MMS22_HUMAN - dbPTM
MMS22_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MMS22_HUMAN
UniProt AC Q6ZRQ5
Protein Name Protein MMS22-like
Gene Name MMS22L
Organism Homo sapiens (Human).
Sequence Length 1243
Subcellular Localization Nucleus . Localizes to DNA damage sites, accumulates at stressed replication forks.
Protein Description Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA..
Protein Sequence MENCSAASTFLTDSLELELGTEWCKPPYFSCAVDNRGGGKHFSGESYLCSGALKRLILNLDPLPTNFEEDTLEIFGIQWVTETALVNSSRELFHLFRQQLYNLETLLQSSCDFGKVSTLHCKADNIRQQCVLFLHYVKVFIFRYLKVQNAESHVPVHPYEALEAQLPSVLIDELHGLLLYIGHLSELPSVNIGAFVNQNQIKLFPPSWHLLHLHLDIHWLVLEILYMLGEKLKQVVYGHQFMNLASDNLTNISLFEEHCETLLCDLISLSLNRYDKVRSSESLMSDQCPCLCIKELWVLLIHLLDHRSKWFVSESFWNWLNKLLKTLLEKSSDRRRSSMPVIQSRDPLGFSWWIITHVASFYKFDRHGVPDEMRKVESNWNFVEELLKKSISVQGVILEEQLRMYLHCCLTLCDFWEPNIAIVTILWEYYSKNLNSSFSISWLPFKGLANTMKSPLSMLEMVKTCCCDKQDQELYKSSSSYTIFLCILAKVVKKAMKSNGPHPWKQVKGRIYSKFHQKRMEELTEVGLQNFFSLFLLLAAVAEVEDVASHVLDLLNFLKPAFVTSQRALIWKGHMAFLLMYAQKNLDIGVLAEKFSCAFREKAKEFLVSKNEEMVQRQTIWTLLSIYIDGVQEVFETSYCLYPSHEKLLNDGFSMLLRACRESELRTVLSFLQAVLARIRSMHQQLCQELQRDNVDLFVQSSLSAKERHLAAVASALWRHFFSFLKSQRMSQVVPFSQLADAAADFTLLAMDMPSTAPSDFQPQPVISIIQLFGWDDIICPQVVARYLSHVLQNSTLCEALSHSGYVSFQALTVRSWIRCVLQMYIKNLSGPDDLLIDKNLEEAVEKEYMKQLVKLTRLLFNLSEVKSIFSKAQVEYLSISEDPKKALVRFFEAVGVTYGNVQTLSDKSAMVTKSLEYLGEVLKYIKPYLGKKVFSAGLQLTYGMMGILVKSWAQIFATSKAQKLLFRIIDCLLLPHAVLQQEKELPAPMLSAIQKSLPLYLQGMCIVCCQSQNPNAYLNQLLGNVIEQYIGRFLPASPYVSDLGQHPVLLALRNTATIPPISSLKKCIVQVIRKSYLEYKGSSPPPRLASILAFILQLFKETNTDIYEVELLLPGILKCLVLVSEPQVKRLATENLQYMVKACQVGSEEEPSSQLTSVFRQFIQDYGMRYYYQVYSILETVATLDQQVVIHLISTLTQSLKDSEQKWGLGRNIAQREAYSKLLSHLGQMGQDEMQRLENDNT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
21PhosphorylationSLELELGTEWCKPPY
CCEEECCCCCCCCCC		38.65-
28PhosphorylationTEWCKPPYFSCAVDN
CCCCCCCCEEEEECC		19.36-
40UbiquitinationVDNRGGGKHFSGESY
ECCCCCCCCCCCCCC		44.7629967540
43PhosphorylationRGGGKHFSGESYLCS
CCCCCCCCCCCCCCH		41.1725072903
46PhosphorylationGKHFSGESYLCSGAL
CCCCCCCCCCCHHHH		27.2525072903
47PhosphorylationKHFSGESYLCSGALK
CCCCCCCCCCHHHHH		13.8725072903
50PhosphorylationSGESYLCSGALKRLI
CCCCCCCHHHHHHHH		25.2225072903
54UbiquitinationYLCSGALKRLILNLD
CCCHHHHHHHHHCCC		44.6221963094
54AcetylationYLCSGALKRLILNLD
CCCHHHHHHHHHCCC		44.6225953088
91UbiquitinationALVNSSRELFHLFRQ
HHHCCHHHHHHHHHH		58.7022817900
115UbiquitinationQSSCDFGKVSTLHCK
HHCCCCCCCEEEEEC		32.76-
207UbiquitinationQIKLFPPSWHLLHLH
CCEECCCCCHHHHHH		27.6322817900
268PhosphorylationTLLCDLISLSLNRYD
HHHHHHHHHHCCCCH		21.1424719451
316UbiquitinationKWFVSESFWNWLNKL
CHHHCHHHHHHHHHH		5.2622817900
326PhosphorylationWLNKLLKTLLEKSSD
HHHHHHHHHHHHCCC		36.2229083192
327UbiquitinationLNKLLKTLLEKSSDR
HHHHHHHHHHHCCCC		5.7822817900
331PhosphorylationLKTLLEKSSDRRRSS
HHHHHHHCCCCHHCC		28.2629083192
332PhosphorylationKTLLEKSSDRRRSSM
HHHHHHCCCCHHCCC		46.3229083192
337PhosphorylationKSSDRRRSSMPVIQS
