MAL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAL2_HUMAN
• UniProt AC: Q969L2
• Protein Name: Protein MAL2
• Gene Name: MAL2
• Organism: Homo sapiens (Human).
• Sequence Length: 176
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Endomembrane system. Cytoplasm, perinuclear region. Associated with lipid rafts. In polarized epithelial cells, restricted to the apical surface. In hepato
• Protein Description: Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway..
• Protein Sequence: MSAGGASVPPPPNPAVSFPPPRVTLPAGPDILRTYSGAFVCLEILFGGLVWILVASSNVPLPLLQGWVMFVSVTAFFFSLLFLGMFLSGMVAQIDANWNFLDFAYHFTVFVFYFGAFLLEAAATSLHDLHCNTTITGQPLLSDNQYNINVAASIFAFMTTACYGCSLGLALRRWRP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSAGGASVP ------CCCCCCCCC	35.30	25849741
7	Phosphorylation	-MSAGGASVPPPPNP -CCCCCCCCCCCCCC	38.13	25841592
17	Phosphorylation	PPPNPAVSFPPPRVT CCCCCCCCCCCCCEE	33.86	27251275
132	N-linked_Glycosylation	SLHDLHCNTTITGQP HHHHCCCCCEECCCC	29.52	12370246

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAL2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAL2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBB5_HUMAN	TUBB	physical	25416956
RAB37_HUMAN	RAB37	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-132, AND MASSSPECTROMETRY.
PubMed: 19159218

"MAL2, a novel raft protein of the MAL family, is an essentialcomponent of the machinery for transcytosis in hepatoma HepG2 cells.";
de Marco M.C., Martin-Belmonte F., Kremer L., Albar J.P., Correas I.,Vaerman J.P., Marazuela M., Byrne J.A., Alonso M.A.;
J. Cell Biol. 159:37-44(2002).
Cited for: FUNCTION, SUBCELLULAR LOCATION, AND GLYCOSYLATION AT ASN-132.
PubMed: 12370246