dbPTM

RIF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RIF1_HUMAN
UniProt AC	Q5UIP0
Protein Name	Telomere-associated protein RIF1 {ECO:0000305}
Gene Name	RIF1 {ECO:0000303\|PubMed:15342490, ECO:0000312\|HGNC:HGNC:23207}
Organism	Homo sapiens (Human).
Sequence Length	2472
Subcellular Localization	Nucleus . Chromosome . Chromosome, telomere . Cytoplasm, cytoskeleton, spindle . Following interaction with TP53BP1, recruited to sites of DNA damage, such as DSBs (By similarity). Exhibits ATM- and TP53BP1-dependent localization to uncapped or aberr
Protein Description	Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs. [PubMed: 15342490]
Protein Sequence	MTARGQSPLAPLLETLEDPSASHGGQTDAYLTLTSRMTGEEGKEVITEIEKKLPRLYKVLKTHISSQNSELSSAALQALGFCLYNPKITSELSEANALELLSKLNDTIKNSDKNVRTRALWVISKQTFPSEVVGKMVSSIIDSLEILFNKGETHSAVVDFEALNVIVRLIEQAPIQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEIASITEQLMTTKLISELQKLFMSKNETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELGFRSGAPMIKKIAFIAWKSLIDNFALNPDILCSAKRLKLLMQPLSSIHVRTETLALTKLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNASPQGNSCHVATSPGLNPMTPVHKGASSPYGAPGTPRMNLSSNLGGMATIPSIQLLGLEMLLHFLLGPEALSFAKQNKLVLSLEPLEHPLISSPSFFSKHANTLITAVHDSFVAVGKDAPDVVVSAIWKELISLVKSVTESGNKKEKPGSEVLTLLLKSLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANMDILNGTPALFLIQLIFNNFLECGVSDERFFLSLESLVGCVLSGPTSPLAFSDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALTLPVNHIFSEQRFPVATMKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLEDEGFSNLLFVDRIIYIITVMVDCIDFSPYNIKYQPKVKSPQRPSDWSKKKNEPLGKLTSLFKLIVKVIYSFHTLSFKEAHSDTLFTIGNSITGIISSVLGHISLPSMIRKIFATLTRPLALFYENSKLDEVPKVYSCLNNKLEKLLGEIIACLQFSYTGTYDSELLEQLSPLLCIIFLHKNKQIRKQSAQFWNATFAKVMMLVYPEELKPVLTQAKQKFLLLLPGLETVEMMEESSGPYSDGTENSQLNVKISGMERKSNGKRDSFLAQTKNKKENMKPAAKLKLESSSLKVKGEILLEEEKSTDFVFIPPEGKDAKERILTDHQKEVLKTKRCDIPAMYNNLDVSQDTLFTQYSQEEPMEIPTLTRKPKEDSKMMITEEQMDSDIVIPQDVTEDCGMAEHLEKSSLSNNECGSLDKTSPEMSNSNNDERKKALISSRKTSTECASSTENSFVVSSSSVSNTTVAGTPPYPTSRRQTFITLEKFDGSENRPFSPSPLNNISSTVTVKNNQETMIKTDFLPKAKQREGTFSKSDSEKIVNGTKRSSRRAGKAEQTGNKRSKPLMRSEPEKNTEESVEGIVVLENNPPGLLNQTECVSDNQVHLSESTMEHDNTKLKAATVENAVLLETNTVEEKNVEINLESKENTPPVVISADQMVNEDSQVQITPNQKTLRRSSRRRSEVVESTTESQDKENSHQKKERRKEEEKPLQKSPLHIKDDVLPKQKLIAEQTLQENLIEKGSNLHEKTLGETSANAETEQNKKKADPENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWKNKSNESVDIQDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSPICEKQDESNTVICQDSTVTSDLLQVPDDLPNVCEEKNETSKYAEYSFTSLPVPESNLRTRNAIKRLHKRDSFDNCSLGESSKIGISDISSLSEKTFQTLECQHKRSRRVRRSKGCDCCGEKSQPQEKSLIGLKNTENNDVEISETKKADVQAPVSPSETSQANPYSEGQFLDEHHSVNFHLGLKEDNDTINDSLIVSETKSKENTMQESLPSGIVNFREEICDMDSSEAMSLESQESPNENFKTVGPCLGDSKNVSQESLETKEEKPEETPKMELSLENVTVEGNACKVTESNLEKAKTMELNVGNEASFHGQERTKTGISEEAAIEENKRNDDSEADTAKLNAKEVATEEFNSDISLSDNTTPVKLNAQTEISEQTAAGELDGGNDVSDLHSSEETNTKMKNNEEMMIGEAMAETGHDGETENEGITTKTSKPDEAETNMLTAEMDNFVCDTVEMSTEEGIIDANKTETNTEYSKSEEKLDNNQMVMESDILQEDHHTSQKVEEPSQCLASGTAISELIIEDNNASPQKLRELDPSLVSANDSPSGMQTRCVWSPLASPSTSILKRGLKRSQEDEISSPVNKVRRVSFADPIYQAGLADDIDRRCSIVRSHSSNSSPIGKSVKTSPTTQSKHNTTSAKGFLSPGSRSPKFKSSKKCLISEMAKESIPCPTESVYPPLVNCVAPVDIILPQITSNMWARGLGQLIRAKNIKTIGDLSTLTASEIKTLPIRSPKVSNVKKALRIYHEQQVKTRGLEEIPVFDISEKTVNGIENKSLSPDEERLVSDIIDPVALEIPLSKNLLAQISALALQLDSEDLHNYSGSQLFEMHEKLSCMANSVIKNLQSRWRSPSHENSI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTARGQSPL ------CCCCCCCCC	36.04	26074081
7	Phosphorylation	-MTARGQSPLAPLLE -CCCCCCCCCHHHHH	25.38	25159151
15	Phosphorylation	PLAPLLETLEDPSAS CCHHHHHHHCCCCHH	35.10	28450419
20	Phosphorylation	LETLEDPSASHGGQT HHHHCCCCHHCCCCC	55.51	28450419
22	Phosphorylation	TLEDPSASHGGQTDA HHCCCCHHCCCCCCE	27.31	28450419
27	Phosphorylation	SASHGGQTDAYLTLT CHHCCCCCCEEEEEC	26.35	28450419
30	Phosphorylation	HGGQTDAYLTLTSRM CCCCCCEEEEECCCC	11.74	26074081
32	Phosphorylation	GQTDAYLTLTSRMTG CCCCEEEEECCCCCC	18.47	27080861
34	Phosphorylation	TDAYLTLTSRMTGEE CCEEEEECCCCCCCC	14.73	27080861
35	Phosphorylation	DAYLTLTSRMTGEEG CEEEEECCCCCCCCC	24.14	27080861
43	Trimethylation	RMTGEEGKEVITEIE CCCCCCCHHHHHHHH	52.68	-
43	Acetylation	RMTGEEGKEVITEIE CCCCCCCHHHHHHHH	52.68	26051181
43	Methylation	RMTGEEGKEVITEIE CCCCCCCHHHHHHHH	52.68	-
43	Ubiquitination	RMTGEEGKEVITEIE CCCCCCCHHHHHHHH	52.68	29967540
47	Phosphorylation	EEGKEVITEIEKKLP CCCHHHHHHHHHHHH	35.77	25690035
51	Acetylation	EVITEIEKKLPRLYK HHHHHHHHHHHHHHH	66.33	26051181
58	Acetylation	KKLPRLYKVLKTHIS HHHHHHHHHHHHHHH	45.76	26051181
61	Ubiquitination	PRLYKVLKTHISSQN HHHHHHHHHHHHCCC	40.83	29967540
