| UniProt ID | RN213_HUMAN | |
|---|---|---|
| UniProt AC | Q63HN8 | |
| Protein Name | E3 ubiquitin-protein ligase RNF213 {ECO:0000305} | |
| Gene Name | RNF213 {ECO:0000312|HGNC:HGNC:14539} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 5207 | |
| Subcellular Localization | Cytoplasm, cytosol . | |
| Protein Description | E3 ubiquitin-protein ligase involved in angiogenesis. [PubMed: 21799892] | |
| Protein Sequence | MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGGPCLFPGSDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKASTLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRVLVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGDWHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNSFFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLPVDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQSWRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDCLSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKLHEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPLSQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSAVITKSWPRTADNFNDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTKVVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEQCAVEEALDWRREELLLLKKEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTVTVRLSTSSNSQRATHYHLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEPEEESERHILELEEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQDQRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRETLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINELKVFVDLASISAGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCDSARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPDTVLHLILPESPGSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGNMLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFVTQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSEAARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAGMGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTFEEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCDGDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVASERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVPVLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSSSALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYLRRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEASLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAPFSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAISHLTGKVIKRDVMTRDLYQGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFRCGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREAENVAFANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHSEEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEKLYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWFHEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFFPKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKPGSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQGKDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDPAKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFFGLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEEVSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFGSGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDLGLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEELCAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPRALTEELHQKVSEEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLERHAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAKCKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKLSRVGRGTAYVGFHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMETEASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQNESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQDALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSDTMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLEELWVQAQYITDAEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVSTEEELKFLQMALWSCTRKLKAASEAPEEEVSLPWVHLAYQRFRSRLQNFSRILTIYPQVLHSLMEARWNHELAGCEMTLDAFAAMACTEMLTRNTLKPSPQAWLQLVKNLSMPLELICSDEHMQGSGSLAQAVIREVRAQWSRIFSTALFVEHVLLGTESRVPELQGLVTEHVFLLDKCLRENSDVKTHGPFEAVMRTLCECKETASKTLSRFGIQPCSICLGDAKDPVCLPCDHVHCLRCLRAWFASEQMICPYCLTALPDEFSPAVSQAHREAIEKHARFRQMCNSFFVDLVSTICFKDNAPPEKEVIESLLSLLFVQKGRLRDAAQRHCEHTKSLSPFNDVVDKTPVIRSVILKLLLKYSFHDVKDYIQEYLTLLKKKAFITEDKTELYMLFINCLEDSILEKTSAYSRNDELNHLEEEGRFLKAYSPASRGREPANEASVEYLQEVARIRLCLDRAADFLSEPEGGPEMAKEKQCYLQQVKQFCIRVENDWHRVYLVRKLSSQRGMEFVQGLSKPGRPHQWVFPKDVVKQQGLRQDHPGQMDRYLVYGDEYKALRDAVAKAVLECKPLGIKTALKACKTPQSQQSAYFLLTLFREVAILYRSHNASLHPTPEQCEAVSKFIGECKILSPPDISRFATSLVDNSVPLLRAGPSDSNLDGTVTEMAIHAAAVLLCGQNELLEPLKNLAFSPATMAHAFLPTMPEDLLAQARRWKGLERVHWYTCPNGHPCSVGECGRPMEQSICIDCHAPIGGIDHKPRDGFHLVKDKADRTQTGHVLGNPQRRDVVTCDRGLPPVVFLLIRLLTHLALLLGASQSSQALINIIKPPVRDPKGFLQQHILKDLEQLAKMLGHSADETIGVVHLVLRRLLQEQHQLSSRRLLNFDTELSTKEMRNNWEKEIAAVISPELEHLDKTLPTMNNLISQDKRISSNPVAKIIYGDPVTFLPHLPRKSVVHCSKIWSCRKRITVEYLQHIVEQKNGKERVPILWHFLQKEAELRLVKFLPEILALQRDLVKQFQNVQQVEYSSIRGFLSKHSSDGLRQLLHNRITVFLSTWNKLRRSLETNGEINLPKDYCSTDLDLDTEFEILLPRRRGLGLCATALVSYLIRLHNEIVYAVEKLSKENNSYSVDAAEVTELHVISYEVERDLTPLILSNCQYQVEEGRETVQEFDLEKIQRQIVSRFLQGKPRLSLKGIPTLVYRHDWNYEHLFMDIKNKMAQDSLPSSVISAISGQLQSYSDACEVLSVVEVTLGFLSTAGGDPNMQLNVYTQDILQMGDQTIHVLKALNRCQLKHTIALWQFLSAHKSEQLLRLHKEPFGEISSRYKADLSPENAKLLSTFLNQTGLDAFLLELHEMIILKLKNPQTQTEERFRPQWSLRDTLVSYMQTKESEILPEMASQFPEEILLASCVSVWKTAAVLKWNREMR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 34 | Phosphorylation | PAAPIADSENNNSTM CCCCCCCCCCCCCCC | 32.95 | 30108239 | |
| 39 | Phosphorylation | ADSENNNSTMASASE CCCCCCCCCCCCCCC | 22.98 | 30108239 | |
| 40 | Phosphorylation | DSENNNSTMASASEG CCCCCCCCCCCCCCC | 20.91 | 30576142 | |
| 43 | Phosphorylation | NNNSTMASASEGEME CCCCCCCCCCCCCCC | 22.85 | 25159151 | |
| 45 | Phosphorylation | NSTMASASEGEMECG CCCCCCCCCCCCCCC | 43.57 | 25159151 | |
| 67 | Phosphorylation | GPCLFPGSDSWQENP CCCCCCCCCCCCCCC | 28.80 | 29507054 | |
| 69 | Phosphorylation | CLFPGSDSWQENPEE CCCCCCCCCCCCCCC | 32.15 | 25159151 | |
| 79 | Phosphorylation | ENPEEPCSKASWTVQ CCCCCCCCCCCCCHH | 41.81 | 27080861 | |
| 82 | O-linked_Glycosylation | EEPCSKASWTVQESK CCCCCCCCCCHHHHH | 27.32 | 30379171 | |
| 82 | Phosphorylation | EEPCSKASWTVQESK CCCCCCCCCCHHHHH | 27.32 | 26657352 | |
| 84 | Phosphorylation | PCSKASWTVQESKKK CCCCCCCCHHHHHHH | 15.15 | 29978859 | |
| 88 | O-linked_Glycosylation | ASWTVQESKKKKRKK CCCCHHHHHHHHHCC | 32.46 | 30379171 | |
| 88 | Phosphorylation | ASWTVQESKKKKRKK CCCCHHHHHHHHHCC | 32.46 | 23401153 | |
| 109 | Phosphorylation | SASSELASLPLSPAS CCCHHHHCCCCCCCC | 43.05 | 26074081 | |
| 113 | Phosphorylation | ELASLPLSPASPCHL HHHCCCCCCCCCCEE | 19.24 | 26074081 | |
| 116 | Phosphorylation | SLPLSPASPCHLTLL CCCCCCCCCCEEEEE | 31.29 | 26074081 | |
| 186 | Phosphorylation | LGEAGVATGSEAQSS HHHCCCCCCCCCCCC | 38.54 | 26074081 | |
| 188 | Phosphorylation | EAGVATGSEAQSSPQ HCCCCCCCCCCCCCC | 25.96 | 26074081 | |
| 192 | Phosphorylation | ATGSEAQSSPQFQDH CCCCCCCCCCCCCCC | 51.54 | 26074081 | |
| 193 | Phosphorylation | TGSEAQSSPQFQDHT CCCCCCCCCCCCCCC | 15.61 | 26074081 | |
| 200 | Phosphorylation | SPQFQDHTEGEDQDA CCCCCCCCCCCCCCC | 54.71 | 26074081 | |
| 208 | Phosphorylation | EGEDQDASIPSGGRG CCCCCCCCCCCCCCC | 43.23 | 26074081 | |
