DDX11_HUMAN - dbPTM
DDX11_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DDX11_HUMAN
UniProt AC Q96FC9
Protein Name ATP-dependent DNA helicase DDX11 {ECO:0000305}
Gene Name DDX11 {ECO:0000312|HGNC:HGNC:2736}
Organism Homo sapiens (Human).
Sequence Length 970
Subcellular Localization Nucleus . Nucleus, nucleolus . Cytoplasm, cytoskeleton, spindle pole . Midbody . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . During the early stages of mitosis, localizes to condensed chromatin and is released from the chroma
Protein Description DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability, including DNA replication, DNA repair and heterochromatin organization as well as in ribosomal RNA synthesis. [PubMed: 10648783]
Protein Sequence MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHSQLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTINDFLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPRTTEALAAPADESQASTLRPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTLKFLLLNPAVHFAQVVKECRAVVIAGGTMQPVSDFRQQLLACAGVEAERVVEFSCGHVIPPDNILPLVICSGISNQPLEFTFQKRELPQMMDEVGRILCNLCGVVPGGVVCFFPSYEYLRQVHAHWEKGGLLGRLAARKKIFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGALLLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLSPRPGTPREGSGGEPVHEGRQPVHRQGHQAPEGFCQRSAPGPAICPAPCPGQAAGLDPSPCGGQSYLWPRHCCCAEVSPGEVGLFLMGNHTTAWRRALPLSCPLETVFVVGVVCGDPVTKVKPRRRVWSPECCQDPGTGVSSRRRKWGNPE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12 (in isoform 3)Ubiquitination-24.6421890473
38 (in isoform 5)Ubiquitination-44.8221906983
38UbiquitinationYRVLEAGKIGIFESP
HHHHHHCCEEEEECC		44.82-
38 (in isoform 4)Ubiquitination-44.8221890473
38 (in isoform 2)Ubiquitination-44.8221890473
38 (in isoform 1)Ubiquitination-44.8221890473
44PhosphorylationGKIGIFESPTGTGKS
CCEEEEECCCCCCHH		19.6025159151
46PhosphorylationIGIFESPTGTGKSLS
EEEEECCCCCCHHHH		57.5727050516
48PhosphorylationIFESPTGTGKSLSLI
EEECCCCCCHHHHHH		43.8730001349
88UbiquitinationTGPLHDEKDESLCLS
CCCCCCCCCCCCEEE		73.23-
104PhosphorylationSCEGAAGTPRPAGEP
CCCCCCCCCCCCCCC		16.0525159151
120UbiquitinationWVTQFVQKKEERDLV
HHHHHHHHHHHHHHH		57.77-
131UbiquitinationRDLVDRLKAEQARRK
HHHHHHHHHHHHHHH		51.26-
154UbiquitinationLQHRVQLKYAAKRLR
HHHHHHHHHHHHHHH		18.76-
192PhosphorylationERLEQLESGEEELVL
HHHHHHHCCCCEEEE		61.1628122231
202 (in isoform 5)Phosphorylation-18.3522210691
202PhosphorylationEELVLAEYESDEEKK
CEEEEEEECCHHHHH		18.3530278072
204 (in isoform 5)Phosphorylation-49.7922210691
204PhosphorylationLVLAEYESDEEKKVA
EEEEEECCHHHHHHH		49.7930266825
237PhosphorylationYYCSRTHSQLAQFVH
HHCCCCHHHHHHHHH		26.6928555341
247UbiquitinationAQFVHEVKKSPFGKD
HHHHHHHHCCCCCCC		44.54-
253UbiquitinationVKKSPFGKDVRLVSL
HHCCCCCCCEEEEEC		54.12-
259PhosphorylationGKDVRLVSLGSRQNL
CCCEEEEECCCCCCE		31.4428634120
262PhosphorylationVRLVSLGSRQNLCVN
EEEEECCCCCCEECC		35.6723403867
273UbiquitinationLCVNEDVKSLGSVQL
EECCCCHHHCCCEEE		52.89-
273 (in isoform 2)Ubiquitination-52.89-
274PhosphorylationCVNEDVKSLGSVQLI
ECCCCHHHCCCEEEE		37.5020068231
277PhosphorylationEDVKSLGSVQLINDR
CCHHHCCCEEEECHH		16.3920068231
303SumoylationKKGAEEEKPKRRRQE
HHCCCCCCHHHHHHH		60.15-
303SumoylationKKGAEEEKPKRRRQE
HHCCCCCCHHHHHHH		60.15-
309 (in isoform 3)Ubiquitination-61.5021890473
311UbiquitinationPKRRRQEKQAACPFY
HHHHHHHHHHCCCCC		36.58-
319 (in isoform 3)Ubiquitination-32.3821890473
