dbPTM

CLAP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CLAP2_HUMAN
UniProt AC	O75122
Protein Name	CLIP-associating protein 2
Gene Name	CLASP2
Organism	Homo sapiens (Human).
Sequence Length	1294
Subcellular Localization	Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle . Golgi apparatus . Golgi apparatus, trans-Golgi network . Cell membrane . Cell projectio
Protein Description	Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. [PubMed: 26003921 Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2]
Protein Sequence	MAMGDDKSFDDEESVDGNRPSSAASAFKVPAPKTSGNPANSARKPGSAGGPKVGGASKEGGAGAVDEDDFIKAFTDVPSIQIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAGAAQYDCFFQHLRLLDGALKLSAKDLRSQVVREACITVAHLSTVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTHVPRLIPLITSNCTSKSVPVRRRSFEFLDLLLQEWQTHSLERHAAVLVETIKKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSGSVASLPQSDRSSSSSQESLNRPFSSKWSTANPSTVAGRVSAGSSKASSLPGSLQRSRSDIDVNAAAGAKAHHAAGQSVRRGRLGAGALNAGSYASLEDTSDKLDGTASEDGRVRAKLSAPLAGMGNAKADSRGRSRTKMVSQSQPGSRSGSPGRVLTTTALSTVSSGVQRVLVNSASAQKRSKIPRSQGCSREASPSRLSVARSSRIPRPSVSQGCSREASRESSRDTSPVRSFQPLASRHHSRSTGALYAPEVYGASGPGYGISQSSRLSSSVSAMRVLNTGSDVEEAVADALKKPARRRYESYGMHSDDDANSDASSACSERSYSSRNGSIPTYMRQTEDVAEVLNRCASSNWSERKEGLLGLQNLLKNQRTLSRVELKRLCEIFTRMFADPHGKRVFSMFLETLVDFIQVHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRFTVDQTQTPSLKVKVAILKYIETLAKQMDPGDFINSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLRNTGNGTQSSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQEDMNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPTHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQFPDDLSLDHSDLVAELLKELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFKNYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQGYDNSESSVRKACVFCLVAVHAVIGDELKPHLSQLTGSKMKLLNLYIKRAQTGSGGADPTTDVSGQS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5 (in isoform 3)	Phosphorylation	-	47.26	27251275
7	Acetylation	-MAMGDDKSFDDEES -CCCCCCCCCCCHHC	58.73	7661771
7	Ubiquitination	-MAMGDDKSFDDEES -CCCCCCCCCCCHHC	58.73	-
8	Phosphorylation	MAMGDDKSFDDEESV CCCCCCCCCCCHHCC	40.68	21955146
14	Phosphorylation	KSFDDEESVDGNRPS CCCCCHHCCCCCCCC	24.38	22167270
14 (in isoform 2)	Phosphorylation	-	24.38	24719451
21	Phosphorylation	SVDGNRPSSAASAFK CCCCCCCCCCHHHCC	29.40	25159151
22	Phosphorylation	VDGNRPSSAASAFKV CCCCCCCCCHHHCCC	30.45	25159151
25	Phosphorylation	NRPSSAASAFKVPAP CCCCCCHHHCCCCCC	33.67	25159151
28	Acetylation	SSAASAFKVPAPKTS CCCHHHCCCCCCCCC	47.20	25953088
28	Ubiquitination	SSAASAFKVPAPKTS CCCHHHCCCCCCCCC	47.20	-
41	Phosphorylation	TSGNPANSARKPGSA CCCCCCCCCCCCCCC	31.40	28555341
47	Phosphorylation	NSARKPGSAGGPKVG CCCCCCCCCCCCCCC	32.06	24275569
