UCK2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UCK2_HUMAN
• UniProt AC: Q9BZX2
• Protein Name: Uridine-cytidine kinase 2
• Gene Name: UCK2
• Organism: Homo sapiens (Human).
• Sequence Length: 261
• Protein Description: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine..
• Protein Sequence: MAGDSEQTLQNHQQPNGGEPFLIGVSGGTASGKSSVCAKIVQLLGQNEVDYRQKQVVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSRKEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVAINLIVQHIQDILNGGPSKRQTNGCLNGYTPSRKRQASESSSRPH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGDSEQTL ------CCCCHHHHH	30.42	19413330
8	Phosphorylation	MAGDSEQTLQNHQQP CCCCHHHHHHHCCCC	26.68	25627689
18	Ubiquitination	NHQQPNGGEPFLIGV HCCCCCCCCCEEEEE	46.15	22053931
33	Ubiquitination	SGGTASGKSSVCAKI ECCCCCCCHHHHHHH	36.74	23000965
39 (in isoform 1)	Ubiquitination	-	37.98	21890473
39	Ubiquitination	GKSSVCAKIVQLLGQ CCHHHHHHHHHHHCC	37.98	21906983
51	Phosphorylation	LGQNEVDYRQKQVVI HCCCCCCCCCCEEEE	21.81	27642862
52 (in isoform 2)	Ubiquitination	-	32.53	21890473
52	Ubiquitination	GQNEVDYRQKQVVIL CCCCCCCCCCEEEEE	32.53	23000965
54	Ubiquitination	NEVDYRQKQVVILSQ CCCCCCCCEEEEEEC	35.74	23000965
54 (in isoform 1)	Ubiquitination	-	35.74	21890473
57	Ubiquitination	DYRQKQVVILSQDSF CCCCCEEEEEECCHH	3.18	23000965
57	Neddylation	DYRQKQVVILSQDSF CCCCCEEEEEECCHH	3.18	32015554
60	Phosphorylation	QKQVVILSQDSFYRV CCEEEEEECCHHHHH	22.33	20873877
63	Phosphorylation	VVILSQDSFYRVLTS EEEEECCHHHHHCCH	19.28	20873877
73 (in isoform 1)	Ubiquitination	-	48.04	21890473
73	Ubiquitination	RVLTSEQKAKALKGQ HHCCHHHHHHHHCCC	48.04	23000965
75 (in isoform 1)	Ubiquitination	-	62.38	21890473
75	Ubiquitination	LTSEQKAKALKGQFN CCHHHHHHHHCCCCC	62.38	23000965
78	Neddylation	EQKAKALKGQFNFDH HHHHHHHCCCCCCCC	56.37	32015554
78	Ubiquitination	EQKAKALKGQFNFDH HHHHHHHCCCCCCCC	56.37	23000965
78 (in isoform 1)	Ubiquitination	-	56.37	21890473
84	Ubiquitination	LKGQFNFDHPDAFDN HCCCCCCCCCCCCCC	54.22	22817900
96	Ubiquitination	FDNELILKTLKEITE CCCHHHHHHHHHHHC	44.83	22817900
99	Ubiquitination	ELILKTLKEITEGKT HHHHHHHHHHHCCCC	52.91	21906983
99 (in isoform 1)	Ubiquitination	-	52.91	21890473
105 (in isoform 1)	Ubiquitination	-	39.01	21890473
105	Ubiquitination	LKEITEGKTVQIPVY HHHHHCCCCEEEEEE	39.01	21906983
106	O-linked_Glycosylation	KEITEGKTVQIPVYD HHHHCCCCEEEEEEE	28.62	23301498
148	Ubiquitination	YSQEVRDLFQMKLFV HCHHHHHHHHCEEEE	1.94	23000965
149	Ubiquitination	SQEVRDLFQMKLFVD CHHHHHHHHCEEEEC	8.59	21890473
157	Phosphorylation	QMKLFVDTDADTRLS HCEEEECCCHHHHHH	27.99	-
162	Methylation	VDTDADTRLSRRVLR ECCCHHHHHHHHHHH	31.08	115919485
180	Ubiquitination	ERGRDLEQILSQYIT HHCCCHHHHHHHHHH	49.58	23000965
181	Ubiquitination	RGRDLEQILSQYITF HCCCHHHHHHHHHHH	2.67	21890473
200	Phosphorylation	FEEFCLPTKKYADVI HHHHCCCCCCCCCEE	27.50	22964224
201	Ubiquitination	EEFCLPTKKYADVII HHHCCCCCCCCCEEE	41.67	23000965
202	Ubiquitination	EFCLPTKKYADVIIP HHCCCCCCCCCEEEC	48.42	23000965
202 (in isoform 1)	Ubiquitination	-	48.42	21890473
214	Ubiquitination	IIPRGADNLVAINLI EECCCCCHHHHHHHH	35.56	33845483
233	Phosphorylation	QDILNGGPSKRQTNG HHHHCCCCCCCCCCC	37.77	33259812
234	Phosphorylation	DILNGGPSKRQTNGC HHHCCCCCCCCCCCC	43.69	26074081
235	Ubiquitination	ILNGGPSKRQTNGCL HHCCCCCCCCCCCCC	52.22	33845483
238	Phosphorylation	GGPSKRQTNGCLNGY CCCCCCCCCCCCCCC	37.30	26074081
245	Phosphorylation	TNGCLNGYTPSRKRQ CCCCCCCCCCCHHHH	17.88	26074081
246	Phosphorylation	NGCLNGYTPSRKRQA CCCCCCCCCCHHHHH	19.04	25159151
248	Phosphorylation	CLNGYTPSRKRQASE CCCCCCCCHHHHHHC	42.51	28985074
254	Phosphorylation	PSRKRQASESSSRPH CCHHHHHHCCCCCCC	29.67	25159151
256	Phosphorylation	RKRQASESSSRPH-- HHHHHHCCCCCCC--	30.99	21955146
257	Phosphorylation	KRQASESSSRPH--- HHHHHCCCCCCC---	26.72	30576142
258	Phosphorylation	RQASESSSRPH---- HHHHCCCCCCC----	60.14	22496350

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UCK2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UCK2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UCK2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UPP1_HUMAN	UPP1	physical	22939629
UCK1_HUMAN	UCK1	physical	28514442
UCKL1_HUMAN	UCKL1	physical	28514442
IAH1_HUMAN	IAH1	physical	28514442
SYVM_HUMAN	VARS2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330

Phosphorylation

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-254, AND MASSSPECTROMETRY.
PubMed: 18691976