CDSN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDSN_HUMAN
• UniProt AC: Q15517
• Protein Name: Corneodesmosin
• Gene Name: CDSN
• Organism: Homo sapiens (Human).
• Sequence Length: 529
• Subcellular Localization: Secreted. Found in corneodesmosomes, the intercellular structures that are involved in desquamation.
• Protein Description: Important for the epidermal barrier integrity..
• Protein Sequence: MGSSRAPWMGRVGGHGMMALLLAGLLLPGTLAKSIGTFSDPCKDPTRITSPNDPCLTGKGDSSGFSSYSGSSSSGSSISSARSSGGGSSGSSSGSSIAQGGSAGSFKPGTGYSQVSYSSGSGSSLQGASGSSQLGSSSSHSGNSGSHSGSSSSHSSSSSSFQFSSSSFQVGNGSALPTNDNSYRGILNPSQPGQSSSSSQTSGVSSSGQSVSSNQRPCSSDIPDSPCSGGPIVSHSGPYIPSSHSVSGGQRPVVVVVDQHGSGAPGVVQGPPCSNGGLPGKPCPPITSVDKSYGGYEVVGGSSDSYLVPGMTYSKGKIYPVGYFTKENPVKGSPGVPSFAAGPPISEGKYFSSNPIIPSQSAASSAIAFQPVGTGGVQLCGGGSTGSKGPCSPSSSRVPSSSSISSSSGSPYHPCGSASQSPCSPPGTGSFSSSSSSQSSGKIILQPCGSKSSSSGHPCMSVSSLTLTGGPDGSPHPDPSAGAKPCGSSSAGKIPCRSIRDILAQVKPLGPQLADPEVFLPQGELLDSP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MGSSRAPWMGR ----CCCCCCCCCCC	27.08	24425749
37	O-linked_Glycosylation	TLAKSIGTFSDPCKD HHHHHHCCCCCCCCC	20.49	55823893
49	O-linked_Glycosylation	CKDPTRITSPNDPCL CCCCCCCCCCCCCCC	34.54	55825687
71	Phosphorylation	GFSSYSGSSSSGSSI CCCCCCCCCCCCCCC	22.55	-
72	Phosphorylation	FSSYSGSSSSGSSIS CCCCCCCCCCCCCCC	31.86	-
73	Phosphorylation	SSYSGSSSSGSSISS CCCCCCCCCCCCCCC	40.18	-
79	Phosphorylation	SSSGSSISSARSSGG CCCCCCCCCCCCCCC	21.64	-
80	Phosphorylation	SSGSSISSARSSGGG CCCCCCCCCCCCCCC	26.49	-
102	Phosphorylation	SSIAQGGSAGSFKPG CCCCCCCCCCCCCCC	35.96	24706070
105	Phosphorylation	AQGGSAGSFKPGTGY CCCCCCCCCCCCCCC	29.79	24706070
172	N-linked_Glycosylation	SSSFQVGNGSALPTN CCCEEECCCCCCCCC	42.25	UniProtKB CARBOHYD
305	Phosphorylation	VVGGSSDSYLVPGMT ECCCCCCCCCCCCEE	23.47	-
325	O-linked_Glycosylation	IYPVGYFTKENPVKG EEECEEECCCCCCCC	29.03	55826207
350	Phosphorylation	PPISEGKYFSSNPII CCCCCCCCCCCCCCC	21.39	24043423
352	Phosphorylation	ISEGKYFSSNPIIPS CCCCCCCCCCCCCCC	26.56	24043423
353	Phosphorylation	SEGKYFSSNPIIPSQ CCCCCCCCCCCCCCC	36.40	24043423
359	Phosphorylation	SSNPIIPSQSAASSA CCCCCCCCCCCCCCC	26.76	24043423
361	Phosphorylation	NPIIPSQSAASSAIA CCCCCCCCCCCCCCC	30.09	24043423
364	Phosphorylation	IPSQSAASSAIAFQP CCCCCCCCCCCCCEE	21.73	24043423
365	Phosphorylation	PSQSAASSAIAFQPV CCCCCCCCCCCCEEE	20.97	24043423
374	Phosphorylation	IAFQPVGTGGVQLCG CCCEEECCCCEEECC	30.88	24043423
384	Phosphorylation	VQLCGGGSTGSKGPC EEECCCCCCCCCCCC	32.63	24043423
385	Phosphorylation	QLCGGGSTGSKGPCS EECCCCCCCCCCCCC	49.07	24043423
387	Phosphorylation	CGGGSTGSKGPCSPS CCCCCCCCCCCCCCC	34.23	24043423
421	Phosphorylation	PCGSASQSPCSPPGT CCCCCCCCCCCCCCC	25.94	-
436	Phosphorylation	GSFSSSSSSQSSGKI CCCCCCCCCCCCCEE	34.05	-
439	Phosphorylation	SSSSSSQSSGKIILQ CCCCCCCCCCEEEEE	42.90	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDSN_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDSN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDSN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDSN_HUMAN	CDSN	physical	11739386
CEP55_HUMAN	CEP55	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.