| 211 | Phosphorylation | DQDASIPSGGRGLSQ CCCCCCCCCCCCCCC | 52.81 | 26074081 | |
| 217 | Phosphorylation | PSGGRGLSQEGTGPP CCCCCCCCCCCCCCC | 29.07 | 23401153 | |
| 221 | Phosphorylation | RGLSQEGTGPPTSAG CCCCCCCCCCCCCCC | 45.84 | 30266825 | |
| 225 | Phosphorylation | QEGTGPPTSAGEGHS CCCCCCCCCCCCCCC | 34.05 | 23403867 | |
| 226 | Phosphorylation | EGTGPPTSAGEGHSR CCCCCCCCCCCCCCC | 39.80 | 23403867 | |
| 232 | Phosphorylation | TSAGEGHSRTEDAAQ CCCCCCCCCCHHHHH | 52.32 | 23403867 | |
| 234 | Phosphorylation | AGEGHSRTEDAAQEL CCCCCCCCHHHHHHH | 41.03 | 27251275 | |
| 246 | Phosphorylation | QELLLPESKGGSSEP HHHHCCCCCCCCCCC | 34.36 | - | |
| 250 | Phosphorylation | LPESKGGSSEPGTEL CCCCCCCCCCCCCCC | 39.95 | 27690223 | |
| 251 | Phosphorylation | PESKGGSSEPGTELQ CCCCCCCCCCCCCCC | 51.60 | 27690223 | |
| 255 | Phosphorylation | GGSSEPGTELQTTEQ CCCCCCCCCCCCHHC | 44.21 | 27690223 | |
| 293 | Phosphorylation | GKEMKEKTQRMKQPP CHHHHHHHHHCCCCC | 23.62 | 26074081 | |
| 302 | Phosphorylation | RMKQPPATTPPFKTH HCCCCCCCCCCCCHH | 45.68 | 28450419 | |
| 303 | Phosphorylation | MKQPPATTPPFKTHC CCCCCCCCCCCCHHH | 30.94 | 25159151 | |
| 307 | Methylation | PATTPPFKTHCQEAE CCCCCCCCHHHHHCC | 43.03 | 115976801 | |
| 308 | Phosphorylation | ATTPPFKTHCQEAET CCCCCCCHHHHHCCC | 28.41 | 26074081 | |
| 353 | Acetylation | NRSAAAVKNEKEQKN CCCHHHHHCHHHHHH | 55.45 | 25953088 | |
| 412 | Ubiquitination | GEEFGESKWDSNICE CHHHCCCCCCCCCEE | 51.20 | - | |
| 446 | Ubiquitination | ISKKHLDKYIPYKYV EEHHHHHHCCCCEEE | 51.98 | - | |
| 447 | Phosphorylation | SKKHLDKYIPYKYVI EHHHHHHCCCCEEEE | 13.54 | - | |
| 461 (in isoform 4) | Ubiquitination | - | 54.13 | - | |
| 466 | Phosphorylation | SFEYEFIYKHQQKKG CEEEEEEEECCHHCC | 14.03 | - | |
| 472 | Ubiquitination | IYKHQQKKGEYVNRC EEECCHHCCCCCCEE | 53.27 | - | |
| 502 | Ubiquitination | YYDIVYMKPHGRLQK EEEEEEECCCCHHHH | 19.04 | - | |
| 509 | Ubiquitination | KPHGRLQKVMNHITD CCCCHHHHHHHHCCC | 48.30 | - | |
| 515 | Phosphorylation | QKVMNHITDGPRKDL HHHHHHCCCCCCHHH | 27.61 | 27794612 | |
| 520 | Ubiquitination | HITDGPRKDLVKGKQ HCCCCCCHHHCCHHH | 59.55 | - | |
| 551 (in isoform 4) | Ubiquitination | - | 25.55 | - | |
| 558 (in isoform 4) | Ubiquitination | - | 41.52 | - | |
| 595 | Ubiquitination | RYLWQHLKKHVVPLP HHHHHHHHHCCEECC | 38.41 | - | |
| 596 | Malonylation | YLWQHLKKHVVPLPD HHHHHHHHCCEECCC | 48.25 | 26320211 | |
| 596 | Ubiquitination | YLWQHLKKHVVPLPD HHHHHHHHCCEECCC | 48.25 | - | |
| 605 | Ubiquitination | VVPLPDGKSTDFLPV CEECCCCCCCCCCCC | 58.52 | - | |
| 606 | Phosphorylation | VPLPDGKSTDFLPVD EECCCCCCCCCCCCC | 38.44 | 28348404 | |
| 607 | Phosphorylation | PLPDGKSTDFLPVDC ECCCCCCCCCCCCCC | 33.97 | 28348404 | |
| 645 (in isoform 4) | Malonylation | - | 1.53 | 26320211 | |
| 645 (in isoform 4) | Ubiquitination | - | 1.53 | - | |
| 654 (in isoform 4) | Ubiquitination | - | 37.78 | - | |
| 737 | Phosphorylation | FREQMLDTSSLLQFM HHHHHCCHHHHHHHH | 19.09 | 20860994 | |
| 738 | Phosphorylation | REQMLDTSSLLQFMR HHHHCCHHHHHHHHH | 20.75 | 20860994 | |
| 739 | Phosphorylation | EQMLDTSSLLQFMRE HHHCCHHHHHHHHHH | 34.88 | 28555341 | |
| 747 | Ubiquitination | LLQFMREKQHLLSID HHHHHHHHHHCCCCC | 32.43 | - | |
| 796 (in isoform 4) | Ubiquitination | - | 6.00 | - | |
| 830 | O-linked_Glycosylation | MLLRLLDTYRDKIPE HHHHHHHHHHHHCCH | 22.04 | 30379171 | |
| 844 | Phosphorylation | EEALSPSYLTVCLKL HHHCCHHHHHHHHHH | 15.13 | - | |
| 860 | Ubiquitination | EAICSSTKLLKFYEL HHHHCCCCCCHHCCC | 54.49 | - | |
| 894 | Phosphorylation | SAGQRDETGNNSVQT CCCCCCCCCCCCHHH | 49.88 | - | |
| 906 | Phosphorylation | VQTVFQGTLAATKRW HHHHHHHHHHHHHHH | 11.48 | - | |
