CDAN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDAN1_HUMAN
• UniProt AC: Q8IWY9
• Protein Name: Codanin-1
• Gene Name: CDAN1
• Organism: Homo sapiens (Human).
• Sequence Length: 1227
• Subcellular Localization: Cytoplasm. Nucleus. Membrane ; Multi-pass membrane protein . Mainly detected as a cytoplasmic protein.
• Protein Description: May act as a negative regulator of ASF1 in chromatin assembly..
• Protein Sequence: MAAVLESLLREEVSVAAVVRWIARSTQGSEDNAGEAAALSSLRALRKEFVPFLLNFLREQSSRVLPQGPPTPAKTPGASAALPGRPGGPPRGSRGARSQLFPPTEAQSTAAEAPLARRGGRRRGPGPARERGGRGLEEGVSGESLPGAGGRRLRGSGSPSRPSLTLSDPPNLSNLEEFPPVGSVPPGPTGTKPSRRINPTPVSEERSLSKPKTCFTSPPISCVPSSQPSALDTSPWGLGLPPGCRSLQEEREMLRKERSKQLQQSPTPTCPTPELGSPLPSRTGSLTDEPADPARVSSRQRLELVALVYSSCIAENLVPNLFLELFFVFQLLTARRMVTAKDSDPELSPAVLDSLESPLFQSIHDCVFFAVQVLECHFQVLSNLDKGTLKLLAENERLLCFSPALQGRLRAAYEGSVAKVSLVMPPSTQAVSFQPETDNRANFSSDRAFHTFKKQRDVFYEVLREWEDHHEEPGWDFEKGLGSRIRAMMGQLSAACSHSHFVRLFQKQLLQMCQSPGGAGGTVLGEAPDVLSMLGADKLGRLWRLQERLMAPQSSGGPCPPPTFPGCQGFFRDFILSASSFQFNQHLMDSLSLKIQELNGLALPQHEPNDEDGESDVDWQGERKQFAVVLLSLRLLAKFLGFVAFLPYRGPEPPPTGELQDSILALRSQVPPVLDVRTLLQRGLQARRAVLTVPWLVEFLSFADHVVPLLEYYRDIFTLLLRLHRSLVLSQESEGKMCFLNKLLLLAVLGWLFQIPTVPEDLFFLEEGPSYAFEVDTVAPEHGLDNAPVVDQQLLYTCCPYIGELRKLLASWVSGSSGRSGGFMRKITPTTTTSLGAQPSQTSQGLQAQLAQAFFHNQPPSLRRTVEFVAERIGSNCVKHIKATLVADLVRQAESLLQEQLVTQGEEGGDPAQLLEILCSQLCPHGAQALALGREFCQRKSPGAVRALLPEETPAAVLSSAENIAVGLATEKACAWLSANITALIRREVKAAVSRTLRAQGPEPAARGERRGCSRACEHHAPLPSHLISEIKDVLSLAVGPRDPDEGVSPEHLEQLLGQLGQTLRCRQFLCPPAEQHLAKCSVELASLLVADQIPILGPPAQYRLERGQARRLLHMLLSLWKEDFQGPVPLQLLLSPRNVGLLADTRPREWDLLLFLLRELVEKGLMGRMEIEACLGSLHQAQWPGDFAEELATLSNLFLAEPHLPEPQLRACELVQPNRGTVLAQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAVLESLL ------CHHHHHHHH	19.99	22223895
40	Phosphorylation	AGEAAALSSLRALRK HHHHHHHHHHHHHHH	23.70	30301811
41	Phosphorylation	GEAAALSSLRALRKE HHHHHHHHHHHHHHH	23.79	25954137
71	Phosphorylation	VLPQGPPTPAKTPGA CCCCCCCCCCCCCCC	38.73	30266825
75	Phosphorylation	GPPTPAKTPGASAAL CCCCCCCCCCCCCCC	29.12	30576142
79	Phosphorylation	PAKTPGASAALPGRP CCCCCCCCCCCCCCC	21.71	30576142
93	Phosphorylation	PGGPPRGSRGARSQL CCCCCCCCCCCHHHC	28.90	22496350
131	Methylation	GPGPARERGGRGLEE CCCCCCCCCCCCCCC	47.52	-
