DDX11_HUMAN - dbPTM
DDX11_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DDX11_HUMAN
UniProt AC Q96FC9
Protein Name ATP-dependent DNA helicase DDX11 {ECO:0000305}
Gene Name DDX11 {ECO:0000312|HGNC:HGNC:2736}
Organism Homo sapiens (Human).
Sequence Length 970
Subcellular Localization Nucleus . Nucleus, nucleolus . Cytoplasm, cytoskeleton, spindle pole . Midbody . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . During the early stages of mitosis, localizes to condensed chromatin and is released from the chroma
Protein Description DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability, including DNA replication, DNA repair and heterochromatin organization as well as in ribosomal RNA synthesis. [PubMed: 10648783]
Protein Sequence MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHSQLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTINDFLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPRTTEALAAPADESQASTLRPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTLKFLLLNPAVHFAQVVKECRAVVIAGGTMQPVSDFRQQLLACAGVEAERVVEFSCGHVIPPDNILPLVICSGISNQPLEFTFQKRELPQMMDEVGRILCNLCGVVPGGVVCFFPSYEYLRQVHAHWEKGGLLGRLAARKKIFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGALLLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLSPRPGTPREGSGGEPVHEGRQPVHRQGHQAPEGFCQRSAPGPAICPAPCPGQAAGLDPSPCGGQSYLWPRHCCCAEVSPGEVGLFLMGNHTTAWRRALPLSCPLETVFVVGVVCGDPVTKVKPRRRVWSPECCQDPGTGVSSRRRKWGNPE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
12 (in isoform 3)Ubiquitination-24.6421890473
38 (in isoform 5)Ubiquitination-44.8221906983
38UbiquitinationYRVLEAGKIGIFESP
HHHHHHCCEEEEECC
44.82-
38 (in isoform 4)Ubiquitination-44.8221890473
38 (in isoform 2)Ubiquitination-44.8221890473
38 (in isoform 1)Ubiquitination-44.8221890473
44PhosphorylationGKIGIFESPTGTGKS
CCEEEEECCCCCCHH
19.6025159151
46PhosphorylationIGIFESPTGTGKSLS
EEEEECCCCCCHHHH
57.5727050516
48PhosphorylationIFESPTGTGKSLSLI
EEECCCCCCHHHHHH
43.8730001349
88UbiquitinationTGPLHDEKDESLCLS
CCCCCCCCCCCCEEE
73.23-
104PhosphorylationSCEGAAGTPRPAGEP
CCCCCCCCCCCCCCC
16.0525159151
120UbiquitinationWVTQFVQKKEERDLV
HHHHHHHHHHHHHHH
57.77-
131UbiquitinationRDLVDRLKAEQARRK
HHHHHHHHHHHHHHH
51.26-
154UbiquitinationLQHRVQLKYAAKRLR
HHHHHHHHHHHHHHH
18.76-
192PhosphorylationERLEQLESGEEELVL
HHHHHHHCCCCEEEE
61.1628122231
202 (in isoform 5)Phosphorylation-18.3522210691
202PhosphorylationEELVLAEYESDEEKK
CEEEEEEECCHHHHH
18.3530278072
204 (in isoform 5)Phosphorylation-49.7922210691
204PhosphorylationLVLAEYESDEEKKVA
EEEEEECCHHHHHHH
49.7930266825
237PhosphorylationYYCSRTHSQLAQFVH
HHCCCCHHHHHHHHH
26.6928555341
247UbiquitinationAQFVHEVKKSPFGKD
HHHHHHHHCCCCCCC
44.54-
253UbiquitinationVKKSPFGKDVRLVSL
HHCCCCCCCEEEEEC
54.12-
259PhosphorylationGKDVRLVSLGSRQNL
CCCEEEEECCCCCCE
31.4428634120
262PhosphorylationVRLVSLGSRQNLCVN
EEEEECCCCCCEECC
35.6723403867
273UbiquitinationLCVNEDVKSLGSVQL
EECCCCHHHCCCEEE
52.89-
273 (in isoform 2)Ubiquitination-52.89-
274PhosphorylationCVNEDVKSLGSVQLI
ECCCCHHHCCCEEEE
37.5020068231
277PhosphorylationEDVKSLGSVQLINDR
CCHHHCCCEEEECHH
16.3920068231
303SumoylationKKGAEEEKPKRRRQE
HHCCCCCCHHHHHHH
60.15-
303SumoylationKKGAEEEKPKRRRQE
HHCCCCCCHHHHHHH
60.15-
309 (in isoform 3)Ubiquitination-61.5021890473
311UbiquitinationPKRRRQEKQAACPFY
HHHHHHHHHHCCCCC
36.58-
319 (in isoform 3)Ubiquitination-32.3821890473