57	Phosphorylation	GPKVGGASKEGGAGA CCCCCCCCCCCCCCC	34.22	-
91	Phosphorylation	SSRELEETLNKIREI CHHHHHHHHHHHHHH	26.67	20860994
94	Acetylation	ELEETLNKIREILSD HHHHHHHHHHHHHHC	46.37	25953088
94	Ubiquitination	ELEETLNKIREILSD HHHHHHHHHHHHHHC	46.37	-
100	Phosphorylation	NKIREILSDDKHDWD HHHHHHHHCCCCCHH	49.80	20860994
113 (in isoform 3)	Phosphorylation	-	6.11	22210691
127 (in isoform 3)	Phosphorylation	-	15.23	22210691
159	Phosphorylation	VVREACITVAHLSTV HHHHHHHHHHHHHHH	16.12	20860994
164	Phosphorylation	CITVAHLSTVLGNKF HHHHHHHHHHHCCCC	13.45	20860994
181	Phosphorylation	GAEAIVPTLFNLVPN CCCCHHHCHHHHCCC	32.84	20068231
189	Phosphorylation	LFNLVPNSAKVMATS HHHHCCCCCHHHHHC	24.32	20068231
193	Sulfoxidation	VPNSAKVMATSGCAA CCCCCHHHHHCCCHH	3.12	21406390
195	Phosphorylation	NSAKVMATSGCAAIR CCCHHHHHCCCHHHH	13.93	20068231
196	Phosphorylation	SAKVMATSGCAAIRF CCHHHHHCCCHHHHH	23.49	20068231
235 (in isoform 3)	Phosphorylation	-	6.40	27251275
241 (in isoform 3)	Phosphorylation	-	50.26	25159151
247 (in isoform 3)	Phosphorylation	-	35.00	25159151
254 (in isoform 3)	Phosphorylation	-	6.80	19276368
258 (in isoform 3)	Phosphorylation	-	30.53	19276368
291 (in isoform 3)	Phosphorylation	-	41.41	22210691
299	Phosphorylation	LYNSLEPSYQKSLQT HHHHCCHHHHHHHHH	30.71	-
300	Phosphorylation	YNSLEPSYQKSLQTY HHHCCHHHHHHHHHH	30.58	-
303	Phosphorylation	LEPSYQKSLQTYLKS CCHHHHHHHHHHHHH	15.35	23532336
310	Phosphorylation	SLQTYLKSSGSVASL HHHHHHHHCCCCCCC	37.02	25159151
311	Phosphorylation	LQTYLKSSGSVASLP HHHHHHHCCCCCCCC	33.24	25159151
313	Phosphorylation	TYLKSSGSVASLPQS HHHHHCCCCCCCCCC	19.23	29255136
316	Phosphorylation	KSSGSVASLPQSDRS HHCCCCCCCCCCCCC	38.13	22617229
320	Phosphorylation	SVASLPQSDRSSSSS CCCCCCCCCCCCCCC	32.81	25159151
322	Methylation	ASLPQSDRSSSSSQE CCCCCCCCCCCCCHH	43.62	-
323	Phosphorylation	SLPQSDRSSSSSQES CCCCCCCCCCCCHHH	39.29	30278072
324	Phosphorylation	LPQSDRSSSSSQESL CCCCCCCCCCCHHHH	34.82	30278072
325	Phosphorylation	PQSDRSSSSSQESLN CCCCCCCCCCHHHHC	34.94	30278072
326	Phosphorylation	QSDRSSSSSQESLNR CCCCCCCCCHHHHCC	37.68	17525332
327	Phosphorylation	SDRSSSSSQESLNRP CCCCCCCCHHHHCCC	39.66	25159151
330	Phosphorylation	SSSSSQESLNRPFSS CCCCCHHHHCCCCCC	24.25	17525332
336	Phosphorylation	ESLNRPFSSKWSTAN HHHCCCCCCCCCCCC	33.42	23403867
337	Phosphorylation	SLNRPFSSKWSTANP HHCCCCCCCCCCCCC	38.22	23403867
340	Phosphorylation	RPFSSKWSTANPSTV CCCCCCCCCCCCCCC	22.75	24719451
345	Phosphorylation	KWSTANPSTVAGRVS CCCCCCCCCCCCEEC	35.01	24719451
352	Phosphorylation	STVAGRVSAGSSKAS CCCCCEECCCCCCHH	26.08	25159151
355	Phosphorylation	AGRVSAGSSKASSLP CCEECCCCCCHHCCC	28.51	26074081
356	Phosphorylation	GRVSAGSSKASSLPG CEECCCCCCHHCCCC	31.18	26074081