| 911 | Ubiquitination | QGTLAATKRWLREVF HHHHHHHHHHHHHHH | 36.53 | - | |
| 919 | Phosphorylation | RWLREVFTKNMLTSS HHHHHHHHHHCCCCC | 27.04 | - | |
| 925 | Phosphorylation | FTKNMLTSSGASFTY HHHHCCCCCCCCEEE | 23.86 | 24667141 | |
| 967 | Ubiquitination | DMEWRLTKEEPLSQI CCEEEECCCCCHHHH | 65.75 | - | |
| 985 | Ubiquitination | CNSCWDTKGLEDSVA CCCCCCCCCCHHHHH | 60.05 | - | |
| 993 | Ubiquitination | GLEDSVAKTFEKCII CCHHHHHHHHHHHHH | 52.14 | - | |
| 1016 (in isoform 4) | Ubiquitination | - | 15.26 | - | |
| 1034 (in isoform 4) | Ubiquitination | - | 16.66 | - | |
| 1036 | Phosphorylation | LSAVITKSWPRTADN EEEHHHCCCCCCCCC | 33.39 | 24719451 | |
| 1042 (in isoform 4) | Ubiquitination | - | 60.69 | - | |
| 1058 | Ubiquitination | LLTLADVKHVFRLCG HHHHHHHHHHHHHHC | 34.30 | - | |
| 1066 | Phosphorylation | HVFRLCGTDEKILAN HHHHHHCCCHHHHHC | 39.73 | - | |
| 1069 | Ubiquitination | RLCGTDEKILANVTE HHHCCCHHHHHCCCH | 45.92 | - | |
| 1079 | Ubiquitination | ANVTEDAKRLIAVAD HCCCHHHHHHHHHHH | 61.12 | - | |
| 1107 (in isoform 4) | Ubiquitination | - | 29.99 | - | |
| 1113 | Ubiquitination | LELIIKHKNQFLDIW HHHHHHCCCCHHHHH | 47.65 | - | |
| 1118 (in isoform 4) | Ubiquitination | - | 41.17 | - | |
| 1128 | Phosphorylation | QLREKSLSPQDEQCA HHHHCCCCHHHHHHH | 27.83 | 28348404 | |
| 1128 (in isoform 4) | Ubiquitination | - | 27.83 | - | |
| 1151 | Sumoylation | REELLLLKKEKRCVD HHHHHHHHHHHHHHH | 59.88 | - | |
| 1151 | Sumoylation | REELLLLKKEKRCVD HHHHHHHHHHHHHHH | 59.88 | 25218447 | |
| 1151 | Ubiquitination | REELLLLKKEKRCVD HHHHHHHHHHHHHHH | 59.88 | - | |
| 1159 | Phosphorylation | KEKRCVDSLLKMCGN HHHHHHHHHHHHHCC | 18.40 | 26074081 | |
| 1162 | Ubiquitination | RCVDSLLKMCGNVKH HHHHHHHHHHCCCHH | 37.12 | - | |
| 1162 (in isoform 4) | Ubiquitination | - | 37.12 | - | |
| 1188 | Phosphorylation | RHSQDLSSKRLNDTV ECCCCCCCCCCCCEE | 29.14 | 18187866 | |
| 1200 (in isoform 4) | Ubiquitination | - | 18.71 | - | |
| 1202 | Phosphorylation | VTVRLSTSSNSQRAT EEEEEECCCCCHHHE | 24.93 | 27251275 | |
| 1203 | Phosphorylation | TVRLSTSSNSQRATH EEEEECCCCCHHHEE | 40.36 | 27251275 | |
| 1205 | Phosphorylation | RLSTSSNSQRATHYH EEECCCCCHHHEEEH | 24.00 | 27251275 | |
| 1211 (in isoform 4) | Ubiquitination | - | 10.49 | - | |
| 1223 | Acetylation | QVQEMAGKIDLLRDS HHHHHHHHHHHHCCH | 24.41 | 19608861 | |
| 1223 | Ubiquitination | QVQEMAGKIDLLRDS HHHHHHHHHHHHCCH | 24.41 | - | |
| 1245 | Phosphorylation | REAAEPLSEPKEDQE HHHCCCCCCCHHHHH | 63.67 | 28464451 | |
| 1248 | Ubiquitination | AEPLSEPKEDQEAAE CCCCCCCHHHHHHHH | 70.62 | - | |
| 1258 | Phosphorylation | QEAAELLSEPEEESE HHHHHHHCCCHHHHH | 64.82 | 29255136 | |
| 1258 | Phosphorylation | QEAAELLSEPEEESE HHHHHHHCCCHHHHH | 64.82 | 18669648 | |
| 1264 | Phosphorylation | LSEPEEESERHILEL HCCCHHHHHHHHHHH | 43.12 | 23927012 | |
| 1272 (in isoform 4) | Ubiquitination | - | 35.72 | - | |
| 1275 | Phosphorylation | ILELEEVYDYLYQPS HHHHHHHHHHHHCHH | 11.36 | 28464451 | |
| 1285 | Ubiquitination | LYQPSYRKFIKLHQD HHCHHHHHHHHHHCC | 43.11 | - | |
| 1288 | Ubiquitination | PSYRKFIKLHQDLKS HHHHHHHHHHCCHHC | 42.95 | - | |
| 1313 | Ubiquitination | IFKDFVNKYTDLDSE HHHHHHHHHCCCCCC | 44.20 | - | |
| 1314 | Phosphorylation | FKDFVNKYTDLDSEL HHHHHHHHCCCCCCC | 10.57 | 25690035 | |
| 1319 | Phosphorylation | NKYTDLDSELKIMCT HHHCCCCCCCEEEEE | 52.72 | 25690035 | |
| 1337 | Ubiquitination | QDQRDWIKDRVEQIK CCHHHHHHHHHHHHH | 34.92 | - | |
| 1337 (in isoform 4) | Ubiquitination | - | 34.92 | - | |
| 1344 | Ubiquitination | KDRVEQIKEYHHLHQ HHHHHHHHHHHHHHH | 52.49 | - | |
| 1357 | Ubiquitination | HQAVHAAKVILQVKE HHHHHHHHHHHHHHH | 30.50 | - | |
