDSESPIEKVLS CCCCCCCCHHHHHHC	34.82	19664994
1396	Phosphorylation	SPIEKVLSPLRSPPL CHHHHHHCCCCCCCC	25.52	22167270
1400	Phosphorylation	KVLSPLRSPPLIGSE HHHCCCCCCCCCCCH	38.25	19664994
1406	Phosphorylation	RSPPLIGSESAYESF CCCCCCCCHHHHHHH	22.76	30266825
1408	Phosphorylation	PPLIGSESAYESFLS CCCCCCHHHHHHHHC	37.54	30266825
1410	Phosphorylation	LIGSESAYESFLSAD CCCCHHHHHHHHCCC	22.76	23927012
1412	Phosphorylation	GSESAYESFLSADDK CCHHHHHHHHCCCHH	20.86	30266825
1415	Phosphorylation	SAYESFLSADDKASG HHHHHHHCCCHHCCC	27.86	23927012
1421	Phosphorylation	LSADDKASGRGAESP HCCCHHCCCCCCCCC	34.46	27422710
1426	Phosphorylation	KASGRGAESPFEEKS HCCCCCCCCCCCCCC	62.86	18088087
1427	Phosphorylation	ASGRGAESPFEEKSG CCCCCCCCCCCCCCC	34.06	19664994
1432	2-Hydroxyisobutyrylation	AESPFEEKSGKQGSP CCCCCCCCCCCCCCC	58.26	-
1433	Phosphorylation	ESPFEEKSGKQGSPD CCCCCCCCCCCCCCC	55.28	22617229
1438	Phosphorylation	EKSGKQGSPDQVSPV CCCCCCCCCCCCCCH	23.86	22167270
1443	Phosphorylation	QGSPDQVSPVSEMTS CCCCCCCCCHHHCCC	17.60	22167270
1446	Phosphorylation	PDQVSPVSEMTSTSL CCCCCCHHHCCCCCC	25.65	30266825
1448	Sulfoxidation	QVSPVSEMTSTSLYQ CCCCHHHCCCCCCCC	2.53	30846556
1449	Phosphorylation	VSPVSEMTSTSLYQD CCCHHHCCCCCCCCC	25.46	30266825
1450	Phosphorylation	SPVSEMTSTSLYQDK CCHHHCCCCCCCCCC	18.06	30266825
1451	Phosphorylation	PVSEMTSTSLYQDKQ CHHHCCCCCCCCCCC	17.37	30266825
1452	Phosphorylation	VSEMTSTSLYQDKQE HHHCCCCCCCCCCCC	25.50	30266825
1454	Phosphorylation	EMTSTSLYQDKQEGK HCCCCCCCCCCCCCC	17.90	23927012
1462	Phosphorylation	QDKQEGKSTDFAPIK CCCCCCCCCCCCCCC	44.03	25850435
1463	Phosphorylation	DKQEGKSTDFAPIKE CCCCCCCCCCCCCCC	38.33	25850435
1476	2-Hydroxyisobutyrylation	KEDFGQEKKTDDVEA CCHHCCCCCCCCHHH	53.75	-
1478	Phosphorylation	DFGQEKKTDDVEAMS HHCCCCCCCCHHHHH	48.80	24117733
1484	Sulfoxidation	KTDDVEAMSSQPALA CCCCHHHHHCCCCHH	2.21	30846556
1485	Phosphorylation	TDDVEAMSSQPALAL CCCHHHHHCCCCHHC	32.63	24117733
1486	Phosphorylation	DDVEAMSSQPALALD CCHHHHHCCCCHHCC	27.39	24117733
1501	Phosphorylation	ERKLGDVSPTQIDVS HHHHCCCCCCEECHH	27.28	19664994
1503	Phosphorylation	KLGDVSPTQIDVSQF HHCCCCCCEECHHHH	30.56	29255136
1508	Phosphorylation	SPTQIDVSQFGSFKE CCCEECHHHHCCCCC	18.95	23927012
1512	Phosphorylation	IDVSQFGSFKEDTKM ECHHHHCCCCCCCCC	34.14	23927012
1517	Phosphorylation	FGSFKEDTKMSISEG HCCCCCCCCCEECCC	29.73	23403867
1518	2-Hydroxyisobutyrylation	GSFKEDTKMSISEGT CCCCCCCCCEECCCC	42.86	-
1520	Phosphorylation	FKEDTKMSISEGTVS CCCCCCCEECCCCCC	25.23	27499020
1522	Phosphorylation	EDTKMSISEGTVSDK CCCCCEECCCCCCCC	23.75	29255136
1525	Phosphorylation	KMSISEGTVSDKSAT CCEECCCCCCCCCCC	16.88	29255136
1527	Phosphorylation	SISEGTVSDKSATPV EECCCCCCCCCCCCC	38.88	29255136
1543	Phosphorylation	EGVAEDTYSHMEGVA CCCCCCHHHCCCCCE	14.65	25884760
1618	Phosphorylation	EECPRPMSISPPDFS CCCCCCCCCCCCCCC	23.69	29255136