89	Ubiquitination	CLYNPKITSELSEAN HHHCCCCCCCCHHHH	23.44	21890473
102	Phosphorylation	ANALELLSKLNDTIK HHHHHHHHHHHHHHH	47.96	20068231
103	Ubiquitination	NALELLSKLNDTIKN HHHHHHHHHHHHHHC	51.81	29967540
107	Phosphorylation	LLSKLNDTIKNSDKN HHHHHHHHHHCCCCC	32.55	28674151
109	Ubiquitination	SKLNDTIKNSDKNVR HHHHHHHHCCCCCHH	53.11	-
111	Phosphorylation	LNDTIKNSDKNVRTR HHHHHHCCCCCHHHH	44.98	28674151
125	Ubiquitination	RALWVISKQTFPSEV HEEEEEECCCCCHHH	42.08	21890473
125	Ubiquitination	RALWVISKQTFPSEV HEEEEEECCCCCHHH	42.08	21890473
125 (in isoform 1)	Ubiquitination	-	42.08	21890473
125 (in isoform 2)	Ubiquitination	-	42.08	21890473
143	Phosphorylation	MVSSIIDSLEILFNK HHHHHHHHHHHHHCC	19.93	-
162	Ubiquitination	SAVVDFEALNVIVRL EEEECHHHHHHHHHH	12.39	21890473
186	Acetylation	EEAVRWAKLVIPLVV HHHHHHHHHHHHHHH	36.01	26051181
198	Ubiquitination	LVVHSAQKVHLRGAT HHHHCCCCHHCCHHH	31.19	21890473
198	Acetylation	LVVHSAQKVHLRGAT HHHHCCCCHHCCHHH	31.19	25953088
198	Ubiquitination	LVVHSAQKVHLRGAT HHHHCCCCHHCCHHH	31.19	21890473
198 (in isoform 1)	Ubiquitination	-	31.19	21890473
198 (in isoform 2)	Ubiquitination	-	31.19	21890473
215	Ubiquitination	EMGMPLLLQKQQEIA HCCHHHHHHHHHHHH	8.67	21890473
223	Phosphorylation	QKQQEIASITEQLMT HHHHHHHHHHHHHHH	35.39	30177828
225	Phosphorylation	QQEIASITEQLMTTK HHHHHHHHHHHHHHH	18.38	30177828
230	Phosphorylation	SITEQLMTTKLISEL HHHHHHHHHHHHHHH	29.39	30177828
231	Phosphorylation	ITEQLMTTKLISELQ HHHHHHHHHHHHHHH	15.19	30177828
232	Ubiquitination	TEQLMTTKLISELQK HHHHHHHHHHHHHHH	34.36	29967540
251	Ubiquitination	KNETYVLKLWPLFVK CCCCHHHHHHHHHHH	38.16	21890473
251	Ubiquitination	KNETYVLKLWPLFVK CCCCHHHHHHHHHHH	38.16	21890473
251 (in isoform 1)	Ubiquitination	-	38.16	21890473
251 (in isoform 2)	Ubiquitination	-	38.16	21890473
279	Ubiquitination	NSLLQLEELGFRSGA HHHHHHHHHCCCCCC	63.89	21963094
282	Ubiquitination	LQLEELGFRSGAPMI HHHHHHCCCCCCCHH	9.81	22817900
284	Ubiquitination	LEELGFRSGAPMIKK HHHHCCCCCCCHHHH	36.73	21963094
287	Ubiquitination	LGFRSGAPMIKKIAF HCCCCCCCHHHHHHH	28.67	22817900
312	S-nitrosocysteine	ALNPDILCSAKRLKL CCCHHHHCCHHHHHH	3.67	-
312	S-nitrosylation	ALNPDILCSAKRLKL CCCHHHHCCHHHHHH	3.67	19483679
315	Acetylation	PDILCSAKRLKLLMQ HHHHCCHHHHHHHHH	41.80	25953088
315	Ubiquitination	PDILCSAKRLKLLMQ HHHHCCHHHHHHHHH	41.80	21963094
318	Acetylation	LCSAKRLKLLMQPLS HCCHHHHHHHHHCHH	43.54	25953088
318	Ubiquitination	LCSAKRLKLLMQPLS HCCHHHHHHHHHCHH	43.54	22817900
344	Phosphorylation	TKLEVWWYLLMRLGP HHHHHHHHHHHHHCC	3.69	-
401	Phosphorylation	TPVHKGASSPYGAPG CCCCCCCCCCCCCCC	40.28	22167270
402	Phosphorylation	PVHKGASSPYGAPGT CCCCCCCCCCCCCCC	22.93	23401153
404	Phosphorylation	HKGASSPYGAPGTPR CCCCCCCCCCCCCCC	28.06	22167270
409	Phosphorylation	SPYGAPGTPRMNLSS CCCCCCCCCCCCCCC	13.48	22167270
411	Methylation	YGAPGTPRMNLSSNL CCCCCCCCCCCCCCC	26.85	54558791
423	Phosphorylation	SNLGGMATIPSIQLL CCCCCCCCCCHHHHH	25.24	-
466	Phosphorylation	PLEHPLISSPSFFSK CCCCCCCCCHHHHHH	43.83	-
467	Phosphorylation	LEHPLISSPSFFSKH CCCCCCCCHHHHHHH	19.98	-
480	Phosphorylation	KHANTLITAVHDSFV HHCCHHHHHHHHHHH	26.24	28555341
507	Phosphorylation	AIWKELISLVKSVTE HHHHHHHHHHHHHHH	39.47	24719451
511	Phosphorylation	ELISLVKSVTESGNK HHHHHHHHHHHCCCC	27.13	21082442
519	Methylation	VTESGNKKEKPGSEV HHHCCCCCCCCCHHH	74.99	23644510
519	Ubiquitination	VTESGNKKEKPGSEV HHHCCCCCCCCCHHH	74.99	29967540
521	Acetylation	ESGNKKEKPGSEVLT HCCCCCCCCCHHHHH	64.65	25953088
521	Methylation	ESGNKKEKPGSEVLT HCCCCCCCCCHHHHH	64.65	23644510
521	Ubiquitination	ESGNKKEKPGSEVLT HCCCCCCCCCHHHHH	64.65	33845483
533	Phosphorylation	VLTLLLKSLESIVKS HHHHHHHHHHHHHHC	37.02	30266825
536	Phosphorylation	LLLKSLESIVKSEVF HHHHHHHHHHHCCCC	37.67	30266825
539	Ubiquitination	KSLESIVKSEVFPVS HHHHHHHHCCCCCCC	38.95	29967540
540	O-linked_Glycosylation	SLESIVKSEVFPVSK HHHHHHHCCCCCCCC	28.26	30379171
642	Ubiquitination	NAKQLENKEHLWKMW CHHHHCCHHHHHHHH	36.82	29967540
663	Ubiquitination	LTELINQTNEVNQGD HHHHHHHCCCCCHHH	28.94	21890473
666	Ubiquitination	LINQTNEVNQGDALE HHHHCCCCCHHHHHH	7.61	21890473
671	Ubiquitination	NEVNQGDALEHNFSA CCCCHHHHHHHHHHH	22.98	21890473
694	Ubiquitination	VNHIFSEQRFPVATM HHHHCCCCCCCHHHH	51.63	21890473
702	Ubiquitination	RFPVATMKTLLRTWS CCCHHHHHHHHHHHH	31.50	21890473
702	Ubiquitination	RFPVATMKTLLRTWS CCCHHHHHHHHHHHH	31.50	21963094
702 (in isoform 1)	Ubiquitination	-	31.50	21890473
702 (in isoform 2)	Ubiquitination	-	31.50	21890473
740	Phosphorylation	ELSSKIMSSLEDEGF HHHHHHHHHCCCCCC	34.93	26546556
