ELP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ELP2_HUMAN
• UniProt AC: Q6IA86
• Protein Name: Elongator complex protein 2
• Gene Name: ELP2
• Organism: Homo sapiens (Human).
• Sequence Length: 826
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Regulates the ligand-dependent activation of STAT3.; Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4..
• Protein Sequence: MVAPVLETSHVFCCPNRVRGVLNWSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTARVNCIQWICKQDGSPSTELVSGGSDNQVIHWEIEDNQLLKAVHLQGHEGPVYAVHAVYQRRTSDPALCTLIVSAAADSAVRLWSKKGPEVMCLQTLNFGNGFALALCLSFLPNTDVPILACGNDDCRIHIFAQQNDQFQKVLSLCGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWKLYIKSTSLETQDDDNIRLKENTFTIENESVKIAFAVTLETVLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNTVNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLFAPWKRKDQSQVTWHEIARPQIHGYDLKCLAMINRFQFVSGADEKVLRVFSAPRNFVENFCAITGQSLNHVLCNQDSDLPEGATVPALGLSNKAVFQGDIASQPSDEEELLTSTGFEYQQVAFQPSILTEPPTEDHLLQNTLWPEVQKLYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVWGECDSTDDCIEHNIGPCSSVLDVGGAVTAVSVCPVLHPSQRYVVAVGLECGKICLYTWKKTDQVPEINDWTHCVETSQSQSHTLAIRKLCWKNCSGKTEQKEAEGAEWLHFASCGEDHTVKIHRVNKCAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
88	Ubiquitination	GGSDNQVIHWEIEDN CCCCCEEEEEEECCC	1.94	22817900
92	Ubiquitination	NQVIHWEIEDNQLLK CEEEEEEECCCCEEE	7.32	21963094
107	Ubiquitination	AVHLQGHEGPVYAVH EEEECCCCCCEEEEE	72.51	27667366
117	Phosphorylation	VYAVHAVYQRRTSDP EEEEEEEEECCCCCH	9.33	-
121	Phosphorylation	HAVYQRRTSDPALCT EEEEECCCCCHHHHH	39.40	30266825
121 (in isoform 6)	Phosphorylation	-	39.40	27251275
122	Phosphorylation	AVYQRRTSDPALCTL EEEECCCCCHHHHHH	39.52	30266825
122 (in isoform 6)	Phosphorylation	-	39.52	24719451
128	Phosphorylation	TSDPALCTLIVSAAA CCCHHHHHHHHHHHH	21.99	28450419
132	Phosphorylation	ALCTLIVSAAADSAV HHHHHHHHHHHHHHH	12.75	23927012
145 (in isoform 5)	Sumoylation	-	74.34	-
163 (in isoform 5)	Ubiquitination	-	3.32	-
165	Ubiquitination	GNGFALALCLSFLPN CCHHHHHHHHHCCCC	2.92	22817900
167	Ubiquitination	GFALALCLSFLPNTD HHHHHHHHHCCCCCC	4.16	22817900
171	Ubiquitination	ALCLSFLPNTDVPIL HHHHHCCCCCCCCEE	39.40	21963094
186	Ubiquitination	ACGNDDCRIHIFAQQ EECCCCCEEEEEEEC	30.43	27667366
211	Ubiquitination	CGHEDWIRGVEWAAF CCCHHHHCCCHHHHC	38.56	22817900
215	Ubiquitination	DWIRGVEWAAFGRDL HHHCCCHHHHCCCCH	7.18	21963094
215 (in isoform 2)	Ubiquitination	-	7.18	21890473
215 (in isoform 3)	Ubiquitination	-	7.18	21890473
230	Ubiquitination	FLASCSQDCLIRIWK HHHHCCHHHHHHHHH	16.94	27667366
230 (in isoform 2)	Ubiquitination	-	16.94	21890473
230 (in isoform 3)	Ubiquitination	-	16.94	21890473
237	Ubiquitination	DCLIRIWKLYIKSTS HHHHHHHHHHHHHCC	29.10	22817900
241	Ubiquitination	RIWKLYIKSTSLETQ HHHHHHHHHCCCCCC	33.84	21906983