1620	Phosphorylation	CPRPMSISPPDFSPK CCCCCCCCCCCCCCC	24.07	29255136
1625	Phosphorylation	SISPPDFSPKTAKSR CCCCCCCCCCCCCCC	32.63	29255136
1628	Phosphorylation	PPDFSPKTAKSRTPV CCCCCCCCCCCCCCC	42.58	-
1631	Phosphorylation	FSPKTAKSRTPVQDH CCCCCCCCCCCCCCC	38.63	21955146
1633	Phosphorylation	PKTAKSRTPVQDHRS CCCCCCCCCCCCCCC	34.60	21955146
1640	Phosphorylation	TPVQDHRSEQSSMSI CCCCCCCCCCCCEEE	36.25	27732954
1643	Phosphorylation	QDHRSEQSSMSIEFG CCCCCCCCCEEEECC	24.77	24117733
1644	Phosphorylation	DHRSEQSSMSIEFGQ CCCCCCCCEEEECCC	19.08	29900121
1645	Sulfoxidation	HRSEQSSMSIEFGQE CCCCCCCEEEECCCC	5.91	30846556
1646	Phosphorylation	RSEQSSMSIEFGQES CCCCCCEEEECCCCC	22.40	19664994
1653	Phosphorylation	SIEFGQESPEQSLAM EEECCCCCHHHHHHH	26.33	19664994
1657	Phosphorylation	GQESPEQSLAMDFSR CCCCHHHHHHHHCCC	19.21	30266825
1660	Sulfoxidation	SPEQSLAMDFSRQSP CHHHHHHHHCCCCCC	6.92	30846556
1663	Phosphorylation	QSLAMDFSRQSPDHP HHHHHHCCCCCCCCC	25.75	26434776
1666	Phosphorylation	AMDFSRQSPDHPTVG HHHCCCCCCCCCCCC	31.05	22167270
1671	Phosphorylation	RQSPDHPTVGAGVLH CCCCCCCCCCCEEEE	28.31	22167270
1680	Phosphorylation	GAGVLHITENGPTEV CCEEEEECCCCCCCC	16.79	23403867
1685	Phosphorylation	HITENGPTEVDYSPS EECCCCCCCCCCCHH	50.46	22167270
1689	Phosphorylation	NGPTEVDYSPSDMQD CCCCCCCCCHHHCCC	27.88	22167270
1690	Phosphorylation	GPTEVDYSPSDMQDS CCCCCCCCHHHCCCC	17.29	22167270
1692	Phosphorylation	TEVDYSPSDMQDSSL CCCCCCHHHCCCCCC	39.51	22167270
1697	Phosphorylation	SPSDMQDSSLSHKIP CHHHCCCCCCCCCCC	19.11	22167270
1698	Phosphorylation	PSDMQDSSLSHKIPP HHHCCCCCCCCCCCC	42.03	22167270
1700	Phosphorylation	DMQDSSLSHKIPPME HCCCCCCCCCCCCCC	25.36	22167270
1729	Phosphorylation	SVSQVEASPSTSSAH EHHEEECCCCCCCCC	13.08	25921289
1731	Phosphorylation	SQVEASPSTSSAHTP HEEECCCCCCCCCCH	38.12	25921289
1732	Phosphorylation	QVEASPSTSSAHTPS EEECCCCCCCCCCHH	30.04	25332170
1737	Phosphorylation	PSTSSAHTPSQIASP CCCCCCCCHHHCCCC	25.09	25332170
1743	Phosphorylation	HTPSQIASPLQEDTL CCHHHCCCCCCCCCH	27.98	-
1759	Sulfoxidation	DVAPPRDMSLYASLT HCCCCCCCHHHHHCC	2.91	30846556
1760	Phosphorylation	VAPPRDMSLYASLTS CCCCCCCHHHHHCCH	23.63	21712546
1762	Phosphorylation	PPRDMSLYASLTSEK CCCCCHHHHHCCHHH	6.19	18707149
1764	Phosphorylation	RDMSLYASLTSEKVQ CCCHHHHHCCHHHHH	20.72	27732954
1766	Phosphorylation	MSLYASLTSEKVQSL CHHHHHCCHHHHHHC	32.14	27732954
1767	Phosphorylation	SLYASLTSEKVQSLE HHHHHCCHHHHHHCC	40.49	27732954
1772	Phosphorylation	LTSEKVQSLEGEKLS CCHHHHHHCCCCCCC	31.23	19664994
1777	Malonylation	VQSLEGEKLSPKSDI HHHCCCCCCCCCCCC	66.19	26320211
1779	Phosphorylation	SLEGEKLSPKSDISP HCCCCCCCCCCCCCC	41.15	19664994
1782	O-linked_Glycosylation	GEKLSPKSDISPLTP CCCCCCCCCCCCCCC	43.49	23301498
1782	Phosphorylation	GEKLSPKSDISPLTP CCCCCCCCCCCCCCC	43.49	19664994
1785	Phosphorylation	LSPKSDISPLTPRES CCCCCCCCCCCCCCC	20.88	19664994
1788	Phosphorylation	KSDISPLTPRESSPL CCCCCCCCCCCCCCC	24.55	19664994
