dbPTM

UBN2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UBN2_HUMAN
UniProt AC	Q6ZU65
Protein Name	Ubinuclein-2
Gene Name	UBN2
Organism	Homo sapiens (Human).
Sequence Length	1347
Subcellular Localization
Protein Description
Protein Sequence	MAEPRRVAFISLSPVRRREAEYPGPEREPEYPREPPRLEPQPYREPARAEPPAPREPAPRSDAQPPSREKPLPQREVSRAEPPMSLQREPPRPEPPPPFPPLPLQPPPPRESASRAEQPPRPPRETVRLELVLKDPTDESCVEFSYPELLLCGEQRKKLIHTEDPFNDEHQERQEVEMLAKKFEMKYGGKPRKHRKDRLQDLIDIGFGYDETDPFIDNSEAYDELVPASLTTKYGGFYINTGTLQFRQASDTEEDDITDNQKHKPPKVPKIKEDDIEMKKRKRKEEGEKEKKPRKKVPKQLGVVALNSHKSEKKKKRYKDSLSLAAMIRKFQKEKDALKKESNPKVPVTLSTPSLNKPPCAAAALGNDVPDLNLSSGDPDLPIFVSTNEHELFQEAENALEMLDDFDFDRLLDAASDGSPLSESGGENGTTTQPTYTSQVMPKVVPTLPEGLPVLLEKRIEDLRVAAKLFDEEGRKKFFTQDMNNILLDIELQLQELGPVIRSGVYSHLEAFVPCNKETLVKRLKKLHLNVQDDRLREPLQKLKLAVSNVMPEQLFKYQEDCQARSQAKCAKLQTDEEREKNGSEEDDDEKPGKRVIGPRKKFHWDDTIRTLLCNLVEIKLGCYELEPNKSQSAEDYLKSFMETEVKPLWPKGWMQARMLFKESRSVHNHLTSAPAKKKVIPAPKPKVKEVMVKTLPLHSFPTMLKECSPKKDQKTPTSLVASVSGPPTSSSTAAIAAASSSSAPAQETICLDDSLDEDLSFHSPSLDLVSEALAVINNGNKGPPVGSRISMPTTKPRPGLREEKLASIMSKLPLATPKKLDSTQTTHSSSLIAGHTGPVPKKPQDLAHTGISSGLIAGSSIQNPKVSLEPLPARLLQQGLQRSSQIHTSSSSQTHVSSSSQAQIAASSHALGTSEAQDASSLTQVTKVHQHSAVQQNYVSPLQATISKSQTNPVVKLSNNPQLSCSSSLIKTSDKPLMYRLPLSTPSPGNGSQGSHPLVSRTVPSTTTSSNYLAKAMVSQISTQGFKSPFSMAASPKLAASPKPATSPKPLPSPKPSASPKPSLSAKPSVSTKLISKSNPTPKPTVSPSSSSPNALVAQGSHSSTNSPVHKQPSGMNISRQSPTLNLLPSSRTSGLPPTKNLQAPSKLTNSSSTGTVGKNSLSGIAMNVPASRGSNLNSSGANRTSLSGGTGSGTQGATKPLSTPHRPSTASGSSVVTASVQSTAGASLLANASPLTLMTSPLSVTNQNVTPFGMLGGLVPVTMPFQFPLEIFGFGTDTAGVTTTSGSTSAAFHHSLTQNLLKGLQPGGAQHAATLSHSPLPAHLQQAFHDGGQSKGDTKLPRKSQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	PRRVAFISLSPVRRR CCEEEEEECCCCCCC	19.15	23927012
13	Phosphorylation	RVAFISLSPVRRREA EEEEEECCCCCCCCC	17.98	29255136
61	Phosphorylation	PREPAPRSDAQPPSR CCCCCCCCCCCCCCC	35.92	28188228
67	Phosphorylation	RSDAQPPSREKPLPQ CCCCCCCCCCCCCCH	60.81	28188228
78	Phosphorylation	PLPQREVSRAEPPMS CCCHHHHCCCCCCCC	22.48	23186163
190	Acetylation	FEMKYGGKPRKHRKD HHHHHCCCCCCCCHH	36.97	26051181
234	Phosphorylation	PASLTTKYGGFYINT CCHHEEEECCEEEEC	22.01	23186163
241	Phosphorylation	YGGFYINTGTLQFRQ ECCEEEECCEEEEEE	23.22	23186163
243	Phosphorylation	GFYINTGTLQFRQAS CEEEECCEEEEEECC	18.49	23917254
250	Phosphorylation	TLQFRQASDTEEDDI EEEEEECCCCCCCCC	36.41	23401153
252	Phosphorylation	QFRQASDTEEDDITD EEEECCCCCCCCCCC	38.49	25159151