241 (in isoform 1)	Ubiquitination	-	33.84	21890473
241 (in isoform 4)	Ubiquitination	-	33.84	21890473
244	Ubiquitination	KLYIKSTSLETQDDD HHHHHHCCCCCCCCC	31.16	22817900
256	Acetylation	DDDNIRLKENTFTIE CCCCEEEECCEEEEC	38.78	23954790
256	Ubiquitination	DDDNIRLKENTFTIE CCCCEEEECCEEEEC	38.78	21906983
256 (in isoform 1)	Ubiquitination	-	38.78	21890473
256 (in isoform 4)	Ubiquitination	-	38.78	21890473
270	Ubiquitination	ENESVKIAFAVTLET CCCCCEEEEEEEHHH	4.80	21890473
272	Ubiquitination	ESVKIAFAVTLETVL CCCEEEEEEEHHHHH	5.60	29967540
276	Ubiquitination	IAFAVTLETVLAGHE EEEEEEHHHHHHCCC	27.75	22817900
280	Ubiquitination	VTLETVLAGHENWVN EEHHHHHHCCCCCCC	16.98	21963094
288	Ubiquitination	GHENWVNAVHWQPVF CCCCCCCCCCCEEEE	5.73	22817900
288 (in isoform 3)	Ubiquitination	-	5.73	21890473
295	Ubiquitination	AVHWQPVFYKDGVLQ CCCCEEEECCCCCCH	8.80	27667366
302	Ubiquitination	FYKDGVLQQPVRLLS ECCCCCCHHHHHHHH	43.03	22817900
306	Ubiquitination	GVLQQPVRLLSASMD CCCHHHHHHHHCCCC	36.27	21963094
310	Ubiquitination	QPVRLLSASMDKTMI HHHHHHHCCCCCEEE	14.62	23000965
314	Ubiquitination	LLSASMDKTMILWAP HHHCCCCCEEEEECC	31.20	22817900
314 (in isoform 1)	Ubiquitination	-	31.20	21890473
314 (in isoform 4)	Ubiquitination	-	31.20	21890473
321	Ubiquitination	KTMILWAPDEESGVW CEEEEECCCCCCCEE	37.65	27667366
349	Ubiquitination	LGFYDCQFNEDGSMI EEEEEEEECCCCCEE	15.81	21890473
349	Ubiquitination	LGFYDCQFNEDGSMI EEEEEEEECCCCCEE	15.81	21890473
349 (in isoform 2)	Ubiquitination	-	15.81	21890473
351	Ubiquitination	FYDCQFNEDGSMIIA EEEEEECCCCCEEEE	66.10	29967540
353	Ubiquitination	DCQFNEDGSMIIAHA EEEECCCCCEEEEEE	16.97	22817900
375	Ubiquitination	WKQNTVNPREWTPEI HHCCCCCCCCCCCCE	31.09	21890473
377	Ubiquitination	QNTVNPREWTPEIVI CCCCCCCCCCCCEEE	57.89	29967540
379	Ubiquitination	TVNPREWTPEIVISG CCCCCCCCCCEEEEE	13.29	22817900
389	Ubiquitination	IVISGHFDGVQDLVW EEEEEECCCCCEEEE	51.16	21890473
389	Ubiquitination	IVISGHFDGVQDLVW EEEEEECCCCCEEEE	51.16	23000965
389 (in isoform 2)	Ubiquitination	-	51.16	21890473
393	Ubiquitination	GHFDGVQDLVWDPEG EECCCCCEEEECCCC	40.56	21890473
393 (in isoform 3)	Ubiquitination	-	40.56	21890473
395	Ubiquitination	FDGVQDLVWDPEGEF CCCCCEEEECCCCCE	7.98	29967540
409	Ubiquitination	FIITVGTDQTTRLFA EEEEEECCCCEEEEC	37.59	23000965
414	Ubiquitination	GTDQTTRLFAPWKRK ECCCCEEEECCCCCC	3.94	21890473
414	Ubiquitination	GTDQTTRLFAPWKRK ECCCCEEEECCCCCC	3.94	21890473
415	Ubiquitination	TDQTTRLFAPWKRKD CCCCEEEECCCCCCC	7.46	23000965
416	Ubiquitination	DQTTRLFAPWKRKDQ CCCEEEECCCCCCCC	17.40	29967540
419	Ubiquitination	TRLFAPWKRKDQSQV EEEECCCCCCCCCCC	48.81	21890473
419 (in isoform 1)	Ubiquitination	-	48.81	21890473
419 (in isoform 4)	Ubiquitination	-	48.81	21890473
421	Ubiquitination	LFAPWKRKDQSQVTW EECCCCCCCCCCCCH	57.29	29967540
