dbPTM

UBN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UBN1_HUMAN
UniProt AC	Q9NPG3
Protein Name	Ubinuclein-1
Gene Name	UBN1
Organism	Homo sapiens (Human).
Sequence Length	1134
Subcellular Localization	Nucleus, nucleoplasm. Nucleus, PML body. Cell junction, tight junction. Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 an
Protein Description	Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly..
Protein Sequence	MSEPHRVQFTSLPGSLNPAFLKKSRKEEAGAGEQHQDCEPAAAAVRITLTLFEPDHKRCPEFFYPELVKNIRGKVKGLQPGDKKKDLSDPFNDEEKERHKVEALARKFEEKYGGKKRRKDRIQDLIDMGYGYDESDSFIDNSEAYDELVPASLTTKYGGFYINSGTLQFRQASESEDDFIKEKKKKSPKKRKLKEGGEKIKKKKKDDTYDKEKKSKKSKFSKAGFTALNASKEKKKKKYSGALSVKEMLKKFQKEKEAQKKREEEHKPVAVPSAEAQGLRELEGASDPLLSLFGSTSDNDLLQAATAMDSLTDLDLEHLLSESPEGSPFRDMDDGSDSLGVGLDQEFRQPSSLPEGLPAPLEKRVKELAQAARAAEGESRQKFFTQDINGILLDIEAQTRELSSQVRSGVYAYLASFLPCSKDALLKRARKLHLYEQGGRLKEPLQKLKEAIGRAMPEQMAKYQDECQAHTQAKVAKMLEEEKDKEQRDRICSDEEEDEEKGGRRIMGPRKKFQWNDEIRELLCQVVKIKLESQDLERNNKAQAWEDCVKGFLDAEVKPLWPKGWMQARTLFKESRRGHGHLTSILAKKKVMAPSKIKVKESSTKPDKKVSVPSGQIGGPIALPSDHQTGGLSIGASSRELPSQASGGLANPPPVNLEDSLDEDLIRNPASSVEAVSKELAALNSRAAGNSEFTLPAPSKAPAEKVGGVLCTEEKRNFAKPSPSAPPPASSLQSPLNFLAEQALALGQSSQEKKPESSGYKELSCQAPLNKGLPEVHQSKAKHHSLPRTSHGPQVAVPVPGPQVKVFHAGTQQQKNFTPPSPFANKLQGPKASPTQCHRSLLQLVKTAAKGQGFHPSAPATSGGLSASSSSSHKTPASSSSALSHPAKPHSVSSAGSSYKNNPFASSISKHGVSSGSSSSGGTPVQSSVSGSLVPGIQPPSVGQATSRPVPSSAGKKMPVSQKLTLVAPPGGPNGDSSGGTQGVAKLLTSPSLKPSAVSSVTSSTSLSKGASGTVLLAGSSLMASPYKSSSPKLSGAMSSNSLGIITPVPIPVHVLSFSADSSAKAGVSKDAIVTGPAPGSFHHGLGHSLLAGLHSSPPHAAPLPHAAVPTHIPQSLPGASQLHGKGPAVPRKL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	EPHRVQFTSLPGSLN CCCCEEECCCCCCCC	16.56	-
11	Phosphorylation	PHRVQFTSLPGSLNP CCCEEECCCCCCCCH	33.58	27251275
15	Phosphorylation	QFTSLPGSLNPAFLK EECCCCCCCCHHHHH	24.04	-
26	Acetylation	AFLKKSRKEEAGAGE HHHHHHHHHCCCCCC	67.98	26051181
64	Phosphorylation	KRCPEFFYPELVKNI HCCHHHHCHHHHHHH	10.91	20068231
88	Phosphorylation	GDKKKDLSDPFNDEE CCCCCCCCCCCCHHH	54.06	27134283
107	Acetylation	KVEALARKFEEKYGG HHHHHHHHHHHHHCC	52.07	30593227
112	Phosphorylation	ARKFEEKYGGKKRRK HHHHHHHHCCCCCCH	34.10	-
130	Phosphorylation	QDLIDMGYGYDESDS HHHHHCCCCCCCCCC	13.08	-
164	Phosphorylation	YGGFYINSGTLQFRQ ECCEEECCCEEEEEE	24.48	23186163
166	Phosphorylation	GFYINSGTLQFRQAS CEEECCCEEEEEECC	19.73	30108239
173	Phosphorylation	TLQFRQASESEDDFI EEEEEECCCCCCHHH	33.06	29255136
175	Phosphorylation	QFRQASESEDDFIKE EEEECCCCCCHHHHH	43.78	29255136
187	Phosphorylation	IKEKKKKSPKKRKLK HHHHHHCCCHHHCCH	51.32	-
199	Acetylation	KLKEGGEKIKKKKKD CCHHHHHHHHHHCCC	64.20	25953088
222	Acetylation	SKKSKFSKAGFTALN CHHHHHHHHHHHHHH	56.51	19608861
226	Phosphorylation	KFSKAGFTALNASKE HHHHHHHHHHHCCHH	29.35	27690223
231	Phosphorylation	GFTALNASKEKKKKK HHHHHHCCHHHHCCC	40.03	30576142