| 1386 (in isoform 4) | Ubiquitination | - | 61.46 | - | |
| 1393 (in isoform 4) | Ubiquitination | - | 3.80 | - | |
| 1404 | Ubiquitination | NQELIQAKKLLQDIS HHHHHHHHHHHHHHH | 27.81 | - | |
| 1405 | Malonylation | QELIQAKKLLQDISE HHHHHHHHHHHHHHH | 58.40 | 26320211 | |
| 1405 | Ubiquitination | QELIQAKKLLQDISE HHHHHHHHHHHHHHH | 58.40 | - | |
| 1411 | Phosphorylation | KKLLQDISEARCKGL HHHHHHHHHHHCCHH | 33.23 | 25002506 | |
| 1416 | Ubiquitination | DISEARCKGLQALSL HHHHHHCCHHHHHHH | 58.04 | - | |
| 1422 | Phosphorylation | CKGLQALSLRKEFIC CCHHHHHHHHHHHHH | 29.19 | 24719451 | |
| 1425 | Ubiquitination | LQALSLRKEFICWVR HHHHHHHHHHHHHHH | 63.37 | - | |
| 1453 (in isoform 4) | Ubiquitination | - | 27.70 | - | |
| 1454 (in isoform 4) | Malonylation | - | 51.99 | 26320211 | |
| 1454 (in isoform 4) | Ubiquitination | - | 51.99 | - | |
| 1465 (in isoform 4) | Ubiquitination | - | 4.16 | - | |
| 1474 (in isoform 4) | Ubiquitination | - | 19.68 | - | |
| 1490 | Acetylation | VDFSAFMKHLKKLWK CCHHHHHHHHHHHHH | 39.05 | 25953088 | |
| 1490 | Ubiquitination | VDFSAFMKHLKKLWK CCHHHHHHHHHHHHH | 39.05 | - | |
| 1497 | Ubiquitination | KHLKKLWKALDKDQY HHHHHHHHHHCCCCC | 49.89 | - | |
| 1501 | Acetylation | KLWKALDKDQYLPRK HHHHHHCCCCCCCHH | 47.81 | 25953088 | |
| 1501 | Ubiquitination | KLWKALDKDQYLPRK HHHHHHCCCCCCCHH | 47.81 | - | |
| 1508 | Ubiquitination | KDQYLPRKLCDSARN CCCCCCHHHHHHHHC | 52.07 | - | |
| 1512 | Phosphorylation | LPRKLCDSARNLEWL CCHHHHHHHHCHHHH | 28.29 | 27067055 | |
| 1520 | Ubiquitination | ARNLEWLKTVNESHG HHCHHHHHHHCCCCC | 52.04 | - | |
| 1525 | Phosphorylation | WLKTVNESHGSVERS HHHHHCCCCCCEECH | 28.13 | 20860994 | |
| 1552 | Ubiquitination | IYVIQAPKGGQKISP EEEEECCCCCCCCCC | 77.89 | - | |
| 1556 | Ubiquitination | QAPKGGQKISPDTVL ECCCCCCCCCCCCEE | 48.72 | - | |
| 1569 (in isoform 4) | Ubiquitination | - | 67.15 | - | |
| 1586 | Ubiquitination | EYSLEEVKELLNKLM CCCHHHHHHHHHHHH | 46.02 | - | |
| 1591 | Ubiquitination | EVKELLNKLMLMSGK HHHHHHHHHHHHHCC | 34.93 | - | |
| 1596 | Phosphorylation | LNKLMLMSGKKDRNN HHHHHHHHCCCCCCC | 43.42 | 24719451 | |
| 1599 | Ubiquitination | LMLMSGKKDRNNTEV HHHHHCCCCCCCCHH | 66.50 | - | |
| 1601 (in isoform 4) | Ubiquitination | - | 47.37 | - | |
| 1635 (in isoform 4) | Ubiquitination | - | 25.78 | - | |
| 1648 (in isoform 4) | Ubiquitination | - | 19.67 | - | |
| 1718 | Ubiquitination | YLSTELRKQPPSDAA HHHHHHHCCCCCHHH | 78.69 | - | |
| 1730 | Phosphorylation | DAALTMLSFIKSNCT HHHHHHHHHHHCCCC | 17.69 | 24719451 | |
| 1733 | Ubiquitination | LTMLSFIKSNCTLRD HHHHHHHHCCCCHHH | 33.34 | - | |
| 1745 | Phosphorylation | LRDVLRASVGCGSEA HHHHHHHHCCCCHHH | 16.77 | 20860994 | |
| 1767 (in isoform 4) | Ubiquitination | - | 3.14 | - | |
| 1782 (in isoform 4) | Ubiquitination | - | 3.40 | - | |
| 1785 | Phosphorylation | LRIIMEQSMRCLPAF HHHHHHHHHCHHHHH | 8.55 | 22210691 | |
| 1971 | Ubiquitination | AGHYRVPKQTLSAAA CCCCCCCCCHHHHHH | 53.72 | - | |
| 1973 | Phosphorylation | HYRVPKQTLSAAAVF CCCCCCCHHHHHHHC | 28.89 | 21955146 | |
| 1975 | Phosphorylation | RVPKQTLSAAAVFND CCCCCHHHHHHHCCC | 21.17 | 21955146 | |
| 1998 | Ubiquitination | SERAGVGKSLYVKRL CCCCCCCCCHHHHHH | 34.58 | - | |
| 1999 | Phosphorylation | ERAGVGKSLYVKRLH CCCCCCCCHHHHHHH | 21.00 | 22210691 | |
| 2001 | Phosphorylation | AGVGKSLYVKRLHDK CCCCCCHHHHHHHHH | 15.83 | 22210691 | |
| 2003 | Ubiquitination | VGKSLYVKRLHDKMK CCCCHHHHHHHHHHC | 35.37 | - | |
| 2010 | Acetylation | KRLHDKMKMQLNVKN HHHHHHHCCCCCCCC | 29.27 | 7467715 | |
| 2010 | Ubiquitination | KRLHDKMKMQLNVKN HHHHHHHCCCCCCCC | 29.27 | - | |