433	Ubiquitination	VTWHEIARPQIHGYD CCHHHCCCCCCCCCH	29.35	23000965
433 (in isoform 3)	Ubiquitination	-	29.35	21890473
438	Ubiquitination	IARPQIHGYDLKCLA CCCCCCCCCHHHHHH	21.19	21963094
441	Ubiquitination	PQIHGYDLKCLAMIN CCCCCCHHHHHHEEE	2.96	22817900
442	Ubiquitination	QIHGYDLKCLAMINR CCCCCHHHHHHEEEC	25.06	22817900
454	Ubiquitination	INRFQFVSGADEKVL EECEEEECCCCHHHH	29.56	21890473
454	Ubiquitination	INRFQFVSGADEKVL EECEEEECCCCHHHH	29.56	23000965
458	Ubiquitination	QFVSGADEKVLRVFS EEECCCCHHHHHEEE	44.52	21890473
459	Ubiquitination	FVSGADEKVLRVFSA EECCCCHHHHHEEEC	47.30	23000965
459 (in isoform 1)	Ubiquitination	-	47.30	21890473
459 (in isoform 4)	Ubiquitination	-	47.30	21890473
460	Ubiquitination	VSGADEKVLRVFSAP ECCCCHHHHHEEECC	3.77	29967540
465	Phosphorylation	EKVLRVFSAPRNFVE HHHHHEEECCCHHHH	34.21	24719451
484	Ubiquitination	ITGQSLNHVLCNQDS HHCCCCCEEECCCCC	21.15	21890473
484	Ubiquitination	ITGQSLNHVLCNQDS HHCCCCCEEECCCCC	21.15	21890473
486	Ubiquitination	GQSLNHVLCNQDSDL CCCCCEEECCCCCCC	1.44	29967540
498	Ubiquitination	SDLPEGATVPALGLS CCCCCCCCCCCCCCC	37.57	23000965
507	Ubiquitination	PALGLSNKAVFQGDI CCCCCCCCCEECCCC	42.42	-
516	Phosphorylation	VFQGDIASQPSDEEE EECCCCCCCCCCHHH	42.85	26074081
517	Ubiquitination	FQGDIASQPSDEEEL ECCCCCCCCCCHHHH	32.28	21963094
519	Phosphorylation	GDIASQPSDEEELLT CCCCCCCCCHHHHHH	50.44	26074081
520	Ubiquitination	DIASQPSDEEELLTS CCCCCCCCHHHHHHC	74.20	22817900
521	Ubiquitination	IASQPSDEEELLTST CCCCCCCHHHHHHCC	58.68	22817900
524	Ubiquitination	QPSDEEELLTSTGFE CCCCHHHHHHCCCCC	7.76	21890473
524	Ubiquitination	QPSDEEELLTSTGFE CCCCHHHHHHCCCCC	7.76	23000965
532	Phosphorylation	LTSTGFEYQQVAFQP HHCCCCCEEEEEECC	11.28	-
533	Ubiquitination	TSTGFEYQQVAFQPS HCCCCCEEEEEECCC	24.87	21963094
537	Ubiquitination	FEYQQVAFQPSILTE CCEEEEEECCCCCCC	13.26	21963094
540	Ubiquitination	QQVAFQPSILTEPPT EEEEECCCCCCCCCC	21.32	22817900
541	Ubiquitination	QVAFQPSILTEPPTE EEEECCCCCCCCCCC	7.60	22817900
543	Ubiquitination	AFQPSILTEPPTEDH EECCCCCCCCCCCCC	44.79	21963094
546	Ubiquitination	PSILTEPPTEDHLLQ CCCCCCCCCCCCHHH	42.03	22817900
547	Ubiquitination	SILTEPPTEDHLLQN CCCCCCCCCCCHHHC	65.83	22817900
561	Ubiquitination	NTLWPEVQKLYGHGY CCCHHHHHHHHCCCC	28.51	21963094
564	Ubiquitination	WPEVQKLYGHGYEIF HHHHHHHHCCCCEEE	17.70	22817900
565	Ubiquitination	PEVQKLYGHGYEIFC HHHHHHHCCCCEEEE	20.41	22817900
579	Ubiquitination	CVTCNSSKTLLASAC EEEECCCHHHHHHHH	42.91	-
582	Ubiquitination	CNSSKTLLASACKAA ECCCHHHHHHHHHHH	4.24	21963094
585	Ubiquitination	SKTLLASACKAAKKE CHHHHHHHHHHHHHH	8.01	22817900
586	Ubiquitination	KTLLASACKAAKKEH HHHHHHHHHHHHHHC	2.60	22817900
587	Acetylation	TLLASACKAAKKEHA HHHHHHHHHHHHHCE	51.61	25953088
587	Malonylation	TLLASACKAAKKEHA HHHHHHHHHHHHHCE	51.61	26320211