748	Phosphorylation	SLEDEGFSNLLFVDR HCCCCCCCHHHHHHH	37.11	26546556
758	Phosphorylation	LFVDRIIYIITVMVD HHHHHHHHHHHHHHH	5.49	-
770	Phosphorylation	MVDCIDFSPYNIKYQ HHHHCCCCCCCCCCC	23.79	19835603
772	Phosphorylation	DCIDFSPYNIKYQPK HHCCCCCCCCCCCCC	28.46	19835603
776	Phosphorylation	FSPYNIKYQPKVKSP CCCCCCCCCCCCCCC	26.67	26074081
781	Ubiquitination	IKYQPKVKSPQRPSD CCCCCCCCCCCCCCH	63.65	29967540
782	Phosphorylation	KYQPKVKSPQRPSDW CCCCCCCCCCCCCHH	29.29	22167270
787	Phosphorylation	VKSPQRPSDWSKKKN CCCCCCCCHHHHHCC	54.63	30266825
790	Phosphorylation	PQRPSDWSKKKNEPL CCCCCHHHHHCCCCC	39.32	23927012
791	Ubiquitination	QRPSDWSKKKNEPLG CCCCHHHHHCCCCCH	64.61	29967540
799	Acetylation	KKNEPLGKLTSLFKL HCCCCCHHHHHHHHH	57.16	20167786
802	Phosphorylation	EPLGKLTSLFKLIVK CCCHHHHHHHHHHHH	42.09	24719451
813	Phosphorylation	LIVKVIYSFHTLSFK HHHHHHHHHHCCCHH	10.22	25599653
818	Phosphorylation	IYSFHTLSFKEAHSD HHHHHCCCHHHHCCC	35.11	24719451
876	Ubiquitination	SKLDEVPKVYSCLNN CCCCCCCHHHHHHHH	60.01	29967540
929	Ubiquitination	HKNKQIRKQSAQFWN HCCHHHHHHHHHHHH	50.67	29967540
947	Phosphorylation	AKVMMLVYPEELKPV HHHHHHHCHHHHHHH	10.85	20068231
952	Ubiquitination	LVYPEELKPVLTQAK HHCHHHHHHHHHHHH	36.04	-
959	Ubiquitination	KPVLTQAKQKFLLLL HHHHHHHHHHHHHHC	44.17	29967540
961	Ubiquitination	VLTQAKQKFLLLLPG HHHHHHHHHHHHCCC	36.95	-
971	Phosphorylation	LLLPGLETVEMMEES HHCCCHHHHHHHHHC	27.15	20873877
978	Phosphorylation	TVEMMEESSGPYSDG HHHHHHHCCCCCCCC	27.56	20068231
979	Phosphorylation	VEMMEESSGPYSDGT HHHHHHCCCCCCCCC	47.25	20068231
982	Phosphorylation	MEESSGPYSDGTENS HHHCCCCCCCCCCCC	23.95	20068231
983	Phosphorylation	EESSGPYSDGTENSQ HHCCCCCCCCCCCCE	32.47	20068231
986	Phosphorylation	SGPYSDGTENSQLNV CCCCCCCCCCCEEEE	36.66	20068231
989	Phosphorylation	YSDGTENSQLNVKIS CCCCCCCCEEEEEEE	29.79	20068231
1002	Phosphorylation	ISGMERKSNGKRDSF EECCCCCCCCCCCCH	57.97	28555341
1008	Phosphorylation	KSNGKRDSFLAQTKN CCCCCCCCHHHHHCC	26.62	23401153
1013	Phosphorylation	RDSFLAQTKNKKENM CCCHHHHHCCHHHCC	30.86	23186163
1014	Ubiquitination	DSFLAQTKNKKENMK CCHHHHHCCHHHCCC	55.48	33845483
1016	Acetylation	FLAQTKNKKENMKPA HHHHHCCHHHCCCCC	64.12	30591925
1017	Acetylation	LAQTKNKKENMKPAA HHHHCCHHHCCCCCH	64.81	30591929
1021	Acetylation	KNKKENMKPAAKLKL CCHHHCCCCCHHHHH	42.98	25953088
1025	Acetylation	ENMKPAAKLKLESSS HCCCCCHHHHHCCCC	48.54	25953088
1027	Acetylation	MKPAAKLKLESSSLK CCCCHHHHHCCCCCE	49.88	25953088
1027	Ubiquitination	MKPAAKLKLESSSLK CCCCHHHHHCCCCCE	49.88	33845483
1030	Phosphorylation	AAKLKLESSSLKVKG CHHHHHCCCCCEEEE	35.35	29214152
1031	Phosphorylation	AKLKLESSSLKVKGE HHHHHCCCCCEEEEE	30.25	23186163
1032	Phosphorylation	KLKLESSSLKVKGEI HHHHCCCCCEEEEEE	41.30	23401153
1034	Ubiquitination	KLESSSLKVKGEILL HHCCCCCEEEEEEEE	43.80	33845483
1036	Ubiquitination	ESSSLKVKGEILLEE CCCCCEEEEEEEEEE	49.60	33845483
1039	Ubiquitination	SLKVKGEILLEEEKS CCEEEEEEEEEECCC	7.88	24816145
1044	Ubiquitination	GEILLEEEKSTDFVF EEEEEEECCCCCEEE	42.82	24816145
1046	Phosphorylation	ILLEEEKSTDFVFIP EEEEECCCCCEEEEC	36.17	30266825
1047	Phosphorylation	LLEEEKSTDFVFIPP EEEECCCCCEEEECC	44.52	30266825
1067	Ubiquitination	KERILTDHQKEVLKT HHHHCCHHHHHHHHH	35.06	24816145
1069	Ubiquitination	RILTDHQKEVLKTKR HHCCHHHHHHHHHCC	46.50	33845483
1075	Ubiquitination	QKEVLKTKRCDIPAM HHHHHHHCCCCCCHH	49.82	24816145
1083	Phosphorylation	RCDIPAMYNNLDVSQ CCCCCHHHCCCCCCH	11.73	27251275
1089	Phosphorylation	MYNNLDVSQDTLFTQ HHCCCCCCHHCCCCC	23.23	22496350
1092	Phosphorylation	NLDVSQDTLFTQYSQ CCCCCHHCCCCCCCC	19.01	25159151
1095	Phosphorylation	VSQDTLFTQYSQEEP CCHHCCCCCCCCCCC	29.70	25159151
1097	Phosphorylation	QDTLFTQYSQEEPME HHCCCCCCCCCCCCC	14.84	26074081
1098	Phosphorylation	DTLFTQYSQEEPMEI HCCCCCCCCCCCCCC	22.69	26074081
1121	Phosphorylation	EDSKMMITEEQMDSD CCCCCCCCHHHCCCC	18.64	29449344
1127	Phosphorylation	ITEEQMDSDIVIPQD CCHHHCCCCEECCCC	24.72	17322306
1148	Phosphorylation	MAEHLEKSSLSNNEC CHHHHHHHCCCCCCC	27.43	23927012
1149	Phosphorylation	AEHLEKSSLSNNECG HHHHHHHCCCCCCCC	47.05	25159151
1151	Phosphorylation	HLEKSSLSNNECGSL HHHHHCCCCCCCCCC	39.29	23401153
1157	Phosphorylation	LSNNECGSLDKTSPE CCCCCCCCCCCCCCC	45.08	23401153
1160	Acetylation	NECGSLDKTSPEMSN CCCCCCCCCCCCCCC	57.08	25953088
1161	Phosphorylation	ECGSLDKTSPEMSNS CCCCCCCCCCCCCCC	49.53	23401153
1162	Phosphorylation	CGSLDKTSPEMSNSN CCCCCCCCCCCCCCC	25.30	25159151
1166	Phosphorylation	DKTSPEMSNSNNDER CCCCCCCCCCCCHHH	35.13	23927012
1168	Phosphorylation	TSPEMSNSNNDERKK CCCCCCCCCCHHHHH	29.69	23927012
