IMPA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IMPA2_HUMAN
• UniProt AC: O14732
• Protein Name: Inositol monophosphatase 2
• Gene Name: IMPA2
• Organism: Homo sapiens (Human).
• Sequence Length: 288
• Protein Description: Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain..
• Protein Sequence: MKPSGEDQAALAAGPWEECFQAAVQLALRAGQIIRKALTEEKRVSTKTSAADLVTETDHLVEDLIISELRERFPSHRFIAEEAAASGAKCVLTHSPTWIIDPIDGTCNFVHRFPTVAVSIGFAVRQELEFGVIYHCTEERLYTGRRGRGAFCNGQRLRVSGETDLSKALVLTEIGPKRDPATLKLFLSNMERLLHAKAHGVRVIGSSTLALCHLASGAADAYYQFGLHCWDLAAATVIIREAGGIVIDTSGGPLDLMACRVVAASTREMAMLIAQALQTINYGRDDEK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Ubiquitination	RAGQIIRKALTEEKR HHHHHHHHHHCCCCC	37.02	-
48	Phosphorylation	EKRVSTKTSAADLVT CCCCCCCCCHHHHHH	24.56	20068231
49	Phosphorylation	KRVSTKTSAADLVTE CCCCCCCCHHHHHHC	24.02	20068231
55	Phosphorylation	TSAADLVTETDHLVE CCHHHHHHCCHHHHH	40.23	20068231
57	Phosphorylation	AADLVTETDHLVEDL HHHHHHCCHHHHHHH	21.25	20068231
64	Ubiquitination	TDHLVEDLIISELRE CHHHHHHHHHHHHHH	2.07	21890473
67	Phosphorylation	LVEDLIISELRERFP HHHHHHHHHHHHHCC	24.47	24719451
86	Phosphorylation	IAEEAAASGAKCVLT HHHHHHHCCCCEEEE	34.26	21815630
157 (in isoform 2)	Ubiquitination	-	4.95	21890473
160	Phosphorylation	NGQRLRVSGETDLSK CCCEEEECCCCCHHH	25.20	20068231
163	Phosphorylation	RLRVSGETDLSKALV EEEECCCCCHHHCEE	45.85	20068231
166	Phosphorylation	VSGETDLSKALVLTE ECCCCCHHHCEEHHC	20.77	20068231
168	Ubiquitination	GETDLSKALVLTEIG CCCCHHHCEEHHCCC	10.26	21890473
177	Ubiquitination	VLTEIGPKRDPATLK EHHCCCCCCCHHHHH	65.31	29967540
182	Phosphorylation	GPKRDPATLKLFLSN CCCCCHHHHHHHHHH	29.79	20068231
184	Ubiquitination	KRDPATLKLFLSNME CCCHHHHHHHHHHHH	32.60	22817900
184 (in isoform 1)	Ubiquitination	-	32.60	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IMPA2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IMPA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IMPA2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IMPA2_HUMAN	IMPA2	physical	25416956
UBA3_HUMAN	UBA3	physical	25416956
ALDOA_HUMAN	ALDOA	physical	26344197
ALDOC_HUMAN	ALDOC	physical	26344197
GDIR1_HUMAN	ARHGDIA	physical	26344197
DUT_HUMAN	DUT	physical	26344197
FSCN1_HUMAN	FSCN1	physical	26344197
GPX4_HUMAN	GPX4	physical	26344197
ITPA_HUMAN	ITPA	physical	26344197
MOES_HUMAN	MSN	physical	26344197
PABP4_HUMAN	PABPC4	physical	26344197
PDCD6_HUMAN	PDCD6	physical	26344197
RADI_HUMAN	RDX	physical	26344197
RISC_HUMAN	SCPEP1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB01356: Lithium