587	Ubiquitination	TLLASACKAAKKEHA HHHHHHHHHHHHHCE	51.61	21963094
590	Ubiquitination	ASACKAAKKEHAAII HHHHHHHHHHCEEEE	64.65	22817900
591	Ubiquitination	SACKAAKKEHAAIIL HHHHHHHHHCEEEEE	50.43	22817900
607	Ubiquitination	NTTSWKQVQNLVFHS ECCCHHHHHHHHHEE	3.46	29967540
612	Ubiquitination	KQVQNLVFHSLTVTQ HHHHHHHHEEEEEEE	3.50	21963094
626	Ubiquitination	QMAFSPNEKFLLAVS EECCCCCCCEEEEEE	48.87	21963094
629	Ubiquitination	FSPNEKFLLAVSRDR CCCCCCEEEEEECHH	4.43	22817900
630	Ubiquitination	SPNEKFLLAVSRDRT CCCCCEEEEEECHHC	5.07	22817900
632	Ubiquitination	NEKFLLAVSRDRTWS CCCEEEEEECHHCHH	4.94	21963094
638	Ubiquitination	AVSRDRTWSLWKKQD EEECHHCHHCCCCCC	7.72	21963094
639	Ubiquitination	VSRDRTWSLWKKQDT EECHHCHHCCCCCCC	24.60	29967540
644	Ubiquitination	TWSLWKKQDTISPEF CHHCCCCCCCCCCCC	49.72	27667366
648	Phosphorylation	WKKQDTISPEFEPVF CCCCCCCCCCCCCCC	22.07	22210691
648	Ubiquitination	WKKQDTISPEFEPVF CCCCCCCCCCCCCCC	22.07	29967540
652	Ubiquitination	DTISPEFEPVFSLFA CCCCCCCCCCCHHHH	38.60	21963094
655	Ubiquitination	SPEFEPVFSLFAFTN CCCCCCCCHHHHCCC	8.43	22817900
656	Ubiquitination	PEFEPVFSLFAFTNK CCCCCCCHHHHCCCC	23.86	21963094
668	Ubiquitination	TNKITSVHSRIIWSC CCCCCEECCEEEEEC	15.89	29967540
677	Ubiquitination	RIIWSCDWSPDSKYF EEEEECCCCCCCCCE	18.98	21963094
682	Ubiquitination	CDWSPDSKYFFTGSR CCCCCCCCCEEECCC	54.15	21963094
686	Ubiquitination	PDSKYFFTGSRDKKV CCCCCEEECCCCCCE	25.09	29967540
706	Ubiquitination	CDSTDDCIEHNIGPC CCCCCCHHHCCCCCC	8.52	29967540
712	Ubiquitination	CIEHNIGPCSSVLDV HHHCCCCCCCCCEEC	15.83	29967540
718	Ubiquitination	GPCSSVLDVGGAVTA CCCCCCEECCCCEEE	34.55	29967540
721	Ubiquitination	SSVLDVGGAVTAVSV CCCEECCCCEEEEEE	19.40	21963094
723	Ubiquitination	VLDVGGAVTAVSVCP CEECCCCEEEEEECC	3.90	27667366
727	Ubiquitination	GGAVTAVSVCPVLHP CCCEEEEEECCCCCC	18.61	29967540
730	Ubiquitination	VTAVSVCPVLHPSQR EEEEEECCCCCCCCC	29.55	29967540
738	Ubiquitination	VLHPSQRYVVAVGLE CCCCCCCEEEEEEEC	7.52	29967540
743	Ubiquitination	QRYVVAVGLECGKIC CCEEEEEEECCCCEE	13.16	27667366
744	Ubiquitination	RYVVAVGLECGKICL CEEEEEEECCCCEEE	3.85	29967540
747	Ubiquitination	VAVGLECGKICLYTW EEEEECCCCEEEEEE	17.00	21963094
749	Ubiquitination	VGLECGKICLYTWKK EEECCCCEEEEEEEC	0.88	27667366
751	Ubiquitination	LECGKICLYTWKKTD ECCCCEEEEEEECCC	4.93	29967540
752	Phosphorylation	ECGKICLYTWKKTDQ CCCCEEEEEEECCCC	13.22	17384208
753	Ubiquitination	CGKICLYTWKKTDQV CCCEEEEEEECCCCC	20.19	29967540
756	Ubiquitination	ICLYTWKKTDQVPEI EEEEEEECCCCCCCC	49.23	29967540
762	Ubiquitination	KKTDQVPEINDWTHC ECCCCCCCCCCCEEE	56.41	29967540
767	Ubiquitination	VPEINDWTHCVETSQ CCCCCCCEEEEECCC	14.30	27667366
771	Ubiquitination	NDWTHCVETSQSQSH CCCEEEEECCCCHHH	48.40	29967540
773	Ubiquitination	WTHCVETSQSQSHTL CEEEEECCCCHHHHH	17.83	29967540