359	Phosphorylation	SAGSSKASSLPGSLQ CCCCCCHHCCCCCHH	35.82	30266825
360	Phosphorylation	AGSSKASSLPGSLQR CCCCCHHCCCCCHHC	43.36	30266825
364	Phosphorylation	KASSLPGSLQRSRSD CHHCCCCCHHCCCCC	21.27	30266825
368	Phosphorylation	LPGSLQRSRSDIDVN CCCCHHCCCCCCCHH	24.15	29255136
370	Phosphorylation	GSLQRSRSDIDVNAA CCHHCCCCCCCHHHH	39.92	29255136
389	Phosphorylation	AHHAAGQSVRRGRLG HHHHCCCCCCCCCCC	19.37	24850871
391	Methylation	HAAGQSVRRGRLGAG HHCCCCCCCCCCCCC	40.35	-
404	Phosphorylation	AGALNAGSYASLEDT CCCCCCCCCCCCCCC	18.34	28796482
405	Phosphorylation	GALNAGSYASLEDTS CCCCCCCCCCCCCCC	10.17	28796482
407	Phosphorylation	LNAGSYASLEDTSDK CCCCCCCCCCCCCCC	24.86	19664995
411	Phosphorylation	SYASLEDTSDKLDGT CCCCCCCCCCCCCCC	29.47	27732954
412	Phosphorylation	YASLEDTSDKLDGTA CCCCCCCCCCCCCCC	45.10	27732954
418	Phosphorylation	TSDKLDGTASEDGRV CCCCCCCCCCCCCCE	27.03	27732954
420	Phosphorylation	DKLDGTASEDGRVRA CCCCCCCCCCCCEEE	35.74	27732954
428	Acetylation	EDGRVRAKLSAPLAG CCCCEEEEEECCCCC	32.20	25953088
430	Phosphorylation	GRVRAKLSAPLAGMG CCEEEEEECCCCCCC	27.42	25159151
436	Sulfoxidation	LSAPLAGMGNAKADS EECCCCCCCCCCCCC	2.88	21406390
443	Phosphorylation	MGNAKADSRGRSRTK CCCCCCCCCCCCCCE	41.30	20068231
447	Phosphorylation	KADSRGRSRTKMVSQ CCCCCCCCCCEEEEC	47.31	20068231
453	Phosphorylation	RSRTKMVSQSQPGSR CCCCEEEECCCCCCC	22.18	26846344
455	Phosphorylation	RTKMVSQSQPGSRSG CCEEEECCCCCCCCC	30.73	29255136
459	Phosphorylation	VSQSQPGSRSGSPGR EECCCCCCCCCCCCC	29.92	29255136
461	Phosphorylation	QSQPGSRSGSPGRVL CCCCCCCCCCCCCEE	45.37	23927012
463	Phosphorylation	QPGSRSGSPGRVLTT CCCCCCCCCCCEEEH	25.98	23927012
469	Phosphorylation	GSPGRVLTTTALSTV CCCCCEEEHHHHHHH	21.17	23927012
470	O-linked_Glycosylation	SPGRVLTTTALSTVS CCCCEEEHHHHHHHC	13.10	23301498
470	Phosphorylation	SPGRVLTTTALSTVS CCCCEEEHHHHHHHC	13.10	28152594
471	Phosphorylation	PGRVLTTTALSTVSS CCCEEEHHHHHHHCC	21.99	28464451
474	Phosphorylation	VLTTTALSTVSSGVQ EEEHHHHHHHCCCCH	25.05	28450419
475	Phosphorylation	LTTTALSTVSSGVQR EEHHHHHHHCCCCHH	25.84	28450419
477	O-linked_Glycosylation	TTALSTVSSGVQRVL HHHHHHHCCCCHHHH	22.82	23301498
477	Phosphorylation	TTALSTVSSGVQRVL HHHHHHHCCCCHHHH	22.82	25159151
478	Phosphorylation	TALSTVSSGVQRVLV HHHHHHCCCCHHHHC	38.35	25159151
487	Phosphorylation	VQRVLVNSASAQKRS CHHHHCCCHHHHHHC	19.00	29255136
489	Phosphorylation	RVLVNSASAQKRSKI HHHCCCHHHHHHCCC	30.93	29255136
492	Acetylation	VNSASAQKRSKIPRS CCCHHHHHHCCCCHH	59.35	25953088
494	Phosphorylation	SASAQKRSKIPRSQG CHHHHHHCCCCHHHC	41.81	24719451
499	Phosphorylation	KRSKIPRSQGCSREA HHCCCCHHHCCCCCC	26.10	22617229
503	Phosphorylation	IPRSQGCSREASPSR CCHHHCCCCCCCHHH	39.72	22617229
507	Phosphorylation	QGCSREASPSRLSVA HCCCCCCCHHHHHHH	20.75	22167270