| 2016 | Ubiquitination | MKMQLNVKNVPLKTI HCCCCCCCCCCCCEE | 51.67 | - | |
| 2020 (in isoform 4) | Ubiquitination | - | 7.14 | - | |
| 2021 | Ubiquitination | NVKNVPLKTIRLIDP CCCCCCCCEEEECCC | 35.52 | - | |
| 2047 (in isoform 4) | Ubiquitination | - | 16.42 | - | |
| 2052 (in isoform 4) | Ubiquitination | - | 11.32 | - | |
| 2059 (in isoform 4) | Ubiquitination | - | 18.23 | - | |
| 2065 (in isoform 4) | Ubiquitination | - | 8.48 | - | |
| 2070 (in isoform 4) | Ubiquitination | - | 2.40 | - | |
| 2104 | Phosphorylation | VEILERRTSVPSRSS HHHHHHCCCCCCCCH | 40.05 | 27282143 | |
| 2105 | Phosphorylation | EILERRTSVPSRSSS HHHHHCCCCCCCCHH | 30.16 | 30576142 | |
| 2108 | Phosphorylation | ERRTSVPSRSSSALR HHCCCCCCCCHHHHH | 42.51 | 30576142 | |
| 2110 | Phosphorylation | RTSVPSRSSSALRTR CCCCCCCCHHHHHCC | 32.74 | 27282143 | |
| 2111 | Phosphorylation | TSVPSRSSSALRTRV CCCCCCCHHHHHCCC | 20.65 | 27282143 | |
| 2112 | Phosphorylation | SVPSRSSSALRTRVP CCCCCCHHHHHCCCC | 32.35 | - | |
| 2131 | Phosphorylation | LDIFPKVTCRPPKEV HHCCCCCCCCCCHHH | 14.66 | 23403867 | |
| 2136 | Ubiquitination | KVTCRPPKEVIDMEL CCCCCCCHHHHCHHH | 68.26 | 2190698 | |
| 2141 | Sulfoxidation | PPKEVIDMELSALRS CCHHHHCHHHHHHHC | 3.71 | 21406390 | |
| 2178 (in isoform 4) | Ubiquitination | - | 42.77 | - | |
| 2185 (in isoform 4) | Ubiquitination | - | 12.35 | - | |
| 2264 | Phosphorylation | FMARDFATPSLHTSD HHHHHCCCCCCCCCC | 17.26 | 23403867 | |
| 2266 | Phosphorylation | ARDFATPSLHTSDQS HHHCCCCCCCCCCCC | 28.55 | 28787133 | |
| 2269 | Phosphorylation | FATPSLHTSDQSPGK CCCCCCCCCCCCCCC | 39.01 | 30266825 | |
| 2270 | Phosphorylation | ATPSLHTSDQSPGKH CCCCCCCCCCCCCCE | 23.93 | 23401153 | |
| 2273 | Phosphorylation | SLHTSDQSPGKHMVT CCCCCCCCCCCEEEE | 40.38 | 29255136 | |
| 2280 | Phosphorylation | SPGKHMVTMDGVREE CCCCEEEEECCCCHH | 11.28 | - | |
| 2367 | Ubiquitination | PFNVDFDKLPRHKKL CCCCCHHHCCCHHHH | 61.45 | - | |
| 2391 | Ubiquitination | PQATDPDKTYELTTD CCCCCCCCCEEECCC | 59.40 | - | |
| 2416 (in isoform 4) | Ubiquitination | - | 4.35 | - | |
| 2426 | Ubiquitination | MGETGCGKTRLIKFL ECCCCCCHHHHHHHH | 34.25 | - | |
| 2431 | Acetylation | CGKTRLIKFLSDLRR CCHHHHHHHHHHHHC | 44.86 | 25953088 | |
| 2431 | Ubiquitination | CGKTRLIKFLSDLRR CCHHHHHHHHHHHHC | 44.86 | - | |
| 2434 | Phosphorylation | TRLIKFLSDLRRGGT HHHHHHHHHHHCCCC | 37.42 | 24719451 | |
| 2438 | Methylation | KFLSDLRRGGTNADT HHHHHHHCCCCCCCC | 56.01 | 115491409 | |
| 2441 | Phosphorylation | SDLRRGGTNADTIKL HHHHCCCCCCCCEEE | 30.01 | - | |
| 2447 | Ubiquitination | GTNADTIKLVKVHGG CCCCCCEEEEEECCC | 49.69 | - | |
| 2450 | Acetylation | ADTIKLVKVHGGTTA CCCEEEEEECCCCHH | 38.66 | 26210075 | |
| 2450 | Ubiquitination | ADTIKLVKVHGGTTA CCCEEEEEECCCCHH | 38.66 | - | |
| 2461 | Phosphorylation | GTTADMIYSRVREAE CCHHHHHHHHHHHHH | 5.47 | - | |
| 2462 | Phosphorylation | TTADMIYSRVREAEN CHHHHHHHHHHHHHH | 17.24 | 24719451 | |
| 2475 (in isoform 4) | Ubiquitination | - | 56.17 | - | |
| 2480 (in isoform 4) | Ubiquitination | - | 6.18 | - | |
| 2496 (in isoform 4) | Ubiquitination | - | 19.48 | - | |
| 2499 (in isoform 4) | Ubiquitination | - | 46.20 | - | |
| 2529 | Ubiquitination | AACNPYRKHSEEMIC EECCCCCCCCHHHHH | 45.71 | - | |
| 2531 | Phosphorylation | CNPYRKHSEEMICRL CCCCCCCCHHHHHHH | 37.98 | 21406692 | |
| 2540 | Phosphorylation | EMICRLESAGLGYRV HHHHHHHHCCCCCCC | 32.03 | 21406692 | |
| 2545 | Phosphorylation | LESAGLGYRVSMEET HHHCCCCCCCCHHHH | 16.94 | 21406692 | |
| 2548 | Phosphorylation | AGLGYRVSMEETADR CCCCCCCCHHHHHHH | 16.10 | 21406692 | |
| 2552 | Phosphorylation | YRVSMEETADRLGSI CCCCHHHHHHHHCCC | 22.13 | 21406692 | |
