dbPTM

ANKL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ANKL2_HUMAN
UniProt AC	Q86XL3
Protein Name	Ankyrin repeat and LEM domain-containing protein 2
Gene Name	ANKLE2
Organism	Homo sapiens (Human).
Sequence Length	938
Subcellular Localization	Endoplasmic reticulum membrane Single-pass type III membrane protein .
Protein Description	Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Involved in brain development. [PubMed: 25259927]
Protein Sequence	MLWPRLAAAEWAALAWELLGASVLLIAVRWLVRRLGPRPGGLGRSGTPVPPPSAAAAPASGEMTMDALLARLKLLNPDDLREEIVKAGLKCGPITSTTRFIFEKKLAQALLEQGGRLSSFYHHEAGVTALSQDPQRILKPAEGNPTDQAGFSEDRDFGYSVGLNPPEEEAVTSKTCSVPPSDTDTYRAGATASKEPPLYYGVCPVYEDVPARNERIYVYENKKEALQAVKMIKGSRFKAFSTREDAEKFARGICDYFPSPSKTSLPLSPVKTAPLFSNDRLKDGLCLSESETVNKERANSYKNPRTQDLTAKLRKAVEKGEEDTFSDLIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAKENQASICQLTLDVLENPDFMRLMYPDDDEAMLQKRIRYVVDLYLNTPDKMGYDTPLHFACKFGNADVVNVLSSHHLIVKNSRNKYDKTPEDVICERSKNKSVELKERIREYLKGHYYVPLLRAEETSSPVIGELWSPDQTAEASHVSRYGGSPRDPVLTLRAFAGPLSPAKAEDFRKLWKTPPREKAGFLHHVKKSDPERGFERVGRELAHELGYPWVEYWEFLGCFVDLSSQEGLQRLEEYLTQQEIGKKAQQETGEREASCRDKATTSGSNSISVRAFLDEDDMSLEEIKNRQNAARNNSPPTVGAFGHTRCSAFPLEQEADLIEAAEPGGPHSSRNGLCHPLNHSRTLAGKRPKAPRGEEAHLPPVSDLTVEFDKLNLQNIGRSVSKTPDESTKTKDQILTSRINAVERDLLEPSPADQLGNGHRRTESEMSARIAKMSLSPSSPRHEDQLEVTREPARRLFLFGEEPSKLDQDVLAALECADVDPHQFPAVHRWKSAVLCYSPSDRQSWPSPAVKGRFKSQLPDLSGPHSYSPGRNSVAGSNPAKPGLGSPGRYSPVHGSQLRRMARLAELAAL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Ubiquitination	PRLAAAEWAALAWEL HHHHHHHHHHHHHHH	5.10	27667366
28	Ubiquitination	ASVLLIAVRWLVRRL HHHHHHHHHHHHHHH	3.41	24816145
45	Phosphorylation	RPGGLGRSGTPVPPP CCCCCCCCCCCCCCC	45.26	30278072
47	Phosphorylation	GGLGRSGTPVPPPSA CCCCCCCCCCCCCCC	23.51	21712546
53	Phosphorylation	GTPVPPPSAAAAPAS CCCCCCCCCCCCCCC	35.99	22199227
60	Phosphorylation	SAAAAPASGEMTMDA CCCCCCCCCCCCHHH	33.94	63732289
64	Phosphorylation	APASGEMTMDALLAR CCCCCCCCHHHHHHH	13.95	26657352
73	Ubiquitination	DALLARLKLLNPDDL HHHHHHHHHCCHHHH	45.43	33845483
86	Ubiquitination	DLREEIVKAGLKCGP HHHHHHHHCCCCCCC	42.26	32015554
90	Ubiquitination	EIVKAGLKCGPITST HHHHCCCCCCCCCCC	35.91	32015554
97	Phosphorylation	KCGPITSTTRFIFEK CCCCCCCCHHHHHHH	17.22	46163677
105	Malonylation	TRFIFEKKLAQALLE HHHHHHHHHHHHHHH	41.69	26320211
105	Ubiquitination	TRFIFEKKLAQALLE HHHHHHHHHHHHHHH	41.69	29967540
118	Phosphorylation	LEQGGRLSSFYHHEA HHCCCCCHHHEECCC	19.62	23401153
119	Phosphorylation	EQGGRLSSFYHHEAG HCCCCCHHHEECCCC	34.12	28796482
121	Phosphorylation	GGRLSSFYHHEAGVT CCCCHHHEECCCCCE	12.29	28796482