1792	Phosphorylation	SPLTPRESSPLYSPT CCCCCCCCCCCCCCC	38.24	29255136
1793	Phosphorylation	PLTPRESSPLYSPTF CCCCCCCCCCCCCCC	17.74	29255136
1796	Phosphorylation	PRESSPLYSPTFSDS CCCCCCCCCCCCCCC	18.91	22167270
1797	Phosphorylation	RESSPLYSPTFSDST CCCCCCCCCCCCCCC	25.75	19664994
1799	Phosphorylation	SSPLYSPTFSDSTSA CCCCCCCCCCCCCHH	29.81	29255136
1801	Phosphorylation	PLYSPTFSDSTSAVK CCCCCCCCCCCHHHH	32.88	22167270
1803	Phosphorylation	YSPTFSDSTSAVKEK CCCCCCCCCHHHHHH	24.06	30266825
1804	Phosphorylation	SPTFSDSTSAVKEKT CCCCCCCCHHHHHHC	26.20	22167270
1805	Phosphorylation	PTFSDSTSAVKEKTA CCCCCCCHHHHHHCC	34.71	22167270
1810	Ubiquitination	STSAVKEKTATCHSS CCHHHHHHCCCCCCC	37.43	-
1811	Phosphorylation	TSAVKEKTATCHSSS CHHHHHHCCCCCCCC	28.43	22167270
1813	Phosphorylation	AVKEKTATCHSSSSP HHHHHCCCCCCCCCC	18.91	22167270
1814	S-nitrosylation	VKEKTATCHSSSSPP HHHHCCCCCCCCCCC	2.44	2212679
1816	Phosphorylation	EKTATCHSSSSPPID HHCCCCCCCCCCCCC	33.78	22167270
1817	Phosphorylation	KTATCHSSSSPPIDA HCCCCCCCCCCCCCH	15.92	22167270
1818	Phosphorylation	TATCHSSSSPPIDAA CCCCCCCCCCCCCHH	50.29	22167270
1819	Phosphorylation	ATCHSSSSPPIDAAS CCCCCCCCCCCCHHH	36.32	22167270
1826	Phosphorylation	SPPIDAASAEPYGFR CCCCCHHHCCCCCHH	34.58	29632367
1830	Phosphorylation	DAASAEPYGFRASVL CHHHCCCCCHHHHHH	22.02	26329039
1835	Phosphorylation	EPYGFRASVLFDTMQ CCCCHHHHHHHHHHH	18.33	28555341
1840	Phosphorylation	RASVLFDTMQHHLAL HHHHHHHHHHHHHHH	16.05	22210691
1841	Sulfoxidation	ASVLFDTMQHHLALN HHHHHHHHHHHHHHC	3.72	30846556
1852	Phosphorylation	LALNRDLSTPGLEKD HHHCCCCCCCCCCCC	36.52	25463755
1853	Phosphorylation	ALNRDLSTPGLEKDS HHCCCCCCCCCCCCC	28.77	22617229
1858	Ubiquitination	LSTPGLEKDSGGKTP CCCCCCCCCCCCCCC	63.34	-
1860	Phosphorylation	TPGLEKDSGGKTPGD CCCCCCCCCCCCCCC	61.59	26074081
1863	Ubiquitination	LEKDSGGKTPGDFSY CCCCCCCCCCCCCCC	55.88	-
1864	Phosphorylation	EKDSGGKTPGDFSYA CCCCCCCCCCCCCCC	35.46	17081983
1869	Phosphorylation	GKTPGDFSYAYQKPE CCCCCCCCCCCCCCC	17.37	23911959
1870	Phosphorylation	KTPGDFSYAYQKPEE CCCCCCCCCCCCCCC	14.88	18707149
1872	Phosphorylation	PGDFSYAYQKPEETT CCCCCCCCCCCCCCC	14.61	18707149
1874	Ubiquitination	DFSYAYQKPEETTRS CCCCCCCCCCCCCCC	41.54	-
1878	Phosphorylation	AYQKPEETTRSPDEE CCCCCCCCCCCCCHH	26.33	21712546
1879	Phosphorylation	YQKPEETTRSPDEED CCCCCCCCCCCCHHH	32.22	21712546
1880	Methylation	QKPEETTRSPDEEDY CCCCCCCCCCCHHHC	54.32	115482551
1881	Phosphorylation	KPEETTRSPDEEDYD CCCCCCCCCCHHHCC	34.31	19664994
1887	Phosphorylation	RSPDEEDYDYESYEK CCCCHHHCCHHHHCC	24.57	23927012
1889	Phosphorylation	PDEEDYDYESYEKTT CCHHHCCHHHHCCCC	10.68	23927012
1891	Phosphorylation	EEDYDYESYEKTTRT HHHCCHHHHCCCCCC	32.15	23663014
1892	Phosphorylation	EDYDYESYEKTTRTS HHCCHHHHCCCCCCC	14.98	23927012
1894	Ubiquitination	YDYESYEKTTRTSDV CCHHHHCCCCCCCCC	47.14	-
