dbPTM

TM206_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TM206_HUMAN
UniProt AC	Q9H813
Protein Name	Transmembrane protein 206
Gene Name	TMEM206
Organism	Homo sapiens (Human).
Sequence Length	350
Subcellular Localization	Membrane Multi-pass membrane protein .
Protein Description
Protein Sequence	MIRQERSTSYQELSEELVQVVENSELADEQDKETVRVQGPGILPGLDSESASSSIRFSKACLKNVFSVLLIFIYLLLMAVAVFLVYRTITDFREKLKHPVMSVSYKEVDRYDAPGIALYPGQAQLLSCKHHYEVIPPLTSPGQPGDMNCTTQRINYTDPFSNQTVKSALIVQGPREVKKRELVFLQFRLNKSSEDFSAIDYLLFSSFQEFLQSPNRVGFMQACESAYSSWKFSGGFRTWVKMSLVKTKEEDGREAVEFRQETSVVNYIDQRPAAKKSAQLFFVVFEWKDPFIQKVQDIVTANPWNTIALLCGAFLALFKAAEFAKLSIKWMIKIRKRYLKRRGQATSHIS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
227	Ubiquitination	MQACESAYSSWKFSG HHHHHHHHCCCCCCC	16.71	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TM206_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TM206_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TM206_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TM147_HUMAN	TMEM147	physical	28514442
NOP9_HUMAN	NOP9	physical	28514442
DCNL5_HUMAN	DCUN1D5	physical	28514442
KNTC1_HUMAN	KNTC1	physical	28514442
WDR3_HUMAN	WDR3	physical	28514442
GNPAT_HUMAN	GNPAT	physical	28514442
THADA_HUMAN	THADA	physical	28514442
ZWILC_HUMAN	ZWILCH	physical	28514442
P4K2A_HUMAN	PI4K2A	physical	28514442
PBIP1_HUMAN	PBXIP1	physical	28514442
IPO9_HUMAN	IPO9	physical	28514442
BIG3_HUMAN	KIAA1244	physical	28514442
PWP2_HUMAN	PWP2	physical	28514442
UFL1_HUMAN	UFL1	physical	28514442
COMD3_HUMAN	COMMD3	physical	28514442
HEAT3_HUMAN	HEATR3	physical	28514442
PCY1A_HUMAN	PCYT1A	physical	28514442
UBP30_HUMAN	USP30	physical	28514442
KIF14_HUMAN	KIF14	physical	28514442
MIGA1_HUMAN	FAM73A	physical	28514442
EI2BE_HUMAN	EIF2B5	physical	28514442
CKAP5_HUMAN	CKAP5	physical	28514442
TM222_HUMAN	TMEM222	physical	28514442
BZW2_HUMAN	BZW2	physical	28514442
RDH14_HUMAN	RDH14	physical	28514442
GBF1_HUMAN	GBF1	physical	28514442
RAB9B_HUMAN	RAB9B	physical	28514442
GBB2_HUMAN	GNB2	physical	28514442
SAAL1_HUMAN	SAAL1	physical	28514442
EI2BD_HUMAN	EIF2B4	physical	28514442
STAT3_HUMAN	STAT3	physical	28514442
XPO7_HUMAN	XPO7	physical	28514442
TNPO2_HUMAN	TNPO2	physical	28514442
EI2BG_HUMAN	EIF2B3	physical	28514442
F1142_HUMAN	FAM114A2	physical	28514442
XPO4_HUMAN	XPO4	physical	28514442
MTCH2_HUMAN	MTCH2	physical	28514442
GLMN_HUMAN	GLMN	physical	28514442
TM38B_HUMAN	TMEM38B	physical	28514442
CK5P3_HUMAN	CDK5RAP3	physical	28514442
ERIC5_HUMAN	ERICH5	physical	28514442
2A5E_HUMAN	PPP2R5E	physical	28514442
TNPO3_HUMAN	TNPO3	physical	28514442
TMM68_HUMAN	TMEM68	physical	28514442
IPO11_HUMAN	IPO11	physical	28514442
MMS22_HUMAN	MMS22L	physical	28514442
RNBP6_HUMAN	RANBP6	physical	28514442
MTOR_HUMAN	MTOR	physical	28514442
MPZL1_HUMAN	MPZL1	physical	28514442
SGPL1_HUMAN	SGPL1	physical	28514442
CCHL_HUMAN	HCCS	physical	28514442
COT2_HUMAN	NR2F2	physical	28514442
IPO7_HUMAN	IPO7	physical	28514442
DAB2P_HUMAN	DAB2IP	physical	28514442
UBP22_HUMAN	USP22	physical	28514442
NU160_HUMAN	NUP160	physical	28514442
TBRG4_HUMAN	TBRG4	physical	28514442
VAMP3_HUMAN	VAMP3	physical	28514442
GPDM_HUMAN	GPD2	physical	28514442
RRP1_HUMAN	RRP1	physical	28514442
ARMX3_HUMAN	ARMCX3	physical	28514442
CISD2_HUMAN	CISD2	physical	28514442
XPO2_HUMAN	CSE1L	physical	28514442
TBC15_HUMAN	TBC1D15	physical	28514442
ARFG1_HUMAN	ARFGAP1	physical	28514442
ASPH2_HUMAN	ASPHD2	physical	28514442
TTYH3_HUMAN	TTYH3	physical	28514442
CS025_HUMAN	C19orf25	physical	28514442
GBB4_HUMAN	GNB4	physical	28514442
RASN_HUMAN	NRAS	physical	28514442
RAP1B_HUMAN	RAP1B	physical	28514442
STAG1_HUMAN	STAG1	physical	28514442
DDRGK_HUMAN	DDRGK1	physical	28514442
RBGP1_HUMAN	RABGAP1	physical	28514442
BZW1_HUMAN	BZW1	physical	28514442
GCP2_HUMAN	TUBGCP2	physical	28514442
GNA13_HUMAN	GNA13	physical	28514442
PRAF2_HUMAN	PRAF2	physical	28514442
MZT2B_HUMAN	MZT2B	physical	28514442
NU155_HUMAN	NUP155	physical	28514442
AT12A_HUMAN	ATP12A	physical	28514442
GHDC_HUMAN	GHDC	physical	28514442
DEGS1_HUMAN	DEGS1	physical	28514442
RINT1_HUMAN	RINT1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TM206_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."; Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.; Nat. Biotechnol. 27:378-386(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-155 AND ASN-162, AND MASSSPECTROMETRY.	19349973 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, AND MASSSPECTROMETRY.	19690332 [Abstract]