128	Phosphorylation	YHHEAGVTALSQDPQ EECCCCCEECCCCHH	22.44	23312004
131	Phosphorylation	EAGVTALSQDPQRIL CCCCEECCCCHHHHC	30.03	23312004
139	Ubiquitination	QDPQRILKPAEGNPT CCHHHHCCCCCCCCC	39.55	29967540
146	Phosphorylation	KPAEGNPTDQAGFSE CCCCCCCCCCCCCCC	44.75	28796482
152	Phosphorylation	PTDQAGFSEDRDFGY CCCCCCCCCCCCCCC	37.36	28796482
159	Phosphorylation	SEDRDFGYSVGLNPP CCCCCCCCCCCCCCC	10.52	28796482
160	Phosphorylation	EDRDFGYSVGLNPPE CCCCCCCCCCCCCCH	15.30	28796482
186	Ubiquitination	PPSDTDTYRAGATAS CCCCCCCCCCCCCCC	10.98	24816145
191	Phosphorylation	DTYRAGATASKEPPL CCCCCCCCCCCCCCC	30.46	21945579
193	Phosphorylation	YRAGATASKEPPLYY CCCCCCCCCCCCCEE	32.95	21945579
194	Ubiquitination	RAGATASKEPPLYYG CCCCCCCCCCCCEEE	72.31	29967540
199	Phosphorylation	ASKEPPLYYGVCPVY CCCCCCCEEEECCCC	12.16	21945579
200	Phosphorylation	SKEPPLYYGVCPVYE CCCCCCEEEECCCCC	15.68	21945579
206	Phosphorylation	YYGVCPVYEDVPARN EEEECCCCCCCCCCC	7.49	21945579
215	Ubiquitination	DVPARNERIYVYENK CCCCCCCEEEEECCH	29.14	24816145
217	Phosphorylation	PARNERIYVYENKKE CCCCCEEEEECCHHH	11.82	28796482
219	Phosphorylation	RNERIYVYENKKEAL CCCEEEEECCHHHHH	9.23	28796482
222	Ubiquitination	RIYVYENKKEALQAV EEEEECCHHHHHHHH	39.80	29967540
223	Ubiquitination	IYVYENKKEALQAVK EEEECCHHHHHHHHH	60.86	29967540
235	Phosphorylation	AVKMIKGSRFKAFST HHHHHHCCCCCCCCC	29.55	20068231
238	Methylation	MIKGSRFKAFSTRED HHHCCCCCCCCCHHH	47.62	-
238	Ubiquitination	MIKGSRFKAFSTRED HHHCCCCCCCCCHHH	47.62	29967540
242	Phosphorylation	SRFKAFSTREDAEKF CCCCCCCCHHHHHHH	31.46	20068231
248	Ubiquitination	STREDAEKFARGICD CCHHHHHHHHHCHHH	46.15	24816145
256	Phosphorylation	FARGICDYFPSPSKT HHHCHHHHCCCCCCC	16.99	30266825
259	Phosphorylation	GICDYFPSPSKTSLP CHHHHCCCCCCCCCC	31.72	19664994
261	Phosphorylation	CDYFPSPSKTSLPLS HHHCCCCCCCCCCCC	53.56	30266825
262	Ubiquitination	DYFPSPSKTSLPLSP HHCCCCCCCCCCCCC	45.58	29967540
263	Phosphorylation	YFPSPSKTSLPLSPV HCCCCCCCCCCCCCC	39.57	30266825
264	Phosphorylation	FPSPSKTSLPLSPVK CCCCCCCCCCCCCCC	31.55	30266825
268	Phosphorylation	SKTSLPLSPVKTAPL CCCCCCCCCCCCCCC	26.21	25159151
271	Ubiquitination	SLPLSPVKTAPLFSN CCCCCCCCCCCCCCC	42.21	29967540
272	Phosphorylation	LPLSPVKTAPLFSND CCCCCCCCCCCCCCC	33.47	23927012
277	Phosphorylation	VKTAPLFSNDRLKDG CCCCCCCCCCCCCCC	45.57	21815630
282	Ubiquitination	LFSNDRLKDGLCLSE CCCCCCCCCCCCCCC	51.12	29967540
295	Ubiquitination	SESETVNKERANSYK CCCHHCCHHHHHHCC	44.21	29967540
300	Phosphorylation	VNKERANSYKNPRTQ CCHHHHHHCCCCHHH	36.18	28857561
301	Phosphorylation	NKERANSYKNPRTQD CHHHHHHCCCCHHHH	18.00	29978859
302	Acetylation	KERANSYKNPRTQDL HHHHHHCCCCHHHHH	61.36	-
