CACL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CACL1_HUMAN
• UniProt AC: Q86Y37
• Protein Name: CDK2-associated and cullin domain-containing protein 1
• Gene Name: CACUL1
• Organism: Homo sapiens (Human).
• Sequence Length: 369
• Protein Description: Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition..
• Protein Sequence: MEESMEEEEGGSYEAMMDDQNHNNWEAAVDGFRQPLPPPPPPSSIPAPAREPPGGQLLAVPAVSVDRKGPKEGLPMGPQPPPEANGVIMMLKSCDAAAAVAKAAPAPTASSTININTSTSKFLMNVITIEDYKSTYWPKLDGAIDQLLTQSPGDYIPISYEQIYSCVYKCVCQQHSEQMYSDLIKKITNHLERVSKELQASPPDLYIERFNIALGQYMGALQSIVPLFIYMNKFYIETKLNRDLKDDLIKLFTEHVAEKHIYSLMPLLLEAQSTPFQVTPSTMANIVKGLYTLRPEWVQMAPTLFSKFIPNILPPAVESELSEYAAQDQKFQRELIQNGFTRGDQSRKRAGDELAYNSSSACASSRGYR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Phosphorylation	LPPPPPPSSIPAPAR CCCCCCCCCCCCCCC		24719451
44	Phosphorylation	PPPPPPSSIPAPARE CCCCCCCCCCCCCCC		24719451
102	Ubiquitination	DAAAAVAKAAPAPTA HHHHHHHHHCCCCCC		29967540
118	O-linked_Glycosylation	STININTSTSKFLMN CEEEECCCCCCEEEE		31492838
119	O-linked_Glycosylation	TININTSTSKFLMNV EEEECCCCCCEEEEE		31492838
186	Ubiquitination	MYSDLIKKITNHLER HHHHHHHHHHHHHHH		29967540
196	Ubiquitination	NHLERVSKELQASPP HHHHHHHHHHHCCCC		23000965
206	Phosphorylation	QASPPDLYIERFNIA HCCCCCCCHHHHHHH		-
233	Ubiquitination	PLFIYMNKFYIETKL HHHHHHCHHHHHHHC		23000965
239	Ubiquitination	NKFYIETKLNRDLKD CHHHHHHHCCCCCHH		23000965
245	Ubiquitination	TKLNRDLKDDLIKLF HHCCCCCHHHHHHHH		23000965
250	Ubiquitination	DLKDDLIKLFTEHVA CCHHHHHHHHHHHHH		29967540
292	Phosphorylation	NIVKGLYTLRPEWVQ HHHHHHHHCCHHHHH		24719451
306	Phosphorylation	QMAPTLFSKFIPNIL HHCHHHHHHHCCCCC		24719451
324	Phosphorylation	VESELSEYAAQDQKF HHHHHHHHHHHCHHH		27642862
330	Ubiquitination	EYAAQDQKFQRELIQ HHHHHCHHHHHHHHH		29967540
356	Phosphorylation	RAGDELAYNSSSACA HHCCCCCCCCHHHHH		23403867
358	Phosphorylation	GDELAYNSSSACASS CCCCCCCCHHHHHHC		23403867
359	Phosphorylation	DELAYNSSSACASSR CCCCCCCHHHHHHCC		23403867
366	Methylation	SSACASSRGYR---- HHHHHHCCCCC----		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CACL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CACL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CACL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANDR_HUMAN	AR	physical	27085459

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.