FANK1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FANK1_HUMAN
• UniProt AC: Q8TC84
• Protein Name: Fibronectin type 3 and ankyrin repeat domains protein 1 {ECO:0000305}
• Gene Name: FANK1 {ECO:0000312|HGNC:HGNC:23527}
• Organism: Homo sapiens (Human).
• Sequence Length: 345
• Subcellular Localization: Nucleus . Cytoplasm, cytosol .
• Protein Description: Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis..
• Protein Sequence: MEPQKIMPPSKPHPPVVGKVTHHSIELYWDLEKKAKRQGPQEQWFRFSIEEEDPKMHTYGIIYTGYATKHVVEGLEPRTLYRFRLKVTSPSGECEYSPLVSVSTTREPISSEHLHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEERKKKQRPKKSCVC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Acetylation	PHPPVVGKVTHHSIE CCCCCCCEECCCEEH	32.14	20167786
33	Acetylation	ELYWDLEKKAKRQGP HHEEEHHHHHHHHCC	66.39	20167786
34	Acetylation	LYWDLEKKAKRQGPQ HEEEHHHHHHHHCCH	50.17	20167786
58	Phosphorylation	EEDPKMHTYGIIYTG CCCCCCEEEEEEEEC	21.68	24260401
59	Phosphorylation	EDPKMHTYGIIYTGY CCCCCEEEEEEEECC	7.52	26074081
63	Phosphorylation	MHTYGIIYTGYATKH CEEEEEEEECCCCHH	7.68	26074081
64	Phosphorylation	HTYGIIYTGYATKHV EEEEEEEECCCCHHH	17.20	26074081
66	Phosphorylation	YGIIYTGYATKHVVE EEEEEECCCCHHHHC	11.87	26074081
119	Phosphorylation	EHLHRAVSVNDEDLL HHHHHCEECCCHHHH	17.76	25106551
259	Methylation	SAVSGNQRVASLLID EECCCCHHHHHEEEE	29.93	-
328	Phosphorylation	FDRQSVVSLLEERKK CCHHHHHHHHHHHHH	25.69	26437602

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FANK1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FANK1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FANK1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSN5_HUMAN	COPS5	physical	20978819
ATG4B_HUMAN	ATG4B	physical	26186194
UBX2B_HUMAN	UBXN2B	physical	26186194
A4GCT_HUMAN	A4GNT	physical	26186194
RYBP_HUMAN	RYBP	physical	27060496
ATG4B_HUMAN	ATG4B	physical	28514442
A4GCT_HUMAN	A4GNT	physical	28514442
UBX2B_HUMAN	UBXN2B	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.