LZTR1_HUMAN - dbPTM
LZTR1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LZTR1_HUMAN
UniProt AC Q8N653
Protein Name Leucine-zipper-like transcriptional regulator 1
Gene Name LZTR1
Organism Homo sapiens (Human).
Sequence Length 840
Subcellular Localization
Protein Description Probable transcriptional regulator that may play a crucial role in embryogenesis..
Protein Sequence MAGPGSTGGQIGAAALAGGARSKVAPSVDFDHSCSDSVEYLTLNFGPFETVHRWRRLPPCDEFVGARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGNARLNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKMFVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVVQPSSDSEVGGAEVPERACASEEVPTLTYEERVGFKKSRDVFGLDFGTTSAKQPTQPASELPSGRLFHAAAVISDAMYIFGGTVDNNIRSGEMYRFQFSCYPKCTLHEDYGRLWESRQFCDVEFVLGEKEECVQGHVAIVTARSRWLRRKITQARERLAQKLEQEAAPVPREAPGVAAGGARPPLLHVAIREAEARPFEVLMQFLYTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQYIEASVDLQNVLVVCESAARLQLSQLKEHCLNFVVKESHFNQVIMMKEFERLSSPLIVEIVRRKQQPPPRTPLDQPVDIGTSLIQDMKAYLEGAGAEFCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESMLRYIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAADKTQALDMKRHCLHIIVHQFTKVSKLPTLRSLSQQLLLDIIDSLASHISDKQCAELGADI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAGPGSTGG
------CCCCCCCCH		32.6522814378
7Phosphorylation-MAGPGSTGGQIGAA
-CCCCCCCCHHHHHH		51.7723286773
101UbiquitinationDLLRFDVKDCSWCRA
HHHHCCCCCCCCCCH		55.66-
111PhosphorylationSWCRAFTTGTPPAPR
CCCCHHCCCCCCCCC		32.38-
113PhosphorylationCRAFTTGTPPAPRYH
CCHHCCCCCCCCCCC		24.81-
119PhosphorylationGTPPAPRYHHSAVVY
CCCCCCCCCCCEEEE		11.65-
141PhosphorylationGGYTGDIYSNSNLKN
CCCCCCCCCCCCCCC		13.41-
149UbiquitinationSNSNLKNKNDLFEYK
CCCCCCCCCCCEEEE		50.69-
166UbiquitinationTGQWTEWKIEGRLPV
CCCCEEEEEEECCCC		25.34-
244PhosphorylationRDKMFVFSGQSGAKI
CCCEEEEECCCCCCC		30.53-
247PhosphorylationMFVFSGQSGAKITNN
EEEEECCCCCCCCCC		44.22-
261UbiquitinationNLFQFEFKDKTWTRI
CEEEEEECCCCCEEC		51.63-
270PhosphorylationKTWTRIPTEHLLRGS
CCCEECCHHHHHCCC		33.40-
275MethylationIPTEHLLRGSPPPPQ
CCHHHHHCCCCCCCC		50.32115482453
277PhosphorylationTEHLLRGSPPPPQRR
HHHHHCCCCCCCCCC		28.0028348404
349PhosphorylationCASEEVPTLTYEERV
HCCCCCCCCCHHHCC		36.5929978859
351PhosphorylationSEEVPTLTYEERVGF
CCCCCCCCHHHCCCC		31.2229978859
352PhosphorylationEEVPTLTYEERVGFK
CCCCCCCHHHCCCCC		20.9329978859
375UbiquitinationDFGTTSAKQPTQPAS
CCCCCCCCCCCCCHH		57.4821906983
406PhosphorylationAMYIFGGTVDNNIRS
CEEEECCEECCCCCC		25.6822210691
417PhosphorylationNIRSGEMYRFQFSCY
CCCCCCCEEEEEEEC		12.1822210691
426UbiquitinationFQFSCYPKCTLHEDY
EEEEECCCCEEECCC		17.24-
484UbiquitinationARERLAQKLEQEAAP
HHHHHHHHHHHHCCC		48.6721906983
569PhosphorylationLEQLCRQYIEASVDL
HHHHHHHHHHHCCCC		4.9527174698
573PhosphorylationCRQYIEASVDLQNVL
HHHHHHHCCCCHHHH		11.9027174698
585PhosphorylationNVLVVCESAARLQLS
HHHHHHHHHHHHCHH		23.3127174698
592PhosphorylationSAARLQLSQLKEHCL
HHHHHCHHHHHHHHH		22.1024719451
615UbiquitinationFNQVIMMKEFERLSS
HCEEEEHHHHHHCCC		41.70-
682UbiquitinationGHPRPAHKAILAARS
CCCCHHHHHHHHHHH		38.95-
690PhosphorylationAILAARSSYFEAMFR
HHHHHHHHHHHHHHH		28.4323532336
691PhosphorylationILAARSSYFEAMFRS
HHHHHHHHHHHHHHH		13.4923532336
726PhosphorylationAFESMLRYIYYGEVN
HHHHHHHHHHHCCCC		6.85-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LZTR1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LZTR1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LZTR1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LZTR1_HUMANLZTR1physical
20211142
NEMO_HUMANIKBKGphysical
20211142
RUVB1_HUMANRUVBL1physical
20211142
MED7_HUMANMED7physical
20211142
HDAC4_HUMANHDAC4physical
20211142
MED16_HUMANMED16physical
20211142
CAF1A_HUMANCHAF1Aphysical
20211142
NR1H3_HUMANNR1H3physical
20211142
SUGP2_HUMANSUGP2physical
20211142
CEBPZ_HUMANCEBPZphysical
20211142
RAI1_HUMANRAI1physical
20211142
WWP1_HUMANWWP1physical
20211142
ZBTB1_HUMANZBTB1physical
20211142
SCMH1_HUMANSCMH1physical
20211142
ZZZ3_HUMANZZZ3physical
20211142
ZN451_HUMANZNF451physical
20211142
AATF_HUMANAATFphysical
20211142
SND1_HUMANSND1physical
20211142
ZN490_HUMANZNF490physical
20211142
PAPOG_HUMANPAPOLGphysical
20211142
E2F8_HUMANE2F8physical
20211142
EHMT1_HUMANEHMT1physical
20211142
ANR53_HUMANANKRD53physical
20211142
RPA2_HUMANPOLR1Bphysical
20211142
LMBL3_HUMANL3MBTL3physical
20211142
KDM2B_HUMANKDM2Bphysical
20211142
TRIM5_HUMANTRIM5physical
20211142
FANK1_HUMANFANK1physical
20211142
ASB12_HUMANASB12physical
20211142
ZN714_HUMANZNF714physical
20211142
ZN584_HUMANZNF584physical
20211142
CNO6L_HUMANCNOT6Lphysical
20211142
LZTR1_HUMANLZTR1physical
25416956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615670Schwannomatosis 2 (SWNTS2)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LZTR1_HUMAN

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Related Literatures of Post-Translational Modification

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