| UniProt ID | 3MG_HUMAN | |
|---|---|---|
| UniProt AC | P29372 | |
| Protein Name | DNA-3-methyladenine glycosylase | |
| Gene Name | MPG | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 298 | |
| Subcellular Localization | Cytoplasm . Mitochondrion matrix, mitochondrion nucleoid . Nucleus . | |
| Protein Description | Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.. | |
| Protein Sequence | MVTPALQMKKPKQFCRRMGQKKQRPARAGQPHSSSDAAQAPAEQPHSSSDAAQAPCPRERCLGPPTTPGPYRSIYFSSPKGHLTRLGLEFFDQPAVPLARAFLGQVLVRRLPNGTELRGRIVETEAYLGPEDEAAHSRGGRQTPRNRGMFMKPGTLYVYIIYGMYFCMNISSQGDGACVLLRALEPLEGLETMRQLRSTLRKGTASRVLKDRELCSGPSKLCQALAINKSFDQRDLAQDEAVWLERGPLEPSEPAVVAAARVGVGHAGEWARKPLRFYVRGSPWVSVVDRVAEQDTQA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 (in isoform 4) | Phosphorylation | - | 10.89 | 26552605 | |
| 5 (in isoform 2) | Phosphorylation | - | 10.89 | 26552605 | |
| 34 | Phosphorylation | RAGQPHSSSDAAQAP CCCCCCCCCCHHHCC | 29.24 | 28165663 | |
| 35 | Phosphorylation | AGQPHSSSDAAQAPA CCCCCCCCCHHHCCC | 33.99 | 28555341 | |
| 48 | Phosphorylation | PAEQPHSSSDAAQAP CCCCCCCCCCHHHCC | 29.24 | 28555341 | |
| 66 | Phosphorylation | ERCLGPPTTPGPYRS HHCCCCCCCCCCCEE | 49.08 | 28348404 | |
| 67 | Phosphorylation | RCLGPPTTPGPYRSI HCCCCCCCCCCCEEE | 31.83 | 22617229 | |
| 71 | Phosphorylation | PPTTPGPYRSIYFSS CCCCCCCCEEEEEEC | 23.94 | 23403867 | |
| 73 | Phosphorylation | TTPGPYRSIYFSSPK CCCCCCEEEEEECCC | 18.79 | 20068231 | |
| 75 | Ubiquitination | PGPYRSIYFSSPKGH CCCCEEEEEECCCCH | 9.92 | 21890473 | |
| 75 (in isoform 2) | Ubiquitination | - | 9.92 | 21890473 | |
| 75 | Phosphorylation | PGPYRSIYFSSPKGH CCCCEEEEEECCCCH | 9.92 | 29396449 | |
| 77 | Phosphorylation | PYRSIYFSSPKGHLT CCEEEEEECCCCHHH | 28.85 | 25159151 | |
| 78 | Phosphorylation | YRSIYFSSPKGHLTR CEEEEEECCCCHHHH | 22.26 | 25159151 | |
| 80 | Ubiquitination | SIYFSSPKGHLTRLG EEEEECCCCHHHHHC | 61.99 | 21890473 | |
| 80 (in isoform 1) | Ubiquitination | - | 61.99 | 21890473 | |
| 115 | Phosphorylation | VRRLPNGTELRGRIV HHCCCCCCEEECEEE | 38.19 | - | |
| 137 | Phosphorylation | PEDEAAHSRGGRQTP CCCHHHHHCCCCCCC | 28.08 | - | |
| 162 | Nitration | TLYVYIIYGMYFCMN CEEEEEEEEHHHHHH | 6.05 | - | |
| 210 | Ubiquitination | GTASRVLKDRELCSG CCHHHHHCCHHHCCC | 52.46 | - | |
| 224 (in isoform 2) | Ubiquitination | - | 9.66 | 21890473 | |
| 224 | Ubiquitination | GPSKLCQALAINKSF CHHHHHHHHHHCCCC | 9.66 | 21890473 | |
| 229 (in isoform 1) | Ubiquitination | - | 46.52 | 21890473 | |
| 229 | Ubiquitination | CQALAINKSFDQRDL HHHHHHCCCCCHHHH | 46.52 | 2189047 | |
| 230 | Phosphorylation | QALAINKSFDQRDLA HHHHHCCCCCHHHHH | 29.57 | 29214152 | |
| 252 | Phosphorylation | ERGPLEPSEPAVVAA HCCCCCCCCCHHHHE | 47.00 | 21082442 | |
| 278 | Phosphorylation | ARKPLRFYVRGSPWV HCCCEEEEECCCCCE | 5.25 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of 3MG_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of 3MG_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of 3MG_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-78, AND MASSSPECTROMETRY. | |
| "Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-252, AND MASSSPECTROMETRY. | |
