| UniProt ID | UHRF2_HUMAN | |
|---|---|---|
| UniProt AC | Q96PU4 | |
| Protein Name | E3 ubiquitin-protein ligase UHRF2 | |
| Gene Name | UHRF2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 802 | |
| Subcellular Localization | Nucleus . Enriched at pericentric heterochromatin (PH). This localization is dependent on the interaction with H3K9me3 (By similarity).. | |
| Protein Description | E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.. | |
| Protein Sequence | MWIQVRTIDGSKTCTIEDVSRKATIEELRERVWALFDVRPECQRLFYRGKQLENGYTLFDYDVGLNDIIQLLVRPDPDHLPGTSTQIEAKPCSNSPPKVKKAPRVGPSNQPSTSARARLIDPGFGIYKVNELVDARDVGLGAWFEAHIHSVTRASDGQSRGKTPLKNGSSCKRTNGNIKHKSKENTNKLDSVPSTSNSDCVAADEDVIYHIQYDEYPESGTLEMNVKDLRPRARTILKWNELNVGDVVMVNYNVESPGQRGFWFDAEITTLKTISRTKKELRVKIFLGGSEGTLNDCKIISVDEIFKIERPGAHPLSFADGKFLRRNDPECDLCGGDPEKKCHSCSCRVCGGKHEPNMQLLCDECNVAYHIYCLNPPLDKVPEEEYWYCPSCKTDSSEVVKAGERLKMSKKKAKMPSASTESRRDWGRGMACVGRTRECTIVPSNHYGPIPGIPVGSTWRFRVQVSEAGVHRPHVGGIHGRSNDGAYSLVLAGGFADEVDRGDEFTYTGSGGKNLAGNKRIGAPSADQTLTNMNRALALNCDAPLDDKIGAESRNWRAGKPVRVIRSFKGRKISKYAPEEGNRYDGIYKVVKYWPEISSSHGFLVWRYLLRRDDVEPAPWTSEGIERSRRLCLRLQYPAGYPSDKEGKKPKGQSKKQPSGTTKRPISDDDCPSASKVYKASDSAEAIEAFQLTPQQQHLIREDCQNQKLWDEVLSHLVEGPNFLKKLEQSFMCVCCQELVYQPVTTECFHNVCKDCLQRSFKAQVFSCPACRHDLGQNYIMIPNEILQTLLDLFFPGYSKGR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 12 | Acetylation | VRTIDGSKTCTIEDV EEEECCCCEEEHHHH | 53.82 | 23954790 | |
| 12 | Ubiquitination | VRTIDGSKTCTIEDV EEEECCCCEEEHHHH | 53.82 | 29967540 | |
| 22 | Ubiquitination | TIEDVSRKATIEELR EHHHHHCCCCHHHHH | 42.23 | 29967540 | |
| 42 | Ubiquitination | LFDVRPECQRLFYRG HHHCCHHHHHHHCCC | 2.94 | 21890473 | |
| 83 | Phosphorylation | DPDHLPGTSTQIEAK CCCCCCCCCCEEEEE | 27.02 | 23312004 | |
| 84 | Phosphorylation | PDHLPGTSTQIEAKP CCCCCCCCCEEEEEE | 24.99 | 23312004 | |
| 85 | Phosphorylation | DHLPGTSTQIEAKPC CCCCCCCCEEEEEEC | 33.14 | 28111955 | |
| 93 | Phosphorylation | QIEAKPCSNSPPKVK EEEEEECCCCCCCCC | 49.20 | 25159151 | |
| 95 | Phosphorylation | EAKPCSNSPPKVKKA EEEECCCCCCCCCCC | 26.70 | 25159151 | |
| 99 | Ubiquitination | CSNSPPKVKKAPRVG CCCCCCCCCCCCCCC | 10.69 | 21890473 | |
| 108 | Phosphorylation | KAPRVGPSNQPSTSA CCCCCCCCCCCCCCH | 42.01 | - | |
| 112 | Phosphorylation | VGPSNQPSTSARARL CCCCCCCCCCHHHHH | 25.82 | 23403867 | |
| 113 | Phosphorylation | GPSNQPSTSARARLI CCCCCCCCCHHHHHC | 32.84 | 23403867 | |
| 114 | Phosphorylation | PSNQPSTSARARLID CCCCCCCCHHHHHCC | 21.79 | 23403867 | |
| 128 | Ubiquitination | DPGFGIYKVNELVDA CCCCCEEEHHHEECH | 36.34 | - | |
