UniProt ID | DDX11_HUMAN | |
---|---|---|
UniProt AC | Q96FC9 | |
Protein Name | ATP-dependent DNA helicase DDX11 {ECO:0000305} | |
Gene Name | DDX11 {ECO:0000312|HGNC:HGNC:2736} | |
Organism | Homo sapiens (Human). | |
Sequence Length | 970 | |
Subcellular Localization | Nucleus . Nucleus, nucleolus . Cytoplasm, cytoskeleton, spindle pole . Midbody . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . During the early stages of mitosis, localizes to condensed chromatin and is released from the chroma | |
Protein Description | DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability, including DNA replication, DNA repair and heterochromatin organization as well as in ribosomal RNA synthesis. [PubMed: 10648783] | |
Protein Sequence | MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHSQLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTINDFLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPRTTEALAAPADESQASTLRPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTLKFLLLNPAVHFAQVVKECRAVVIAGGTMQPVSDFRQQLLACAGVEAERVVEFSCGHVIPPDNILPLVICSGISNQPLEFTFQKRELPQMMDEVGRILCNLCGVVPGGVVCFFPSYEYLRQVHAHWEKGGLLGRLAARKKIFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGALLLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLSPRPGTPREGSGGEPVHEGRQPVHRQGHQAPEGFCQRSAPGPAICPAPCPGQAAGLDPSPCGGQSYLWPRHCCCAEVSPGEVGLFLMGNHTTAWRRALPLSCPLETVFVVGVVCGDPVTKVKPRRRVWSPECCQDPGTGVSSRRRKWGNPE | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
12 (in isoform 3) | Ubiquitination | - | 24.64 | 21890473 | |
38 (in isoform 5) | Ubiquitination | - | 44.82 | 21906983 | |
38 | Ubiquitination | YRVLEAGKIGIFESP HHHHHHCCEEEEECC | 44.82 | - | |
38 (in isoform 4) | Ubiquitination | - | 44.82 | 21890473 | |
38 (in isoform 2) | Ubiquitination | - | 44.82 | 21890473 | |
38 (in isoform 1) | Ubiquitination | - | 44.82 | 21890473 | |
44 | Phosphorylation | GKIGIFESPTGTGKS CCEEEEECCCCCCHH | 19.60 | 25159151 | |
46 | Phosphorylation | IGIFESPTGTGKSLS EEEEECCCCCCHHHH | 57.57 | 27050516 | |
48 | Phosphorylation | IFESPTGTGKSLSLI EEECCCCCCHHHHHH | 43.87 | 30001349 | |
88 | Ubiquitination | TGPLHDEKDESLCLS CCCCCCCCCCCCEEE | 73.23 | - | |
104 | Phosphorylation | SCEGAAGTPRPAGEP CCCCCCCCCCCCCCC | 16.05 | 25159151 | |
120 | Ubiquitination | WVTQFVQKKEERDLV HHHHHHHHHHHHHHH | 57.77 | - | |
131 | Ubiquitination | RDLVDRLKAEQARRK HHHHHHHHHHHHHHH | 51.26 | - | |
154 | Ubiquitination | LQHRVQLKYAAKRLR HHHHHHHHHHHHHHH | 18.76 | - | |
192 | Phosphorylation | ERLEQLESGEEELVL HHHHHHHCCCCEEEE | 61.16 | 28122231 | |
202 (in isoform 5) | Phosphorylation | - | 18.35 | 22210691 | |
202 | Phosphorylation | EELVLAEYESDEEKK CEEEEEEECCHHHHH | 18.35 | 30278072 | |
204 (in isoform 5) | Phosphorylation | - | 49.79 | 22210691 | |
204 | Phosphorylation | LVLAEYESDEEKKVA EEEEEECCHHHHHHH | 49.79 | 30266825 | |
237 | Phosphorylation | YYCSRTHSQLAQFVH HHCCCCHHHHHHHHH | 26.69 | 28555341 | |
247 | Ubiquitination | AQFVHEVKKSPFGKD HHHHHHHHCCCCCCC | 44.54 | - | |
253 | Ubiquitination | VKKSPFGKDVRLVSL HHCCCCCCCEEEEEC | 54.12 | - | |
259 | Phosphorylation | GKDVRLVSLGSRQNL CCCEEEEECCCCCCE | 31.44 | 28634120 | |
262 | Phosphorylation | VRLVSLGSRQNLCVN EEEEECCCCCCEECC | 35.67 | 23403867 | |
273 | Ubiquitination | LCVNEDVKSLGSVQL EECCCCHHHCCCEEE | 52.89 | - | |
273 (in isoform 2) | Ubiquitination | - | 52.89 | - | |
274 | Phosphorylation | CVNEDVKSLGSVQLI ECCCCHHHCCCEEEE | 37.50 | 20068231 | |
277 | Phosphorylation | EDVKSLGSVQLINDR CCHHHCCCEEEECHH | 16.39 | 20068231 | |
303 | Sumoylation | KKGAEEEKPKRRRQE HHCCCCCCHHHHHHH | 60.15 | - | |
303 | Sumoylation | KKGAEEEKPKRRRQE HHCCCCCCHHHHHHH | 60.15 | - | |
309 (in isoform 3) | Ubiquitination | - | 61.50 | 21890473 | |
311 | Ubiquitination | PKRRRQEKQAACPFY HHHHHHHHHHCCCCC | 36.58 | - | |
319 (in isoform 3) | Ubiquitination | - | 32.38 | 21890473 | |
335 (in isoform 2) | Ubiquitination | - | 42.75 | 21890473 | |