335 (in isoform 2)Ubiquitination-42.7521890473
335UbiquitinationDEALAEVKDMEQLLA
HHHHHHCCCHHHHHH
42.75-
335 (in isoform 1)Ubiquitination-42.7521890473
335 (in isoform 4)Ubiquitination-42.7521890473
345 (in isoform 2)Ubiquitination-49.3921890473
345 (in isoform 1)Ubiquitination-49.3921890473
345 (in isoform 4)Ubiquitination-49.3921890473
345UbiquitinationEQLLALGKEARACPY
HHHHHHCHHHHCCCC
49.39-
434 (in isoform 3)Ubiquitination-62.4421890473
460 (in isoform 2)Ubiquitination-48.2821890473
460 (in isoform 1)Ubiquitination-48.2821890473
460 (in isoform 4)Ubiquitination-48.2821890473
460UbiquitinationAVLGGNIKQNPNTQS
HHHCCCCCCCCCCCC
48.28-
467PhosphorylationKQNPNTQSLSQTGTE
CCCCCCCCCCCCCCC
28.13-
469PhosphorylationNPNTQSLSQTGTELK
CCCCCCCCCCCCCEE
30.83-
500 (in isoform 3)Ubiquitination-38.9521890473
501UbiquitinationKVQRYCEKSMISRKL
HHHHHHHHHHHHHHH
41.59-
507UbiquitinationEKSMISRKLFGFTER
HHHHHHHHHHCCHHH
41.18-
526 (in isoform 1)Ubiquitination-51.1421890473
526 (in isoform 2)Ubiquitination-51.1421890473
526 (in isoform 4)Ubiquitination-51.1421890473
526UbiquitinationFSSREQPKLAGFQQF
ECCCCCHHHHHHHHH
51.14-
541PhosphorylationLQSLQPRTTEALAAP
HHHCCCCCHHHHCCC
35.3527732954
542PhosphorylationQSLQPRTTEALAAPA
HHCCCCCHHHHCCCC
22.1227732954
552PhosphorylationLAAPADESQASTLRP
HCCCCCHHHHHCCCC
31.4327732954
589PhosphorylationVILSRQGSLSQSTLK
EEEECCCCCCHHHHH
19.26-
596UbiquitinationSLSQSTLKFLLLNPA
CCCHHHHHHHHHCCH
33.77-
596 (in isoform 2)Ubiquitination-33.77-
611UbiquitinationVHFAQVVKECRAVVI
HHHHHHHHHCCEEEE
52.84-
611 (in isoform 2)Ubiquitination-52.84-
627PhosphorylationGGTMQPVSDFRQQLL
CCCCCCHHHHHHHHH
37.4022210691
722UbiquitinationQVHAHWEKGGLLGRL
HHHHHHHHCCHHHHH
53.76-
733UbiquitinationLGRLAARKKIFQEPK
HHHHHHHHHHHCCCC
45.56-
734UbiquitinationGRLAARKKIFQEPKS
HHHHHHHHHHCCCCC
43.11-
740UbiquitinationKKIFQEPKSAHQVEQ
HHHHCCCCCHHHHHH
60.57-
752PhosphorylationVEQVLLAYSRCIQAC
HHHHHHHHHHHHHHH
9.16-
753PhosphorylationEQVLLAYSRCIQACG
HHHHHHHHHHHHHHC
18.31-
761 (in isoform 4)Ubiquitination-36.7821890473
785 (in isoform 3)Ubiquitination-10.3021890473
805PhosphorylationMPFPNIRSAELQEKM
CCCCCCCCHHHHHHH
23.4624505115
811UbiquitinationRSAELQEKMAYLDQT
CCHHHHHHHHHHCCC
18.83-
811 (in isoform 2)Ubiquitination-18.8321890473
814PhosphorylationELQEKMAYLDQTLSP
HHHHHHHHHCCCCCC
13.8130108239
818PhosphorylationKMAYLDQTLSPRPGT
HHHHHCCCCCCCCCC
28.9530108239
820PhosphorylationAYLDQTLSPRPGTPR
HHHCCCCCCCCCCCC
23.4230108239
825PhosphorylationTLSPRPGTPREGSGG
CCCCCCCCCCCCCCC
23.12-
853 (in isoform 2)Ubiquitination-2.82-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DDX11_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DDX11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DDX11_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PROF2_HUMANPFN2physical
16169070
KAT7_HUMANKAT7physical
16169070
CTF18_HUMANCHTF18physical
18499658
DCC1_HUMANDSCC1physical
18499658
RFC2_HUMANRFC2physical
18499658
FEN1_HUMANFEN1physical
18499658
FANCA_HUMANFANCAphysical
28215707

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
613398Warsaw breakage syndrome (WBRS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DDX11_HUMAN

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Related Literatures of Post-Translational Modification

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