783	Ubiquitination	QSHTLAIRKLCWKNC HHHHHHHHHHHHHCC	21.93	29967540
788	Acetylation	AIRKLCWKNCSGKTE HHHHHHHHCCCCCCC	47.26	25953088
788	Ubiquitination	AIRKLCWKNCSGKTE HHHHHHHHCCCCCCC	47.26	27667366
791	Ubiquitination	KLCWKNCSGKTEQKE HHHHHCCCCCCCCHH	53.36	29967540
792	Ubiquitination	LCWKNCSGKTEQKEA HHHHCCCCCCCCHHH	43.00	29967540
793	Ubiquitination	CWKNCSGKTEQKEAE HHHCCCCCCCCHHHC	32.37	27667366
795	Ubiquitination	KNCSGKTEQKEAEGA HCCCCCCCCHHHCCC	64.24	29967540
797	Ubiquitination	CSGKTEQKEAEGAEW CCCCCCCHHHCCCCE	53.30	29967540
812	Ubiquitination	LHFASCGEDHTVKIH EEEEECCCCCCEEEE	51.45	29967540
817	Ubiquitination	CGEDHTVKIHRVNKC CCCCCCEEEEEECCC	33.67	29967540
821	Ubiquitination	HTVKIHRVNKCAL-- CCEEEEEECCCCC--	5.06	29967540
823	Ubiquitination	VKIHRVNKCAL---- EEEEEECCCCC----	20.30	-
827	Ubiquitination	RVNKCAL-------- EECCCCC--------		29967540
832	Ubiquitination	AL------------- CC-------------		27667366
836	Ubiquitination	----------------- -----------------		29967540
853	Ubiquitination	---------------------------------- ----------------------------------		29967540
856	Ubiquitination	------------------------------------- -------------------------------------		29967540
858	Ubiquitination	--------------------------------------- ---------------------------------------		27667366
862	Ubiquitination	------------------------------------------- -------------------------------------------		29967540
882	Ubiquitination	--------------------------------------------------------------- ---------------------------------------------------------------		29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ELP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ELP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ELP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STAT1_HUMAN	STAT1	physical	10954736
STAT3_HUMAN	STAT3	physical	10954736
STA5B_HUMAN	STAT5B	physical	10954736
JAK1_HUMAN	JAK1	physical	10954736
JAK2_HUMAN	JAK2	physical	10954736
TYK2_HUMAN	TYK2	physical	10954736
ELP1_HUMAN	IKBKAP	physical	19834596
ELP3_HUMAN	ELP3	physical	19834596
ELP4_HUMAN	ELP4	physical	19834596
ELP1_HUMAN	IKBKAP	physical	11818576
CTDP1_HUMAN	CTDP1	physical	11818576
ELP3_HUMAN	ELP3	physical	22939629
ELP4_HUMAN	ELP4	physical	22939629
CD2AP_HUMAN	CD2AP	physical	22863883
WASC4_HUMAN	KIAA1033	physical	22863883
KINH_HUMAN	KIF5B	physical	22863883
NRBP_HUMAN	NRBP1	physical	22863883
PAAF1_HUMAN	PAAF1	physical	22863883
KPRB_HUMAN	PRPSAP2	physical	22863883
RU2B_HUMAN	SNRPB2	physical	22863883
UBP34_HUMAN	USP34	physical	22863883
WRIP1_HUMAN	WRNIP1	physical	22863883
ELP1_HUMAN	IKBKAP	physical	26344197
ELP1_HUMAN	IKBKAP	physical	25960406
ELP3_HUMAN	ELP3	physical	25960406

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.