MARH3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MARH3_HUMAN
• UniProt AC: Q86UD3
• Protein Name: E3 ubiquitin-protein ligase MARCH3
• Gene Name: 3-Mar
• Organism: Homo sapiens (Human).
• Sequence Length: 253
• Subcellular Localization: Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Early endosome membrane ; Multi-pass membrane protein .
• Protein Description: E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates..
• Protein Sequence: MTTSRCSHLPEVLPDCTSSAAPVVKTVEDCGSLVNGQPQYVMQVSAKDGQLLSTVVRTLATQSPFNDRPMCRICHEGSSQEDLLSPCECTGTLGTIHRSCLEHWLSSSNTSYCELCHFRFAVERKPRPLVEWLRNPGPQHEKRTLFGDMVCFLFITPLATISGWLCLRGAVDHLHFSSRLEAVGLIALTVALFTIYLFWTLVSFRYHCRLYNEWRRTNQRVILLIPKSVNVPSNQPSLLGLHSVKRNSKETVV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	LVNGQPQYVMQVSAK HHCCCCCEEEEEECC	12.46	-
53	Phosphorylation	AKDGQLLSTVVRTLA CCCCHHHHHHHHHHH	27.96	29978859
54	Phosphorylation	KDGQLLSTVVRTLAT CCCHHHHHHHHHHHC	24.00	24719451
78	Phosphorylation	CRICHEGSSQEDLLS CEECCCCCCHHHHCC	26.34	28270605
79	Phosphorylation	RICHEGSSQEDLLSP EECCCCCCHHHHCCC	48.74	28270605
85	Phosphorylation	SSQEDLLSPCECTGT CCHHHHCCCCCCCCC	34.50	30108239
111	Phosphorylation	WLSSSNTSYCELCHF HHHCCCCCCCHHHCC	31.85	-
112	Phosphorylation	LSSSNTSYCELCHFR HHCCCCCCCHHHCCE	6.47	-
194	Phosphorylation	ALTVALFTIYLFWTL HHHHHHHHHHHHHHH	15.01	-
196	Phosphorylation	TVALFTIYLFWTLVS HHHHHHHHHHHHHHH	7.87	-
206	Phosphorylation	WTLVSFRYHCRLYNE HHHHHHHHHHHHHHH	11.85	-
211	Phosphorylation	FRYHCRLYNEWRRTN HHHHHHHHHHHHHHC	7.53	-
217	Phosphorylation	LYNEWRRTNQRVILL HHHHHHHHCCEEEEE	27.42	29449344
233	Phosphorylation	PKSVNVPSNQPSLLG ECCCCCCCCCCCHHC	43.76	28842319
237	Phosphorylation	NVPSNQPSLLGLHSV CCCCCCCCHHCCEEC	26.85	23186163
243	Phosphorylation	PSLLGLHSVKRNSKE CCHHCCEECCCCCCC	34.08	14702039

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MARH3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MARH3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MARH3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.