dbPTM

RM50_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RM50_HUMAN
UniProt AC	Q8N5N7
Protein Name	39S ribosomal protein L50, mitochondrial
Gene Name	MRPL50
Organism	Homo sapiens (Human).
Sequence Length	158
Subcellular Localization	Mitochondrion .
Protein Description
Protein Sequence	MAARSVSGITRRVFMWTVSGTPCREFWSRFRKEKEPVVVETVEEKKEPILVCPPLRSRAYTPPEDLQSRLESYVKEVFGSSLPSNWQDISLEDSRLKFNLLAHLADDLGHVVPNSRLHQMCRVRDVLDFYNVPIQDRSKFDELSASNLPPNLKITWSY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MAARSVSGITRRVF -CCCCCCCCCCEEEE	26.23	24719451
19	Phosphorylation	RVFMWTVSGTPCREF EEEEEEECCCCHHHH	29.58	24719451
21	Phosphorylation	FMWTVSGTPCREFWS EEEEECCCCHHHHHH	16.23	24719451
32	Ubiquitination	EFWSRFRKEKEPVVV HHHHHHHHCCCCEEE	71.12	22817900
34	Ubiquitination	WSRFRKEKEPVVVET HHHHHHCCCCEEEEE	71.06	22817900
34	Ubiquitination	WSRFRKEKEPVVVET HHHHHHCCCCEEEEE	71.06	21890473
46	Ubiquitination	VETVEEKKEPILVCP EEECCCCCCCEEECC	72.50	24816145
60	Phosphorylation	PPLRSRAYTPPEDLQ CCCCCCCCCCCHHHH	20.76	-
68	Phosphorylation	TPPEDLQSRLESYVK CCCHHHHHHHHHHHH	46.24	-
139	Ubiquitination	VPIQDRSKFDELSAS CCCCCHHHHHHHHHH	58.70	22817900
155	Phosphorylation	LPPNLKITWSY---- CCCCCEEEECC----	13.53	17924679
157	Phosphorylation	PNLKITWSY------ CCCEEEECC------	16.59	17924679
158	Phosphorylation	NLKITWSY------- CCEEEECC-------	17.71	17924679

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RM50_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RM50_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RM50_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RT09_HUMAN	MRPS9	physical	22939629
VPP1_HUMAN	ATP6V0A1	physical	22939629
TSR1_HUMAN	TSR1	physical	22939629
SUCB2_HUMAN	SUCLG2	physical	22939629
RT63_HUMAN	MRPL57	physical	22939629
VATB1_HUMAN	ATP6V1B1	physical	22939629
TM177_HUMAN	TMEM177	physical	22939629
RM49_HUMAN	MRPL49	physical	26496610
DIC_HUMAN	SLC25A10	physical	26496610
HNRPU_HUMAN	HNRNPU	physical	26496610
ICT1_HUMAN	ICT1	physical	26496610
OXA1L_HUMAN	OXA1L	physical	26496610
RM23_HUMAN	MRPL23	physical	26496610
RM12_HUMAN	MRPL12	physical	26496610
TLN1_HUMAN	TLN1	physical	26496610
THTR_HUMAN	TST	physical	26496610
XRCC2_HUMAN	XRCC2	physical	26496610
SMC1A_HUMAN	SMC1A	physical	26496610
KCAB2_HUMAN	KCNAB2	physical	26496610
TF3C3_HUMAN	GTF3C3	physical	26496610
GDF15_HUMAN	GDF15	physical	26496610
ATPK_HUMAN	ATP5J2	physical	26496610
RM33_HUMAN	MRPL33	physical	26496610
RM19_HUMAN	MRPL19	physical	26496610
HNRPQ_HUMAN	SYNCRIP	physical	26496610
RM28_HUMAN	MRPL28	physical	26496610
RT30_HUMAN	MRPS30	physical	26496610
TBCD8_HUMAN	TBC1D8	physical	26496610
RM03_HUMAN	MRPL3	physical	26496610
FAKD2_HUMAN	FASTKD2	physical	26496610
EXOS7_HUMAN	EXOSC7	physical	26496610
F120A_HUMAN	FAM120A	physical	26496610
UBR2_HUMAN	UBR2	physical	26496610
RM46_HUMAN	MRPL46	physical	26496610
TRUB2_HUMAN	TRUB2	physical	26496610
RM42_HUMAN	MRPL42	physical	26496610
RM13_HUMAN	MRPL13	physical	26496610
RM18_HUMAN	MRPL18	physical	26496610
RM15_HUMAN	MRPL15	physical	26496610
RM22_HUMAN	MRPL22	physical	26496610
MTEF3_HUMAN	MTERF3	physical	26496610
SYYM_HUMAN	YARS2	physical	26496610
RM02_HUMAN	MRPL2	physical	26496610
RM04_HUMAN	MRPL4	physical	26496610
RM37_HUMAN	MRPL37	physical	26496610
RM51_HUMAN	MRPL51	physical	26496610
RM30_HUMAN	MRPL30	physical	26496610
RM27_HUMAN	MRPL27	physical	26496610
RM35_HUMAN	MRPL35	physical	26496610
NGRN_HUMAN	NGRN	physical	26496610
PCF11_HUMAN	PCF11	physical	26496610
RM48_HUMAN	MRPL48	physical	26496610
RM39_HUMAN	MRPL39	physical	26496610