1179	Phosphorylation	ERKKALISSRKTSTE HHHHHHHHCCCCCCC	25.58	26074081
1180	Phosphorylation	RKKALISSRKTSTEC HHHHHHHCCCCCCCC	30.70	26074081
1183	Phosphorylation	ALISSRKTSTECASS HHHHCCCCCCCCCCC	39.51	28450419
1184	Phosphorylation	LISSRKTSTECASST HHHCCCCCCCCCCCC	25.83	27273156
1185	Phosphorylation	ISSRKTSTECASSTE HHCCCCCCCCCCCCC	40.07	27273156
1189	Phosphorylation	KTSTECASSTENSFV CCCCCCCCCCCCEEE	49.83	28450419
1190	Phosphorylation	TSTECASSTENSFVV CCCCCCCCCCCEEEE	22.63	28450419
1191	Phosphorylation	STECASSTENSFVVS CCCCCCCCCCEEEEE	36.37	28450419
1194	Phosphorylation	CASSTENSFVVSSSS CCCCCCCEEEEECCC	17.12	28450419
1198	Phosphorylation	TENSFVVSSSSVSNT CCCEEEEECCCCCCC	21.14	27080861
1199	Phosphorylation	ENSFVVSSSSVSNTT CCEEEEECCCCCCCC	18.28	27080861
1200	Phosphorylation	NSFVVSSSSVSNTTV CEEEEECCCCCCCCC	27.53	28450419
1201	Phosphorylation	SFVVSSSSVSNTTVA EEEEECCCCCCCCCC	31.36	27080861
1203	Phosphorylation	VVSSSSVSNTTVAGT EEECCCCCCCCCCCC	30.33	27080861
1205	Phosphorylation	SSSSVSNTTVAGTPP ECCCCCCCCCCCCCC	18.36	27080861
1206	Phosphorylation	SSSVSNTTVAGTPPY CCCCCCCCCCCCCCC	16.77	27080861
1210	Phosphorylation	SNTTVAGTPPYPTSR CCCCCCCCCCCCCCC	16.02	27251275
1210	Ubiquitination	SNTTVAGTPPYPTSR CCCCCCCCCCCCCCC	16.02	24816145
1213	Phosphorylation	TVAGTPPYPTSRRQT CCCCCCCCCCCCCCE	21.98	-
1215	Phosphorylation	AGTPPYPTSRRQTFI CCCCCCCCCCCCEEE	29.08	-
1220	Phosphorylation	YPTSRRQTFITLEKF CCCCCCCEEEEEEEC	18.39	25159151
1223	Phosphorylation	SRRQTFITLEKFDGS CCCCEEEEEEECCCC	25.36	-
1230	Phosphorylation	TLEKFDGSENRPFSP EEEECCCCCCCCCCC	33.28	29255136
1236	Phosphorylation	GSENRPFSPSPLNNI CCCCCCCCCCCCCCC	27.44	23401153
1238	Phosphorylation	ENRPFSPSPLNNISS CCCCCCCCCCCCCCC	40.60	23401153
1244	Phosphorylation	PSPLNNISSTVTVKN CCCCCCCCCEEEEEC	23.29	23403867
1245	Phosphorylation	SPLNNISSTVTVKNN CCCCCCCCEEEEECC	24.09	23403867
1246	Phosphorylation	PLNNISSTVTVKNNQ CCCCCCCEEEEECCC	17.26	23403867
1248	Phosphorylation	NNISSTVTVKNNQET CCCCCEEEEECCCEE	26.33	23403867
1264	Ubiquitination	IKTDFLPKAKQREGT EEECCCCHHHHCCCC	71.06	33845483
1274	Acetylation	QREGTFSKSDSEKIV HCCCCCCCCHHHHHH	54.83	19608861
1293	Acetylation	RSSRRAGKAEQTGNK CCCHHCCCHHHCCCC	48.00	18585871
1293	Methylation	RSSRRAGKAEQTGNK CCCHHCCCHHHCCCC	48.00	18585871
1297	Phosphorylation	RAGKAEQTGNKRSKP HCCCHHHCCCCCCCC	33.94	30576142
1302	Phosphorylation	EQTGNKRSKPLMRSE HHCCCCCCCCCCCCC	39.99	24719451
1308	Phosphorylation	RSKPLMRSEPEKNTE CCCCCCCCCCCCCCC	43.46	28258704
1317	Phosphorylation	PEKNTEESVEGIVVL CCCCCCCCEEEEEEE	21.16	30576142
1338	Ubiquitination	LLNQTECVSDNQVHL CCCCEEECCCCCEEE	7.01	21890473
1370	Phosphorylation	ENAVLLETNTVEEKN ECEEEEECCCCCEEC	35.84	30576142
1372	Phosphorylation	AVLLETNTVEEKNVE EEEEECCCCCEECEE	36.39	30576142
1384	Phosphorylation	NVEINLESKENTPPV CEEEECCCCCCCCCE	48.73	20363803
1388	Phosphorylation	NLESKENTPPVVISA ECCCCCCCCCEEEEE	30.02	30266825
1394	Phosphorylation	NTPPVVISADQMVNE CCCCEEEEEHHCCCC	17.74	30266825
1395	Ubiquitination	TPPVVISADQMVNED CCCEEEEEHHCCCCC	10.42	24816145
1398	Ubiquitination	VVISADQMVNEDSQV EEEEEHHCCCCCCCC	3.44	24816145
1403	Phosphorylation	DQMVNEDSQVQITPN HHCCCCCCCCCCCCC	26.52	30266825
1403	Ubiquitination	DQMVNEDSQVQITPN HHCCCCCCCCCCCCC	26.52	24816145
1408	Phosphorylation	EDSQVQITPNQKTLR CCCCCCCCCCHHHHH	10.09	30576142
1413	Phosphorylation	QITPNQKTLRRSSRR CCCCCHHHHHHHHHH	18.74	26074081
1417	Phosphorylation	NQKTLRRSSRRRSEV CHHHHHHHHHHHHHH	23.05	26074081
1418	Phosphorylation	QKTLRRSSRRRSEVV HHHHHHHHHHHHHHH	28.17	26074081
1422	Phosphorylation	RRSSRRRSEVVESTT HHHHHHHHHHHHHCC	32.69	29255136
1426	Ubiquitination	RRRSEVVESTTESQD HHHHHHHHHCCHHHH	47.76	24816145
1427	Phosphorylation	RRSEVVESTTESQDK HHHHHHHHCCHHHHH	29.08	23401153
1428	Phosphorylation	RSEVVESTTESQDKE HHHHHHHCCHHHHHC	22.52	29255136
1429	Phosphorylation	SEVVESTTESQDKEN HHHHHHCCHHHHHCC	42.81	23401153
1431	Phosphorylation	VVESTTESQDKENSH HHHHCCHHHHHCCCH	41.40	29255136
1434	Acetylation	STTESQDKENSHQKK HCCHHHHHCCCHHHH	51.67	26051181
1434	Ubiquitination	STTESQDKENSHQKK HCCHHHHHCCCHHHH	51.67	24816145
1437	Phosphorylation	ESQDKENSHQKKERR HHHHHCCCHHHHHHH	28.52	29255136
1453	Ubiquitination	EEEKPLQKSPLHIKD HHCCCCCCCCCCCCC	62.82	33845483
1454	Phosphorylation	EEKPLQKSPLHIKDD HCCCCCCCCCCCCCC	21.52	29255136
1459	Acetylation	QKSPLHIKDDVLPKQ CCCCCCCCCCCCCCH	36.81	26051181
1465	Ubiquitination	IKDDVLPKQKLIAEQ CCCCCCCCHHHHHHH	56.77	33845483
1467	Ubiquitination	DDVLPKQKLIAEQTL CCCCCCHHHHHHHHH	48.24	29967540
1473	Phosphorylation	QKLIAEQTLQENLIE HHHHHHHHHHHHHHH	23.16	28122231
