RMD5B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RMD5B_HUMAN
• UniProt AC: Q96G75
• Protein Name: Protein RMD5 homolog B
• Gene Name: RMND5B
• Organism: Homo sapiens (Human).
• Sequence Length: 393
• Protein Sequence: MEQCACVERELDKVLQKFLTYGQHCERSLEELLHYVGQLRAELASAALQGTPLSATLSLVMSQCCRKIKDTVQKLASDHKDIHSSVSRVGKAIDRNFDSEICGVVSDAVWDAREQQQQILQMAIVEHLYQQGMLSVAEELCQESTLNVDLDFKQPFLELNRILEALHEQDLGPALEWAVSHRQRLLELNSSLEFKLHRLHFIRLLAGGPAKQLEALSYARHFQPFARLHQREIQVMMGSLVYLRLGLEKSPYCHLLDSSHWAEICETFTRDACSLLGLSVESPLSVSFASGCVALPVLMNIKAVIEQRQCTGVWNHKDELPIEIELGMKCWYHSVFACPILRQQTSDSNPPIKLICGHVISRDALNKLINGGKLKCPYCPMEQNPADGKRIIF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEQCACVE -------CCCHHHHH	7.87	22814378
13	Ubiquitination	CVERELDKVLQKFLT HHHHHHHHHHHHHHH	58.43	-
17	Ubiquitination	ELDKVLQKFLTYGQH HHHHHHHHHHHHHHH	37.87	-
20 (in isoform 2)	Ubiquitination	-	28.83	21906983
69	Ubiquitination	SQCCRKIKDTVQKLA HHHHHHHHHHHHHHH	50.83	-
74	Ubiquitination	KIKDTVQKLASDHKD HHHHHHHHHHHCCHH	41.50	-
77	Phosphorylation	DTVQKLASDHKDIHS HHHHHHHHCCHHHHH	51.16	27794612
80 (in isoform 1)	Ubiquitination	-	64.47	21906983
80	Ubiquitination	QKLASDHKDIHSSVS HHHHHCCHHHHHHHH	64.47	-
84	Phosphorylation	SDHKDIHSSVSRVGK HCCHHHHHHHHHHHH	32.54	27794612
85	Phosphorylation	DHKDIHSSVSRVGKA CCHHHHHHHHHHHHH	15.22	27794612
87	Phosphorylation	KDIHSSVSRVGKAID HHHHHHHHHHHHHHH	24.17	27794612
151 (in isoform 2)	Ubiquitination	-	44.21	21906983
211	Ubiquitination	LLAGGPAKQLEALSY HHCCCCHHHHHHHHH	59.56	2190698
211 (in isoform 1)	Ubiquitination	-	59.56	21906983
242	Phosphorylation	VMMGSLVYLRLGLEK HHHHHHHHHHHCCCC	7.44	-
346	Phosphorylation	PILRQQTSDSNPPIK HHHCHHCCCCCCCCE	34.40	23532336
348	Phosphorylation	LRQQTSDSNPPIKLI HCHHCCCCCCCCEEE	51.51	29970186
353	Ubiquitination	SDSNPPIKLICGHVI CCCCCCCEEEECEEE	37.26	-
361	Phosphorylation	LICGHVISRDALNKL EEECEEECHHHHHHH	24.02	30622161
367	Ubiquitination	ISRDALNKLINGGKL ECHHHHHHHHCCCCC	52.15	-
373	Ubiquitination	NKLINGGKLKCPYCP HHHHCCCCCCCCCCC	46.28	-
375	Ubiquitination	LINGGKLKCPYCPME HHCCCCCCCCCCCCC	36.33	-
389	Ubiquitination	EQNPADGKRIIF--- CCCCCCCCCCCC---	40.76	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RMD5B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RMD5B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RMD5B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MAEA_HUMAN	MAEA	physical	27173435
ARMC8_HUMAN	ARMC8	physical	27173435
PGRC2_HUMAN	PGRMC2	physical	27173435
YPEL5_HUMAN	YPEL5	physical	27173435
RANB9_HUMAN	RANBP9	physical	27173435
WDR26_HUMAN	WDR26	physical	27173435
PSMD6_HUMAN	PSMD6	physical	27173435
UCK2_HUMAN	UCK2	physical	27173435
SETD5_HUMAN	SETD5	physical	27173435
UBE2H_HUMAN	UBE2H	physical	27173435
CCHL_HUMAN	HCCS	physical	27173435
MKLN1_HUMAN	MKLN1	physical	27173435
RBP10_HUMAN	RANBP10	physical	27173435
RAB8A_HUMAN	RAB8A	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.