| 130 | Ubiquitination | GFGIYKVNELVDARD CCCEEEHHHEECHHH | 32.50 | 24816145 | |
| 187 | Ubiquitination | HKSKENTNKLDSVPS CCCCCCCCCCCCCCC | 55.25 | 24816145 | |
| 238 | Sumoylation | PRARTILKWNELNVG HHHHHHEECCCCCCC | 44.09 | - | |
| 249 | Ubiquitination | LNVGDVVMVNYNVES CCCCCEEEEEECCCC | 1.30 | 21890473 | |
| 290 | Phosphorylation | VKIFLGGSEGTLNDC EEEEECCCCCCCCCC | 30.93 | - | |
| 292 | Ubiquitination | IFLGGSEGTLNDCKI EEECCCCCCCCCCEE | 36.88 | 22817900 | |
| 295 | Ubiquitination | GGSEGTLNDCKIISV CCCCCCCCCCEEEEH | 53.09 | 21890473 | |
| 307 | Ubiquitination | ISVDEIFKIERPGAH EEHHHEEEECCCCCC | 49.68 | 29967540 | |
| 309 | Ubiquitination | VDEIFKIERPGAHPL HHHEEEECCCCCCCC | 54.11 | 21890473 | |
| 312 | Ubiquitination | IFKIERPGAHPLSFA EEEECCCCCCCCCCC | 42.62 | 22817900 | |
| 322 | Ubiquitination | PLSFADGKFLRRNDP CCCCCCCCCCCCCCC | 41.60 | 23000965 | |
| 322 (in isoform 1) | Ubiquitination | - | 41.60 | 21890473 | |
| 322 (in isoform 2) | Ubiquitination | - | 41.60 | 21890473 | |
| 337 | Ubiquitination | ECDLCGGDPEKKCHS CCCCCCCCHHCCCCC | 33.21 | 24816145 | |
| 349 | Ubiquitination | CHSCSCRVCGGKHEP CCCCCCEECCCCCCC | 4.11 | 22817900 | |
| 352 | Ubiquitination | CSCRVCGGKHEPNMQ CCCEECCCCCCCCCE | 24.03 | 21890473 | |
| 366 | Ubiquitination | QLLCDECNVAYHIYC EEECCCCCCEEEEEE | 21.29 | 21890473 | |
| 369 | Ubiquitination | CDECNVAYHIYCLNP CCCCCCEEEEEECCC | 5.62 | 22817900 | |
| 393 | Ubiquitination | YWYCPSCKTDSSEVV CEECCCCCCCHHHHH | 60.76 | 29967540 | |
| 401 | Sumoylation | TDSSEVVKAGERLKM CCHHHHHHHHHHHHC | 56.71 | - | |
| 401 | Ubiquitination | TDSSEVVKAGERLKM CCHHHHHHHHHHHHC | 56.71 | - | |
| 401 | Sumoylation | TDSSEVVKAGERLKM CCHHHHHHHHHHHHC | 56.71 | - | |
| 410 | Ubiquitination | GERLKMSKKKAKMPS HHHHHCCHHCCCCCC | 55.59 | 24816145 | |
| 417 | Phosphorylation | KKKAKMPSASTESRR HHCCCCCCCCCHHHH | 31.21 | 27134283 | |
| 422 | Phosphorylation | MPSASTESRRDWGRG CCCCCCHHHHHHCCC | 32.48 | 27134283 | |
| 428 | Methylation | ESRRDWGRGMACVGR HHHHHHCCCCCCCCC | 27.71 | 115919525 | |
| 447 | Phosphorylation | TIVPSNHYGPIPGIP EEECCCCCCCCCCCC | 28.93 | - | |
| 482 (in isoform 2) | Phosphorylation | - | 43.81 | 22210691 | |
| 487 | Phosphorylation | GRSNDGAYSLVLAGG CCCCCCCEEEEEECC | 14.20 | 27642862 | |
| 499 | Ubiquitination | AGGFADEVDRGDEFT ECCCCCCCCCCCCEE | 6.64 | 22817900 | |
| 502 | Ubiquitination | FADEVDRGDEFTYTG CCCCCCCCCCEEEEC | 34.04 | 21890473 | |
| 510 | Phosphorylation | DEFTYTGSGGKNLAG CCEEEECCCCCCCCC | 36.25 | 21815630 | |
| 516 | Ubiquitination | GSGGKNLAGNKRIGA CCCCCCCCCCCCCCC | 28.98 | 21890473 | |