509	Phosphorylation	CSREASPSRLSVARS CCCCCCHHHHHHHHH	43.27	22167270
512	Phosphorylation	EASPSRLSVARSSRI CCCHHHHHHHHHCCC	16.78	22167270
516	Phosphorylation	SRLSVARSSRIPRPS HHHHHHHHCCCCCCC	17.77	20363803
517	Phosphorylation	RLSVARSSRIPRPSV HHHHHHHCCCCCCCH	28.77	20068231
523	Phosphorylation	SSRIPRPSVSQGCSR HCCCCCCCHHHCCCH	35.36	26503892
525	Phosphorylation	RIPRPSVSQGCSREA CCCCCCHHHCCCHHH	25.78	29255136
528	Carbamidation	RPSVSQGCSREASRE CCCHHHCCCHHHHHH	2.41	17322306
529	Phosphorylation	PSVSQGCSREASRES CCHHHCCCHHHHHHC	39.72	29255136
533	Phosphorylation	QGCSREASRESSRDT HCCCHHHHHHCCCCC	31.65	20363803
536	Phosphorylation	SREASRESSRDTSPV CHHHHHHCCCCCCCC	29.57	20363803
537	Phosphorylation	REASRESSRDTSPVR HHHHHHCCCCCCCCC	29.44	29255136
540	Phosphorylation	SRESSRDTSPVRSFQ HHHCCCCCCCCCCHH	33.54	20363803
541	Phosphorylation	RESSRDTSPVRSFQP HHCCCCCCCCCCHHC	26.20	20068231
545	Phosphorylation	RDTSPVRSFQPLASR CCCCCCCCHHCHHHC	28.59	30576142
551	Phosphorylation	RSFQPLASRHHSRST CCHHCHHHCCCCCCC	39.57	-
557	Phosphorylation	ASRHHSRSTGALYAP HHCCCCCCCCCEECC	33.92	24117733
558	Phosphorylation	SRHHSRSTGALYAPE HCCCCCCCCCEECCC	25.93	24117733
562	Phosphorylation	SRSTGALYAPEVYGA CCCCCCEECCCCCCC	21.41	27732954
574	Phosphorylation	YGASGPGYGISQSSR CCCCCCCCCCCHHHH	17.89	30576142
580	Phosphorylation	GYGISQSSRLSSSVS CCCCCHHHHHCCCCC	29.60	30576142
583	Phosphorylation	ISQSSRLSSSVSAMR CCHHHHHCCCCCCHH	21.32	23403867
584	Phosphorylation	SQSSRLSSSVSAMRV CHHHHHCCCCCCHHH	39.07	29255136
585	Phosphorylation	QSSRLSSSVSAMRVL HHHHHCCCCCCHHHH	19.40	29255136
587	Phosphorylation	SRLSSSVSAMRVLNT HHHCCCCCCHHHHCC	20.49	29255136
594	Phosphorylation	SAMRVLNTGSDVEEA CCHHHHCCCCCHHHH	33.62	22167270
596	Phosphorylation	MRVLNTGSDVEEAVA HHHHCCCCCHHHHHH	36.12	19664994
607	Acetylation	EAVADALKKPARRRY HHHHHHHHHHHHHHH	59.43	25953088
607	Ubiquitination	EAVADALKKPARRRY HHHHHHHHHHHHHHH	59.43	-
614	Phosphorylation	KKPARRRYESYGMHS HHHHHHHHHHCCCCC	13.86	28450419
616	Phosphorylation	PARRRYESYGMHSDD HHHHHHHHCCCCCCC	20.32	28450419
617	Phosphorylation	ARRRYESYGMHSDDD HHHHHHHCCCCCCCC	13.41	28450419
621	Phosphorylation	YESYGMHSDDDANSD HHHCCCCCCCCCCCC	33.57	22617229
627	Phosphorylation	HSDDDANSDASSACS CCCCCCCCCHHHHHH	35.95	29507054
630	Phosphorylation	DDANSDASSACSERS CCCCCCHHHHHHHHH	24.37	28450419
631	Phosphorylation	DANSDASSACSERSY CCCCCHHHHHHHHHH	34.71	28450419
634	Phosphorylation	SDASSACSERSYSSR CCHHHHHHHHHHHCC	35.44	28450419
637	Phosphorylation	SSACSERSYSSRNGS HHHHHHHHHHCCCCC	25.89	22210691
638	Phosphorylation	SACSERSYSSRNGSI HHHHHHHHHCCCCCC	19.52	28450419
639	Phosphorylation	ACSERSYSSRNGSIP HHHHHHHHCCCCCCC	24.86	28450419
640	Phosphorylation	CSERSYSSRNGSIPT HHHHHHHCCCCCCCC	22.87	28450419