| 2558 | Phosphorylation | ETADRLGSIPLRQLV HHHHHHCCCCHHHHH | 26.14 | 24719451 | |
| 2578 (in isoform 4) | Ubiquitination | - | 4.89 | - | |
| 2628 | Ubiquitination | ASQGFMRKTEDECSF HCCCCCCCCCCCCCE | 44.47 | - | |
| 2677 (in isoform 4) | Ubiquitination | - | 47.76 | - | |
| 2684 | Phosphorylation | ERDPVLWSLMLAIGV CCCHHHHHHHHHHHH | 10.35 | - | |
| 2693 | Phosphorylation | MLAIGVCYHASLEKK HHHHHHHHHHHHCCH | 9.67 | - | |
| 2696 | Phosphorylation | IGVCYHASLEKKDSY HHHHHHHHHCCHHHH | 24.61 | - | |
| 2702 | Phosphorylation | ASLEKKDSYRKAIAR HHHCCHHHHHHHHHH | 35.40 | 24144214 | |
| 2703 | Phosphorylation | SLEKKDSYRKAIARF HHCCHHHHHHHHHHH | 26.68 | 24144214 | |
| 2713 | Ubiquitination | AIARFFPKPYDDSRL HHHHHCCCCCCCHHH | 51.56 | - | |
| 2740 | Ubiquitination | LDGVPLRKTIAKNLA CCCCCHHHHHHHHHH | 52.55 | - | |
| 2744 | Ubiquitination | PLRKTIAKNLALKEN CHHHHHHHHHHCCCC | 48.95 | - | |
| 2762 (in isoform 4) | Ubiquitination | - | 29.50 | - | |
| 2770 | Ubiquitination | IPLFLVGKPGSSKSL CCEEEECCCCCCHHH | 38.43 | - | |
| 2774 | Phosphorylation | LVGKPGSSKSLAKTI EECCCCCCHHHHHHH | 31.98 | 26699800 | |
| 2775 | Ubiquitination | VGKPGSSKSLAKTIV ECCCCCCHHHHHHHH | 51.70 | - | |
| 2776 | Phosphorylation | GKPGSSKSLAKTIVA CCCCCCHHHHHHHHH | 35.19 | - | |
| 2779 | Ubiquitination | GSSKSLAKTIVADAM CCCHHHHHHHHHHHH | 44.04 | - | |
| 2798 | Phosphorylation | AYSDLFRSLKQVHLV HHHHHHHHHCEEEEE | 32.36 | 24719451 | |
| 2800 | Ubiquitination | SDLFRSLKQVHLVSF HHHHHHHCEEEEEEE | 52.07 | - | |
| 2810 | Phosphorylation | HLVSFQCSPHSTPQG EEEEEECCCCCCCCH | 18.18 | 24719451 | |
| 2819 (in isoform 4) | Ubiquitination | - | 3.98 | - | |
| 2828 (in isoform 4) | Ubiquitination | - | 3.19 | - | |
| 2832 | Ubiquitination | CARFQQGKDLQQYVS HHHHHCCCCHHHHEE | 51.43 | - | |
| 2849 (in isoform 4) | Ubiquitination | - | 16.78 | - | |
| 2858 | Ubiquitination | DSPKMPLKTLHPLLE CCCCCCCCCHHHHHH | 43.07 | - | |
| 2877 | Acetylation | EDDPAPHKKVGFVGI CCCCCCCCEEEEEEE | 48.36 | 23749302 | |
| 2877 | Ubiquitination | EDDPAPHKKVGFVGI CCCCCCCCEEEEEEE | 48.36 | - | |
| 2878 | Ubiquitination | DDPAPHKKVGFVGIS CCCCCCCEEEEEEEC | 44.55 | - | |
| 2893 | Ubiquitination | NWALDPAKMNRGIFV CCCCCHHHCCCCEEE | 41.94 | - | |
| 2901 | Phosphorylation | MNRGIFVSRGSPNET CCCCEEECCCCCCHH | 21.85 | 27067055 | |
| 2907 (in isoform 4) | Ubiquitination | - | 47.22 | - | |
| 2915 | Ubiquitination | TELIESAKGICSSDI HHHHHHCCCCCCCCC | 59.07 | - | |
| 2926 (in isoform 4) | Ubiquitination | - | 45.28 | - | |
| 2927 (in isoform 4) | Ubiquitination | - | 12.93 | - | |
| 2931 | Phosphorylation | VQDRVQGYFASFAKA HHHHHHHHHHHHHHH | 4.47 | 20090780 | |
| 2934 | Phosphorylation | RVQGYFASFAKAYET HHHHHHHHHHHHHHH | 18.81 | 28060719 | |
| 2937 | Ubiquitination | GYFASFAKAYETVCK HHHHHHHHHHHHHHH | 49.87 | - | |
| 2942 (in isoform 4) | Ubiquitination | - | 2.12 | - | |
| 2944 | Ubiquitination | KAYETVCKRQDKEFF HHHHHHHHHCCCCCC | 49.08 | - | |
| 2948 | Ubiquitination | TVCKRQDKEFFGLRD HHHHHCCCCCCCCHH | 48.35 | - | |
| 2958 | Phosphorylation | FGLRDYYSLIKMVFA CCCHHHHHHHHHHHH | 19.86 | 24719451 | |
| 2964 (in isoform 4) | Ubiquitination | - | 3.24 | - | |
| 2968 | Ubiquitination | KMVFAAAKASNRKPS HHHHHHHHHHCCCCC | 47.85 | - | |
| 2973 | Ubiquitination | AAKASNRKPSPQDIA HHHHHCCCCCHHHHH | 54.84 | - | |
| 2986 (in isoform 4) | Ubiquitination | - | 48.34 | - | |
| 2990 | Ubiquitination | VLRNFSGKDDIQALD HHHHCCCCHHHHHHH | 51.54 | - | |
| 2997 (in isoform 4) | Ubiquitination | - | 32.39 | - | |
| 3007 | Ubiquitination | LANLPEAKCSEEVSP HHCCCCCCCCCCCCH | 36.31 | - | |