335 | Ubiquitination | DEALAEVKDMEQLLA HHHHHHCCCHHHHHH | 42.75 | - | |
335 (in isoform 1) | Ubiquitination | - | 42.75 | 21890473 | |
335 (in isoform 4) | Ubiquitination | - | 42.75 | 21890473 | |
345 (in isoform 2) | Ubiquitination | - | 49.39 | 21890473 | |
345 (in isoform 1) | Ubiquitination | - | 49.39 | 21890473 | |
345 (in isoform 4) | Ubiquitination | - | 49.39 | 21890473 | |
345 | Ubiquitination | EQLLALGKEARACPY HHHHHHCHHHHCCCC | 49.39 | - | |
434 (in isoform 3) | Ubiquitination | - | 62.44 | 21890473 | |
460 (in isoform 2) | Ubiquitination | - | 48.28 | 21890473 | |
460 (in isoform 1) | Ubiquitination | - | 48.28 | 21890473 | |
460 (in isoform 4) | Ubiquitination | - | 48.28 | 21890473 | |
460 | Ubiquitination | AVLGGNIKQNPNTQS HHHCCCCCCCCCCCC | 48.28 | - | |
467 | Phosphorylation | KQNPNTQSLSQTGTE CCCCCCCCCCCCCCC | 28.13 | - | |
469 | Phosphorylation | NPNTQSLSQTGTELK CCCCCCCCCCCCCEE | 30.83 | - | |
500 (in isoform 3) | Ubiquitination | - | 38.95 | 21890473 | |
501 | Ubiquitination | KVQRYCEKSMISRKL HHHHHHHHHHHHHHH | 41.59 | - | |
507 | Ubiquitination | EKSMISRKLFGFTER HHHHHHHHHHCCHHH | 41.18 | - | |
526 (in isoform 1) | Ubiquitination | - | 51.14 | 21890473 | |
526 (in isoform 2) | Ubiquitination | - | 51.14 | 21890473 | |
526 (in isoform 4) | Ubiquitination | - | 51.14 | 21890473 | |
526 | Ubiquitination | FSSREQPKLAGFQQF ECCCCCHHHHHHHHH | 51.14 | - | |
541 | Phosphorylation | LQSLQPRTTEALAAP HHHCCCCCHHHHCCC | 35.35 | 27732954 | |
542 | Phosphorylation | QSLQPRTTEALAAPA HHCCCCCHHHHCCCC | 22.12 | 27732954 | |
552 | Phosphorylation | LAAPADESQASTLRP HCCCCCHHHHHCCCC | 31.43 | 27732954 | |
589 | Phosphorylation | VILSRQGSLSQSTLK EEEECCCCCCHHHHH | 19.26 | - | |
596 | Ubiquitination | SLSQSTLKFLLLNPA CCCHHHHHHHHHCCH | 33.77 | - | |
596 (in isoform 2) | Ubiquitination | - | 33.77 | - | |
611 | Ubiquitination | VHFAQVVKECRAVVI HHHHHHHHHCCEEEE | 52.84 | - | |
611 (in isoform 2) | Ubiquitination | - | 52.84 | - | |
627 | Phosphorylation | GGTMQPVSDFRQQLL CCCCCCHHHHHHHHH | 37.40 | 22210691 | |
722 | Ubiquitination | QVHAHWEKGGLLGRL HHHHHHHHCCHHHHH | 53.76 | - | |
733 | Ubiquitination | LGRLAARKKIFQEPK HHHHHHHHHHHCCCC | 45.56 | - | |
734 | Ubiquitination | GRLAARKKIFQEPKS HHHHHHHHHHCCCCC | 43.11 | - | |
740 | Ubiquitination | KKIFQEPKSAHQVEQ HHHHCCCCCHHHHHH | 60.57 | - | |
752 | Phosphorylation | VEQVLLAYSRCIQAC HHHHHHHHHHHHHHH | 9.16 | - | |
753 | Phosphorylation | EQVLLAYSRCIQACG HHHHHHHHHHHHHHC | 18.31 | - | |
761 (in isoform 4) | Ubiquitination | - | 36.78 | 21890473 | |
785 (in isoform 3) | Ubiquitination | - | 10.30 | 21890473 | |
805 | Phosphorylation | MPFPNIRSAELQEKM CCCCCCCCHHHHHHH | 23.46 | 24505115 | |
811 | Ubiquitination | RSAELQEKMAYLDQT CCHHHHHHHHHHCCC | 18.83 | - | |
811 (in isoform 2) | Ubiquitination | - | 18.83 | 21890473 | |
814 | Phosphorylation | ELQEKMAYLDQTLSP HHHHHHHHHCCCCCC | 13.81 | 30108239 | |
818 | Phosphorylation | KMAYLDQTLSPRPGT HHHHHCCCCCCCCCC | 28.95 | 30108239 | |
820 | Phosphorylation | AYLDQTLSPRPGTPR HHHCCCCCCCCCCCC | 23.42 | 30108239 | |
825 | Phosphorylation | TLSPRPGTPREGSGG CCCCCCCCCCCCCCC | 23.12 | - | |
853 (in isoform 2) | Ubiquitination | - | 2.82 | - |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DDX11_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DDX11_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DDX11_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
PROF2_HUMAN | PFN2 | physical | 16169070 | |
KAT7_HUMAN | KAT7 | physical | 16169070 | |
CTF18_HUMAN | CHTF18 | physical | 18499658 | |
DCC1_HUMAN | DSCC1 | physical | 18499658 | |
RFC2_HUMAN | RFC2 | physical | 18499658 | |
FEN1_HUMAN | FEN1 | physical | 18499658 | |
FANCA_HUMAN | FANCA | physical | 28215707 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
613398 | Warsaw breakage syndrome (WBRS) | |||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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