1895	Phosphorylation	DYESYEKTTRTSDVG CHHHHCCCCCCCCCC	15.01	23403867
1896	Phosphorylation	YESYEKTTRTSDVGG HHHHCCCCCCCCCCC	42.91	23403867
1898	O-linked_Glycosylation	SYEKTTRTSDVGGYY HHCCCCCCCCCCCCE	27.47	23301498
1898	Phosphorylation	SYEKTTRTSDVGGYY HHCCCCCCCCCCCCE	27.47	22617229
1899	Phosphorylation	YEKTTRTSDVGGYYY HCCCCCCCCCCCCEE	27.32	22617229
1904	Phosphorylation	RTSDVGGYYYEKIER CCCCCCCCEEEEEEE	9.28	23911959
1905	Phosphorylation	TSDVGGYYYEKIERT CCCCCCCEEEEEEEE	14.39	23911959
1906	Phosphorylation	SDVGGYYYEKIERTT CCCCCCEEEEEEEEC	11.41	20007894
1908	2-Hydroxyisobutyrylation	VGGYYYEKIERTTKS CCCCEEEEEEEECCC	33.47	-
1908	Ubiquitination	VGGYYYEKIERTTKS CCCCEEEEEEEECCC	33.47	21890473
1912	Phosphorylation	YYEKIERTTKSPSDS EEEEEEEECCCCCCC	26.28	22167270
1913	Phosphorylation	YEKIERTTKSPSDSG EEEEEEECCCCCCCC	35.43	22167270
1914	Ubiquitination	EKIERTTKSPSDSGY EEEEEECCCCCCCCC	60.81	-
1915	Phosphorylation	KIERTTKSPSDSGYS EEEEECCCCCCCCCC	27.78	19664994
1917	Phosphorylation	ERTTKSPSDSGYSYE EEECCCCCCCCCCCE	52.04	29255136
1919	Phosphorylation	TTKSPSDSGYSYETI ECCCCCCCCCCCEEC	43.92	30266825
1921	Phosphorylation	KSPSDSGYSYETIGK CCCCCCCCCCEECCC	16.42	22167270
1922	Phosphorylation	SPSDSGYSYETIGKT CCCCCCCCCEECCCC	21.73	22167270
1923	Phosphorylation	PSDSGYSYETIGKTT CCCCCCCCEECCCCE	14.49	23927012
1925	Phosphorylation	DSGYSYETIGKTTKT CCCCCCEECCCCEEC	27.14	23927012
1928	Ubiquitination	YSYETIGKTTKTPED CCCEECCCCEECCCC	49.52	21890473
1929	Phosphorylation	SYETIGKTTKTPEDG CCEECCCCEECCCCC	28.45	23927012
1930	Phosphorylation	YETIGKTTKTPEDGD CEECCCCEECCCCCC	36.08	23927012
1931	Ubiquitination	ETIGKTTKTPEDGDY EECCCCEECCCCCCC	68.28	-
1932	Phosphorylation	TIGKTTKTPEDGDYS ECCCCEECCCCCCCC	29.80	19664994
1938	Phosphorylation	KTPEDGDYSYEIIEK ECCCCCCCCEEEEEC	20.77	23927012
1939	Phosphorylation	TPEDGDYSYEIIEKT CCCCCCCCEEEEECC	22.49	23927012
1940	Phosphorylation	PEDGDYSYEIIEKTT CCCCCCCEEEEECCC	12.62	23927012
1945	Ubiquitination	YSYEIIEKTTRTPEE CCEEEEECCCCCCCC	44.80	-
1946	Phosphorylation	SYEIIEKTTRTPEEG CEEEEECCCCCCCCC	14.55	23927012
1947	Phosphorylation	YEIIEKTTRTPEEGG EEEEECCCCCCCCCC	43.54	23927012
1949	Phosphorylation	IIEKTTRTPEEGGYS EEECCCCCCCCCCCE	32.72	19664994
1955	Phosphorylation	RTPEEGGYSYDISEK CCCCCCCCEEECCCC	18.21	23927012
1956	Phosphorylation	TPEEGGYSYDISEKT CCCCCCCEEECCCCC	21.43	23927012
1957	Phosphorylation	PEEGGYSYDISEKTT CCCCCCEEECCCCCC	14.60	23927012
1960	Phosphorylation	GGYSYDISEKTTSPP CCCEEECCCCCCCCC	30.09	23403867
1962	Ubiquitination	YSYDISEKTTSPPEV CEEECCCCCCCCCCC	50.76	-
1963	Phosphorylation	SYDISEKTTSPPEVS EEECCCCCCCCCCCC	28.58	19664994
1964	Phosphorylation	YDISEKTTSPPEVSG EECCCCCCCCCCCCC	50.75	19664994
1965	O-linked_Glycosylation	DISEKTTSPPEVSGY ECCCCCCCCCCCCCC	43.63	23301498
1965	Phosphorylation	DISEKTTSPPEVSGY ECCCCCCCCCCCCCC	43.63	19664994
1970	Phosphorylation	TTSPPEVSGYSYEKT CCCCCCCCCCCHHCC	30.28	22167270
