| UniProt ID | DCC1_HUMAN | |
|---|---|---|
| UniProt AC | Q9BVC3 | |
| Protein Name | Sister chromatid cohesion protein DCC1 | |
| Gene Name | DSCC1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 393 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3.. | |
| Protein Sequence | MKRTRDEVDATLQIAKLNAAELLPAVHCLGFGPGASGAAAGDFCLLELEPTLCQQLEDGHSLVIRGDKDEQAVLCSKDKTYDLKIADTSNMLLFIPGCKTPDQLKKEDSHCNIIHTEIFGFSNNYWELRRRRPKLKKLKKLLMENPYEGPDSQKEKDSNSSKYTTEDLLDQIQASEEEIMTQLQVLNACKIGGYWRILEFDYEMKLLNHVTQLVDSESWSFGKVPLNTCLQELGPLEPEEMIEHCLKCYGKKYVDEGEVYFELDADKICRAAARMLLQNAVKFNLAEFQEVWQQSVPEGMVTSLDQLKGLALVDRHSRPEIIFLLKVDDLPEDNQERFNSLFSLREKWTEEDIAPYIQDLCGEKQTIGALLTKYSHSSMQNGVKVYNSRRPIS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 68 | Ubiquitination | SLVIRGDKDEQAVLC EEEECCCCCCCEEEE | 67.02 | - | |
| 79 | Ubiquitination | AVLCSKDKTYDLKIA EEEECCCCCCEEEEE | 53.36 | - | |
| 84 | Ubiquitination | KDKTYDLKIADTSNM CCCCCEEEEECCCCE | 32.71 | - | |
| 88 | Phosphorylation | YDLKIADTSNMLLFI CEEEEECCCCEEEEE | 16.99 | 26074081 | |
| 89 | Phosphorylation | DLKIADTSNMLLFIP EEEEECCCCEEEEEC | 22.31 | 26074081 | |
| 99 | Ubiquitination | LLFIPGCKTPDQLKK EEEECCCCCHHHHHC | 69.84 | 29967540 | |
| 100 | Phosphorylation | LFIPGCKTPDQLKKE EEECCCCCHHHHHCC | 35.85 | 22617229 | |
| 105 | Ubiquitination | CKTPDQLKKEDSHCN CCCHHHHHCCCCCCC | 48.78 | 29967540 | |
| 140 | Sumoylation | PKLKKLKKLLMENPY HHHHHHHHHHHHCCC | 58.24 | - | |
| 140 | Ubiquitination | PKLKKLKKLLMENPY HHHHHHHHHHHHCCC | 58.24 | 29967540 | |
| 140 | Sumoylation | PKLKKLKKLLMENPY HHHHHHHHHHHHCCC | 58.24 | - | |
| 152 | Phosphorylation | NPYEGPDSQKEKDSN CCCCCCCCCCCCCCC | 46.41 | - | |
| 154 | Ubiquitination | YEGPDSQKEKDSNSS CCCCCCCCCCCCCCC | 71.35 | 22817900 | |
| 156 | Ubiquitination | GPDSQKEKDSNSSKY CCCCCCCCCCCCCCC | 73.77 | 22817900 | |
| 162 | Ubiquitination | EKDSNSSKYTTEDLL CCCCCCCCCCHHHHH | 46.57 | - | |
| 202 | Ubiquitination | WRILEFDYEMKLLNH EEEEECCHHHHHHHH | 24.20 | 21963094 | |
| 206 | Ubiquitination | EFDYEMKLLNHVTQL ECCHHHHHHHHHHHH | 5.82 | 22817900 | |
| 207 | Ubiquitination | FDYEMKLLNHVTQLV CCHHHHHHHHHHHHH | 3.30 | 22817900 | |
| 223 | Ubiquitination | SESWSFGKVPLNTCL CCCCCCCCCCHHHHH | 38.37 | 29967540 | |
| 247 | Ubiquitination | EMIEHCLKCYGKKYV HHHHHHHHHHCCCCC | 30.70 | 21963094 | |
| 251 | Ubiquitination | HCLKCYGKKYVDEGE HHHHHHCCCCCCCCE | 17.92 | 22817900 | |
| 252 | Ubiquitination | CLKCYGKKYVDEGEV HHHHHCCCCCCCCEE | 46.25 | 22817900 | |
| 275 | Sulfoxidation | ICRAAARMLLQNAVK HHHHHHHHHHHHHHH | 3.62 | 21406390 | |
| 347 | Ubiquitination | SLFSLREKWTEEDIA HHHHHHHHCCHHHHH | 53.64 | 29967540 | |
| 364 | Ubiquitination | IQDLCGEKQTIGALL HHHHHCCCCHHHHHH | 37.72 | 29967540 | |
| 374 | Phosphorylation | IGALLTKYSHSSMQN HHHHHHHCCCCHHHC | 13.33 | - | |
| 384 | Ubiquitination | SSMQNGVKVYNSRRP CHHHCCCEEECCCCC | 40.16 | 29967540 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DCC1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DCC1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DCC1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CTF18_HUMAN | CHTF18 | physical | 12766176 | |
| DDX11_HUMAN | DDX11 | physical | 18499658 | |
| CTF8_HUMAN | CHTF8 | physical | 26186194 | |
| RFC4_HUMAN | RFC4 | physical | 26186194 | |
| RFC3_HUMAN | RFC3 | physical | 26186194 | |
| RFC5_HUMAN | RFC5 | physical | 26186194 | |
| RFC2_HUMAN | RFC2 | physical | 26186194 | |
| T2FA_HUMAN | GTF2F1 | physical | 26186194 | |
| CTF18_HUMAN | CHTF18 | physical | 26186194 | |
| BBS7_HUMAN | BBS7 | physical | 26186194 | |
| THOC1_HUMAN | THOC1 | physical | 26344197 | |
| RFC3_HUMAN | RFC3 | physical | 12766176 | |
| RFC4_HUMAN | RFC4 | physical | 28514442 | |
| CTF8_HUMAN | CHTF8 | physical | 28514442 | |
| CTF18_HUMAN | CHTF18 | physical | 28514442 | |
| RFC2_HUMAN | RFC2 | physical | 28514442 | |
| RFC3_HUMAN | RFC3 | physical | 28514442 | |
| T2FA_HUMAN | GTF2F1 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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