644	Phosphorylation	SYSSRNGSIPTYMRQ HHHCCCCCCCCCCCC	29.01	28450419
647	Phosphorylation	SRNGSIPTYMRQTED CCCCCCCCCCCCHHH	28.42	-
648	Phosphorylation	RNGSIPTYMRQTEDV CCCCCCCCCCCHHHH	5.73	-
671	Ubiquitination	SSNWSERKEGLLGLQ CCCHHHHHHHHHHHH	52.67	-
671 (in isoform 1)	Ubiquitination	-	52.67	21890473
686	Phosphorylation	NLLKNQRTLSRVELK HHHHCCCCCCHHHHH	21.22	20068231
688	Phosphorylation	LKNQRTLSRVELKRL HHCCCCCCHHHHHHH	33.40	20068231
710	Methylation	FADPHGKRVFSMFLE HCCCCHHHHHHHHHH	39.03	-
752	Phosphorylation	MGADLLGSVQAKVQK CCCHHHHHHHHHHHH	15.83	23532336
767 (in isoform 3)	Phosphorylation	-	42.59	27174698
770 (in isoform 3)	Phosphorylation	-	61.69	27174698
771 (in isoform 3)	Phosphorylation	-	41.93	27174698
774 (in isoform 3)	Phosphorylation	-	8.80	27174698
775 (in isoform 3)	Phosphorylation	-	17.33	25849741
779 (in isoform 3)	Phosphorylation	-	22.19	27174698
781	Phosphorylation	FNILMRFTVDQTQTP EEEEEEEECCCCCCC	16.89	23186163
785	Phosphorylation	MRFTVDQTQTPSLKV EEEECCCCCCCCHHH	29.91	28450419
787	Phosphorylation	FTVDQTQTPSLKVKV EECCCCCCCCHHHHH	20.45	25159151
787 (in isoform 3)	Phosphorylation	-	20.45	29978859
789	Phosphorylation	VDQTQTPSLKVKVAI CCCCCCCCHHHHHHH	44.18	28450419
790 (in isoform 3)	Phosphorylation	-	8.55	21406692
792 (in isoform 3)	Phosphorylation	-	7.96	21406692
793 (in isoform 3)	Phosphorylation	-	25.10	21406692
797 (in isoform 3)	Phosphorylation	-	2.19	25159151
799	Phosphorylation	VKVAILKYIETLAKQ HHHHHHHHHHHHHHH	10.67	23403867
807 (in isoform 3)	Phosphorylation	-	7.09	24117733
809 (in isoform 3)	Phosphorylation	-	38.62	24117733
838 (in isoform 3)	Phosphorylation	-	28.08	29507054
842 (in isoform 3)	Phosphorylation	-	38.64	29507054
857	Phosphorylation	ELNTPEFTMLLGALP CCCCHHHHHHHCCCC	12.78	-
866	Phosphorylation	LLGALPKTFQDGATK HHCCCCCCCCCCHHH	25.29	-
872	Phosphorylation	KTFQDGATKLLHNHL CCCCCCHHHHHHHHH	27.96	-
873	Ubiquitination	TFQDGATKLLHNHLR CCCCCHHHHHHHHHH	48.82	-
882	Phosphorylation	LHNHLRNTGNGTQSS HHHHHHHCCCCCCCC	26.11	29978859
886	Phosphorylation	LRNTGNGTQSSMGSP HHHCCCCCCCCCCCC	29.31	28450419
888	Phosphorylation	NTGNGTQSSMGSPLT HCCCCCCCCCCCCCC	23.33	26055452
889	Phosphorylation	TGNGTQSSMGSPLTR CCCCCCCCCCCCCCC	19.83	21712546
892	Phosphorylation	GTQSSMGSPLTRPTP CCCCCCCCCCCCCCC	14.22	25159151
895	Phosphorylation	SSMGSPLTRPTPRSP CCCCCCCCCCCCCCC	37.68	28450419
898	Phosphorylation	GSPLTRPTPRSPANW CCCCCCCCCCCCCCC	28.22	28450419
900	Methylation	PLTRPTPRSPANWSS CCCCCCCCCCCCCCC	58.72	-
901	Phosphorylation	LTRPTPRSPANWSSP CCCCCCCCCCCCCCC	29.57	28348404
906	Phosphorylation	PRSPANWSSPLTSPT CCCCCCCCCCCCCCC	23.14	28348404
907	Phosphorylation	RSPANWSSPLTSPTN CCCCCCCCCCCCCCC	18.62	25921289