1972	Phosphorylation	SPPEVSGYSYEKTER CCCCCCCCCHHCCHH	10.69	22167270
1973	Phosphorylation	PPEVSGYSYEKTERS CCCCCCCCHHCCHHH	30.27	22167270
1974	Phosphorylation	PEVSGYSYEKTERSR CCCCCCCHHCCHHHH	16.98	22167270
1976	Ubiquitination	VSGYSYEKTERSRRL CCCCCHHCCHHHHHH	47.67	21890473
1977	Phosphorylation	SGYSYEKTERSRRLL CCCCHHCCHHHHHHH	25.37	29978859
1988	Phosphorylation	RRLLDDISNGYDDSE HHHHHHHHCCCCCCC	31.06	22617229
1991	Phosphorylation	LDDISNGYDDSEDGG HHHHHCCCCCCCCCC	22.34	23403867
1994	Phosphorylation	ISNGYDDSEDGGHTL HHCCCCCCCCCCCCC	34.39	23403867
2000	Phosphorylation	DSEDGGHTLGDPSYS CCCCCCCCCCCCCCC	35.39	23403867
2005	Phosphorylation	GHTLGDPSYSYETTE CCCCCCCCCCEECCC	31.30	23403867
2006	Phosphorylation	HTLGDPSYSYETTEK CCCCCCCCCEECCCC	22.21	25884760
2007	Phosphorylation	TLGDPSYSYETTEKI CCCCCCCCEECCCCC	22.34	23403867
2008	Phosphorylation	LGDPSYSYETTEKIT CCCCCCCEECCCCCC	14.73	23403867
2010	Phosphorylation	DPSYSYETTEKITSF CCCCCEECCCCCCCC	31.83	23403867
2011	Phosphorylation	PSYSYETTEKITSFP CCCCEECCCCCCCCC	24.28	23403867
2015	Phosphorylation	YETTEKITSFPESEG EECCCCCCCCCHHCC	35.07	23663014
2016	Phosphorylation	ETTEKITSFPESEGY ECCCCCCCCCHHCCC	42.13	23663014
2020	Phosphorylation	KITSFPESEGYSYET CCCCCCHHCCCCEEC	36.24	23663014
2023	Phosphorylation	SFPESEGYSYETSTK CCCHHCCCCEECCCC	12.20	23663014
2024	Phosphorylation	FPESEGYSYETSTKT CCHHCCCCEECCCCC	27.61	22199227
2025	Phosphorylation	PESEGYSYETSTKTT CHHCCCCEECCCCCE	18.10	18707149
2027	Phosphorylation	SEGYSYETSTKTTRT HCCCCEECCCCCEEC	33.20	23663014
2028	Phosphorylation	EGYSYETSTKTTRTP CCCCEECCCCCEECC	18.90	23663014
2029	Phosphorylation	GYSYETSTKTTRTPD CCCEECCCCCEECCC	39.57	29978859
2030	Ubiquitination	YSYETSTKTTRTPDT CCEECCCCCEECCCC	47.90	-
2031	Phosphorylation	SYETSTKTTRTPDTS CEECCCCCEECCCCC	22.92	22617229
2032	Phosphorylation	YETSTKTTRTPDTST EECCCCCEECCCCCC	33.82	21712546
2034	Phosphorylation	TSTKTTRTPDTSTYC CCCCCEECCCCCCCC	24.35	19664994
2037	Phosphorylation	KTTRTPDTSTYCYET CCEECCCCCCCCCCC	24.95	22167270
2038	Phosphorylation	TTRTPDTSTYCYETA CEECCCCCCCCCCCH	25.43	22167270
2039	Phosphorylation	TRTPDTSTYCYETAE EECCCCCCCCCCCHH	21.50	29691806
2040	Phosphorylation	RTPDTSTYCYETAEK ECCCCCCCCCCCHHH	7.87	21712546
2042	Phosphorylation	PDTSTYCYETAEKIT CCCCCCCCCCHHHHC	13.10	20007894
2044	Phosphorylation	TSTYCYETAEKITRT CCCCCCCCHHHHCCC	17.40	29691806
2047	Ubiquitination	YCYETAEKITRTPQA CCCCCHHHHCCCCCC	47.08	-
2049	Phosphorylation	YETAEKITRTPQAST CCCHHHHCCCCCCCC	39.29	22199227
2051	Phosphorylation	TAEKITRTPQASTYS CHHHHCCCCCCCCCE	15.88	23927012
2055	Phosphorylation	ITRTPQASTYSYETS HCCCCCCCCCEEECC	23.72	23403867
2056	Phosphorylation	TRTPQASTYSYETSD CCCCCCCCCEEECCC	21.36	23403867
2057	Phosphorylation	RTPQASTYSYETSDL CCCCCCCCEEECCCC	13.53	23403867
2058	Phosphorylation	TPQASTYSYETSDLC CCCCCCCEEECCCCE	19.31	23403867
