RAB37_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAB37_HUMAN
• UniProt AC: Q96AX2
• Protein Name: Ras-related protein Rab-37
• Gene Name: RAB37
• Organism: Homo sapiens (Human).
• Sequence Length: 223
• Subcellular Localization: Cytoplasmic vesicle. Secretory granules..
• Protein Sequence: MTGTPGAVATRDGEAPERSPPCSPSYDLTGKVMLLGDTGVGKTCFLIQFKDGAFLSGTFIATVGIDFRNKVVTVDGVRVKLQIWDTAGQERFRSVTHAYYRDAQALLLLYDITNKSSFDNIRAWLTEIHEYAQRDVVIMLLGNKADMSSERVIRSEDGETLAREYGVPFLETSAKTGMNVELAFLAIAKELKYRAGHQADEPSFQIRDYVESQKKRSSCCSFM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MTGTPGAVA ------CCCCCCCEE	50.16	12665801
4	Phosphorylation	----MTGTPGAVATR ----CCCCCCCEECC	14.91	22115753
19	Phosphorylation	DGEAPERSPPCSPSY CCCCCCCCCCCCCCC	31.37	28450419
23	Phosphorylation	PERSPPCSPSYDLTG CCCCCCCCCCCCCCC	23.74	26657352
25	Phosphorylation	RSPPCSPSYDLTGKV CCCCCCCCCCCCCCE	18.26	28060719
26	Phosphorylation	SPPCSPSYDLTGKVM CCCCCCCCCCCCCEE	20.53	28060719
29	Phosphorylation	CSPSYDLTGKVMLLG CCCCCCCCCCEEEEC	31.87	26074081
38	Phosphorylation	KVMLLGDTGVGKTCF CEEEECCCCCCCEEE	31.78	26074081
43	Phosphorylation	GDTGVGKTCFLIQFK CCCCCCCEEEEEEEC	11.54	26074081
80	Ubiquitination	TVDGVRVKLQIWDTA EECCEEEEEEEECCC	24.90	-
86	Phosphorylation	VKLQIWDTAGQERFR EEEEEECCCCCHHHH	20.07	28857561
131	Phosphorylation	WLTEIHEYAQRDVVI HHHHHHHHHCCCEEE	8.22	-
144	Methylation	VIMLLGNKADMSSER EEEECCCCCCCCCCE	43.92	-
172	Phosphorylation	YGVPFLETSAKTGMN HCCCEEECCCCCCCC	35.81	-
203	Phosphorylation	GHQADEPSFQIRDYV CCCCCCCCCHHHHHH	27.95	28787133
219	Geranylgeranylation	SQKKRSSCCSFM--- HHHHHHCCCCCC---	2.07	-
220	Methylation	QKKRSSCCSFM---- HHHHHCCCCCC----	3.67	-
220	Geranylgeranylation	QKKRSSCCSFM---- HHHHHCCCCCC----	3.67	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
172	T	Phosphorylation	Kinase	PRKCA	P17252	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RAB37_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAB37_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of RAB37_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Exploring proteomes and analyzing protein processing by massspectrometric identification of sorted N-terminal peptides.";
Gevaert K., Goethals M., Martens L., Van Damme J., Staes A.,Thomas G.R., Vandekerckhove J.;
Nat. Biotechnol. 21:566-569(2003).
Cited for: PROTEIN SEQUENCE OF 2-11, AND ACETYLATION AT THR-2.
PubMed: 12665801