232	Acetylation	FTALNASKEKKKKKY HHHHHCCHHHHCCCC	71.75	26051181
239	Phosphorylation	KEKKKKKYSGALSVK HHHHCCCCCCCCCHH	22.63	29759185
240	Phosphorylation	EKKKKKYSGALSVKE HHHCCCCCCCCCHHH	26.86	25159151
244	Phosphorylation	KKYSGALSVKEMLKK CCCCCCCCHHHHHHH	30.52	29759185
246	Acetylation	YSGALSVKEMLKKFQ CCCCCCHHHHHHHHH	33.75	25953088
261	Acetylation	KEKEAQKKREEEHKP HHHHHHHHHHHHCCC	53.62	19608861
267	Acetylation	KKREEEHKPVAVPSA HHHHHHCCCCCCCCH	44.46	23749302
321	Phosphorylation	LDLEHLLSESPEGSP CCHHHHHCCCCCCCC	42.25	26074081
323	Phosphorylation	LEHLLSESPEGSPFR HHHHHCCCCCCCCCC	25.52	26074081
327	Phosphorylation	LSESPEGSPFRDMDD HCCCCCCCCCCCCCC	21.14	22468782
336	Phosphorylation	FRDMDDGSDSLGVGL CCCCCCCCCCCCCCC	30.90	29255136
338	Phosphorylation	DMDDGSDSLGVGLDQ CCCCCCCCCCCCCCH	28.81	29255136
351	Phosphorylation	DQEFRQPSSLPEGLP CHHHCCCCCCCCCCC	35.85	28674151
352	Phosphorylation	QEFRQPSSLPEGLPA HHHCCCCCCCCCCCC	55.41	28674151
449	2-Hydroxyisobutyrylation	KEPLQKLKEAIGRAM HHHHHHHHHHHHHHC	52.73	-
449	Succinylation	KEPLQKLKEAIGRAM HHHHHHHHHHHHHHC	52.73	23954790
474	Acetylation	CQAHTQAKVAKMLEE HHHHHHHHHHHHHHH	32.67	26051181
474	Ubiquitination	CQAHTQAKVAKMLEE HHHHHHHHHHHHHHH	32.67	29967540
477	Acetylation	HTQAKVAKMLEEEKD HHHHHHHHHHHHHCC	47.18	7959869
493	Phosphorylation	EQRDRICSDEEEDEE HHHHHCCCCHHHHHH	45.76	29255136
530	Sumoylation	LCQVVKIKLESQDLE HHHHHHHHHHHHHHH	40.25	-
530	Sumoylation	LCQVVKIKLESQDLE HHHHHHHHHHHHHHH	40.25	-
541	Acetylation	QDLERNNKAQAWEDC HHHHHHHHHHHHHHH	45.48	25953088
541	Ubiquitination	QDLERNNKAQAWEDC HHHHHHHHHHHHHHH	45.48	29967540
573	Methylation	MQARTLFKESRRGHG HHHHHHHHHHHCCCC	58.87	115978995
575	Phosphorylation	ARTLFKESRRGHGHL HHHHHHHHHCCCCCH	28.06	25278378
583	Phosphorylation	RRGHGHLTSILAKKK HCCCCCHHHHHHHCC	14.19	25278378
584	Phosphorylation	RGHGHLTSILAKKKV CCCCCHHHHHHHCCC	23.20	25278378
596	Acetylation	KKVMAPSKIKVKESS CCCCCCCCCEEECCC	45.55	25953088
603	Phosphorylation	KIKVKESSTKPDKKV CCEEECCCCCCCCCE	41.35	20068231
604	Phosphorylation	IKVKESSTKPDKKVS CEEECCCCCCCCCEE	56.74	20068231
633	Phosphorylation	DHQTGGLSIGASSRE CCCCCCEECCCCCCC	23.42	27135362
637	Phosphorylation	GGLSIGASSRELPSQ CCEECCCCCCCCCCC	25.39	30631047
643	Phosphorylation	ASSRELPSQASGGLA CCCCCCCCCCCCCCC	51.51	30108239
646	Phosphorylation	RELPSQASGGLANPP CCCCCCCCCCCCCCC	26.25	30108239
660	Phosphorylation	PPVNLEDSLDEDLIR CCCCCCCCCCHHHHH	28.48	30266825
671	Phosphorylation	DLIRNPASSVEAVSK HHHHCCHHHHHHHHH	35.85	30243723
672	Phosphorylation	LIRNPASSVEAVSKE HHHCCHHHHHHHHHH	26.53	30266825
677	Phosphorylation	ASSVEAVSKELAALN HHHHHHHHHHHHHHH	27.71	22199227
685	Phosphorylation	KELAALNSRAAGNSE HHHHHHHCCCCCCCC	24.93	30001349
700	Acetylation	FTLPAPSKAPAEKVG CCCCCCCCCCHHHHC	58.28	25953088
705	Acetylation	PSKAPAEKVGGVLCT CCCCCHHHHCCEECC	48.57	25953088