2059	Phosphorylation	PQASTYSYETSDLCY CCCCCCEEECCCCEE	16.89	23403867
2061	Phosphorylation	ASTYSYETSDLCYTA CCCCEEECCCCEEEE	21.22	23403867
2062	Phosphorylation	STYSYETSDLCYTAE CCCEEECCCCEEEEC	19.35	23403867
2066	Phosphorylation	YETSDLCYTAEKKSP EECCCCEEEECCCCH	19.11	23403867
2067	Phosphorylation	ETSDLCYTAEKKSPS ECCCCEEEECCCCHH	27.61	23927012
2070	2-Hydroxyisobutyrylation	DLCYTAEKKSPSEAR CCEEEECCCCHHHHH	56.96	-
2072	Phosphorylation	CYTAEKKSPSEARQD EEEECCCCHHHHHHC	44.73	23927012
2074	Phosphorylation	TAEKKSPSEARQDVD EECCCCHHHHHHCCC	51.48	23927012
2086	Phosphorylation	DVDLCLVSSCEYKHP CCCEEEEECCCCCCC	19.14	29978859
2087	Phosphorylation	VDLCLVSSCEYKHPK CCEEEEECCCCCCCC	11.95	29978859
2090	Phosphorylation	CLVSSCEYKHPKTEL EEEECCCCCCCCCCC	20.94	29978859
2095	Phosphorylation	CEYKHPKTELSPSFI CCCCCCCCCCCHHHC	46.76	30183078
2098	Phosphorylation	KHPKTELSPSFINPN CCCCCCCCHHHCCCC	16.56	30183078
2100	Phosphorylation	PKTELSPSFINPNPL CCCCCCHHHCCCCCC	35.07	19276368
2112	Phosphorylation	NPLEWFASEEPTEES CCCHHHCCCCCCCCC	32.78	29632367
2116	Phosphorylation	WFASEEPTEESEKPL HHCCCCCCCCCCCCC	56.52	29632367
2119	Phosphorylation	SEEPTEESEKPLTQS CCCCCCCCCCCCCCC	44.69	29632367
2124	Phosphorylation	EESEKPLTQSGGAPP CCCCCCCCCCCCCCC	29.26	23403867
2126	Phosphorylation	SEKPLTQSGGAPPPP CCCCCCCCCCCCCCC	33.68	29514088
2145	Phosphorylation	QGRQCDETPPTSVSE CCCCCCCCCCCCCCC	22.71	28348404
2148	Phosphorylation	QCDETPPTSVSESAP CCCCCCCCCCCCCCC	42.86	28348404
2149	Phosphorylation	CDETPPTSVSESAPS CCCCCCCCCCCCCCC	29.44	28348404
2151	Phosphorylation	ETPPTSVSESAPSQT CCCCCCCCCCCCCCC	26.12	28348404
2153	Phosphorylation	PPTSVSESAPSQTDS CCCCCCCCCCCCCCC	37.66	28348404
2156	Phosphorylation	SVSESAPSQTDSDVP CCCCCCCCCCCCCCC	45.49	28348404
2158	Phosphorylation	SESAPSQTDSDVPPE CCCCCCCCCCCCCCC	41.63	28348404
2160	Phosphorylation	SAPSQTDSDVPPETE CCCCCCCCCCCCCCC	43.85	28348404
2171	Phosphorylation	PETEECPSITADANI CCCCCCCCCCCCCCC	44.20	28348404
2173	Phosphorylation	TEECPSITADANIDS CCCCCCCCCCCCCCC	23.87	28348404
2180	Phosphorylation	TADANIDSEDESETI CCCCCCCCCCCCCCC	43.05	27251275
2184	Phosphorylation	NIDSEDESETIPTDK CCCCCCCCCCCCCCC	52.97	28348404
2186	Phosphorylation	DSEDESETIPTDKTV CCCCCCCCCCCCCCE	41.35	28348404
2192	Phosphorylation	ETIPTDKTVTYKHMD CCCCCCCCEEEECCC	22.38	20068231
2194	Phosphorylation	IPTDKTVTYKHMDPP CCCCCCEEEECCCCC	31.89	20068231
2195	Phosphorylation	PTDKTVTYKHMDPPP CCCCCEEEECCCCCC	8.44	20068231
2198	Sulfoxidation	KTVTYKHMDPPPAPV CCEEEECCCCCCCCC	7.87	30846556
2208	Methylation	PPAPVQDRSPSPRHP CCCCCCCCCCCCCCC	33.12	115482527
2209	Phosphorylation	PAPVQDRSPSPRHPD CCCCCCCCCCCCCCC	37.71	29255136
2211	Phosphorylation	PVQDRSPSPRHPDVS CCCCCCCCCCCCCCC	35.49	29255136
2218	Phosphorylation	SPRHPDVSMVDPEAL CCCCCCCCCCCHHHH	22.07	23403867
2237	Acetylation	NLGKALKKDLKEKTK HHHHHHHHHHHHHHC	69.97	19813213