134	Methylation	PARERGGRGLEEGVS CCCCCCCCCCCCCCC	49.72	-
141	Phosphorylation	RGLEEGVSGESLPGA CCCCCCCCCCCCCCC	47.93	28555341
144	Phosphorylation	EEGVSGESLPGAGGR CCCCCCCCCCCCCCC	43.31	28555341
156	Phosphorylation	GGRRLRGSGSPSRPS CCCCCCCCCCCCCCC	29.66	28122231
158	Phosphorylation	RRLRGSGSPSRPSLT CCCCCCCCCCCCCCC	22.77	22817900
160	Phosphorylation	LRGSGSPSRPSLTLS CCCCCCCCCCCCCCC	59.53	28122231
163	Phosphorylation	SGSPSRPSLTLSDPP CCCCCCCCCCCCCCC	32.64	28122231
165	Phosphorylation	SPSRPSLTLSDPPNL CCCCCCCCCCCCCCC	28.67	28122231
167	Phosphorylation	SRPSLTLSDPPNLSN CCCCCCCCCCCCCCC	42.72	28122231
173	Phosphorylation	LSDPPNLSNLEEFPP CCCCCCCCCCCCCCC	46.11	28122231
194	Phosphorylation	GPTGTKPSRRINPTP CCCCCCCCCCCCCCC	35.43	25072903
200	Phosphorylation	PSRRINPTPVSEERS CCCCCCCCCCCCCCC	31.66	25072903
203	Phosphorylation	RINPTPVSEERSLSK CCCCCCCCCCCCCCC	34.64	21815630
203	O-linked_Glycosylation	RINPTPVSEERSLSK CCCCCCCCCCCCCCC	34.64	30620550
209	Phosphorylation	VSEERSLSKPKTCFT CCCCCCCCCCCCCCC	48.43	24719451
259	Phosphorylation	EMLRKERSKQLQQSP HHHHHHHHHHHHHCC	26.33	28111955
260	Ubiquitination	MLRKERSKQLQQSPT HHHHHHHHHHHHCCC	62.34	-
264 (in isoform 1)	Phosphorylation	-	61.03	28842319
265	Phosphorylation	RSKQLQQSPTPTCPT HHHHHHHCCCCCCCC	20.13	30278072
267	Phosphorylation	KQLQQSPTPTCPTPE HHHHHCCCCCCCCCC	36.16	30278072
269	Phosphorylation	LQQSPTPTCPTPELG HHHCCCCCCCCCCCC	33.33	30278072
272	Phosphorylation	SPTPTCPTPELGSPL CCCCCCCCCCCCCCC	31.38	22617229
277	Phosphorylation	CPTPELGSPLPSRTG CCCCCCCCCCCCCCC	35.57	30278072
281	Phosphorylation	ELGSPLPSRTGSLTD CCCCCCCCCCCCCCC	50.59	30278072
283	Phosphorylation	GSPLPSRTGSLTDEP CCCCCCCCCCCCCCC	35.15	30108239
285	Phosphorylation	PLPSRTGSLTDEPAD CCCCCCCCCCCCCCC	27.73	23927012
287	Phosphorylation	PSRTGSLTDEPADPA CCCCCCCCCCCCCHH	39.76	28450419
390	Ubiquitination	NLDKGTLKLLAENER CCCHHHHHHHHHCCC	41.09	29967540
413	Phosphorylation	QGRLRAAYEGSVAKV HHHHHHHHCCCEEEE	21.60	22985185
416	Phosphorylation	LRAAYEGSVAKVSLV HHHHHCCCEEEEEEE	13.63	22985185
453	Ubiquitination	DRAFHTFKKQRDVFY HHHHHHHHHHHHHHH	49.50	29967540
515	Phosphorylation	QLLQMCQSPGGAGGT HHHHHHCCCCCCCCE	22.15	-
522	Phosphorylation	SPGGAGGTVLGEAPD CCCCCCCEECCCCCC	16.19	-