302	Ubiquitination	KERANSYKNPRTQDL HHHHHHCCCCHHHHH	61.36	29967540
306	Phosphorylation	NSYKNPRTQDLTAKL HHCCCCHHHHHHHHH	27.91	29978859
312	Ubiquitination	RTQDLTAKLRKAVEK HHHHHHHHHHHHHHC	43.52	29967540
319	Ubiquitination	KLRKAVEKGEEDTFS HHHHHHHCCCCCCHH	66.09	29967540
320	Ubiquitination	LRKAVEKGEEDTFSD HHHHHHCCCCCCHHH	29.98	24816145
332	Ubiquitination	FSDLIWSNPRYLIGS HHHHHCCCCCEEECC	15.29	22817900
339	Phosphorylation	NPRYLIGSGDNPTIV CCCEEECCCCCCHHH	35.66	25159151
363	Ubiquitination	HVAAKENQASICQLT EHHHHCCCCCEEHHH	37.26	24816145
384	Phosphorylation	PDFMRLMYPDDDEAM CCCHHHCCCCCHHHH	14.22	24043423
394	Ubiquitination	DDEAMLQKRIRYVVD CHHHHHHHHHHHHHH	45.92	22817900
394 (in isoform 1)	Ubiquitination	-	45.92	21906983
394 (in isoform 2)	Ubiquitination	-	45.92	21906983
398	Phosphorylation	MLQKRIRYVVDLYLN HHHHHHHHHHHHHHC	11.49	18452278
403	Phosphorylation	IRYVVDLYLNTPDKM HHHHHHHHHCCCCCC	8.08	20068231
403	Ubiquitination	IRYVVDLYLNTPDKM HHHHHHHHHCCCCCC	8.08	24816145
406	Phosphorylation	VVDLYLNTPDKMGYD HHHHHHCCCCCCCCC	30.21	20068231
439	Ubiquitination	SSHHLIVKNSRNKYD HHCEEEEECCCCCCC	42.06	29967540
447	Ubiquitination	NSRNKYDKTPEDVIC CCCCCCCCCHHHCCC	63.99	29967540
448	Phosphorylation	SRNKYDKTPEDVICE CCCCCCCCHHHCCCH	29.07	21815630
458	Ubiquitination	DVICERSKNKSVELK HCCCHHHCCCCHHHH	74.70	29967540
460	Ubiquitination	ICERSKNKSVELKER CCHHHCCCCHHHHHH	60.66	29967540
465	Ubiquitination	KNKSVELKERIREYL CCCCHHHHHHHHHHH	31.29	24816145
472	Ubiquitination	KERIREYLKGHYYVP HHHHHHHHCCCCEEE	4.61	24816145
473	Ubiquitination	ERIREYLKGHYYVPL HHHHHHHCCCCEEEE	42.62	29967540
476	Phosphorylation	REYLKGHYYVPLLRA HHHHCCCCEEEEEEC	18.15	28796482
477	Phosphorylation	EYLKGHYYVPLLRAE HHHCCCCEEEEEECC	7.01	28796482
486	Phosphorylation	PLLRAEETSSPVIGE EEEECCCCCCCCCCC	26.47	25159151
487	Phosphorylation	LLRAEETSSPVIGEL EEECCCCCCCCCCCC	35.60	23927012
488	Phosphorylation	LRAEETSSPVIGELW EECCCCCCCCCCCCC	30.52	23927012
496	Phosphorylation	PVIGELWSPDQTAEA CCCCCCCCCCCCCCH	31.09	23927012
500	Phosphorylation	ELWSPDQTAEASHVS CCCCCCCCCCHHHHH	33.57	22199227
504	Phosphorylation	PDQTAEASHVSRYGG CCCCCCHHHHHHCCC	18.87	23927012
507	Phosphorylation	TAEASHVSRYGGSPR CCCHHHHHHCCCCCC	17.86	22199227
509	Phosphorylation	EASHVSRYGGSPRDP CHHHHHHCCCCCCCC	20.52	30266825
512	Phosphorylation	HVSRYGGSPRDPVLT HHHHCCCCCCCCCCH	16.64	30266825
519	Phosphorylation	SPRDPVLTLRAFAGP CCCCCCCHHHHHCCC	17.90	30266825
528	Phosphorylation	RAFAGPLSPAKAEDF HHHCCCCCHHHHHHH	26.41	23401153
531	Ubiquitination	AGPLSPAKAEDFRKL CCCCCHHHHHHHHHH	56.55	29967540
540	Ubiquitination	EDFRKLWKTPPREKA HHHHHHCCCCHHHHC	62.68	29967540