| 519 | Ubiquitination | GKNLAGNKRIGAPSA CCCCCCCCCCCCCCH | 44.46 | 22817900 | |
| 548 | Ubiquitination | CDAPLDDKIGAESRN CCCCCCCCCCCCCCC | 42.58 | 32015554 | |
| 548 | Acetylation | CDAPLDDKIGAESRN CCCCCCCCCCCCCCC | 42.58 | 26051181 | |
| 572 | Ubiquitination | IRSFKGRKISKYAPE EEECCCCCCCCCCCC | 61.06 | 22817900 | |
| 575 (in isoform 1) | Ubiquitination | - | 49.24 | 21890473 | |
| 575 | Ubiquitination | FKGRKISKYAPEEGN CCCCCCCCCCCCCCC | 49.24 | 22817900 | |
| 584 | Phosphorylation | APEEGNRYDGIYKVV CCCCCCCCCCHHHHH | 23.63 | - | |
| 588 | Phosphorylation | GNRYDGIYKVVKYWP CCCCCCHHHHHHHCH | 11.85 | - | |
| 589 (in isoform 1) | Ubiquitination | - | 38.33 | 21890473 | |
| 589 | Ubiquitination | NRYDGIYKVVKYWPE CCCCCHHHHHHHCHH | 38.33 | 27667366 | |
| 592 | Ubiquitination | DGIYKVVKYWPEISS CCHHHHHHHCHHHHH | 44.58 | 33845483 | |
| 637 | Phosphorylation | RLCLRLQYPAGYPSD HHHHHHCCCCCCCCC | 10.31 | 23403867 | |
| 641 | Phosphorylation | RLQYPAGYPSDKEGK HHCCCCCCCCCCCCC | 11.15 | 23403867 | |
| 643 | Phosphorylation | QYPAGYPSDKEGKKP CCCCCCCCCCCCCCC | 53.48 | 22115753 | |
| 645 | Ubiquitination | PAGYPSDKEGKKPKG CCCCCCCCCCCCCCC | 73.10 | 33845483 | |
| 654 | Phosphorylation | GKKPKGQSKKQPSGT CCCCCCCCCCCCCCC | 50.95 | - | |
| 659 | Phosphorylation | GQSKKQPSGTTKRPI CCCCCCCCCCCCCCC | 46.40 | 26074081 | |
| 661 | Phosphorylation | SKKQPSGTTKRPISD CCCCCCCCCCCCCCC | 33.22 | 26074081 | |
| 662 | Phosphorylation | KKQPSGTTKRPISDD CCCCCCCCCCCCCCC | 28.69 | 26074081 | |
| 663 | Ubiquitination | KQPSGTTKRPISDDD CCCCCCCCCCCCCCC | 56.89 | 29967540 | |
| 667 | Phosphorylation | GTTKRPISDDDCPSA CCCCCCCCCCCCCCH | 37.36 | 29255136 | |
| 673 | Phosphorylation | ISDDDCPSASKVYKA CCCCCCCCHHHEEHH | 52.05 | 23927012 | |
| 675 | Phosphorylation | DDDCPSASKVYKASD CCCCCCHHHEEHHCC | 27.30 | 23927012 | |
| 676 | Acetylation | DDCPSASKVYKASDS CCCCCHHHEEHHCCC | 49.66 | 25953088 | |
| 676 | Ubiquitination | DDCPSASKVYKASDS CCCCCHHHEEHHCCC | 49.66 | 29967540 | |
| 679 | Ubiquitination | PSASKVYKASDSAEA CCHHHEEHHCCCHHH | 44.39 | 29967540 | |
| 681 | Phosphorylation | ASKVYKASDSAEAIE HHHEEHHCCCHHHHH | 28.13 | 27251275 | |
| 683 | Phosphorylation | KVYKASDSAEAIEAF HEEHHCCCHHHHHHH | 26.05 | 25849741 | |
| 708 | Ubiquitination | REDCQNQKLWDEVLS HHHHHCCHHHHHHHH | 60.12 | 29967540 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of UHRF2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UHRF2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UHRF2_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-667, AND MASSSPECTROMETRY. | |