1481	Acetylation	LQENLIEKGSNLHEK HHHHHHHHCCCCCHH	61.72	25953088
1481	Ubiquitination	LQENLIEKGSNLHEK HHHHHHHHCCCCCHH	61.72	33845483
1488	Acetylation	KGSNLHEKTLGETSA HCCCCCHHHHCCCCC	38.00	26051181
1488	Ubiquitination	KGSNLHEKTLGETSA HCCCCCHHHHCCCCC	38.00	33845483
1489	Phosphorylation	GSNLHEKTLGETSAN CCCCCHHHHCCCCCC	36.69	22199227
1493	Phosphorylation	HEKTLGETSANAETE CHHHHCCCCCCHHHH	31.20	22199227
1494	Phosphorylation	EKTLGETSANAETEQ HHHHCCCCCCHHHHH	18.41	21815630
1512	Ubiquitination	KADPENIKSEGDGTQ HCCHHHHCCCCCCHH	54.78	33845483
1513	Phosphorylation	ADPENIKSEGDGTQD CCHHHHCCCCCCHHH	42.91	17525332
1518	Phosphorylation	IKSEGDGTQDIVDKS HCCCCCCHHHHCCCC	28.01	17525332
1524	Acetylation	GTQDIVDKSSEKLVR CHHHHCCCCHHHHHC	45.01	26051181
1524	Ubiquitination	GTQDIVDKSSEKLVR CHHHHCCCCHHHHHC	45.01	33845483
1525	Phosphorylation	TQDIVDKSSEKLVRG HHHHCCCCHHHHHCC	38.99	29496963
1526	Phosphorylation	QDIVDKSSEKLVRGR HHHCCCCHHHHHCCC	44.48	29496963
1528	Ubiquitination	IVDKSSEKLVRGRTR HCCCCHHHHHCCCCH	54.98	33845483
1534	Phosphorylation	EKLVRGRTRYQTRRA HHHHCCCCHHHHHHH	36.23	23882029
1536	Phosphorylation	LVRGRTRYQTRRASQ HHCCCCHHHHHHHHH	17.39	26074081
1538	Phosphorylation	RGRTRYQTRRASQGL CCCCHHHHHHHHHHH	17.12	26074081
1542	Phosphorylation	RYQTRRASQGLLSSI HHHHHHHHHHHHHHH	23.99	29255136
1547	Phosphorylation	RASQGLLSSIENSES HHHHHHHHHHHCCCC	34.02	23927012
1548	Phosphorylation	ASQGLLSSIENSESD HHHHHHHHHHCCCCC	33.61	23927012
1552	Phosphorylation	LLSSIENSESDSSEA HHHHHHCCCCCCHHH	26.20	29255136
1554	Phosphorylation	SSIENSESDSSEAKE HHHHCCCCCCHHHHH	42.48	29255136
1556	Phosphorylation	IENSESDSSEAKEEG HHCCCCCCHHHHHHH	39.08	30266825
1557	Phosphorylation	ENSESDSSEAKEEGS HCCCCCCHHHHHHHC	46.71	30266825
1564	Phosphorylation	SEAKEEGSRKKRSGK HHHHHHHCCCCCCCC	44.18	23401153
1575	Ubiquitination	RSGKWKNKSNESVDI CCCCCCCCCCCCCCC	51.43	33845483
1576	Phosphorylation	SGKWKNKSNESVDIQ CCCCCCCCCCCCCCC	56.05	25159151
1579	Phosphorylation	WKNKSNESVDIQDQE CCCCCCCCCCCCHHH	29.37	25159151
1588	Ubiquitination	DIQDQEEKVVKQECI CCCHHHHHHHHHHHH	52.13	33845483
1601	Phosphorylation	CIKAENQSHDYKATS HHHHHHCCCCCCCCC	29.88	26074081
1604	Phosphorylation	AENQSHDYKATSEED HHHCCCCCCCCCHHH	9.33	26074081
1607	Phosphorylation	QSHDYKATSEEDVSI CCCCCCCCCHHHCCC	32.30	30266825
1608	Phosphorylation	SHDYKATSEEDVSIK CCCCCCCCHHHCCCC	43.80	23401153
1613	Phosphorylation	ATSEEDVSIKSPICE CCCHHHCCCCCCCCC	36.30	30266825
1615	Ubiquitination	SEEDVSIKSPICEKQ CHHHCCCCCCCCCCC	42.55	33845483
1616	Phosphorylation	EEDVSIKSPICEKQD HHHCCCCCCCCCCCC	20.16	29255136
1625	Phosphorylation	ICEKQDESNTVICQD CCCCCCCCCCEEECC	46.20	28348404
1627	Phosphorylation	EKQDESNTVICQDST CCCCCCCCEEECCCC	22.11	28348404
1633	Phosphorylation	NTVICQDSTVTSDLL CCEEECCCCCCHHHC	10.01	28348404
1634	Phosphorylation	TVICQDSTVTSDLLQ CEEECCCCCCHHHCC	35.77	28348404
1636	Phosphorylation	ICQDSTVTSDLLQVP EECCCCCCHHHCCCC	19.33	28348404
1637	Phosphorylation	CQDSTVTSDLLQVPD ECCCCCCHHHCCCCC	23.17	28348404
1656	Phosphorylation	VCEEKNETSKYAEYS CCCCCCCCCCCEEEE	39.65	21712546
1658	Ubiquitination	EEKNETSKYAEYSFT CCCCCCCCCEEEECC	56.77	29967540
1659	Phosphorylation	EKNETSKYAEYSFTS CCCCCCCCEEEECCC	12.39	28796482
1662	Phosphorylation	ETSKYAEYSFTSLPV CCCCCEEEECCCCCC	10.83	28796482
1663	Phosphorylation	TSKYAEYSFTSLPVP CCCCEEEECCCCCCC	17.35	25159151
1665	Phosphorylation	KYAEYSFTSLPVPES CCEEEECCCCCCCHH	24.34	22199227
1666	Phosphorylation	YAEYSFTSLPVPESN CEEEECCCCCCCHHH	28.76	21815630
1672	Phosphorylation	TSLPVPESNLRTRNA CCCCCCHHHHHHHHH	34.79	29396449
1676	Phosphorylation	VPESNLRTRNAIKRL CCHHHHHHHHHHHHH	31.29	26074081
1688	Phosphorylation	KRLHKRDSFDNCSLG HHHHHCCCCCCCCCC	38.23	29255136
1693	Phosphorylation	RDSFDNCSLGESSKI CCCCCCCCCCCCCCC	45.74	30266825
1697	Phosphorylation	DNCSLGESSKIGISD CCCCCCCCCCCCCCC	34.82	22167270
1698	Phosphorylation	NCSLGESSKIGISDI CCCCCCCCCCCCCCH	24.80	22167270
1699	Ubiquitination	CSLGESSKIGISDIS CCCCCCCCCCCCCHH	54.98	23000965
1702	Ubiquitination	GESSKIGISDISSLS CCCCCCCCCCHHHCC	3.68	23000965
1703	Phosphorylation	ESSKIGISDISSLSE CCCCCCCCCHHHCCH	24.55	25262027
1705	Ubiquitination	SKIGISDISSLSEKT CCCCCCCHHHCCHHH	2.11	23000965
1706	Phosphorylation	KIGISDISSLSEKTF CCCCCCHHHCCHHHH	30.16	25159151
1707	Phosphorylation	IGISDISSLSEKTFQ CCCCCHHHCCHHHHH	35.93	25159151
1707	Ubiquitination	IGISDISSLSEKTFQ CCCCCHHHCCHHHHH	35.93	23000965
1708	Ubiquitination	GISDISSLSEKTFQT CCCCHHHCCHHHHHH	6.47	23000965
1709	Phosphorylation	ISDISSLSEKTFQTL CCCHHHCCHHHHHHH	38.71	25159151