910	Phosphorylation	ANWSSPLTSPTNTSQ CCCCCCCCCCCCCCC	35.72	25921289
911	Phosphorylation	NWSSPLTSPTNTSQN CCCCCCCCCCCCCCC	37.09	25921289
913	Phosphorylation	SSPLTSPTNTSQNTL CCCCCCCCCCCCCCC	51.39	28348404
915	Phosphorylation	PLTSPTNTSQNTLSP CCCCCCCCCCCCCCC	33.88	28348404
916	Phosphorylation	LTSPTNTSQNTLSPS CCCCCCCCCCCCCCH	24.41	28348404
919	Phosphorylation	PTNTSQNTLSPSAFD CCCCCCCCCCCHHHC	22.45	28348404
921	Phosphorylation	NTSQNTLSPSAFDYD CCCCCCCCCHHHCCC	18.12	28348404
927	Phosphorylation	LSPSAFDYDTENMNS CCCHHHCCCCCCCCH	20.50	27251275
929	Phosphorylation	PSAFDYDTENMNSED CHHHCCCCCCCCHHH	24.03	28348404
938	Phosphorylation	NMNSEDIYSSLRGVT CCCHHHHHHHHHHHH	12.43	25884760
945	Phosphorylation	YSSLRGVTEAIQNFS HHHHHHHHHHHHHCC	23.64	26074081
952	Phosphorylation	TEAIQNFSFRSQEDM HHHHHHCCCCCHHHC	27.57	23401153
955	Phosphorylation	IQNFSFRSQEDMNEP HHHCCCCCHHHCCCC	35.59	23401153
967	Phosphorylation	NEPLKRDSKKDDGDS CCCCCCCCCCCCCCC	45.71	22210691
974	Phosphorylation	SKKDDGDSMCGGPGM CCCCCCCCCCCCCCC	22.85	22210691
982	Phosphorylation	MCGGPGMSDPRAGGD CCCCCCCCCCCCCCC	50.83	-
991	Phosphorylation	PRAGGDATDSSQTAL CCCCCCCCCCHHHHH	40.95	29396449
993	Phosphorylation	AGGDATDSSQTALDN CCCCCCCCHHHHHHC	21.71	25627689
994	Phosphorylation	GGDATDSSQTALDNK CCCCCCCHHHHHHCH	34.07	17525332
996	Phosphorylation	DATDSSQTALDNKAS CCCCCHHHHHHCHHH	31.00	29396449
1001	Ubiquitination	SQTALDNKASLLHSM HHHHHHCHHHHHHCC	38.73	-
1003	Phosphorylation	TALDNKASLLHSMPT HHHHCHHHHHHCCCC	32.83	23403867
1007	Phosphorylation	NKASLLHSMPTHSSP CHHHHHHCCCCCCCC	26.82	23927012
1010	Phosphorylation	SLLHSMPTHSSPRSR HHHHCCCCCCCCCCC	26.25	30266825
1012	Phosphorylation	LHSMPTHSSPRSRDY HHCCCCCCCCCCCCC	44.51	29255136
1013	Phosphorylation	HSMPTHSSPRSRDYN HCCCCCCCCCCCCCC	19.41	29255136
1016	Phosphorylation	PTHSSPRSRDYNPYN CCCCCCCCCCCCCCC	32.65	26074081
1019	Phosphorylation	SSPRSRDYNPYNYSD CCCCCCCCCCCCCCC	19.54	28152594
1022	Phosphorylation	RSRDYNPYNYSDSIS CCCCCCCCCCCCCCC	24.08	28796482
1024	Phosphorylation	RDYNPYNYSDSISPF CCCCCCCCCCCCCCC	14.17	21712546
1025	Phosphorylation	DYNPYNYSDSISPFN CCCCCCCCCCCCCCC	22.65	25159151
1027	Phosphorylation	NPYNYSDSISPFNKS CCCCCCCCCCCCCHH	21.01	25159151
1029	Phosphorylation	YNYSDSISPFNKSAL CCCCCCCCCCCHHHH	27.65	25159151
1034	Phosphorylation	SISPFNKSALKEAMF CCCCCCHHHHHHHCC	39.68	26462736
1053	Phosphorylation	DQFPDDLSLDHSDLV HHCCCCCCCCHHHHH	38.45	26657352
1057	Phosphorylation	DDLSLDHSDLVAELL CCCCCCHHHHHHHHH	32.10	22199227
1078	"N6,N6-dimethyllysine"	NERVEERKIALYELM CHHHHHHHHHHHHHH	35.29	-
1078	Methylation	NERVEERKIALYELM CHHHHHHHHHHHHHH	35.29	23644510
1082	Phosphorylation	EERKIALYELMKLTQ HHHHHHHHHHHHHHH	9.67	-
1088	Phosphorylation	LYELMKLTQEESFSV HHHHHHHHHHCCCHH	28.54	-