2242	Acetylation	LKKDLKEKTKTKKPG HHHHHHHHHCCCCCC	54.45	19813223
2246	Acetylation	LKEKTKTKKPGTKTK HHHHHCCCCCCCCCC	59.53	7681225
2247	Acetylation	KEKTKTKKPGTKTKS HHHHCCCCCCCCCCC	54.64	7681237
2252	Phosphorylation	TKKPGTKTKSSSPVK CCCCCCCCCCCCCCC	35.68	29514088
2253	Acetylation	KKPGTKTKSSSPVKK CCCCCCCCCCCCCCC	50.31	7681249
2254	Phosphorylation	KPGTKTKSSSPVKKS CCCCCCCCCCCCCCC	41.08	29514088
2255	Phosphorylation	PGTKTKSSSPVKKSD CCCCCCCCCCCCCCC	39.97	29514088
2256	Phosphorylation	GTKTKSSSPVKKSDG CCCCCCCCCCCCCCC	40.58	29514088
2259	Acetylation	TKSSSPVKKSDGKSK CCCCCCCCCCCCCCC	50.36	24431167
2261	Phosphorylation	SSSPVKKSDGKSKPL CCCCCCCCCCCCCCC	45.97	26074081
2265	Phosphorylation	VKKSDGKSKPLAASP CCCCCCCCCCCCCCC	45.06	23403867
2271	Phosphorylation	KSKPLAASPKPAGLK CCCCCCCCCCCCCCC	28.05	23927012
2280	Phosphorylation	KPAGLKESSDKVSRV CCCCCCCCCHHHHHC	42.10	29514088
2281	Phosphorylation	PAGLKESSDKVSRVA CCCCCCCCHHHHHCC	42.41	29514088
2289	Phosphorylation	DKVSRVASPKKKESV HHHHHCCCCCHHHHH	34.10	17081983
2295	Phosphorylation	ASPKKKESVEKAAKP CCCCHHHHHHHHCCC	44.44	26699800
2303	Phosphorylation	VEKAAKPTTTPEVKA HHHHCCCCCCHHHHH	42.46	30266825
2304	Phosphorylation	EKAAKPTTTPEVKAA HHHCCCCCCHHHHHH	49.21	30266825
2305	Phosphorylation	KAAKPTTTPEVKAAR HHCCCCCCHHHHHHC	21.67	30266825
2325	N-linked_Glycosylation	KETKNAANASASKSA HHHHHHHHHHHCCCC	31.83	-
2325	N-linked_Glycosylation	KETKNAANASASKSA HHHHHHHHHHHCCCC	31.83	10899930
2334	Phosphorylation	SASKSAKTATAGPGT HHCCCCCCCCCCCCC	29.02	22817900
2365	N-linked_Glycosylation	LDLCYIPNHSNSKNV EEEEECCCCCCCCCC	41.48	-
2365	N-linked_Glycosylation	LDLCYIPNHSNSKNV EEEEECCCCCCCCCC	41.48	10899930
2378	2-Hydroxyisobutyrylation	NVDVEFFKRVRSSYY CCCHHHHHHHHCCEE	56.13	-
2382	Phosphorylation	EFFKRVRSSYYVVSG HHHHHHHCCEEEEEC	21.60	27732954
2383	Phosphorylation	FFKRVRSSYYVVSGN HHHHHHCCEEEEECC	15.21	27732954
2398	Phosphorylation	DPAAEEPSRAVLDAL CCCCCCCCHHHHHHH	35.83	20068231
2414	Phosphorylation	EGKAQWGSNMQVTLI HCCCCCCCCCEEEEE	26.60	28509920
2416	Sulfoxidation	KAQWGSNMQVTLIPT CCCCCCCCEEEEEEC	3.48	30846556
2419	Phosphorylation	WGSNMQVTLIPTHDS CCCCCEEEEEECCCH	11.32	27732954
2423	Phosphorylation	MQVTLIPTHDSEVMR CEEEEEECCCHHHHH	31.18	29978859
2426	Phosphorylation	TLIPTHDSEVMREWY EEEECCCHHHHHHHH	25.20	29978859
2429	Sulfoxidation	PTHDSEVMREWYQET ECCCHHHHHHHHHHH	2.56	30846556
2433	Phosphorylation	SEVMREWYQETHEKQ HHHHHHHHHHHHHHH	7.54	29978859
2436	Phosphorylation	MREWYQETHEKQQDL HHHHHHHHHHHHCCE	21.58	29978859
2450	Phosphorylation	LNIMVLASSSTVVMQ EEEEEEECCCEEEEC	22.21	-
2464	S-nitrosocysteine	QDESFPACKIEL--- CCCCCCCCEECC---	4.67	-
2464	S-nitrosylation	QDESFPACKIEL--- CCCCCCCCEECC---	4.67	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	MARCHF5	Q9NX47	PMID:22308378
-	K	Ubiquitination	E3 ubiquitin ligase	GAN	Q9H2C0	PMID:16227972