1711	Ubiquitination	DISSLSEKTFQTLEC CHHHCCHHHHHHHHH	51.79	23000965
1712	Phosphorylation	ISSLSEKTFQTLECQ HHHCCHHHHHHHHHH	19.54	25159151
1713	Ubiquitination	SSLSEKTFQTLECQH HHCCHHHHHHHHHHH	8.49	23000965
1714	Ubiquitination	SLSEKTFQTLECQHK HCCHHHHHHHHHHHH	50.86	23000965
1715	Phosphorylation	LSEKTFQTLECQHKR CCHHHHHHHHHHHHH	21.97	28555341
1719	Ubiquitination	TFQTLECQHKRSRRV HHHHHHHHHHHHHHH	35.44	23000965
1721	Methylation	QTLECQHKRSRRVRR HHHHHHHHHHHHHHH	26.62	115976689
1721	Ubiquitination	QTLECQHKRSRRVRR HHHHHHHHHHHHHHH	26.62	-
1723	Phosphorylation	LECQHKRSRRVRRSK HHHHHHHHHHHHHCC	29.28	30631047
1730	Ubiquitination	SRRVRRSKGCDCCGE HHHHHHCCCCCCCCC	62.84	23000965
1736	Ubiquitination	SKGCDCCGEKSQPQE CCCCCCCCCCCCCCC	52.26	23000965
1738	Ubiquitination	GCDCCGEKSQPQEKS CCCCCCCCCCCCCHH	39.41	23000965
1742	Ubiquitination	CGEKSQPQEKSLIGL CCCCCCCCCHHCCCC	64.21	23000965
1744	Acetylation	EKSQPQEKSLIGLKN CCCCCCCHHCCCCCC	45.36	26051181
1744	Ubiquitination	EKSQPQEKSLIGLKN CCCCCCCHHCCCCCC	45.36	23000965
1745	Phosphorylation	KSQPQEKSLIGLKNT CCCCCCHHCCCCCCC	25.19	22199227
1750	Ubiquitination	EKSLIGLKNTENNDV CHHCCCCCCCCCCCC	57.52	23000965
1752	Phosphorylation	SLIGLKNTENNDVEI HCCCCCCCCCCCCEE	38.20	29083192
1760	Phosphorylation	ENNDVEISETKKADV CCCCCEEECCCCCCC	26.21	25159151
1762	Phosphorylation	NDVEISETKKADVQA CCCEEECCCCCCCCC	30.93	29083192
1763	Ubiquitination	DVEISETKKADVQAP CCEEECCCCCCCCCC	41.74	33845483
1772	Phosphorylation	ADVQAPVSPSETSQA CCCCCCCCCCCCCCC	22.96	25159151
1774	Phosphorylation	VQAPVSPSETSQANP CCCCCCCCCCCCCCC	46.10	26307563
1776	Phosphorylation	APVSPSETSQANPYS CCCCCCCCCCCCCCC	30.40	26307563
1777	Phosphorylation	PVSPSETSQANPYSE CCCCCCCCCCCCCCC	24.20	26307563
1782	Phosphorylation	ETSQANPYSEGQFLD CCCCCCCCCCCCCCC	21.11	20068231
1783	Phosphorylation	TSQANPYSEGQFLDE CCCCCCCCCCCCCCC	36.19	26074081
1793	Phosphorylation	QFLDEHHSVNFHLGL CCCCCCCCEEEEEEE	22.21	30576142
1806	Phosphorylation	GLKEDNDTINDSLIV EECCCCCCCCCCCEE	28.12	29255136
1810	Phosphorylation	DNDTINDSLIVSETK CCCCCCCCCEEECCC	18.59	29255136
1814	Phosphorylation	INDSLIVSETKSKEN CCCCCEEECCCCCCC	32.33	29255136
1816	Phosphorylation	DSLIVSETKSKENTM CCCEEECCCCCCCCC	32.86	29396449
1817	Ubiquitination	SLIVSETKSKENTMQ CCEEECCCCCCCCCC	56.32	32015554
1818	Phosphorylation	LIVSETKSKENTMQE CEEECCCCCCCCCCC	53.25	21712546
1819	Ubiquitination	IVSETKSKENTMQES EEECCCCCCCCCCCC	57.44	29967540
1822	Phosphorylation	ETKSKENTMQESLPS CCCCCCCCCCCCCCC	22.71	21815630
1826	Phosphorylation	KENTMQESLPSGIVN CCCCCCCCCCCCCCC	28.78	21815630
1843	Phosphorylation	EEICDMDSSEAMSLE HHHHCCCHHHCCCCC	24.36	30631047
1844	Phosphorylation	EICDMDSSEAMSLES HHHCCCHHHCCCCCC	25.72	28985074
1848	Phosphorylation	MDSSEAMSLESQESP CCHHHCCCCCCCCCC	35.71	27732954
1851	Phosphorylation	SEAMSLESQESPNEN HHCCCCCCCCCCCCC	44.53	17525332
1854	Phosphorylation	MSLESQESPNENFKT CCCCCCCCCCCCCCC	25.95	30278072
1861	Phosphorylation	SPNENFKTVGPCLGD CCCCCCCCCHHCCCC	26.93	26074081
1869	Phosphorylation	VGPCLGDSKNVSQES CHHCCCCCCCCCHHH	25.08	22199227
1873	Phosphorylation	LGDSKNVSQESLETK CCCCCCCCHHHHCCC	37.31	29255136
1876	Phosphorylation	SKNVSQESLETKEEK CCCCCHHHHCCCCCC	24.70	29255136
1879	Phosphorylation	VSQESLETKEEKPEE CCHHHHCCCCCCCCC	49.39	29255136
1880	Sumoylation	SQESLETKEEKPEET CHHHHCCCCCCCCCC	55.27	-
1880	Sumoylation	SQESLETKEEKPEET CHHHHCCCCCCCCCC	55.27	-
1887	Phosphorylation	KEEKPEETPKMELSL CCCCCCCCCCCEEEE	26.92	30108239
1893	Phosphorylation	ETPKMELSLENVTVE CCCCCEEEEEEEEEE	21.96	25159151
1898	Phosphorylation	ELSLENVTVEGNACK EEEEEEEEEECCEEE	25.15	21712546
1913	Acetylation	VTESNLEKAKTMELN ECHHHHHHCCEEEEE	59.35	26051181
1926	Phosphorylation	LNVGNEASFHGQERT EECCCCHHHCCCCCC	16.17	25159151
1952	Phosphorylation	ENKRNDDSEADTAKL HHHCCCCCHHHHHHH	37.23	22496350
1956	Phosphorylation	NDDSEADTAKLNAKE CCCCHHHHHHHCHHH	32.51	28102081
1966	Phosphorylation	LNAKEVATEEFNSDI HCHHHHHHHHHCCCC	41.02	25159151
1971	Phosphorylation	VATEEFNSDISLSDN HHHHHHCCCCCCCCC	41.46	25159151
1974	Phosphorylation	EEFNSDISLSDNTTP HHHCCCCCCCCCCCC	27.15	25159151
1976	Phosphorylation	FNSDISLSDNTTPVK HCCCCCCCCCCCCCE	23.25	30576142
1979	Phosphorylation	DISLSDNTTPVKLNA CCCCCCCCCCCEECC	37.15	30576142
1980	Phosphorylation	ISLSDNTTPVKLNAQ CCCCCCCCCCEECCC	32.13	30576142
1988	Phosphorylation	PVKLNAQTEISEQTA CCEECCCCCCCCCCC	32.64	26471730
1991	Phosphorylation	LNAQTEISEQTAAGE ECCCCCCCCCCCCCC	19.88	26471730
1994	Phosphorylation	QTEISEQTAAGELDG CCCCCCCCCCCCCCC	17.89	26471730
2006	Phosphorylation	LDGGNDVSDLHSSEE CCCCCCHHHCCCCHH	37.00	30576142