715	Acetylation	GVLCTEEKRNFAKPS CEECCHHHCCCCCCC	46.54	26051181
722	Phosphorylation	KRNFAKPSPSAPPPA HCCCCCCCCCCCCCH	30.68	25627689
730	Phosphorylation	PSAPPPASSLQSPLN CCCCCCHHHCCCHHH	37.04	28348404
731	Phosphorylation	SAPPPASSLQSPLNF CCCCCHHHCCCHHHH	32.31	28348404
734	Phosphorylation	PPASSLQSPLNFLAE CCHHHCCCHHHHHHH	36.33	25159151
754	Acetylation	GQSSQEKKPESSGYK CCCCCCCCCCCCCCC	53.95	25953088
761	Acetylation	KPESSGYKELSCQAP CCCCCCCCEEECCCC	56.56	25953088
764	Phosphorylation	SSGYKELSCQAPLNK CCCCCEEECCCCCCC	12.79	25159151
771	Acetylation	SCQAPLNKGLPEVHQ ECCCCCCCCCCHHHH	70.30	26051181
780	Acetylation	LPEVHQSKAKHHSLP CCHHHHHHHHCCCCC	55.68	25953088
790	Phosphorylation	HHSLPRTSHGPQVAV CCCCCCCCCCCEEEE	27.94	28555341
805	Acetylation	PVPGPQVKVFHAGTQ ECCCCEEEEEECCCC	33.66	22424773
818	Phosphorylation	TQQQKNFTPPSPFAN CCCCCCCCCCCCCHH	43.62	25159151
821	Phosphorylation	QKNFTPPSPFANKLQ CCCCCCCCCCHHHCC	33.58	25159151
826	Acetylation	PPSPFANKLQGPKAS CCCCCHHHCCCCCCC	38.46	25953088
833	Phosphorylation	KLQGPKASPTQCHRS HCCCCCCCHHHHHHH	34.31	23898821
840	Phosphorylation	SPTQCHRSLLQLVKT CHHHHHHHHHHHHHH	15.12	28555341
850	Acetylation	QLVKTAAKGQGFHPS HHHHHHHCCCCCCCC	49.67	26051181
861	O-linked_Glycosylation	FHPSAPATSGGLSAS CCCCCCCCCCCCCCC	27.18	30059200
862	O-linked_Glycosylation	HPSAPATSGGLSASS CCCCCCCCCCCCCCC	32.73	30059200
866	O-linked_Glycosylation	PATSGGLSASSSSSH CCCCCCCCCCCCCCC	29.40	30059200
870	Phosphorylation	GGLSASSSSSHKTPA CCCCCCCCCCCCCCC	33.11	28555341
871	Phosphorylation	GLSASSSSSHKTPAS CCCCCCCCCCCCCCC	38.11	28555341
872	O-linked_Glycosylation	LSASSSSSHKTPASS CCCCCCCCCCCCCCC	30.83	30059200
875	O-linked_Glycosylation	SSSSSHKTPASSSSA CCCCCCCCCCCCCCH	20.75	30059200
878	O-linked_Glycosylation	SSHKTPASSSSALSH CCCCCCCCCCCHHCC	31.77	30059200
879	O-linked_Glycosylation	SHKTPASSSSALSHP CCCCCCCCCCHHCCC	30.34	30059200
880	O-linked_Glycosylation	HKTPASSSSALSHPA CCCCCCCCCHHCCCC	19.69	30059200
881	O-linked_Glycosylation	KTPASSSSALSHPAK CCCCCCCCHHCCCCC	34.87	30059200
888	Acetylation	SALSHPAKPHSVSSA CHHCCCCCCCCCCCC	47.95	23749302
891	O-linked_Glycosylation	SHPAKPHSVSSAGSS CCCCCCCCCCCCCCC	32.02	30059200
891	Phosphorylation	SHPAKPHSVSSAGSS CCCCCCCCCCCCCCC	32.02	28555341
894	O-linked_Glycosylation	AKPHSVSSAGSSYKN CCCCCCCCCCCCCCC	34.20	30059200
897	O-linked_Glycosylation	HSVSSAGSSYKNNPF CCCCCCCCCCCCCCC	30.15	30059200
906	Phosphorylation	YKNNPFASSISKHGV CCCCCCHHHHHHCCC	28.69	28348404
907	Phosphorylation	KNNPFASSISKHGVS CCCCCHHHHHHCCCC	27.70	28348404
909	Phosphorylation	NPFASSISKHGVSSG CCCHHHHHHCCCCCC	22.13	28348404
941	Phosphorylation	VPGIQPPSVGQATSR CCCCCCCCCCCCCCC	45.63	25332170
952	Phosphorylation	ATSRPVPSSAGKKMP CCCCCCCCCCCCCCC	32.81	27732954
953	Phosphorylation	TSRPVPSSAGKKMPV CCCCCCCCCCCCCCC	34.66	27732954