HCCCCHHCCCCCCCC		29.2228555341
338PhosphorylationSSDRRRSSMPVIQSR
CCCCHHCCCCCCCCC		25.8728674419
366MethylationASFYKFDRHGVPDEM
HHHHCCCCCCCCHHH		31.4354554911
374MethylationHGVPDEMRKVESNWN
CCCCHHHHHHHHCCH		37.5154554917
375UbiquitinationGVPDEMRKVESNWNF
CCCHHHHHHHHCCHH		49.3929967540
384UbiquitinationESNWNFVEELLKKSI
HHCCHHHHHHHHHCC		38.5022817900
388UbiquitinationNFVEELLKKSISVQG
HHHHHHHHHCCCCCC		58.0429967540
389UbiquitinationFVEELLKKSISVQGV
HHHHHHHHCCCCCCC		53.65-
445UbiquitinationFSISWLPFKGLANTM
CEEEEECCCCHHHCC		10.3127667366
453AcetylationKGLANTMKSPLSMLE
CCHHHCCCCHHHHHH		47.0525953088
453UbiquitinationKGLANTMKSPLSMLE
CCHHHCCCCHHHHHH		47.0529967540
469UbiquitinationVKTCCCDKQDQELYK
HHHHHCCCCCHHHHH		41.69-
477PhosphorylationQDQELYKSSSSYTIF
CCHHHHHCCCHHHHH		23.1528348404
478PhosphorylationDQELYKSSSSYTIFL
CHHHHHCCCHHHHHH		21.1028348404
479PhosphorylationQELYKSSSSYTIFLC
HHHHHCCCHHHHHHH		34.1628348404
480PhosphorylationELYKSSSSYTIFLCI
HHHHCCCHHHHHHHH		28.3928348404
481PhosphorylationLYKSSSSYTIFLCIL
HHHCCCHHHHHHHHH		13.0528348404
482PhosphorylationYKSSSSYTIFLCILA
HHCCCHHHHHHHHHH		13.7528348404
505UbiquitinationSNGPHPWKQVKGRIY
HCCCCCHHHHCHHHH		50.0629967540
508UbiquitinationPHPWKQVKGRIYSKF
CCCHHHHCHHHHHHH		39.72-
514UbiquitinationVKGRIYSKFHQKRME
HCHHHHHHHHHHHHH		29.8729967540
561UbiquitinationLLNFLKPAFVTSQRA
HHHHHHHHHHCCCHH		15.2327667366
562UbiquitinationLNFLKPAFVTSQRAL
HHHHHHHHHCCCHHH		9.2727667366
570UbiquitinationVTSQRALIWKGHMAF
HCCCHHHHHHHHHHH		3.3122817900
594UbiquitinationDIGVLAEKFSCAFRE
CHHHHHHHHCHHHHH		36.6529967540
602UbiquitinationFSCAFREKAKEFLVS
HCHHHHHHHHHHHHC		61.5829967540
604UbiquitinationCAFREKAKEFLVSKN
HHHHHHHHHHHHCCC		61.1329967540
610UbiquitinationAKEFLVSKNEEMVQR
HHHHHHCCCHHHHHH		61.9822817900
610 (in isoform 1)Ubiquitination-61.9821906983
654PhosphorylationKLLNDGFSMLLRACR
HHHCCHHHHHHHHHH		17.6622496350
663PhosphorylationLLRACRESELRTVLS
HHHHHHHHHHHHHHH		23.6826437602
670UbiquitinationSELRTVLSFLQAVLA
HHHHHHHHHHHHHHH		21.4127667366
678UbiquitinationFLQAVLARIRSMHQQ
HHHHHHHHHHHHHHH		22.2327667366
681UbiquitinationAVLARIRSMHQQLCQ
HHHHHHHHHHHHHHH		20.4627667366
723PhosphorylationALWRHFFSFLKSQRM
HHHHHHHHHHHHCCH		28.8224719451
738UbiquitinationSQVVPFSQLADAAAD
HHCCCHHHHHHHHHH		40.8427667366
787UbiquitinationCPQVVARYLSHVLQN
CHHHHHHHHHHHHCC		11.6527667366
798UbiquitinationVLQNSTLCEALSHSG
HHCCCHHHHHHCCCC		2.6627667366
827AcetylationCVLQMYIKNLSGPDD
HHHHHHHHHCCCCCC		34.0626051181
839UbiquitinationPDDLLIDKNLEEAVE
CCCEEECCCHHHHHH		57.3429967540
847UbiquitinationNLEEAVEKEYMKQLV
CHHHHHHHHHHHHHH		47.7729967540
849PhosphorylationEEAVEKEYMKQLVKL
HHHHHHHHHHHHHHH		22.23-
855UbiquitinationEYMKQLVKLTRLLFN
HHHHHHHHHHHHHHC		53.3727667366
871PhosphorylationSEVKSIFSKAQVEYL
HHHHHHHCHHHHEEE		25.9724719451
918PhosphorylationMVTKSLEYLGEVLKY
HHHHHHHHHHHHHHH		25.87-
924UbiquitinationEYLGEVLKYIKPYLG
HHHHHHHHHHHHHCC		50.5427667366
925PhosphorylationYLGEVLKYIKPYLGK