2010	Phosphorylation	NDVSDLHSSEETNTK CCHHHCCCCHHHCCC	46.90	26471730
2011	Phosphorylation	DVSDLHSSEETNTKM CHHHCCCCHHHCCCC	28.80	30576142
2014	Phosphorylation	DLHSSEETNTKMKNN HCCCCHHHCCCCCCC	44.10	26471730
2016	Phosphorylation	HSSEETNTKMKNNEE CCCHHHCCCCCCCHH	39.68	30576142
2017	Acetylation	SSEETNTKMKNNEEM CCHHHCCCCCCCHHH	50.36	26051181
2046	Phosphorylation	TENEGITTKTSKPDE CCCCCCCCCCCCCCH	30.33	-
2048	Phosphorylation	NEGITTKTSKPDEAE CCCCCCCCCCCCHHH	39.63	22210691
2070	Phosphorylation	MDNFVCDTVEMSTEE HCCEEECEEEECCCC	17.15	22210691
2116	Phosphorylation	ILQEDHHTSQKVEEP HHHCCCCCCCCCCCH	29.45	28555341
2117	Phosphorylation	LQEDHHTSQKVEEPS HHCCCCCCCCCCCHH	24.52	28555341
2124	Phosphorylation	SQKVEEPSQCLASGT CCCCCCHHHHCCCCC	36.48	29255136
2129	Phosphorylation	EPSQCLASGTAISEL CHHHHCCCCCCHHHH	24.59	29255136
2131	Phosphorylation	SQCLASGTAISELII HHHCCCCCCHHHHEE	20.51	29255136
2134	Phosphorylation	LASGTAISELIIEDN CCCCCCHHHHEECCC	24.72	29255136
2144	Phosphorylation	IIEDNNASPQKLREL EECCCCCCHHHHHHC	29.95	29255136
2147	Ubiquitination	DNNASPQKLRELDPS CCCCCHHHHHHCCHH	53.55	29967540
2154	Phosphorylation	KLRELDPSLVSANDS HHHHCCHHHCCCCCC	40.86	20068231
2157	Phosphorylation	ELDPSLVSANDSPSG HCCHHHCCCCCCCCC	27.01	30266825
2161	Phosphorylation	SLVSANDSPSGMQTR HHCCCCCCCCCCCCC	22.29	29255136
2161	Ubiquitination	SLVSANDSPSGMQTR HHCCCCCCCCCCCCC	22.29	24816145
2163	Phosphorylation	VSANDSPSGMQTRCV CCCCCCCCCCCCCEE	51.34	29255136
2164	Ubiquitination	SANDSPSGMQTRCVW CCCCCCCCCCCCEEE	18.66	24816145
2165	Sulfoxidation	ANDSPSGMQTRCVWS CCCCCCCCCCCEEEC	4.28	21406390
2167	Phosphorylation	DSPSGMQTRCVWSPL CCCCCCCCCEEECCC	19.69	23927012
2169	Ubiquitination	PSGMQTRCVWSPLAS CCCCCCCEEECCCCC	4.11	24816145
2172	Phosphorylation	MQTRCVWSPLASPST CCCCEEECCCCCCCH	6.94	23927012
2176	Phosphorylation	CVWSPLASPSTSILK EEECCCCCCCHHHHH	27.37	26503892
2178	Phosphorylation	WSPLASPSTSILKRG ECCCCCCCHHHHHHH	32.09	23927012
2179	Phosphorylation	SPLASPSTSILKRGL CCCCCCCHHHHHHHH	24.14	23927012
2180	Phosphorylation	PLASPSTSILKRGLK CCCCCCHHHHHHHHH	30.20	25159151
2183	Ubiquitination	SPSTSILKRGLKRSQ CCCHHHHHHHHHHCC	42.63	29967540
2187	Ubiquitination	SILKRGLKRSQEDEI HHHHHHHHHCCCCCC	53.48	29967540
2189	Phosphorylation	LKRGLKRSQEDEISS HHHHHHHCCCCCCCC	36.01	25159151
2192	Ubiquitination	GLKRSQEDEISSPVN HHHHCCCCCCCCCCC	51.39	24816145
2195	Phosphorylation	RSQEDEISSPVNKVR HCCCCCCCCCCCHHH	26.92	23401153
2196	Phosphorylation	SQEDEISSPVNKVRR CCCCCCCCCCCHHHC	38.23	29255136
2200	Ubiquitination	EISSPVNKVRRVSFA CCCCCCCHHHCEECC	37.03	33845483
2205	Phosphorylation	VNKVRRVSFADPIYQ CCHHHCEECCCCHHH	16.95	25463755
2211	Phosphorylation	VSFADPIYQAGLADD EECCCCHHHCCCHHH	9.56	28796482
2224	Phosphorylation	DDIDRRCSIVRSHSS HHHHHCCCCEECCCC	23.47	24719451
2228	Phosphorylation	RRCSIVRSHSSNSSP HCCCCEECCCCCCCC	19.48	27251275
2230	Phosphorylation	CSIVRSHSSNSSPIG CCCEECCCCCCCCCC	32.25	29396449
2231	Phosphorylation	SIVRSHSSNSSPIGK CCEECCCCCCCCCCC	34.99	25262027
2233	Phosphorylation	VRSHSSNSSPIGKSV EECCCCCCCCCCCCC	39.16	25159151
2233 (in isoform 2)	Phosphorylation	-	39.16	22210691
2234	Phosphorylation	RSHSSNSSPIGKSVK ECCCCCCCCCCCCCC	25.45	25159151
2238	Acetylation	SNSSPIGKSVKTSPT CCCCCCCCCCCCCCC	53.44	25953088
2238	Ubiquitination	SNSSPIGKSVKTSPT CCCCCCCCCCCCCCC	53.44	29967540
2239	Phosphorylation	NSSPIGKSVKTSPTT CCCCCCCCCCCCCCC	24.51	28176443
2241	Acetylation	SPIGKSVKTSPTTQS CCCCCCCCCCCCCCC	50.83	25953088
2241	Ubiquitination	SPIGKSVKTSPTTQS CCCCCCCCCCCCCCC	50.83	29967540
2242	Phosphorylation	PIGKSVKTSPTTQSK CCCCCCCCCCCCCCC	37.47	28176443
2242 (in isoform 2)	Phosphorylation	-	37.47	-
2243	Phosphorylation	IGKSVKTSPTTQSKH CCCCCCCCCCCCCCC	17.96	28176443
2245	Phosphorylation	KSVKTSPTTQSKHNT CCCCCCCCCCCCCCC	36.92	23403867
2246	Phosphorylation	SVKTSPTTQSKHNTT CCCCCCCCCCCCCCC	33.94	23403867
2248	Phosphorylation	KTSPTTQSKHNTTSA CCCCCCCCCCCCCCC	33.52	23403867
2249	Acetylation	TSPTTQSKHNTTSAK CCCCCCCCCCCCCCC	30.93	19608861
2251 (in isoform 2)	Phosphorylation	-	49.11	-
2252	Phosphorylation	TTQSKHNTTSAKGFL CCCCCCCCCCCCCCC	23.11	20068231
2256	Acetylation	KHNTTSAKGFLSPGS CCCCCCCCCCCCCCC	50.38	25953088
2256	Ubiquitination	KHNTTSAKGFLSPGS CCCCCCCCCCCCCCC	50.38	29967540
2260	Phosphorylation	TSAKGFLSPGSRSPK CCCCCCCCCCCCCCC	25.59	30266825
2263	Phosphorylation	KGFLSPGSRSPKFKS CCCCCCCCCCCCCCC	32.73	30266825
2265	Phosphorylation	FLSPGSRSPKFKSSK CCCCCCCCCCCCCCC	33.85	25159151
2270	Phosphorylation	SRSPKFKSSKKCLIS CCCCCCCCCCCHHHH	50.99	24850871
