RISC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RISC_HUMAN
• UniProt AC: Q9HB40
• Protein Name: Retinoid-inducible serine carboxypeptidase
• Gene Name: SCPEP1
• Organism: Homo sapiens (Human).
• Sequence Length: 452
• Subcellular Localization: Secreted .
• Protein Description: May be involved in vascular wall and kidney homeostasis..
• Protein Sequence: MELALRRSPVPRWLLLLPLLLGLNAGAVIDWPTEEGKEVWDYVTVRKDAYMFWWLYYATNSCKNFSELPLVMWLQGGPGGSSTGFGNFEEIGPLDSDLKPRKTTWLQAASLLFVDNPVGTGFSYVNGSGAYAKDLAMVASDMMVLLKTFFSCHKEFQTVPFYIFSESYGGKMAAGIGLELYKAIQRGTIKCNFAGVALGDSWISPVDSVLSWGPYLYSMSLLEDKGLAEVSKVAEQVLNAVNKGLYREATELWGKAEMIIEQNTDGVNFYNILTKSTPTSTMESSLEFTQSHLVCLCQRHVRHLQRDALSQLMNGPIRKKLKIIPEDQSWGGQATNVFVNMEEDFMKPVISIVDELLEAGINVTVYNGQLDLIVDTMGQEAWVRKLKWPELPKFSQLKWKALYSDPKSLETSAFVKSYKNLAFYWILKAGHMVPSDQGDMALKMMRLVTQQE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Phosphorylation	EGKEVWDYVTVRKDA CCCCEEEEEEEECHH	5.15	-
64	N-linked_Glycosylation	YATNSCKNFSELPLV HHHCCCCCHHHCCEE	50.43	UniProtKB CARBOHYD
126	N-linked_Glycosylation	GTGFSYVNGSGAYAK CCCCCEECCCCCHHH	30.58	12754519
126	N-linked_Glycosylation	GTGFSYVNGSGAYAK CCCCCEECCCCCHHH	30.58	12754519
243	Ubiquitination	QVLNAVNKGLYREAT HHHHHHHHCHHHHHH	43.63	21890473
243 (in isoform 1)	Ubiquitination	-	43.63	21890473
243 (in isoform 2)	Ubiquitination	-	43.63	21890473
280	O-linked_Glycosylation	LTKSTPTSTMESSLE EECCCCCCCCHHHHH	27.28	29351928
281	O-linked_Glycosylation	TKSTPTSTMESSLEF ECCCCCCCCHHHHHH	27.69	29351928
362	N-linked_Glycosylation	ELLEAGINVTVYNGQ HHHHCCCCEEEECCE	23.61	UniProtKB CARBOHYD
400	Ubiquitination	KFSQLKWKALYSDPK CCCHHCHHHHHCCCC	27.25	-
404	Phosphorylation	LKWKALYSDPKSLET HCHHHHHCCCCCCCH	48.57	-
407	Ubiquitination	KALYSDPKSLETSAF HHHHCCCCCCCHHHH	73.07	-
407	2-Hydroxyisobutyrylation	KALYSDPKSLETSAF HHHHCCCCCCCHHHH	73.07	-
408	Phosphorylation	ALYSDPKSLETSAFV HHHCCCCCCCHHHHH	36.50	-
411	Phosphorylation	SDPKSLETSAFVKSY CCCCCCCHHHHHHHH	30.56	-
416	Ubiquitination	LETSAFVKSYKNLAF CCHHHHHHHHHHHHH	41.43	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RISC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RISC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RISC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBA1A_HUMAN	TUBA1A	physical	22863883
TBB5_HUMAN	TUBB	physical	22863883
XPO1_HUMAN	XPO1	physical	22863883
1433E_HUMAN	YWHAE	physical	22863883
CD2AP_HUMAN	CD2AP	physical	26344197
PRDX6_HUMAN	PRDX6	physical	26344197
ZN507_HUMAN	ZNF507	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Identification and quantification of N-linked glycoproteins usinghydrazide chemistry, stable isotope labeling and mass spectrometry.";
Zhang H., Li X.-J., Martin D.B., Aebersold R.;
Nat. Biotechnol. 21:660-666(2003).
Cited for: GLYCOSYLATION AT ASN-126.
PubMed: 12754519