UCK1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UCK1_HUMAN
• UniProt AC: Q9HA47
• Protein Name: Uridine-cytidine kinase 1
• Gene Name: UCK1
• Organism: Homo sapiens (Human).
• Sequence Length: 277
• Protein Description: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine..
• Protein Sequence: MASAGGEDCESPAPEADRPHQRPFLIGVSGGTASGKSTVCEKIMELLGQNEVEQRQRKVVILSQDRFYKVLTAEQKAKALKGQYNFDHPDAFDNDLMHRTLKNIVEGKTVEVPTYDFVTHSRLPETTVVYPADVVLFEGILVFYSQEIRDMFHLRLFVDTDSDVRLSRRVLRDVRRGRDLEQILTQYTTFVKPAFEEFCLPTKKYADVIIPRGVDNMVAINLIVQHIQDILNGDICKWHRGGSNGRSYKRTFSEPGDHPGMLTSGKRSHLESSSRPH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASAGGEDCE -----CCCCCCCCCC	26.58	19413330
11	Phosphorylation	AGGEDCESPAPEADR CCCCCCCCCCCCCCC	32.47	25849741
29	Phosphorylation	RPFLIGVSGGTASGK CCEEEEECCCCCCCC	26.71	19413330
44	Sulfoxidation	STVCEKIMELLGQNE HHHHHHHHHHHCCCH	4.38	21406390
63	Phosphorylation	QRKVVILSQDRFYKV HHEEEEECCHHHHHH	20.93	-
66	Methylation	VVILSQDRFYKVLTA EEEECCHHHHHHCCH	29.20	115919481
76	Ubiquitination	KVLTAEQKAKALKGQ HHCCHHHHHHHHCCC	43.28	-
81	Ubiquitination	EQKAKALKGQYNFDH HHHHHHHCCCCCCCC	49.15	-
84	Phosphorylation	AKALKGQYNFDHPDA HHHHCCCCCCCCCCC	26.85	-
86	Ubiquitination	ALKGQYNFDHPDAFD HHCCCCCCCCCCCCC	8.53	-
102	Ubiquitination	DLMHRTLKNIVEGKT HHHHHHHHHHHCCCE	43.97	-
108	Ubiquitination	LKNIVEGKTVEVPTY HHHHHCCCEEEECCC	35.57	-
113	Ubiquitination	EGKTVEVPTYDFVTH CCCEEEECCCCCCCC	16.25	-
165	Methylation	VDTDSDVRLSRRVLR ECCCCHHHHHHHHHH	31.75	115919477
195	Ubiquitination	TTFVKPAFEEFCLPT HHHHHHHHHHHCCCC	14.51	21890473
202	Phosphorylation	FEEFCLPTKKYADVI HHHHCCCCCCCCCEE	27.50	22964224
203	Ubiquitination	EEFCLPTKKYADVII HHHCCCCCCCCCEEE	41.67	-
204	Ubiquitination	EFCLPTKKYADVIIP HHCCCCCCCCCEEEC	48.42	2189047
209	Ubiquitination	TKKYADVIIPRGVDN CCCCCCEEECCCCCH	3.55	21890473
243	Phosphorylation	CKWHRGGSNGRSYKR CCCCCCCCCCCCEEE	38.65	24275569
251	Phosphorylation	NGRSYKRTFSEPGDH CCCCEEEECCCCCCC	27.62	25159151
253	Phosphorylation	RSYKRTFSEPGDHPG CCEEEECCCCCCCCC	42.12	25159151
258	Phosphorylation	TFSEPGDHPGMLTSG ECCCCCCCCCCCCCC	27.08	27251275
263	Phosphorylation	GDHPGMLTSGKRSHL CCCCCCCCCCCHHHH	26.92	23403867
264	Phosphorylation	DHPGMLTSGKRSHLE CCCCCCCCCCHHHHC	38.05	28060719
266	Acetylation	PGMLTSGKRSHLESS CCCCCCCCHHHHCCC	50.96	25953088
272	Phosphorylation	GKRSHLESSSRPH-- CCHHHHCCCCCCC--	39.72	30576142
273	Phosphorylation	KRSHLESSSRPH--- CHHHHCCCCCCC---	22.46	30576142
274	Phosphorylation	RSHLESSSRPH---- HHHHCCCCCCC----	60.14	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UCK1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UCK1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UCK1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UCK1_HUMAN	UCK1	physical	16169070
UCK1_HUMAN	UCK1	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.