| UniProt ID | A4GCT_HUMAN | |
|---|---|---|
| UniProt AC | Q9UNA3 | |
| Protein Name | Alpha-1,4-N-acetylglucosaminyltransferase | |
| Gene Name | A4GNT | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 340 | |
| Subcellular Localization |
Golgi apparatus membrane Single-pass type II membrane protein . |
|
| Protein Description | Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. [PubMed: 10430883 Necessary for the synthesis of type III mucin which is specifically produced in the stomach, duodenum, and pancreatic duct] | |
| Protein Sequence | MRKELQLSLSVTLLLVCGFLYQFTLKSSCLFCLPSFKSHQGLEALLSHRRGIVFLETSERMEPPHLVSCSVESAAKIYPEWPVVFFMKGLTDSTPMPSNSTYPAFSFLSAIDNVFLFPLDMKRLLEDTPLFSWYNQINASAERNWLHISSDASRLAIIWKYGGIYMDTDVISIRPIPEENFLAAQASRYSSNGIFGFLPHHPFLWECMENFVEHYNSAIWGNQGPELMTRMLRVWCKLEDFQEVSDLRCLNISFLHPQRFYPISYREWRRYYEVWDTEPSFNVSYALHLWNHMNQEGRAVIRGSNTLVENLYRKHCPRTYRDLIKGPEGSVTGELGPGNK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 35 | Phosphorylation | SCLFCLPSFKSHQGL CCEEECCCCCCCHHH | 32.15 | 24719451 | |
| 99 | N-linked_Glycosylation | DSTPMPSNSTYPAFS CCCCCCCCCCCCHHH | 32.28 | UniProtKB CARBOHYD | |
| 138 | N-linked_Glycosylation | FSWYNQINASAERNW HHHHHHHCCCHHCCC | 20.34 | UniProtKB CARBOHYD | |
| 251 | N-linked_Glycosylation | VSDLRCLNISFLHPQ HCCCEEEEEEECCCC | 31.33 | UniProtKB CARBOHYD | |
| 282 | N-linked_Glycosylation | WDTEPSFNVSYALHL ECCCCCCCHHHHHHH | 26.60 | UniProtKB CARBOHYD |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of A4GCT_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of A4GCT_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of A4GCT_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| POMT1_HUMAN | POMT1 | physical | 26186194 | |
| GP1BB_HUMAN | GP1BB | physical | 26186194 | |
| LMF2_HUMAN | LMF2 | physical | 26186194 | |
| POTEF_HUMAN | POTEF | physical | 26186194 | |
| IMPA2_HUMAN | IMPA2 | physical | 26186194 | |
| F213A_HUMAN | FAM213A | physical | 26186194 | |
| GLBL2_HUMAN | GLB1L2 | physical | 26186194 | |
| PDXD1_HUMAN | PDXDC1 | physical | 26186194 | |
| ARF5_HUMAN | ARF5 | physical | 26186194 | |
| FA69A_HUMAN | FAM69A | physical | 26186194 | |
| TM206_HUMAN | TMEM206 | physical | 26186194 | |
| BLK_HUMAN | BLK | physical | 26186194 | |
| FAM3C_HUMAN | FAM3C | physical | 26186194 | |
| ICK_HUMAN | ICK | physical | 26186194 | |
| COMD3_HUMAN | COMMD3 | physical | 26186194 | |
| JMJD8_HUMAN | JMJD8 | physical | 26186194 | |
| HXD13_HUMAN | HOXD13 | physical | 26186194 | |
| RN167_HUMAN | RNF167 | physical | 26186194 | |
| JMJD8_HUMAN | JMJD8 | physical | 28514442 | |
| ICK_HUMAN | ICK | physical | 28514442 | |
| POTEF_HUMAN | POTEF | physical | 28514442 | |
| RN167_HUMAN | RNF167 | physical | 28514442 | |
| F213A_HUMAN | FAM213A | physical | 28514442 | |
| FAM3C_HUMAN | FAM3C | physical | 28514442 | |
| FA69A_HUMAN | FAM69A | physical | 28514442 | |
| IMPA2_HUMAN | IMPA2 | physical | 28514442 | |
| ABHEA_HUMAN | ABHD14A | physical | 28514442 | |
| ARF5_HUMAN | ARF5 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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