2271	Phosphorylation	RSPKFKSSKKCLISE CCCCCCCCCCHHHHH	36.40	24850871
2273	Ubiquitination	PKFKSSKKCLISEMA CCCCCCCCHHHHHHH	35.90	29967540
2289	Ubiquitination	ESIPCPTESVYPPLV HCCCCCCHHCCCCCC	24.29	21890473
2292	Ubiquitination	PCPTESVYPPLVNCV CCCCHHCCCCCCCCC	14.38	21890473
2297	Ubiquitination	SVYPPLVNCVAPVDI HCCCCCCCCCCCHHH	23.41	21890473
2302	Ubiquitination	LVNCVAPVDIILPQI CCCCCCCHHHHHHHH	6.26	21890473
2302	Ubiquitination	LVNCVAPVDIILPQI CCCCCCCHHHHHHHH	6.26	21890473
2302 (in isoform 2)	Ubiquitination	-	6.26	21890473
2316	Ubiquitination	ITSNMWARGLGQLIR HCCHHHHHHHHHHHH	25.92	29967540
2320	Ubiquitination	MWARGLGQLIRAKNI HHHHHHHHHHHHCCC	38.47	21890473
2328	Acetylation	LIRAKNIKTIGDLST HHHHCCCEEECCHHC	43.41	25953088
2328	Ubiquitination	LIRAKNIKTIGDLST HHHHCCCEEECCHHC	43.41	29967540
2328 (in isoform 1)	Ubiquitination	-	43.41	21890473
2329	Phosphorylation	IRAKNIKTIGDLSTL HHHCCCEEECCHHCC	26.79	29396449
2334	Phosphorylation	IKTIGDLSTLTASEI CEEECCHHCCCHHHC	26.55	25850435
2335	Phosphorylation	KTIGDLSTLTASEIK EEECCHHCCCHHHCC	35.11	25850435
2337	Phosphorylation	IGDLSTLTASEIKTL ECCHHCCCHHHCCCC	28.38	29255136
2339	Phosphorylation	DLSTLTASEIKTLPI CHHCCCHHHCCCCCC	34.32	29255136
2341	Ubiquitination	STLTASEIKTLPIRS HCCCHHHCCCCCCCC	3.70	29967540
2342	Ubiquitination	TLTASEIKTLPIRSP CCCHHHCCCCCCCCC	39.70	29967540
2343	Phosphorylation	LTASEIKTLPIRSPK CCHHHCCCCCCCCCC	43.35	23403867
2348	Phosphorylation	IKTLPIRSPKVSNVK CCCCCCCCCCCCCHH	29.77	23927012
2352	Phosphorylation	PIRSPKVSNVKKALR CCCCCCCCCHHHHHH	41.87	25159151
2356	Ubiquitination	PKVSNVKKALRIYHE CCCCCHHHHHHHHHH	48.66	29967540
2364	Ubiquitination	ALRIYHEQQVKTRGL HHHHHHHHHHHHCCC	39.80	32015554
2367	Methylation	IYHEQQVKTRGLEEI HHHHHHHHHCCCCCC	28.32	23644510
2367	Ubiquitination	IYHEQQVKTRGLEEI HHHHHHHHHCCCCCC	28.32	29967540
2382	Ubiquitination	PVFDISEKTVNGIEN CEEECCCCCCCCCCC	51.48	29967540
2390	Ubiquitination	TVNGIENKSLSPDEE CCCCCCCCCCCCCHH	39.73	32015554
2391	Phosphorylation	VNGIENKSLSPDEER CCCCCCCCCCCCHHH	45.74	30266825
2393	Phosphorylation	GIENKSLSPDEERLV CCCCCCCCCCHHHHH	37.08	29255136
2401	Phosphorylation	PDEERLVSDIIDPVA CCHHHHHHHCCCHHH	27.90	28464451
2414	Phosphorylation	VALEIPLSKNLLAQI HHHCCCCCHHHHHHH	17.72	23898821
2457	Acetylation	CMANSVIKNLQSRWR HHHHHHHHHHHHHHC	49.83	26051181
2465	Phosphorylation	NLQSRWRSPSHENSI HHHHHHCCCCCCCCC	24.64	25159151
2467	Phosphorylation	QSRWRSPSHENSI-- HHHHCCCCCCCCC--	44.68	22617229
2471	Phosphorylation	RSPSHENSI------ CCCCCCCCC------	27.04	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1851	S	Phosphorylation	Kinase	ATM	Q13315	PSP
2205	S	Phosphorylation	Kinase	AURKB	Q96GD4	GPS
2205	S	Phosphorylation	Kinase	CHEK1	O14757	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RIF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RIF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TOIP1_HUMAN	TOR1AIP1	physical	22939629
SUCA_HUMAN	SUCLG1	physical	22939629
TMED9_HUMAN	TMED9	physical	22939629
RM50_HUMAN	MRPL50	physical	22939629
TE2IP_HUMAN	TERF2IP	physical	12753906
SMRD1_HUMAN	SMARCD1	physical	21988832
MRGBP_HUMAN	MRGBP	physical	26344197
CPSF5_HUMAN	NUDT21	physical	26344197
2AAA_HUMAN	PPP2R1A	physical	26344197
THOC6_HUMAN	THOC6	physical	26344197
PP1R7_HUMAN	PPP1R7	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RIF1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1274, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7; THR-409; SER-979;THR-1047; SER-1552; SER-1554; SER-1579; SER-1688; THR-1806; SER-1873;SER-1971; SER-2161; SER-2163; SER-2189 AND SER-2196, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-401; SER-402; TYR-404;THR-409; SER-1148; SER-1157 AND SER-2196, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-402; THR-409; SER-1162;SER-1236; SER-1238; SER-1422; SER-1552; SER-1554; SER-1576; SER-1579;SER-1616; SER-1688; SER-1693; SER-1810; SER-2144; SER-2172; SER-2176;SER-2196; SER-2205; SER-2260; SER-2265; SER-2339; SER-2391; SER-2393;SER-2465 AND SER-2471, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2196, AND MASSSPECTROMETRY.	19007248 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1513; THR-1518; SER-1542AND SER-1851, AND MASS SPECTROMETRY.	17525332 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2243, AND MASSSPECTROMETRY.	17924679 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1579, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-782; SER-1454; SER-1688AND SER-2161, AND MASS SPECTROMETRY.	17081983 [Abstract]