335 (in isoform 2)Ubiquitination-42.7521890473
335UbiquitinationDEALAEVKDMEQLLA
HHHHHHCCCHHHHHH		42.75-
335 (in isoform 1)Ubiquitination-42.7521890473
335 (in isoform 4)Ubiquitination-42.7521890473
345 (in isoform 2)Ubiquitination-49.3921890473
345 (in isoform 1)Ubiquitination-49.3921890473
345 (in isoform 4)Ubiquitination-49.3921890473
345UbiquitinationEQLLALGKEARACPY
HHHHHHCHHHHCCCC		49.39-
434 (in isoform 3)Ubiquitination-62.4421890473
460 (in isoform 2)Ubiquitination-48.2821890473
460 (in isoform 1)Ubiquitination-48.2821890473
460 (in isoform 4)Ubiquitination-48.2821890473
460UbiquitinationAVLGGNIKQNPNTQS
HHHCCCCCCCCCCCC		48.28-
467PhosphorylationKQNPNTQSLSQTGTE
CCCCCCCCCCCCCCC		28.13-
469PhosphorylationNPNTQSLSQTGTELK
CCCCCCCCCCCCCEE		30.83-
500 (in isoform 3)Ubiquitination-38.9521890473
501UbiquitinationKVQRYCEKSMISRKL
HHHHHHHHHHHHHHH		41.59-
507UbiquitinationEKSMISRKLFGFTER
HHHHHHHHHHCCHHH		41.18-
526 (in isoform 1)Ubiquitination-51.1421890473
526 (in isoform 2)Ubiquitination-51.1421890473
526 (in isoform 4)Ubiquitination-51.1421890473
526UbiquitinationFSSREQPKLAGFQQF
ECCCCCHHHHHHHHH		51.14-
541PhosphorylationLQSLQPRTTEALAAP
HHHCCCCCHHHHCCC		35.3527732954
542PhosphorylationQSLQPRTTEALAAPA
HHCCCCCHHHHCCCC		22.1227732954
552PhosphorylationLAAPADESQASTLRP
HCCCCCHHHHHCCCC		31.4327732954
589PhosphorylationVILSRQGSLSQSTLK
EEEECCCCCCHHHHH		19.26-
596UbiquitinationSLSQSTLKFLLLNPA
CCCHHHHHHHHHCCH		33.77-
596 (in isoform 2)Ubiquitination-33.77-
611UbiquitinationVHFAQVVKECRAVVI
HHHHHHHHHCCEEEE		52.84-
611 (in isoform 2)Ubiquitination-52.84-
627PhosphorylationGGTMQPVSDFRQQLL
CCCCCCHHHHHHHHH		37.4022210691
722UbiquitinationQVHAHWEKGGLLGRL
HHHHHHHHCCHHHHH		53.76-
733UbiquitinationLGRLAARKKIFQEPK
HHHHHHHHHHHCCCC		45.56-
734UbiquitinationGRLAARKKIFQEPKS
HHHHHHHHHHCCCCC		43.11-
740UbiquitinationKKIFQEPKSAHQVEQ
HHHHCCCCCHHHHHH		60.57-
752PhosphorylationVEQVLLAYSRCIQAC
HHHHHHHHHHHHHHH		9.16-
753PhosphorylationEQVLLAYSRCIQACG
HHHHHHHHHHHHHHC		18.31-
761 (in isoform 4)Ubiquitination-36.7821890473
785 (in isoform 3)Ubiquitination-10.3021890473
805PhosphorylationMPFPNIRSAELQEKM
CCCCCCCCHHHHHHH		23.4624505115
811UbiquitinationRSAELQEKMAYLDQT
CCHHHHHHHHHHCCC		18.83-
811 (in isoform 2)Ubiquitination-18.8321890473
814PhosphorylationELQEKMAYLDQTLSP
HHHHHHHHHCCCCCC		13.8130108239
818PhosphorylationKMAYLDQTLSPRPGT
HHHHHCCCCCCCCCC		28.9530108239
820PhosphorylationAYLDQTLSPRPGTPR
HHHCCCCCCCCCCCC		23.4230108239
825PhosphorylationTLSPRPGTPREGSGG
CCCCCCCCCCCCCCC		23.12-
853 (in isoform 2)Ubiquitination-2.82-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DDX11_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DDX11_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DDX11_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PROF2_HUMANPFN2physical
16169070
KAT7_HUMANKAT7physical
16169070
CTF18_HUMANCHTF18physical
18499658
DCC1_HUMANDSCC1physical
18499658
RFC2_HUMANRFC2physical
18499658
FEN1_HUMANFEN1physical
18499658
FANCA_HUMANFANCAphysical
28215707
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
613398Warsaw breakage syndrome (WBRS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DDX11_HUMAN

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Related Literatures of Post-Translational Modification

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