956	Acetylation	PVPSSAGKKMPVSQK CCCCCCCCCCCCCCE	45.69	25953088
957	Acetylation	VPSSAGKKMPVSQKL CCCCCCCCCCCCCEE	47.74	25953088
963	Acetylation	KKMPVSQKLTLVAPP CCCCCCCEEEEEECC	35.61	25953088
965	Phosphorylation	MPVSQKLTLVAPPGG CCCCCEEEEEECCCC	26.65	29514088
977	Phosphorylation	PGGPNGDSSGGTQGV CCCCCCCCCCCHHHH	32.08	25262027
978	Phosphorylation	GGPNGDSSGGTQGVA CCCCCCCCCCHHHHH	46.08	25262027
981	Phosphorylation	NGDSSGGTQGVAKLL CCCCCCCHHHHHHHH	26.19	25262027
989	O-linked_Glycosylation	QGVAKLLTSPSLKPS HHHHHHHCCCCCCHH	49.37	30059200
989	Phosphorylation	QGVAKLLTSPSLKPS HHHHHHHCCCCCCHH	49.37	28450419
990	Phosphorylation	GVAKLLTSPSLKPSA HHHHHHCCCCCCHHH	16.68	28464451
992	Phosphorylation	AKLLTSPSLKPSAVS HHHHCCCCCCHHHCE	49.11	28450419
994	Acetylation	LLTSPSLKPSAVSSV HHCCCCCCHHHCEEC	41.06	26051181
996	Phosphorylation	TSPSLKPSAVSSVTS CCCCCCHHHCEECCC	39.45	28450419
999	O-linked_Glycosylation	SLKPSAVSSVTSSTS CCCHHHCEECCCCCC	20.86	30059200
999	Phosphorylation	SLKPSAVSSVTSSTS CCCHHHCEECCCCCC	20.86	28450419
1003	O-linked_Glycosylation	SAVSSVTSSTSLSKG HHCEECCCCCCCCCC	29.48	30059200
1003	Phosphorylation	SAVSSVTSSTSLSKG HHCEECCCCCCCCCC	29.48	25627689
1004	O-linked_Glycosylation	AVSSVTSSTSLSKGA HCEECCCCCCCCCCC	16.79	30059200
1012	Phosphorylation	TSLSKGASGTVLLAG CCCCCCCCCEEEEEC	43.60	24400094
1014	Phosphorylation	LSKGASGTVLLAGSS CCCCCCCEEEEECCC	12.89	24400094
1020	Phosphorylation	GTVLLAGSSLMASPY CEEEEECCCHHCCCC	18.07	27080861
1021	Phosphorylation	TVLLAGSSLMASPYK EEEEECCCHHCCCCC	22.65	28450419
1025	Phosphorylation	AGSSLMASPYKSSSP ECCCHHCCCCCCCCC	18.13	25159151
1027	Phosphorylation	SSLMASPYKSSSPKL CCHHCCCCCCCCCCC	22.47	28450419
1029	Phosphorylation	LMASPYKSSSPKLSG HHCCCCCCCCCCCCC	30.15	21712546
1030	Phosphorylation	MASPYKSSSPKLSGA HCCCCCCCCCCCCCC	46.65	21712546
1031	Phosphorylation	ASPYKSSSPKLSGAM CCCCCCCCCCCCCCC	32.90	21712546

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of UBN1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UBN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UBN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HIRA_HUMAN	HIRA	physical	22195966
CABIN_HUMAN	CABIN1	physical	22195966
RPB1_HUMAN	POLR2A	physical	22195966
HIRA_HUMAN	HIRA	physical	22401310
CABIN_HUMAN	CABIN1	physical	22401310
ASF1A_HUMAN	ASF1A	physical	22401310
ZN606_HUMAN	ZNF606	physical	22939629
WDR36_HUMAN	WDR36	physical	22939629
ZO2_HUMAN	TJP2	physical	22939629

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UBN1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-222, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-336; SER-660; SER-677AND SER-1025, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-173; SER-175 ANDSER-493, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-493, AND MASSSPECTROMETRY.	15302935 [Abstract]