| UniProt ID | SIMC1_HUMAN | |
|---|---|---|
| UniProt AC | Q8NDZ2 | |
| Protein Name | SUMO-interacting motif-containing protein 1 | |
| Gene Name | SIMC1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 872 | |
| Subcellular Localization | ||
| Protein Description | ||
| Protein Sequence | MAPASASGEDLRKLPTMAEVNGEQDFIDLTRETRPRTKDRSGLYVIDLTRAEGENRPIATLDLTLEPVTPSQKEPTSLQTCASLSGKAVMEGHVDRSSQPTARRIINSDPVDLDLVEENTFVGPPPATSISGGSVYPTEPNCSSATFTGNLSFLASLQLSSDVSSLSPTSNNSRSSSSSSNQKAPLPCPQQDVSRPPQALPCPLRPLPCPPRASPCPPRASSCPPRALSCPSQTMQCQLPALTHPPQEVPCPRQNIPGPPQDSLGLPQDVPGLPQSILHPQDVAYLQDMPRSPGDVPQSPSDVSPSPDAPQSPGGMPHLPGDVLHSPGDMPHSSGDVTHSPRDIPHLPGDRPDFTQNDVQNRDMPMDISALSSPSCSPSPQSETPLEKVPWLSVMETPARKEISLSEPAKPGSAHVQSRTPQGGLYNRPCLHRLKYFLRPPVHHLFFQTLIPDKDTRENKGQKLEPIPHRRLRMVTNTIEENFPLGTVQFLMDFVSPQHYPPREIVAHIIQKILLSGSETVDVLKEAYMLLMKIQQLHPANAKTVEWDWKLLTYVMEEEGQTLPGRVLFLRYVVQTLEDDFQQTLRRQRQHLQQSIANMVLSCDKQPHNVRDVIKWLVKAVTEDGLTQPPNGNQTSSGTGILKASSSHPSSQPNLTKNTNQLIVCQLQRMLSIAVEVDRTPTCSSNKIAEMMFGFVLDIPERSQREMFFTTMESHLLRCKVLEIIFLHSCETPTRLPLSLAQALYFLNNSTSLLKCQSDKSQWQTWDELVEHLQFLLSSYQHVLREHLRSSVIDRKDLIIKRIKPKPQQGDDITVVDVEKQIEAFRSRLIQMLGEPLVPQLQDKVHLLKLLLFYAADLNPDAEPFQKGWSGS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | O-linked_Glycosylation | -MAPASASGEDLRKL -CCCCCCCHHHHHCC | 30379171 | ||
| 8 | Phosphorylation | MAPASASGEDLRKLP CCCCCCCHHHHHCCC | 28450419 | ||
| 8 (in isoform 3) | Phosphorylation | - | 28450419 | ||
| 11 | Phosphorylation | ASASGEDLRKLPTMA CCCCHHHHHCCCCCE | 28450419 | ||
| 11 (in isoform 3) | Phosphorylation | - | 28450419 | ||
| 13 | Phosphorylation | ASGEDLRKLPTMAEV CCHHHHHCCCCCEEE | 20363803 | ||
| 13 (in isoform 3) | Phosphorylation | - | 20363803 | ||
| 15 | Phosphorylation | GEDLRKLPTMAEVNG HHHHHCCCCCEEECC | 28450419 | ||
| 15 (in isoform 3) | Phosphorylation | - | 28450419 | ||
| 16 (in isoform 3) | Phosphorylation | - | 30177828 | ||
| 16 | Phosphorylation | EDLRKLPTMAEVNGE HHHHCCCCCEEECCC | 30177828 | ||
| 30 | Phosphorylation | EQDFIDLTRETRPRT CCCCHHCCCCCCCCC | 22210691 | ||
| 34 (in isoform 3) | Phosphorylation | - | 23684312 | ||
| 34 | Phosphorylation | IDLTRETRPRTKDRS HHCCCCCCCCCCCCC | 23684312 | ||
| 35 (in isoform 3) | Phosphorylation | - | 23684312 | ||
| 35 | Phosphorylation | DLTRETRPRTKDRSG HCCCCCCCCCCCCCC | 23684312 | ||
| 44 | Phosphorylation | TKDRSGLYVIDLTRA CCCCCCEEEEECEEC | 29496907 | ||
| 76 (in isoform 4) | Ubiquitination | - | 21890473 | ||
| 80 (in isoform 4) | Ubiquitination | - | 21890473 | ||
| 104 (in isoform 4) | Ubiquitination | - | 21890473 | ||
| 128 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 175 | Phosphorylation | PTSNNSRSSSSSSNQ CCCCCCCCCCCCCCC | 29052541 | ||
| 176 | Phosphorylation | TSNNSRSSSSSSNQK CCCCCCCCCCCCCCC | 29052541 | ||
| 177 | Phosphorylation | SNNSRSSSSSSNQKA CCCCCCCCCCCCCCC | 29052541 | ||
| 178 | Phosphorylation | NNSRSSSSSSNQKAP CCCCCCCCCCCCCCC | 29052541 | ||
| 179 | Phosphorylation | NSRSSSSSSNQKAPL CCCCCCCCCCCCCCC | 29052541 | ||
| 180 | Phosphorylation | SRSSSSSSNQKAPLP CCCCCCCCCCCCCCC | 29052541 | ||
