| UniProt ID | KBTB4_HUMAN | |
|---|---|---|
| UniProt AC | Q9NVX7 | |
| Protein Name | Kelch repeat and BTB domain-containing protein 4 | |
| Gene Name | KBTBD4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 518 | |
| Subcellular Localization | ||
| Protein Description | ||
| Protein Sequence | MESPEEPGASMDENYFVNYTFKDRSHSGRVAQGIMKLCLEEELFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVSESVFQLLVDYIYHGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQVMWLADRHSDPELYTAAKHCAKTHLAQLQNTEEFLHLPHRLLTDIISDGVPCSQNPTEAIEAWINFNKEEREAFAESLRTSLKEIGENVHIYLIGKESSRTHSLAVSLHCAEDDSISVSGQNSLCHQITAACKHGGDLYVVGGSIPRRMWKCNNATVDWEWCAPLPRDRLQHTLVSVPGKDAIYSLGGKTLQDTLSNAVIYYRVGDNVWTETTQLEVAVSGAAGANLNGIIYLLGGEENDLDFFTKPSRLIQCFDTETDKCHVKPYVLPFAGRMHAAVHKDLVFIVAEGDSLVCYNPLLDSFTRLCLPEAWSSAPSLWKIASCNGSIYVFRDRYKKGDANTYKLDPATSAVTVTRGIKVLLTNLQFVLA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 (in isoform 2) | Methylation | - | 75.01 | - | |
| 3 | Phosphorylation | -----MESPEEPGAS -----CCCCCCCCCC | 35.99 | 27251275 | |
| 10 | Phosphorylation | SPEEPGASMDENYFV CCCCCCCCCCCCEEE | 32.45 | - | |
| 15 | Phosphorylation | GASMDENYFVNYTFK CCCCCCCEEEEEEEC | 13.57 | - | |
| 19 | Phosphorylation | DENYFVNYTFKDRSH CCCEEEEEEECCCCC | 14.30 | - | |
| 20 | Phosphorylation | ENYFVNYTFKDRSHS CCEEEEEEECCCCCC | 21.00 | - | |
| 31 (in isoform 2) | Phosphorylation | - | 10.67 | - | |
| 35 (in isoform 2) | Phosphorylation | - | 3.29 | - | |
| 36 (in isoform 2) | Phosphorylation | - | 33.84 | - | |
| 75 | Phosphorylation | CFFRSMFTSNLKEAH HHHHHHHHCCHHHHH | 14.20 | 24719451 | |
| 167 | Ubiquitination | PELYTAAKHCAKTHL HHHHHHHHHHHHHHH | 36.43 | - | |
| 171 | Ubiquitination | TAAKHCAKTHLAQLQ HHHHHHHHHHHHHHC | 41.70 | - | |
| 183 (in isoform 2) | Ubiquitination | - | 4.19 | - | |
| 187 (in isoform 2) | Ubiquitination | - | 10.37 | - | |
| 232 | Ubiquitination | ESLRTSLKEIGENVH HHHHHHHHHHHCCEE | 47.23 | 21890473 | |
| 241 | Phosphorylation | IGENVHIYLIGKESS HHCCEEEEEECCCCC | 4.20 | - | |
| 245 | Ubiquitination | VHIYLIGKESSRTHS EEEEEECCCCCCCEE | 47.64 | - | |
| 248 (in isoform 2) | Ubiquitination | - | 42.14 | - | |
| 261 (in isoform 2) | Ubiquitination | - | 68.68 | - | |
| 300 | Ubiquitination | SIPRRMWKCNNATVD CCCCCCCCCCCCEEC | 20.10 | - | |
| 316 (in isoform 2) | Ubiquitination | - | 49.73 | - | |
| 329 | Ubiquitination | TLVSVPGKDAIYSLG EEEECCCCHHHHCCC | 37.61 | - | |
| 338 | Ubiquitination | AIYSLGGKTLQDTLS HHHCCCCCCHHHHHH | 44.24 | 21890473 | |
| 345 (in isoform 2) | Ubiquitination | - | 25.49 | - | |
| 350 | Phosphorylation | TLSNAVIYYRVGDNV HHHCCEEEEEECCCE | 4.42 | - | |
| 351 | Phosphorylation | LSNAVIYYRVGDNVW HHCCEEEEEECCCEE | 6.41 | - | |
| 409 | Ubiquitination | CFDTETDKCHVKPYV EEECCCCCCCCCCEE | 33.39 | - | |
| 413 | Ubiquitination | ETDKCHVKPYVLPFA CCCCCCCCCEEECCC | 13.63 | - | |
| 415 | Phosphorylation | DKCHVKPYVLPFAGR CCCCCCCEEECCCCC | 14.65 | - | |
| 425 (in isoform 2) | Ubiquitination | - | 11.22 | - | |
| 429 (in isoform 2) | Ubiquitination | - | 46.27 | - | |
| 492 | Ubiquitination | KGDANTYKLDPATSA CCCCCCEECCCCCCE | 44.36 | 2190698 | |
| 498 | Phosphorylation | YKLDPATSAVTVTRG EECCCCCCEEECCCC | 23.89 | 22210691 | |
| 501 | Phosphorylation | DPATSAVTVTRGIKV CCCCCEEECCCCHHH | 18.84 | 22210691 | |
| 503 | Phosphorylation | ATSAVTVTRGIKVLL CCCEEECCCCHHHHE | 17.51 | 25332170 | |
| 511 | Phosphorylation | RGIKVLLTNLQFVLA CCHHHHEEEEEHHCC | 29.71 | 22210691 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KBTB4_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KBTB4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KBTB4_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CACL1_HUMAN | CACUL1 | physical | 28514442 | |
| DDX11_HUMAN | DDX11 | physical | 28514442 | |
| CUL3_HUMAN | CUL3 | physical | 28514442 | |
| PEX6_HUMAN | PEX6 | physical | 28514442 | |
| NUDC3_HUMAN | NUDCD3 | physical | 28514442 | |
| TCPB_HUMAN | CCT2 | physical | 28514442 | |
| P4K2B_HUMAN | PI4K2B | physical | 28514442 | |
| IMA7_HUMAN | KPNA6 | physical | 28514442 | |
| IMA6_HUMAN | KPNA5 | physical | 28514442 | |
| LZTR1_HUMAN | LZTR1 | physical | 28514442 | |
| HSP7C_HUMAN | HSPA8 | physical | 28514442 | |
| TCPA_HUMAN | TCP1 | physical | 28514442 | |
| SIMC1_HUMAN | SIMC1 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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