258	Phosphorylation	DTEEDDITDNQKHKP CCCCCCCCCCCCCCC	35.57	28985074
272	Sumoylation	PPKVPKIKEDDIEMK CCCCCCCCHHHHHHH	62.31	-
272	Sumoylation	PPKVPKIKEDDIEMK CCCCCCCCHHHHHHH	62.31	28112733
299	Acetylation	KPRKKVPKQLGVVAL CCCCCCCHHHCCHHC	62.23	26051181
308	Phosphorylation	LGVVALNSHKSEKKK HCCHHCCCCCCHHHH	32.89	23186163
310	Acetylation	VVALNSHKSEKKKKR CHHCCCCCCHHHHHH	61.19	25953088
310	Ubiquitination	VVALNSHKSEKKKKR CHHCCCCCCHHHHHH	61.19	-
311	Phosphorylation	VALNSHKSEKKKKRY HHCCCCCCHHHHHHH	49.58	23917254
318	Phosphorylation	SEKKKKRYKDSLSLA CHHHHHHHHHHHHHH	28.20	29052541
321	Phosphorylation	KKKRYKDSLSLAAMI HHHHHHHHHHHHHHH	18.73	29052541
323	Phosphorylation	KRYKDSLSLAAMIRK HHHHHHHHHHHHHHH	21.66	29052541
349	Phosphorylation	SNPKVPVTLSTPSLN CCCCCCEEECCCCCC	14.66	21406692
351	Phosphorylation	PKVPVTLSTPSLNKP CCCCEEECCCCCCCC	28.98	21406692
352	Phosphorylation	KVPVTLSTPSLNKPP CCCEEECCCCCCCCC	21.73	21406692
354	Phosphorylation	PVTLSTPSLNKPPCA CEEECCCCCCCCCCH	44.66	21406692
416	Phosphorylation	DRLLDAASDGSPLSE HHHHHHHCCCCCCCC	44.20	30177828
419	Phosphorylation	LDAASDGSPLSESGG HHHHCCCCCCCCCCC	27.88	30177828
422	Phosphorylation	ASDGSPLSESGGENG HCCCCCCCCCCCCCC	32.85	30177828
424	Phosphorylation	DGSPLSESGGENGTT CCCCCCCCCCCCCCC	49.04	30177828
430	Phosphorylation	ESGGENGTTTQPTYT CCCCCCCCCCCCCEE	37.95	17525332
431	Phosphorylation	SGGENGTTTQPTYTS CCCCCCCCCCCCEEC	25.49	30177828
432	Phosphorylation	GGENGTTTQPTYTSQ CCCCCCCCCCCEECC	32.18	17525332
435	Phosphorylation	NGTTTQPTYTSQVMP CCCCCCCCEECCCCC	29.61	30177828
436	Phosphorylation	GTTTQPTYTSQVMPK CCCCCCCEECCCCCC	15.86	30177828
437	Phosphorylation	TTTQPTYTSQVMPKV CCCCCCEECCCCCCC	18.37	30177828
458	Ubiquitination	GLPVLLEKRIEDLRV CCCHHHHHHHHHHHH	59.66	29967540
468	Ubiquitination	EDLRVAAKLFDEEGR HHHHHHHHHCCHHHH	39.69	29967540
542	Ubiquitination	RLREPLQKLKLAVSN HHHHHHHHHHHHHHC	56.10	29967540
544	Ubiquitination	REPLQKLKLAVSNVM HHHHHHHHHHHHCCC	41.24	-
557	Ubiquitination	VMPEQLFKYQEDCQA CCHHHHHHHHHHHHH	55.40	29967540
575	Phosphorylation	AKCAKLQTDEEREKN HHHHHCCCHHHHHHC	56.68	30576142
584	Phosphorylation	EEREKNGSEEDDDEK HHHHHCCCCCCCCCC	47.40	17287340
611	Phosphorylation	HWDDTIRTLLCNLVE CCHHHHHHHHHHHHH	21.89	-
624	Phosphorylation	VEIKLGCYELEPNKS HHHHCCCEECCCCCC	23.04	-
630	Ubiquitination	CYELEPNKSQSAEDY CEECCCCCCCCHHHH	61.66	29967540