GAR1_HUMAN	GAR1	physical	26496610
RM16_HUMAN	MRPL16	physical	26496610
MOCOS_HUMAN	MOCOS	physical	26496610
RM20_HUMAN	MRPL20	physical	26496610
RT18A_HUMAN	MRPS18A	physical	26496610
ZC3HF_HUMAN	ZC3H15	physical	26496610
RM47_HUMAN	MRPL47	physical	26496610
RN213_HUMAN	RNF213	physical	26496610
RT35_HUMAN	MRPS35	physical	26496610
RM17_HUMAN	MRPL17	physical	26496610
RM14_HUMAN	MRPL14	physical	26496610
RT06_HUMAN	MRPS6	physical	26496610
RM41_HUMAN	MRPL41	physical	26496610
RM40_HUMAN	MRPL40	physical	26496610
RM38_HUMAN	MRPL38	physical	26496610
RM34_HUMAN	MRPL34	physical	26496610
RM32_HUMAN	MRPL32	physical	26496610
RM09_HUMAN	MRPL9	physical	26496610
RM01_HUMAN	MRPL1	physical	26496610
RM44_HUMAN	MRPL44	physical	26496610
CORO7_HUMAN	CORO7	physical	26496610
RM24_HUMAN	MRPL24	physical	26496610
THAP9_HUMAN	THAP9	physical	26496610
RCC1L_HUMAN	WBSCR16	physical	26496610
RM43_HUMAN	MRPL43	physical	26496610
RT4I1_HUMAN	RTN4IP1	physical	26496610
MILK1_HUMAN	MICALL1	physical	26496610
G45IP_HUMAN	GADD45GIP1	physical	26496610
RM53_HUMAN	MRPL53	physical	26496610
RM54_HUMAN	MRPL54	physical	26496610
RM52_HUMAN	MRPL52	physical	26496610
RM10_HUMAN	MRPL10	physical	26496610
RM55_HUMAN	MRPL55	physical	26496610
RM21_HUMAN	MRPL21	physical	26496610
REEP3_HUMAN	REEP3	physical	26496610
RUSD3_HUMAN	RPUSD3	physical	26496610
RT30_HUMAN	MRPS30	physical	28514442
RM47_HUMAN	MRPL47	physical	28514442
RM10_HUMAN	MRPL10	physical	28514442
RM04_HUMAN	MRPL4	physical	28514442
RM55_HUMAN	MRPL55	physical	28514442
RT18A_HUMAN	MRPS18A	physical	28514442
RM51_HUMAN	MRPL51	physical	28514442
G45IP_HUMAN	GADD45GIP1	physical	28514442
RM28_HUMAN	MRPL28	physical	28514442
RM27_HUMAN	MRPL27	physical	28514442
ICT1_HUMAN	ICT1	physical	28514442
RM02_HUMAN	MRPL2	physical	28514442
RM30_HUMAN	MRPL30	physical	28514442
RM16_HUMAN	MRPL16	physical	28514442
RM35_HUMAN	MRPL35	physical	28514442
RM17_HUMAN	MRPL17	physical	28514442
RM13_HUMAN	MRPL13	physical	28514442
RM40_HUMAN	MRPL40	physical	28514442
RM38_HUMAN	MRPL38	physical	28514442
RM39_HUMAN	MRPL39	physical	28514442
RM24_HUMAN	MRPL24	physical	28514442
GTPBA_HUMAN	GTPBP10	physical	28514442
RM49_HUMAN	MRPL49	physical	28514442
RM22_HUMAN	MRPL22	physical	28514442
RM01_HUMAN	MRPL1	physical	28514442
RM44_HUMAN	MRPL44	physical	28514442
CYB_HUMAN	CYTB	physical	28514442
RM11_HUMAN	MRPL11	physical	28514442
MRM3_HUMAN	RNMTL1	physical	28514442
RM48_HUMAN	MRPL48	physical	28514442
RM52_HUMAN	MRPL52	physical	28514442
MTEF3_HUMAN	MTERF3	physical	28514442
RM32_HUMAN	MRPL32	physical	28514442
MASU1_HUMAN	MALSU1	physical	28514442
RT63_HUMAN	MRPL57	physical	28514442
RM46_HUMAN	MRPL46	physical	28514442
RM20_HUMAN	MRPL20	physical	28514442
RM43_HUMAN	MRPL43	physical	28514442
RM03_HUMAN	MRPL3	physical	28514442
TRUB2_HUMAN	TRUB2	physical	28514442
RM15_HUMAN	MRPL15	physical	28514442
RM33_HUMAN	MRPL33	physical	28514442
RM19_HUMAN	MRPL19	physical	28514442
RM37_HUMAN	MRPL37	physical	28514442
RM09_HUMAN	MRPL9	physical	28514442
RM41_HUMAN	MRPL41	physical	28514442
PTCD1_HUMAN	PTCD1	physical	28514442
RM14_HUMAN	MRPL14	physical	28514442
RM12_HUMAN	MRPL12	physical	28514442
RM21_HUMAN	MRPL21	physical	28514442
RM18_HUMAN	MRPL18	physical	28514442
RM23_HUMAN	MRPL23	physical	28514442
SSDH_HUMAN	ALDH5A1	physical	28514442
RM53_HUMAN	MRPL53	physical	28514442
NU5M_HUMAN	ND5	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RM50_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-155; SER-157 ANDTYR-158, AND MASS SPECTROMETRY.	17924679 [Abstract]