UBE2W_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBE2W_HUMAN
• UniProt AC: Q96B02
• Protein Name: Ubiquitin-conjugating enzyme E2 W
• Gene Name: UBE2W
• Organism: Homo sapiens (Human).
• Sequence Length: 151
• Subcellular Localization: Nucleus . In the nucleus, colocalizes with FANCL.
• Protein Description: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. [PubMed: 20061386 Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini]
• Protein Sequence: MASMQKRLQKELLALQNDPPPGMTLNEKSVQNSITQWIVDMEGAPGTLYEGEKFQLLFKFSSRYPFDSPQVMFTGENIPVHPHVYSNGHICLSILTEDWSPALSVQSVCLSIISMLSSCKEKRRPPDNSFYVRTCNKNPKKTKWWYHDDTC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7 (in isoform 2)	Phosphorylation	-	26.01	-
29	Phosphorylation	GMTLNEKSVQNSITQ CCCCCHHHHHHHHHH	23.82	-
33	Phosphorylation	NEKSVQNSITQWIVD CHHHHHHHHHHHHHC	15.21	-
39	Ubiquitination	NSITQWIVDMEGAPG HHHHHHHHCCCCCCC	5.37	-
129	Phosphorylation	KRRPPDNSFYVRTCN HCCCCCCCEEEEECC	25.90	28555341
175 (in isoform 3)	Phosphorylation	-		27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBE2W_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1	M	ubiquitylation	Autoubiquitinated at Met-1.	23560854

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBE2W_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UFM1_HUMAN	UFM1	physical	19690564
AMFR_HUMAN	AMFR	physical	19690564
BIRC2_HUMAN	BIRC2	physical	19690564
MUL1_HUMAN	MUL1	physical	19690564
CAPS2_HUMAN	CADPS2	physical	19690564
CNOT4_HUMAN	CNOT4	physical	19690564
RN103_HUMAN	RNF103	physical	19690564
M3K1_HUMAN	MAP3K1	physical	19690564
MIB1_HUMAN	MIB1	physical	19690564
PJA2_HUMAN	PJA2	physical	19690564
RMD5B_HUMAN	RMND5B	physical	19690564
RN111_HUMAN	RNF111	physical	19690564
RN150_HUMAN	RNF150	physical	19690564
RN152_HUMAN	RNF152	physical	19690564
RN165_HUMAN	RNF165	physical	19690564
RN167_HUMAN	RNF167	physical	19690564
RNF26_HUMAN	RNF26	physical	19690564
RNF4_HUMAN	RNF4	physical	19690564
TOPRS_HUMAN	TOPORS	physical	19690564
UHRF2_HUMAN	UHRF2	physical	19690564
RN115_HUMAN	RNF115	physical	19690564
ZNRF4_HUMAN	ZNRF4	physical	19690564
RNF37_HUMAN	UBOX5	physical	19549727
RNF14_HUMAN	RNF14	physical	19549727
ZNRF1_HUMAN	ZNRF1	physical	19549727
TRIM8_HUMAN	TRIM8	physical	19549727
AMFR_HUMAN	AMFR	physical	19549727
DTX3L_HUMAN	DTX3L	physical	19549727
DZIP3_HUMAN	DZIP3	physical	19549727
TRI18_HUMAN	MID1	physical	19549727
RN166_HUMAN	RNF166	physical	19549727
RNF8_HUMAN	RNF8	physical	19549727
TRI17_HUMAN	TRIM17	physical	19549727
TRI35_HUMAN	TRIM35	physical	19549727
XIAP_HUMAN	XIAP	physical	19549727
BIRC8_HUMAN	BIRC8	physical	19549727
RN125_HUMAN	RNF125	physical	19549727
RN138_HUMAN	RNF138	physical	19549727
BFAR_HUMAN	BFAR	physical	19549727
RNF4_HUMAN	RNF4	physical	19549727
RNF5_HUMAN	RNF5	physical	19549727
MARH3_HUMAN	MARCH3	physical	19549727
DTX3_HUMAN	DTX3	physical	19549727
RN114_HUMAN	RNF114	physical	19549727
LRSM1_HUMAN	LRSAM1	physical	19549727
CHFR_HUMAN	CHFR	physical	19549727
MARH5_HUMAN	MARCH5	physical	19549727
MGRN1_HUMAN	MGRN1	physical	19549727
MKRN3_HUMAN	MKRN3	physical	19549727
TRI39_HUMAN	TRIM39	physical	19549727
TRI27_HUMAN	TRIM27	physical	19549727
RFWD3_HUMAN	RFWD3	physical	19549727
RNF10_HUMAN	RNF10	physical	19549727
RN111_HUMAN	RNF111	physical	19549727
RN185_HUMAN	RNF185	physical	19549727
RING2_HUMAN	RNF2	physical	19549727
TRIM2_HUMAN	TRIM2	physical	19549727
TRI31_HUMAN	TRIM31	physical	19549727
FANCL_HUMAN	FANCL	physical	21229326
EED_HUMAN	EED	physical	21900206
MKRN1_HUMAN	MKRN1	physical	21900206
DNM3B_HUMAN	DNMT3B	physical	21900206
UBE2W_HUMAN	UBE2W	physical	20061386
RN123_HUMAN	RNF123	physical	19549727
RNF26_HUMAN	RNF26	physical	19549727
USBP1_HUMAN	USHBP1	physical	25416956
CHIP_HUMAN	STUB1	physical	21855799
RPAB3_HUMAN	POLR2H	physical	25436519
TAU_HUMAN	MAPT	physical	25436519
PPIP1_HUMAN	PSTPIP1	physical	21516116

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.