1092	Phosphorylation	MKLTQEESFSVWDEH HHHHHHCCCHHHHHH	23.28	-
1102	Phosphorylation	VWDEHFKTILLLLLE HHHHHHHHHHHHHHH	18.86	21406692
1110	Phosphorylation	ILLLLLETLGDKEPT HHHHHHHHHCCCCHH	35.69	21406692
1117	Phosphorylation	TLGDKEPTIRALALK HHCCCCHHHHHHHHH	24.96	24719451
1124	Ubiquitination	TIRALALKVLREILR HHHHHHHHHHHHHHH	33.35	-
1140	Phosphorylation	QPARFKNYAELTVMK CCCCCCCHHHHHHHH	11.31	28064214
1204	Ubiquitination	AAIKMQTKVIERVSK HHHHHHHHHHHHHCH	25.07	-
1260	Phosphorylation	DELKPHLSQLTGSKM HHHHHHHHHHHCCHH	21.80	22210691
1273	Phosphorylation	KMKLLNLYIKRAQTG HHHHHHHHHHHHHCC	11.88	-
1279	Phosphorylation	LYIKRAQTGSGGADP HHHHHHHCCCCCCCC	32.12	25627689
1281	Phosphorylation	IKRAQTGSGGADPTT HHHHHCCCCCCCCCC	37.12	25627689
1287	Phosphorylation	GSGGADPTTDVSGQS CCCCCCCCCCCCCCC	35.85	28450419
1288	Phosphorylation	SGGADPTTDVSGQS- CCCCCCCCCCCCCC-	39.53	28450419
1294	Phosphorylation	TTDVSGQS------- CCCCCCCC-------	45.79	28450419

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
499	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
503	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
507	S	Phosphorylation	Kinase	CDK1	P06493	PSP
507	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
533	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
537	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
541	S	Phosphorylation	Kinase	CDK1	P06493	PSP
541	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
1012	S	Phosphorylation	Kinase	CDK1	P06493	PSP
1013	S	Phosphorylation	Kinase	CDK1	P06493	PSP
1027	S	Phosphorylation	Kinase	PLK1	P53350	PSP
1029	S	Phosphorylation	Kinase	CDK1	P06493	PSP
1034	S	Phosphorylation	Kinase	PLK1	P53350	PSP
1053	S	Phosphorylation	Kinase	PLK1	P53350	PSP
1092	S	Phosphorylation	Kinase	PLK1	P53350	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CLAP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CLAP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GOPC_HUMAN	GOPC	physical	26186194
FA43A_HUMAN	FAM43A	physical	26186194
FA43A_HUMAN	FAM43A	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CLAP2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-370; SER-596; SER-1029;SER-1053 AND SER-1057, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-368, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-370; SER-525; SER-529;SER-596 AND SER-1029, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-523 AND SER-525, ANDMASS SPECTROMETRY.	18187866 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-583, AND MASSSPECTROMETRY.	19007248 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-326; SER-327; SER-330;SER-525; SER-529 AND SER-994, AND MASS SPECTROMETRY.	17525332 [Abstract]