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
2464	C	S-nitrosylation	S-nitrosylation at Cys-2464 enhances interaction with microtubules, and may act as an effector modification for neuronal nitric oxide synthase control of growth-cone size, growth-cone collapse and axon retraction.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAP1B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AN32A_HUMAN	ANP32A	physical	12807913
MARH5_HUMAN	MARCH5	physical	22308378
MARH5_MOUSE	March5	physical	22308378
MARH5_HUMAN	MARCH5	genetic	22308378
ACTN1_HUMAN	ACTN1	physical	7908020
LRRK2_HUMAN	LRRK2	physical	21159966
PARK7_HUMAN	PARK7	physical	21645326

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-506, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1387; SER-1396; SER-1779AND SER-1792, AND MASS SPECTROMETRY.
PubMed: 19369195

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-831; SER-832; THR-1066;THR-1067; THR-1069; SER-1252; SER-1254; SER-1256; SER-1265; THR-1282;SER-1298; SER-1312; SER-1322; SER-1324; SER-1326; TYR-1337; SER-1378;SER-1389; SER-1438; SER-1443; SER-1501; SER-1785; THR-1788; SER-1792;SER-1793; TYR-1796; SER-1797; SER-1917; SER-1965 AND SER-2098, ANDMASS SPECTROMETRY.
PubMed: 19413330

"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography.";
Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.;
Proteomics 8:1346-1361(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1016, AND MASSSPECTROMETRY.
PubMed: 18318008

"Phosphoproteome of resting human platelets.";
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.;
J. Proteome Res. 7:526-534(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1427, AND MASSSPECTROMETRY.
PubMed: 18088087

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-336, AND MASSSPECTROMETRY.
PubMed: 17525332

"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-828; SER-831; SER-832AND SER-1016, AND MASS SPECTROMETRY.
PubMed: 17287340

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-541; SER-544; THR-569;SER-828; SER-831; SER-832; SER-992; SER-995; SER-1016; THR-1067;SER-1154; SER-1256; SER-1260; SER-1265; SER-1276; SER-1280; THR-1282;SER-1376; SER-1378; SER-1396; SER-1400; SER-1427; SER-1438; SER-1443;SER-1501; SER-1618; SER-1620; SER-1625; THR-1633; SER-1772; SER-1779;SER-1782; SER-1785; THR-1788; SER-2209; SER-2211; SER-2289 ANDTHR-2334, AND MASS SPECTROMETRY.
PubMed: 17081983

"Phosphoproteome analysis of HeLa cells using stable isotope labelingwith amino acids in cell culture (SILAC).";
Amanchy R., Kalume D.E., Iwahori A., Zhong J., Pandey A.;
J. Proteome Res. 4:1661-1671(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1062; TYR-1762;TYR-1796; TYR-1830; TYR-1870; TYR-1872; TYR-1904; TYR-1905; TYR-1938;TYR-1940; TYR-1957; TYR-1974 AND TYR-2025, AND MASS SPECTROMETRY.
PubMed: 16212419