HHHHHHHHHHHHCCC		15.26-
927UbiquitinationGEVLKYIKPYLGKKV
HHHHHHHHHHCCCCH		25.2329967540
927AcetylationGEVLKYIKPYLGKKV
HHHHHHHHHHCCCCH		25.2326051181
936PhosphorylationYLGKKVFSAGLQLTY
HCCCCHHHHHCCCHH		25.1422210691
942PhosphorylationFSAGLQLTYGMMGIL
HHHHCCCHHHHHHHH		12.6922210691
943PhosphorylationSAGLQLTYGMMGILV
HHHCCCHHHHHHHHH		16.1822210691
964AcetylationFATSKAQKLLFRIID
HCCHHHHHHHHHHHH		52.6030587349
964UbiquitinationFATSKAQKLLFRIID
HCCHHHHHHHHHHHH		52.6027667366
1038PhosphorylationIGRFLPASPYVSDLG
HHHHCCCCCCCHHCC		18.15-
1041UbiquitinationFLPASPYVSDLGQHP
HCCCCCCCHHCCCCC		3.9927667366
1063PhosphorylationTATIPPISSLKKCIV
CCCCCCHHHHHHHHH		35.0824719451
1081UbiquitinationRKSYLEYKGSSPPPR
HHHHHHHCCCCCCHH		42.8327667366
1084PhosphorylationYLEYKGSSPPPRLAS
HHHHCCCCCCHHHHH		50.5217081983
1148PhosphorylationVKACQVGSEEEPSSQ
HHHHHCCCCCCCHHH		42.87-
1153PhosphorylationVGSEEEPSSQLTSVF
CCCCCCCHHHHHHHH		33.71-
1154PhosphorylationGSEEEPSSQLTSVFR
CCCCCCHHHHHHHHH		39.67-
1171PhosphorylationIQDYGMRYYYQVYSI
HHHHCHHHHHHHHHH		9.5324043423
1172PhosphorylationQDYGMRYYYQVYSIL
HHHCHHHHHHHHHHH		4.1424043423
1173PhosphorylationDYGMRYYYQVYSILE
HHCHHHHHHHHHHHH		5.2024043423
1176PhosphorylationMRYYYQVYSILETVA
HHHHHHHHHHHHHHH		3.7224043423
1177PhosphorylationRYYYQVYSILETVAT
HHHHHHHHHHHHHHC		23.1124043423
1181PhosphorylationQVYSILETVATLDQQ
HHHHHHHHHHCCCHH		16.4024043423
1184PhosphorylationSILETVATLDQQVVI
HHHHHHHCCCHHHHH		26.9124043423
1195PhosphorylationQVVIHLISTLTQSLK
HHHHHHHHHHHHHHC		24.5924043423
1196PhosphorylationVVIHLISTLTQSLKD
HHHHHHHHHHHHHCH		27.1624043423
1198PhosphorylationIHLISTLTQSLKDSE
HHHHHHHHHHHCHHH		19.0524043423
1200PhosphorylationLISTLTQSLKDSEQK
HHHHHHHHHCHHHHH		31.9524043423
1207UbiquitinationSLKDSEQKWGLGRNI
HHCHHHHHHCCCCCH		38.9029967540
1222UbiquitinationAQREAYSKLLSHLGQ
HHHHHHHHHHHHHHH		40.5529967540
1225PhosphorylationEAYSKLLSHLGQMGQ
HHHHHHHHHHHHCCH		27.4024043423
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MMS22_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MMS22_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MMS22_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FBXW7_HUMANFBXW7physical
16169070
TONSL_HUMANTONSLphysical
21055985
SP16H_HUMANSUPT16Hphysical
21055985
SSRP1_HUMANSSRP1physical
21055985
MCM2_HUMANMCM2physical
21055985
MCM4_HUMANMCM4physical
21055985
MCM6_HUMANMCM6physical
21055985
MCM7_HUMANMCM7physical
21055985
TONSL_HUMANTONSLphysical
21113133
IN80C_HUMANINO80Cphysical
22939629
RENT2_HUMANUPF2physical
22939629
TONSL_HUMANTONSLphysical
21055984
ASF1A_HUMANASF1Aphysical
21055984
ASF1B_HUMANASF1Bphysical
21055984
MCM6_HUMANMCM6physical
21055984
H31T_HUMANHIST3H3physical
21055984
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MMS22_HUMAN

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Related Literatures of Post-Translational Modification

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