dbPTM

ASF1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ASF1A_HUMAN
UniProt AC	Q9Y294
Protein Name	Histone chaperone ASF1A
Gene Name	ASF1A
Organism	Homo sapiens (Human).
Sequence Length	204
Subcellular Localization	Nucleus .
Protein Description	Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit..
Protein Sequence	MAKVQVNNVVVLDNPSPFYNPFQFEITFECIEDLSEDLEWKIIYVGSAESEEYDQVLDSVLVGPVPAGRHMFVFQADAPNPGLIPDADAVGVTVVLITCTYRGQEFIRVGYYVNNEYTETELRENPPVKPDFSKLQRNILASNPRVTRFHINWEDNTEKLEDAESSNPNLQSLLSTDALPSASKGWSTSENSLNVMLESHMDCM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
120	Phosphorylation	VNNEYTETELRENPP ECCCCCCCCHHHCCC	32.30	19562805
129	Ubiquitination	LRENPPVKPDFSKLQ HHHCCCCCCCHHHHH	44.64	24816145
142	Phosphorylation	LQRNILASNPRVTRF HHHHHHHCCCCEEEE	43.87	26055452
157	Phosphorylation	HINWEDNTEKLEDAE EEECCCCHHHHHHHH	46.98	26657352
159	Ubiquitination	NWEDNTEKLEDAESS ECCCCHHHHHHHHHC	55.95	29967540
165	Phosphorylation	EKLEDAESSNPNLQS HHHHHHHHCCCCHHH	36.82	30266825
166	Phosphorylation	KLEDAESSNPNLQSL HHHHHHHCCCCHHHH	48.05	25159151
172	Phosphorylation	SSNPNLQSLLSTDAL HCCCCHHHHHCCCCC	34.15	30266825
175	Phosphorylation	PNLQSLLSTDALPSA CCHHHHHCCCCCCCC	29.54	30266825
176	Phosphorylation	NLQSLLSTDALPSAS CHHHHHCCCCCCCCC	25.84	30266825
181	Phosphorylation	LSTDALPSASKGWST HCCCCCCCCCCCCCC	46.13	23898821
183	Phosphorylation	TDALPSASKGWSTSE CCCCCCCCCCCCCCC	35.72	25159151
189	Phosphorylation	ASKGWSTSENSLNVM CCCCCCCCCHHHHHH	29.30	27080861
192	Phosphorylation	GWSTSENSLNVMLES CCCCCCHHHHHHHHH	19.78	14680630

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
192	S	Phosphorylation	Kinase	TLK2	Q86UE8	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
192	S	Phosphorylation		20016786
TLK2-mediated phosphorylation at Ser-192 prevents proteasome-dependent degradation.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ASF1A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CAF1A_HUMAN	CHAF1A	physical	11897662
CAF1B_HUMAN	CHAF1B	physical	11897662
HIRA_HUMAN	HIRA	physical	16980972
HIRA_HUMAN	HIRA	physical	15621527
HTAI2_HUMAN	HTATIP2	physical	15073177
H31T_HUMAN	HIST3H3	physical	17242207
HIRA_HUMAN	HIRA	physical	17242207
TAF1_HUMAN	TAF1	physical	20393127
H31_HUMAN	HIST1H3A	physical	20393127
CDAN1_HUMAN	CDAN1	physical	22407294
IPO4_HUMAN	IPO4	physical	22407294
NASP_HUMAN	NASP	physical	22407294
RBBP7_HUMAN	RBBP7	physical	22407294
RBBP4_HUMAN	RBBP4	physical	22407294
H31_HUMAN	HIST1H3A	physical	22407294
MCM2_HUMAN	MCM2	physical	22407294
MCM4_HUMAN	MCM4	physical	22407294
MCM6_HUMAN	MCM6	physical	22407294
MCM7_HUMAN	MCM7	physical	22407294
TONSL_HUMAN	TONSL	physical	22407294
ASF1B_HUMAN	ASF1B	physical	22407294
H31_HUMAN	HIST1H3A	physical	15664198
NASP_HUMAN	NASP	physical	15664198
RBBP4_HUMAN	RBBP4	physical	15664198
H4_XENLA	hist1h4a	physical	23178455
H33_HUMAN	H3F3A	physical	23075851
H31T_HUMAN	HIST3H3	physical	24209620
H33_HUMAN	H3F3A	physical	24209620
SYSC_HUMAN	SARS	physical	22863883
FBW1A_HUMAN	BTRC	physical	24700029
CUL1_HUMAN	CUL1	physical	24700029
PRR3_HUMAN	PRR3	physical	25416956
CENPB_HUMAN	CENPB	physical	26496610
COPB_HUMAN	COPB1	physical	26496610
NASP_HUMAN	NASP	physical	26496610
PP1A_HUMAN	PPP1CA	physical	26496610
PP1B_HUMAN	PPP1CB	physical	26496610
RBBP4_HUMAN	RBBP4	physical	26496610
RBBP7_HUMAN	RBBP7	physical	26496610
SPTN2_HUMAN	SPTBN2	physical	26496610
HIRA_HUMAN	HIRA	physical	26496610
HAT1_HUMAN	HAT1	physical	26496610
TLK2_HUMAN	TLK2	physical	26496610
ANKL2_HUMAN	ANKLE2	physical	26496610
CABIN_HUMAN	CABIN1	physical	26496610
UBN1_HUMAN	UBN1	physical	26496610
RIF1_HUMAN	RIF1	physical	26496610
ASF1B_HUMAN	ASF1B	physical	26496610
IPO4_HUMAN	IPO4	physical	26496610
ARFG2_HUMAN	ARFGAP2	physical	26496610
CO041_HUMAN	C15orf41	physical	26496610
CDAN1_HUMAN	CDAN1	physical	26496610
UBN2_HUMAN	UBN2	physical	26496610
CO041_HUMAN	C15orf41	physical	28514442
CDAN1_HUMAN	CDAN1	physical	28514442
UBN2_HUMAN	UBN2	physical	28514442
PAN3_HUMAN	PAN3	physical	28514442
UBN1_HUMAN	UBN1	physical	28514442
CABIN_HUMAN	CABIN1	physical	28514442
HIRA_HUMAN	HIRA	physical	28514442
TLK1_HUMAN	TLK1	physical	28514442
TLK2_HUMAN	TLK2	physical	28514442
PAN2_HUMAN	PAN2	physical	28514442
TONSL_HUMAN	TONSL	physical	28514442
NASP_HUMAN	NASP	physical	28514442
IPO4_HUMAN	IPO4	physical	28514442
MCM2_HUMAN	MCM2	physical	28514442
MCM4_HUMAN	MCM4	physical	28514442
MCM6_HUMAN	MCM6	physical	28514442
RBBP4_HUMAN	RBBP4	physical	28514442
RIF1_HUMAN	RIF1	physical	28514442
MCM7_HUMAN	MCM7	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ASF1A_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphorylation-mediated control of histone chaperone ASF1 levels byTousled-like kinases."; Pilyugin M., Demmers J., Verrijzer C.P., Karch F., Moshkin Y.M.; PLoS ONE 4:E8328-E8328(2009). Cited for: PHOSPHORYLATION AT SER-192 BY TLK2.	20016786 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166 AND SER-172, ANDMASS SPECTROMETRY.	19413330 [Abstract]

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