631	Phosphorylation	YELEPNKSQSAEDYL EECCCCCCCCHHHHH	35.69	25159151
633	Phosphorylation	LEPNKSQSAEDYLKS CCCCCCCCHHHHHHH	40.49	25627689
639	Ubiquitination	QSAEDYLKSFMETEV CCHHHHHHHHHHHCC	35.10	29967540
644	Phosphorylation	YLKSFMETEVKPLWP HHHHHHHHCCCCCCC	34.00	22210691
677	Ubiquitination	HLTSAPAKKKVIPAP HHCCCCCCCCCCCCC	52.66	29967540
694	Acetylation	KVKEVMVKTLPLHSF CCEEEEEEECCHHHH	26.67	25953088
695	Phosphorylation	VKEVMVKTLPLHSFP CEEEEEEECCHHHHC	23.38	22210691
703	Phosphorylation	LPLHSFPTMLKECSP CCHHHHCHHHHHCCC	32.88	24719451
709	Phosphorylation	PTMLKECSPKKDQKT CHHHHHCCCCCCCCC	40.63	22210691
712	Acetylation	LKECSPKKDQKTPTS HHHCCCCCCCCCCCC	69.63	19817201
808	Phosphorylation	LREEKLASIMSKLPL CCHHHHHHHHHCCCC	29.30	23403867
811	Phosphorylation	EKLASIMSKLPLATP HHHHHHHHCCCCCCC	29.39	23403867
812	Acetylation	KLASIMSKLPLATPK HHHHHHHCCCCCCCC	36.42	26051181
817	Phosphorylation	MSKLPLATPKKLDST HHCCCCCCCCCCCCC	43.24	23312004
819	Acetylation	KLPLATPKKLDSTQT CCCCCCCCCCCCCCC	62.71	26051181
823	Phosphorylation	ATPKKLDSTQTTHSS CCCCCCCCCCCCCCC	32.62	23312004
824	Phosphorylation	TPKKLDSTQTTHSSS CCCCCCCCCCCCCCC	29.60	23312004
826	Phosphorylation	KKLDSTQTTHSSSLI CCCCCCCCCCCCCCC	26.94	30576142
827	Phosphorylation	KLDSTQTTHSSSLIA CCCCCCCCCCCCCCC	15.22	23312004
829	Phosphorylation	DSTQTTHSSSLIAGH CCCCCCCCCCCCCCC	21.38	23312004
830	Phosphorylation	STQTTHSSSLIAGHT CCCCCCCCCCCCCCC	22.89	30576142
831	Phosphorylation	TQTTHSSSLIAGHTG CCCCCCCCCCCCCCC	27.15	23312004
837	Phosphorylation	SSLIAGHTGPVPKKP CCCCCCCCCCCCCCH	42.11	30576142
843	Acetylation	HTGPVPKKPQDLAHT CCCCCCCCHHHHCCC	41.67	26051181
939	Phosphorylation	HSAVQQNYVSPLQAT CCHHHHCCCCCHHHC	9.66	27642862
941	Phosphorylation	AVQQNYVSPLQATIS HHHHCCCCCHHHCCC	14.99	29496963
946	Phosphorylation	YVSPLQATISKSQTN CCCCHHHCCCCCCCC	16.90	20068231
948	O-linked_Glycosylation	SPLQATISKSQTNPV CCHHHCCCCCCCCCE	23.15	30059200
949	Ubiquitination	PLQATISKSQTNPVV CHHHCCCCCCCCCEE	42.61	29967540
950	Phosphorylation	LQATISKSQTNPVVK HHHCCCCCCCCCEEE	35.13	27251275
969	Phosphorylation	PQLSCSSSLIKTSDK CCCCCCCEEEECCCC	20.16	24719451
976	Acetylation	SLIKTSDKPLMYRLP EEEECCCCCEEEEEE	39.56	23749302
985	O-linked_Glycosylation	LMYRLPLSTPSPGNG EEEEEECCCCCCCCC	36.01	30059200
985	Phosphorylation	LMYRLPLSTPSPGNG EEEEEECCCCCCCCC	36.01	20068231
986	Phosphorylation	MYRLPLSTPSPGNGS EEEEECCCCCCCCCC	35.15	20068231