532	Phosphorylation	GEAPDVLSMLGADKL CCCCCHHHHHCHHHH	16.29	-
590	Phosphorylation	FNQHLMDSLSLKIQE HCHHHHHHHHHHHHH	13.09	24719451
592	Phosphorylation	QHLMDSLSLKIQELN HHHHHHHHHHHHHHC	31.41	24719451
662	Phosphorylation	PTGELQDSILALRSQ CCCCHHHHHHHHHCC	13.41	-
668	Phosphorylation	DSILALRSQVPPVLD HHHHHHHCCCCCCCC	36.06	-
701	Phosphorylation	PWLVEFLSFADHVVP HHHHHHHHHCHHHHH	24.57	-
712	Phosphorylation	HVVPLLEYYRDIFTL HHHHHHHHHHHHHHH	12.08	-
713	Phosphorylation	VVPLLEYYRDIFTLL HHHHHHHHHHHHHHH	7.76	-
811	Phosphorylation	ELRKLLASWVSGSSG HHHHHHHHHHCCCCC	28.16	28270605
814	Phosphorylation	KLLASWVSGSSGRSG HHHHHHHCCCCCCCC	27.05	28270605
816	Phosphorylation	LASWVSGSSGRSGGF HHHHHCCCCCCCCCC	23.32	28270605
817	Phosphorylation	ASWVSGSSGRSGGFM HHHHCCCCCCCCCCC	41.57	28270605
828	Ubiquitination	GGFMRKITPTTTTSL CCCCCCCCCCCCCCC	20.02	24816145
879	Ubiquitination	RIGSNCVKHIKATLV HHCHHHHHHHHHHHH	41.64	29967540
882	Ubiquitination	SNCVKHIKATLVADL HHHHHHHHHHHHHHH	34.73	-
940	Acetylation	GREFCQRKSPGAVRA CHHHHHCCCCCHHHH	34.81	7822375
1025	Phosphorylation	EHHAPLPSHLISEIK HCCCCCCHHHHHHHH	38.31	29083192
1029	Phosphorylation	PLPSHLISEIKDVLS CCCHHHHHHHHHHHH	39.36	29083192
1136	Phosphorylation	VPLQLLLSPRNVGLL CCCHHEECCCCCCCC	23.06	24719451
1164	Ubiquitination	LLRELVEKGLMGRME HHHHHHHCCCCCCHH	50.28	24816145
1165	Ubiquitination	LRELVEKGLMGRMEI HHHHHHCCCCCCHHH	13.85	24816145
1172	Ubiquitination	GLMGRMEIEACLGSL CCCCCHHHHHHHHHH	2.73	24816145
1173	Ubiquitination	LMGRMEIEACLGSLH CCCCHHHHHHHHHHH	21.74	24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDAN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDAN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDAN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IPO4_HUMAN	IPO4	physical	22407294
ASF1A_HUMAN	ASF1A	physical	22407294
ASF1B_HUMAN	ASF1B	physical	22407294
ACTN1_HUMAN	ACTN1	physical	22863883
SF3A3_HUMAN	SF3A3	physical	22863883

Drug and Disease Associations

• Kegg Disease
• H00917: Congenital dyserythropoietic anemias (CDAs)
• OMIM Disease
• 224120: Anemia, congenital dyserythropoietic, 1A (CDAN1A)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-71; SER-265 AND SER-277,AND MASS SPECTROMETRY.
PubMed: 19413330