541	Phosphorylation	DFRKLWKTPPREKAG HHHHHCCCCHHHHCC	27.26	21949786
546	Ubiquitination	WKTPPREKAGFLHHV CCCCHHHHCCCCHHC	55.90	29967540
554	Ubiquitination	AGFLHHVKKSDPERG CCCCHHCCCCCHHCC	42.05	29967540
555	Acetylation	GFLHHVKKSDPERGF CCCHHCCCCCHHCCH	60.03	20167786
556	Phosphorylation	FLHHVKKSDPERGFE CCHHCCCCCHHCCHH	53.32	28555341
590	Ubiquitination	FLGCFVDLSSQEGLQ HHCCCCCCCCHHHHH	4.45	24816145
610	Ubiquitination	LTQQEIGKKAQQETG HHHHHHHHHHHHHHC	51.07	-
624	Methylation	GEREASCRDKATTSG CCCCHHHHHCCCCCC	46.07	-
626	Ubiquitination	REASCRDKATTSGSN CCHHHHHCCCCCCCC	28.42	29967540
629	Phosphorylation	SCRDKATTSGSNSIS HHHHCCCCCCCCCEE	35.63	25627689
630	Phosphorylation	CRDKATTSGSNSISV HHHCCCCCCCCCEEE	35.55	25159151
632	Phosphorylation	DKATTSGSNSISVRA HCCCCCCCCCEEEEE	27.46	25159151
634	Phosphorylation	ATTSGSNSISVRAFL CCCCCCCCEEEEEEE	20.24	25159151
646	Sulfoxidation	AFLDEDDMSLEEIKN EEECCCCCCHHHHHH	8.34	21406390
647	Phosphorylation	FLDEDDMSLEEIKNR EECCCCCCHHHHHHH	39.36	22199227
652	Ubiquitination	DMSLEEIKNRQNAAR CCCHHHHHHHHHHHH	49.73	24816145
662	Phosphorylation	QNAARNNSPPTVGAF HHHHHCCCCCCHHHC	35.49	29255136
665	Phosphorylation	ARNNSPPTVGAFGHT HHCCCCCCHHHCCCC	34.65	30266825
672	Phosphorylation	TVGAFGHTRCSAFPL CHHHCCCCCCCCCCH	33.48	23927012
675	Phosphorylation	AFGHTRCSAFPLEQE HCCCCCCCCCCHHHH	29.65	26074081
695	Ubiquitination	AAEPGGPHSSRNGLC HCCCCCCCCCCCCCC	41.50	24816145
708	Phosphorylation	LCHPLNHSRTLAGKR CCCCCCCCCCCCCCC	26.36	28555341
730	Phosphorylation	EAHLPPVSDLTVEFD CCCCCCCCCEEEEEE	32.45	46163655
733	Phosphorylation	LPPVSDLTVEFDKLN CCCCCCEEEEEEHHC	23.99	46163667
738	Ubiquitination	DLTVEFDKLNLQNIG CEEEEEEHHCHHHHC	44.59	24816145
747	Phosphorylation	NLQNIGRSVSKTPDE CHHHHCCCCCCCCCC	26.06	29514088
749	Phosphorylation	QNIGRSVSKTPDEST HHHCCCCCCCCCCCC	31.87	29514088
751	Phosphorylation	IGRSVSKTPDESTKT HCCCCCCCCCCCCCC	28.59	28985074
757	Ubiquitination	KTPDESTKTKDQILT CCCCCCCCCHHHHHH	63.96	24816145
758	Phosphorylation	TPDESTKTKDQILTS CCCCCCCCHHHHHHH	39.68	46163673
759	Ubiquitination	PDESTKTKDQILTSR CCCCCCCHHHHHHHH	49.55	29967540
764	Phosphorylation	KTKDQILTSRINAVE CCHHHHHHHHHHHHH	20.00	24719451
778	Phosphorylation	ERDLLEPSPADQLGN HHHHCCCCHHHHCCC	24.28	25159151
790	Phosphorylation	LGNGHRRTESEMSAR CCCCCCCCHHHHHHH	43.76	29449344
792	Phosphorylation	NGHRRTESEMSARIA CCCCCCHHHHHHHHH	37.68	29449344
800	Ubiquitination	EMSARIAKMSLSPSS HHHHHHHHHCCCCCC	27.01	24816145
802	Phosphorylation	SARIAKMSLSPSSPR HHHHHHHCCCCCCCC	25.62	25159151
804	Phosphorylation	RIAKMSLSPSSPRHE HHHHHCCCCCCCCCH	18.54	25159151
806	Phosphorylation	AKMSLSPSSPRHEDQ HHHCCCCCCCCCHHH	49.99	25159151