| 200 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 204 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 214 | Phosphorylation | LPCPPRASPCPPRAS CCCCCCCCCCCCCHH | 28985074 | ||
| 228 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 305 (in isoform 4) | Ubiquitination | - | 21890473 | ||
| 312 | Phosphorylation | PSPDAPQSPGGMPHL CCCCCCCCCCCCCCC | 26074081 | ||
| 328 (in isoform 4) | Ubiquitination | - | 21890473 | ||
| 401 | Ubiquitination | VMETPARKEISLSEP EECCCCCCEECCCCC | - | ||
| 410 | Ubiquitination | ISLSEPAKPGSAHVQ ECCCCCCCCCCCCCC | - | ||
| 420 | Phosphorylation | SAHVQSRTPQGGLYN CCCCCCCCCCCCCCC | 28985074 | ||
| 426 | Phosphorylation | RTPQGGLYNRPCLHR CCCCCCCCCCHHHHH | 29496907 | ||
| 429 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 452 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 463 | Ubiquitination | TRENKGQKLEPIPHR CCCCCCCCCCCCCHH | - | ||
| 520 | Phosphorylation | ILLSGSETVDVLKEA HHHCCCCHHHHHHHH | - | ||
| 528 | Phosphorylation | VDVLKEAYMLLMKIQ HHHHHHHHHHHHHHH | 27762562 | ||
| 543 | Ubiquitination | QLHPANAKTVEWDWK HHCCCCCCCEEEHHH | 21890473 | ||
| 543 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 550 | Acetylation | KTVEWDWKLLTYVME CCEEEHHHHHHHHHH | 20167786 | ||
| 553 | Phosphorylation | EWDWKLLTYVMEEEG EEHHHHHHHHHHHCC | - | ||
| 584 | Phosphorylation | LEDDFQQTLRRQRQH HHHHHHHHHHHHHHH | - | ||
| 605 | Ubiquitination | NMVLSCDKQPHNVRD HHHHHCCCCCCCHHH | - | ||
| 615 | Ubiquitination | HNVRDVIKWLVKAVT CCHHHHHHHHHHHHC | 21890473 | ||
| 615 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 619 | Ubiquitination | DVIKWLVKAVTEDGL HHHHHHHHHHCCCCC | 21906983 | ||
| 619 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 643 | Ubiquitination | SSGTGILKASSSHPS CCCCCEEECCCCCCC | 21906983 | ||
| 643 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 647 | Phosphorylation | GILKASSSHPSSQPN CEEECCCCCCCCCCC | - | ||
| 651 | Phosphorylation | ASSSHPSSQPNLTKN CCCCCCCCCCCCCCC | 17525332 | ||
| 657 | Ubiquitination | SSQPNLTKNTNQLIV CCCCCCCCCCCHHHH | - | ||
| 752 | Phosphorylation | YFLNNSTSLLKCQSD HHHHCCCCHHCCCCC | 24719451 | ||
| 791 | Phosphorylation | LREHLRSSVIDRKDL HHHHHHHHCCCCHHH | 14729942 | ||
| 804 | Ubiquitination | DLIIKRIKPKPQQGD HHEEEECCCCCCCCC | - | ||
| 806 | Ubiquitination | IIKRIKPKPQQGDDI EEEECCCCCCCCCCE | - | ||
| 820 | Ubiquitination | ITVVDVEKQIEAFRS EEEEEHHHHHHHHHH | - | ||
| 844 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 844 | Ubiquitination | LVPQLQDKVHLLKLL CHHHHHHHHHHHHHH | 2190698 | ||
| 849 | Ubiquitination | QDKVHLLKLLLFYAA HHHHHHHHHHHHHHH | - | ||
| 867 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 867 | Ubiquitination | PDAEPFQKGWSGS-- CCCCCCCCCCCCC-- | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SIMC1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SIMC1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SIMC1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SUMO2_HUMAN | SUMO2 | physical | 23086935 | |
| SUMO1_HUMAN | SUMO1 | physical | 23086935 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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