988	Phosphorylation	RLPLSTPSPGNGSQG EEECCCCCCCCCCCC	45.59	20068231
993	Phosphorylation	TPSPGNGSQGSHPLV CCCCCCCCCCCCCCC	35.05	20068231
1003	O-linked_Glycosylation	SHPLVSRTVPSTTTS CCCCCCCCCCCCCCC	29.30	30059200
1006	O-linked_Glycosylation	LVSRTVPSTTTSSNY CCCCCCCCCCCCHHH	33.77	30059200
1007	O-linked_Glycosylation	VSRTVPSTTTSSNYL CCCCCCCCCCCHHHH	28.20	30059200
1010	O-linked_Glycosylation	TVPSTTTSSNYLAKA CCCCCCCCHHHHHHH	17.94	30059200
1023	Phosphorylation	KAMVSQISTQGFKSP HHHHHHHHCCCCCCC	13.67	28555341
1024	Phosphorylation	AMVSQISTQGFKSPF HHHHHHHCCCCCCCC	34.05	27251275
1028	Acetylation	QISTQGFKSPFSMAA HHHCCCCCCCCCCCC	65.13	25953088
1028	Methylation	QISTQGFKSPFSMAA HHHCCCCCCCCCCCC	65.13	115978987
1029	Phosphorylation	ISTQGFKSPFSMAAS HHCCCCCCCCCCCCC	28.99	22199227
1032	Phosphorylation	QGFKSPFSMAASPKL CCCCCCCCCCCCCCC	15.76	23186163
1036	Phosphorylation	SPFSMAASPKLAASP CCCCCCCCCCCCCCC	17.03	22199227
1042	Phosphorylation	ASPKLAASPKPATSP CCCCCCCCCCCCCCC	28.05	20873877
1047	Phosphorylation	AASPKPATSPKPLPS CCCCCCCCCCCCCCC	54.83	29255136
1048	Phosphorylation	ASPKPATSPKPLPSP CCCCCCCCCCCCCCC	32.79	29255136
1050	Acetylation	PKPATSPKPLPSPKP CCCCCCCCCCCCCCC	59.98	26051181
1054	Phosphorylation	TSPKPLPSPKPSASP CCCCCCCCCCCCCCC	53.92	20873877
1056	Acetylation	PKPLPSPKPSASPKP CCCCCCCCCCCCCCC	56.81	26051181
1058	Phosphorylation	PLPSPKPSASPKPSL CCCCCCCCCCCCCCC	47.72	20873877
1060	Phosphorylation	PSPKPSASPKPSLSA CCCCCCCCCCCCCCC	37.48	20873877
1064	Phosphorylation	PSASPKPSLSAKPSV CCCCCCCCCCCCCCC	40.87	27732954
1068	Acetylation	PKPSLSAKPSVSTKL CCCCCCCCCCCEEEE	34.15	26051181
1070	Phosphorylation	PSLSAKPSVSTKLIS CCCCCCCCCEEEEEC	28.17	21949786
1072	Phosphorylation	LSAKPSVSTKLISKS CCCCCCCEEEEECCC	24.94	21949786
1073	Phosphorylation	SAKPSVSTKLISKSN CCCCCCEEEEECCCC	27.93	21949786
1074	Acetylation	AKPSVSTKLISKSNP CCCCCEEEEECCCCC	36.00	25953088
1077	Phosphorylation	SVSTKLISKSNPTPK CCEEEEECCCCCCCC	40.23	30001349
1079	Phosphorylation	STKLISKSNPTPKPT EEEEECCCCCCCCCC	41.05	21949786
1082	Phosphorylation	LISKSNPTPKPTVSP EECCCCCCCCCCCCC	48.47	21949786
1084	Acetylation	SKSNPTPKPTVSPSS CCCCCCCCCCCCCCC	56.66	26051181
1086	Phosphorylation	SNPTPKPTVSPSSSS CCCCCCCCCCCCCCC	39.48	25159151
1088	Phosphorylation	PTPKPTVSPSSSSPN CCCCCCCCCCCCCCC	22.88	25159151
1090	Phosphorylation	PKPTVSPSSSSPNAL CCCCCCCCCCCCCEE	35.03	25159151
