THAP9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: THAP9_HUMAN
• UniProt AC: Q9H5L6
• Protein Name: DNA transposase THAP9
• Gene Name: THAP9
• Organism: Homo sapiens (Human).
• Sequence Length: 903
• Protein Description: Active transposase that specifically recognizes the bipartite 5'-TXXGGGX(A/T)-3' consensus motif and mediates transposition..
• Protein Sequence: MTRSCSAVGCSTRDTVLSRERGLSFHQFPTDTIQRSKWIRAVNRVDPRSKKIWIPGPGAILCSKHFQESDFESYGIRRKLKKGAVPSVSLYKIPQGVHLKGKARQKILKQPLPDNSQEVATEDHNYSLKTPLTIGAEKLAEVQQMLQVSKKRLISVKNYRMIKKRKGLRLIDALVEEKLLSEETECLLRAQFSDFKWELYNWRETDEYSAEMKQFACTLYLCSSKVYDYVRKILKLPHSSILRTWLSKCQPSPGFNSNIFSFLQRRVENGDQLYQYCSLLIKSMPLKQQLQWDPSSHSLQGFMDFGLGKLDADETPLASETVLLMAVGIFGHWRTPLGYFFVNRASGYLQAQLLRLTIGKLSDIGITVLAVTSDATAHSVQMAKALGIHIDGDDMKCTFQHPSSSSQQIAYFFDSCHLLRLIRNAFQNFQSIQFINGIAHWQHLVELVALEEQELSNMERIPSTLANLKNHVLKVNSATQLFSESVASALEYLLSLDLPPFQNCIGTIHFLRLINNLFDIFNSRNCYGKGLKGPLLPETYSKINHVLIEAKTIFVTLSDTSNNQIIKGKQKLGFLGFLLNAESLKWLYQNYVFPKVMPFPYLLTYKFSHDHLELFLKMLRQVLVTSSSPTCMAFQKAYYNLETRYKFQDEVFLSKVSIFDISIARRKDLALWTVQRQYGVSVTKTVFHEEGICQDWSHCSLSEALLDLSDHRRNLICYAGYVANKLSALLTCEDCITALYASDLKASKIGSLLFVKKKNGLHFPSESLCRVINICERVVRTHSRMAIFELVSKQRELYLQQKILCELSGHINLFVDVNKHLFDGEVCAINHFVKLLKDIIICFLNIRAKNVAQNPLKHHSERTDMKTLSRKHWSSVQDYKCSSFANTSSKFRHLLSNDGYPFK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTRSCSAVG ------CCCCCCCCC	31.15	29449344
4	Phosphorylation	----MTRSCSAVGCS ----CCCCCCCCCCC	11.85	29449344
6	Phosphorylation	--MTRSCSAVGCSTR --CCCCCCCCCCCCH	27.51	29449344
11	Phosphorylation	SCSAVGCSTRDTVLS CCCCCCCCCHHHHHH	22.13	29449344
12	Phosphorylation	CSAVGCSTRDTVLSR CCCCCCCCHHHHHHC	36.32	29449344
15	Phosphorylation	VGCSTRDTVLSRERG CCCCCHHHHHHCCCC	21.76	29449344
18	Phosphorylation	STRDTVLSRERGLSF CCHHHHHHCCCCCCC	27.97	29449344
127	Phosphorylation	ATEDHNYSLKTPLTI CCCCCCCCCCCCCCC	28.80	24719451
155	Phosphorylation	VSKKRLISVKNYRMI HCHHHHHHHHHHHHH	31.47	24719451
240	Phosphorylation	ILKLPHSSILRTWLS HHCCCCHHHHHHHHH	23.70	24719451
492	Phosphorylation	SVASALEYLLSLDLP HHHHHHHHHHHCCCC	17.50	23879269
495	Phosphorylation	SALEYLLSLDLPPFQ HHHHHHHHCCCCCCC	19.76	23879269
552	Phosphorylation	HVLIEAKTIFVTLSD HHEEEEEEEEEECCC	27.05	32142685
645	Phosphorylation	YYNLETRYKFQDEVF HHCCHHHHCCCCHHH	24.47	-
667	Methylation	DISIARRKDLALWTV EEEECCCCHHHHHHH	52.09	23644510
667	Trimethylation	DISIARRKDLALWTV EEEECCCCHHHHHHH	52.09	-
731	Phosphorylation	NKLSALLTCEDCITA HHHHHHHCHHHHHHH	18.07	29116813
857	Ubiquitination	NVAQNPLKHHSERTD CHHCCCCCCCCCCCC	40.29	29967540
871	Ubiquitination	DMKTLSRKHWSSVQD CHHHHHHHHCHHHCC	46.15	29967540
880	Methylation	WSSVQDYKCSSFANT CHHHCCCCCHHHCCC	35.61	115979965
890	Ubiquitination	SFANTSSKFRHLLSN HHCCCHHHHHHHHHC	46.30	-
896	Phosphorylation	SKFRHLLSNDGYPFK HHHHHHHHCCCCCCC	38.95	29083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of THAP9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of THAP9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of THAP9_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of THAP9_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.