807	Phosphorylation	KMSLSPSSPRHEDQL HHCCCCCCCCCHHHH	29.36	25159151
817	Phosphorylation	HEDQLEVTREPARRL CHHHHHHCCHHHHHH	21.68	27174698
832	Phosphorylation	FLFGEEPSKLDQDVL HHHCCCCCCCCHHHH	49.48	50565243
833	Ubiquitination	LFGEEPSKLDQDVLA HHCCCCCCCCHHHHH	67.79	29967540
847	Ubiquitination	AALECADVDPHQFPA HHHHHCCCCHHHCCH	7.02	24816145
859	Ubiquitination	FPAVHRWKSAVLCYS CCHHHCCCCEEEEEC	28.61	29967540
860	Phosphorylation	PAVHRWKSAVLCYSP CHHHCCCCEEEEECC	19.36	22199227
865	Phosphorylation	WKSAVLCYSPSDRQS CCCEEEEECCCCCCC	21.32	22199227
866	Phosphorylation	KSAVLCYSPSDRQSW CCEEEEECCCCCCCC	19.55	25159151
868	Phosphorylation	AVLCYSPSDRQSWPS EEEEECCCCCCCCCC	39.21	21712546
872	Phosphorylation	YSPSDRQSWPSPAVK ECCCCCCCCCCHHHC	41.68	22199227
875	Phosphorylation	SDRQSWPSPAVKGRF CCCCCCCCHHHCCCH	21.16	25159151
883	Methylation	PAVKGRFKSQLPDLS HHHCCCHHHCCCCCC	35.61	-
883	Ubiquitination	PAVKGRFKSQLPDLS HHHCCCHHHCCCCCC	35.61	29967540
884	Phosphorylation	AVKGRFKSQLPDLSG HHCCCHHHCCCCCCC	33.95	29396449
890	Phosphorylation	KSQLPDLSGPHSYSP HHCCCCCCCCCCCCC	58.62	20068231
894	Phosphorylation	PDLSGPHSYSPGRNS CCCCCCCCCCCCCCC	30.36	25159151
895	Phosphorylation	DLSGPHSYSPGRNSV CCCCCCCCCCCCCCC	18.82	22199227
896	Phosphorylation	LSGPHSYSPGRNSVA CCCCCCCCCCCCCCC	24.72	25159151
901	Phosphorylation	SYSPGRNSVAGSNPA CCCCCCCCCCCCCCC	16.39	23663014
905	Phosphorylation	GRNSVAGSNPAKPGL CCCCCCCCCCCCCCC	29.87	23663014
909	Ubiquitination	VAGSNPAKPGLGSPG CCCCCCCCCCCCCCC	40.66	24816145
914	Phosphorylation	PAKPGLGSPGRYSPV CCCCCCCCCCCCCCC	29.26	25159151
918	Phosphorylation	GLGSPGRYSPVHGSQ CCCCCCCCCCCCHHH	24.20	21712546
919	Phosphorylation	LGSPGRYSPVHGSQL CCCCCCCCCCCHHHH	21.05	25159151
924	Phosphorylation	RYSPVHGSQLRRMAR CCCCCCHHHHHHHHH	15.91	23401153
927	Methylation	PVHGSQLRRMARLAE CCCHHHHHHHHHHHH	20.77	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
528	S	Phosphorylation	Kinase	CDK2	P24941	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ANKL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ANKL2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
2AAA_HUMAN	PPP2R1A	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ANKL2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-259; SER-268; SER-487;SER-488; SER-496; SER-512; SER-528; SER-662; SER-896; SER-914 ANDSER-919, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-896, AND MASSSPECTROMETRY.	18220336 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-259 AND SER-528, ANDMASS SPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-662, AND MASSSPECTROMETRY.	17081983 [Abstract]