1091	Phosphorylation	KPTVSPSSSSPNALV CCCCCCCCCCCCEEE	37.91	25159151
1092	Phosphorylation	PTVSPSSSSPNALVA CCCCCCCCCCCEEEE	54.90	25159151
1093	Phosphorylation	TVSPSSSSPNALVAQ CCCCCCCCCCEEEEC	24.91	25159151
1102	Phosphorylation	NALVAQGSHSSTNSP CEEEECCCCCCCCCC	14.23	25159151
1104	Phosphorylation	LVAQGSHSSTNSPVH EEECCCCCCCCCCCC	40.32	25159151
1105	Phosphorylation	VAQGSHSSTNSPVHK EECCCCCCCCCCCCC	26.61	25159151
1106	Phosphorylation	AQGSHSSTNSPVHKQ ECCCCCCCCCCCCCC	42.61	25159151
1108	Phosphorylation	GSHSSTNSPVHKQPS CCCCCCCCCCCCCCC	28.52	25159151
1115	Phosphorylation	SPVHKQPSGMNISRQ CCCCCCCCCCCCCCC	48.45	20860994
1120	Phosphorylation	QPSGMNISRQSPTLN CCCCCCCCCCCCCCC	21.18	20860994
1123	Phosphorylation	GMNISRQSPTLNLLP CCCCCCCCCCCCCCC	20.81	25159151
1125	Phosphorylation	NISRQSPTLNLLPSS CCCCCCCCCCCCCCC	33.26	23312004
1141	Acetylation	TSGLPPTKNLQAPSK CCCCCCCCCCCCCCC	62.53	26051181
1148	Acetylation	KNLQAPSKLTNSSST CCCCCCCCCCCCCCC	59.27	19608861
1150	Phosphorylation	LQAPSKLTNSSSTGT CCCCCCCCCCCCCCC	36.47	-
1155	Phosphorylation	KLTNSSSTGTVGKNS CCCCCCCCCCCCCCC	38.53	-
1157	Phosphorylation	TNSSSTGTVGKNSLS CCCCCCCCCCCCCCC	26.61	-
1160	Acetylation	SSTGTVGKNSLSGIA CCCCCCCCCCCCCEE	38.74	26051181
1164	Phosphorylation	TVGKNSLSGIAMNVP CCCCCCCCCEEEECC	28.16	-
1173	O-linked_Glycosylation	IAMNVPASRGSNLNS EEEECCCCCCCCCCC	30.98	30059200
1174	Methylation	AMNVPASRGSNLNSS EEECCCCCCCCCCCC	55.45	115919417
1186	Phosphorylation	NSSGANRTSLSGGTG CCCCCCCCCCCCCCC	33.55	20068231
1187	Phosphorylation	SSGANRTSLSGGTGS CCCCCCCCCCCCCCC	19.80	20068231
1189	Phosphorylation	GANRTSLSGGTGSGT CCCCCCCCCCCCCCC	34.64	20068231
1192	Phosphorylation	RTSLSGGTGSGTQGA CCCCCCCCCCCCCCC	31.53	20068231
1200	Phosphorylation	GSGTQGATKPLSTPH CCCCCCCCCCCCCCC	39.76	20068231
1320	Phosphorylation	HAATLSHSPLPAHLQ HHEECCCCCCCHHHH	25.42	28555341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of UBN2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UBN2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UBN2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of UBN2_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UBN2_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1148, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-584, AND MASSSPECTROMETRY.	17287340 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-430 AND THR-432, ANDMASS SPECTROMETRY.	17525332 [Abstract]