SYVM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYVM_HUMAN
• UniProt AC: Q5ST30
• Protein Name: Valine--tRNA ligase, mitochondrial
• Gene Name: VARS2
• Organism: Homo sapiens (Human).
• Sequence Length: 1063
• Subcellular Localization: Mitochondrion .
• Protein Sequence: MPHLPLASFRPPFWGLRHSRGLPRFHSVSTQSEPHGSPISRRNREAKQKRLREKQATLEAEIAGESKSPAESIKAWRPKELVLYEIPTKPGEKKDVSGPLPPAYSPRYVEAAWYPWWVREGFFKPEYQARLPQATGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSDHAGIATQAVVEKQLWKERGVRRHELSREAFLREVWQWKEAKGGEICEQLRALGASLDWDRECFTMDVGSSVAVTEAFVRLYKAGLLYRNHQLVNWSCALRSAISDIEVENRPLPGHTQLRLPGCPTPVSFGLLFSVAFPVDGEPDAEVVVGTTRPETLPGDVAVAVHPDDSRYTHLHGRQLRHPLMGQPLPLITDYAVQPHVGTGAVKVTPAHSPADAEMGARHGLSPLNVIAEDGTMTSLCGDWLQGLHRFVAREKIMSVLSEWGLFRGLQNHPMVLPICSRSGDVIEYLLKNQWFVRCQEMGARAAKAVESGALELSPSFHQKNWQHWFSHIGDWCVSRQLWWGHQIPAYLVVEDHAQGEEDCWVVGRSEAEAREVAAELTGRPGAELTLERDPDVLDTWFSSALFPFSALGWPQETPDLARFYPLSLLETGSDLLLFWVGRMVMLGTQLTGQLPFSKVLLHPMVRDRQGRKMSKSLGNVLDPRDIISGVEMQVLQEKLRSGNLDPAELAIVAAAQKKDFPHGIPECGTDALRFTLCSHGVQAGDLHLSVSEVQSCRHFCNKIWNALRFILNALGEKFVPQPAEELSPSSPMDAWILSRLALAAQECERGFLTRELSLVTHALHHFWLHNLCDVYLEAVKPVLWHSPRPLGPPQVLFSCADLGLRLLAPLMPFLAEELWQRLPPRPGCPPAPSISVAPYPSACSLEHWRQPELERRFSRVQEVVQVLRALRATYQLTKARPRVLLQSSEPGDQGLFEAFLEPLGTLGYCGAVGLLPPGAAAPSGWAQAPLSDTAQVYMELQGLVDPQIQLPLLAARRYKLQKQLDSLTARTPSEGEAGTQRQQKLSSLQLELSKLDKAASHLRQLMDEPPAPGSPEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MPHLPLASFRPPFWG CCCCCHHHCCCCCCC	29.48	24719451
29	Phosphorylation	LPRFHSVSTQSEPHG CCCCEECCCCCCCCC	24.60	24719451
40	Phosphorylation	EPHGSPISRRNREAK CCCCCCCHHHHHHHH	28.68	17081983
54	Ubiquitination	KQKRLREKQATLEAE HHHHHHHHHHHHHHH	38.51	21890473
54 (in isoform 1)	Ubiquitination	-	38.51	21890473
57	Phosphorylation	RLREKQATLEAEIAG HHHHHHHHHHHHHHC	23.72	23917254
59	Phosphorylation	REKQATLEAEIAGES HHHHHHHHHHHHCCC	39.64	24719451
68	Phosphorylation	EIAGESKSPAESIKA HHHCCCCCHHHHHHH	38.32	24719451
74	Ubiquitination	KSPAESIKAWRPKEL CCHHHHHHHCCCCEE	51.69	21890473
74 (in isoform 1)	Ubiquitination	-	51.69	21890473
84	Ubiquitination	RPKELVLYEIPTKPG CCCEEEEEECCCCCC	12.34	21890473
84	Ubiquitination	RPKELVLYEIPTKPG CCCEEEEEECCCCCC	12.34	21890473
89	Ubiquitination	VLYEIPTKPGEKKDV EEEECCCCCCCCCCC	45.75	-
98	Phosphorylation	GEKKDVSGPLPPAYS CCCCCCCCCCCCCCC	27.84	24719451
104	Ubiquitination	SGPLPPAYSPRYVEA CCCCCCCCCCHHHHH	25.61	21890473
104	Ubiquitination	SGPLPPAYSPRYVEA CCCCCCCCCCHHHHH	25.61	21890473
105	Phosphorylation	GPLPPAYSPRYVEAA CCCCCCCCCHHHHHH	12.66	24719451
122 (in isoform 2)	Ubiquitination	-	6.44	21906983
124	Ubiquitination	WVREGFFKPEYQARL HHHCCCCCHHHHCCC	34.38	-
141 (in isoform 2)	Ubiquitination	-	1.78	21906983
225	Ubiquitination	VWQWKEAKGGEICEQ HHHHHHHHCHHHHHH	69.41	-
285	Phosphorylation	NWSCALRSAISDIEV CHHHHHHHHHHCCEE	30.70	30622161
288	Phosphorylation	CALRSAISDIEVENR HHHHHHHHCCEECCC	32.05	30622161
357	Phosphorylation	VHPDDSRYTHLHGRQ ECCCCCCCCCCCCCC	11.49	-
466	Phosphorylation	PMVLPICSRSGDVIE CEEEEEECCCCCHHH	30.15	-
474	Phosphorylation	RSGDVIEYLLKNQWF CCCCHHHHHHHCCHH	13.25	-
503	Phosphorylation	ESGALELSPSFHQKN HCCCCEECHHHHHHC	14.77	-
634	Phosphorylation	GRMVMLGTQLTGQLP HHHHHHCCCCCCCCC	19.22	22210691
660	Phosphorylation	DRQGRKMSKSLGNVL CCCCCCCHHHHCCCC	23.33	-
662	Phosphorylation	QGRKMSKSLGNVLDP CCCCCHHHHCCCCCH	33.91	-
684 (in isoform 1)	Ubiquitination	-	35.92	21890473
684	Ubiquitination	EMQVLQEKLRSGNLD HHHHHHHHHHCCCCC	35.92	21906983
703 (in isoform 1)	Ubiquitination	-	49.97	21890473
703	Ubiquitination	AIVAAAQKKDFPHGI HHHHHHHHCCCCCCC	49.97	2190698
704	Ubiquitination	IVAAAQKKDFPHGIP HHHHHHHCCCCCCCC	53.15	-
721	Phosphorylation	GTDALRFTLCSHGVQ CCHHHHHHHHHCCCC	22.03	24719451
776	Phosphorylation	AEELSPSSPMDAWIL HHHCCCCCCHHHHHH	27.85	-
1032	Phosphorylation	TQRQQKLSSLQLELS HHHHHHHHHHHHHHH	35.72	30622161
1033	Phosphorylation	QRQQKLSSLQLELSK HHHHHHHHHHHHHHH	30.48	30622161
1039	Phosphorylation	SSLQLELSKLDKAAS HHHHHHHHHHHHHHH	23.07	29255136
1043	Ubiquitination	LELSKLDKAASHLRQ HHHHHHHHHHHHHHH	57.18	-
1046	Phosphorylation	SKLDKAASHLRQLMD HHHHHHHHHHHHHHC	28.10	24505115

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYVM_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYVM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYVM_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MAL2_HUMAN	MAL2	physical	25416956
CKLF5_HUMAN	CMTM5	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615917: Combined oxidative phosphorylation deficiency 20 (COXPD20)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.