| 3009 | O-linked_Glycosylation | NLPEAKCSEEVSPMQ CCCCCCCCCCCCHHH | 35.76 | 30379171 | |
| 3017 (in isoform 4) | Ubiquitination | - | 4.26 | - | |
| 3019 | Ubiquitination | VSPMQLIKQNIFGPS CCHHHHHHCCCCCCC | 45.98 | - | |
| 3022 (in isoform 4) | Ubiquitination | - | 3.80 | - | |
| 3028 | Ubiquitination | NIFGPSQKVPGGEQE CCCCCCCCCCCCCCC | 55.52 | - | |
| 3039 | Phosphorylation | GEQEDAESRYLLVLT CCCCCHHHCEEEEEC | 28.13 | - | |
| 3039 (in isoform 4) | Ubiquitination | - | 28.13 | - | |
| 3068 (in isoform 4) | Ubiquitination | - | 3.93 | - | |
| 3077 (in isoform 4) | Ubiquitination | - | 46.94 | - | |
| 3091 | Ubiquitination | CRNINRVKICMETGK HHHCCCEEEEHHHCC | 27.27 | - | |
| 3158 | Phosphorylation | IEEKDVVYKHFPIPL EEECCCEEECCCHHH | 9.90 | 20058876 | |
| 3159 | Ubiquitination | EEKDVVYKHFPIPLI EECCCEEECCCHHHH | 27.45 | - | |
| 3171 | Ubiquitination | PLINRLEKHYLDINT HHHHHHHHHCCCHHH | 41.99 | - | |
| 3182 | Ubiquitination | DINTVLEKWQKSIVE CHHHHHHHHHHHHHH | 51.25 | - | |
| 3202 | Ubiquitination | VEKFINVKAHHFQKR HHHHHHCHHHHHHHH | 37.20 | - | |
| 3208 | Acetylation | VKAHHFQKRHKYSPS CHHHHHHHHCCCCHH | 56.37 | 7826069 | |
| 3208 | Ubiquitination | VKAHHFQKRHKYSPS CHHHHHHHHCCCCHH | 56.37 | - | |
| 3208 (in isoform 4) | Ubiquitination | - | 56.37 | - | |
| 3231 (in isoform 4) | Ubiquitination | - | 2.93 | - | |
| 3249 | Ubiquitination | LTEELHQKVSEEAKS HHHHHHHHHCHHHHH | 36.66 | - | |
| 3255 | Ubiquitination | QKVSEEAKSILLNCA HHHCHHHHHHHHHCC | 41.11 | - | |
| 3298 (in isoform 4) | Ubiquitination | - | 42.66 | - | |
| 3304 (in isoform 4) | Ubiquitination | - | 4.26 | - | |
| 3311 | Methylation | LHTADLERHAIFTEI HHHHHHHHHHHHHHH | 31.66 | 115387049 | |
| 3357 | Phosphorylation | QQFDTEYSFLKEVRN EECCHHHHHHHHHHH | 20.19 | 24719451 | |
| 3371 | Ubiquitination | NCLTNTAKCKILIFQ HHHHHHCCCEEEEEE | 33.74 | - | |
| 3395 | Ubiquitination | AQLIASAKYSVINEI HHHHHHHHHHHHHHH | 35.25 | - | |
| 3396 | Phosphorylation | QLIASAKYSVINEIN HHHHHHHHHHHHHHH | 14.11 | 20068231 | |
| 3397 | Phosphorylation | LIASAKYSVINEINK HHHHHHHHHHHHHHH | 18.80 | 20068231 | |
| 3420 (in isoform 4) | Ubiquitination | - | 2.71 | - | |
| 3448 | Phosphorylation | HIDDLRRSTLMVSDV EHHHHHHCEEECCCC | 21.32 | 26074081 | |
| 3449 | Phosphorylation | IDDLRRSTLMVSDVT HHHHHHCEEECCCCC | 19.64 | 26074081 | |
| 3453 | Phosphorylation | RRSTLMVSDVTRLQH HHCEEECCCCCCCEE | 16.64 | 26074081 | |
| 3456 | Phosphorylation | TLMVSDVTRLQHVTI EEECCCCCCCEEEEH | 30.56 | 26074081 | |
| 3462 | Phosphorylation | VTRLQHVTISQLFAP CCCCEEEEHHHHCCC | 16.88 | 26074081 | |
| 3464 | Phosphorylation | RLQHVTISQLFAPGD CCEEEEHHHHCCCCC | 16.09 | 26074081 | |
| 3491 | Phosphorylation | GHEEAMETEASTSGE CCHHHHHCCCCCCHH | 24.62 | 28857561 | |
| 3494 | Phosphorylation | EAMETEASTSGEVAE HHHHCCCCCCHHHHH | 19.51 | 28857561 | |
| 3495 | Phosphorylation | AMETEASTSGEVAEV HHHCCCCCCHHHHHH | 48.04 | 26657352 | |
| 3496 | Phosphorylation | METEASTSGEVAEVA HHCCCCCCHHHHHHH | 30.38 | 30576142 | |
| 3517 | Ubiquitination | ESSEKVGKETSELGG CCHHHHCCCHHHCCC | 61.89 | - | |
| 3520 | Phosphorylation | EKVGKETSELGGSDV HHHCCCHHHCCCCCC | 31.73 | 28674419 | |
| 3525 | Phosphorylation | ETSELGGSDVSILDT CHHHCCCCCCHHHHH | 32.80 | 27067055 | |
| 3538 | Phosphorylation | DTTRLLRSCVQSAVG HHHHHHHHHHHHHHH | 20.71 | - | |
| 3559 | Methylation | ESCTRNMRRVVLLLG HHHHHHHHHHHHHHH | 31.61 | 115387057 | |
| 3566 (in isoform 4) | Ubiquitination | - | 28.25 | - | |
| 3577 | Phosphorylation | EDDACHASFLRVSKM CCCCCCHHHHHHHHH | 10.93 | 24719451 | |
| 3580 | Methylation | ACHASFLRVSKMRLS CCCHHHHHHHHHHHH | 28.75 | 115387065 | |
| 3592 | Ubiquitination | RLSVFLKKQEESQFH HHHEEECCCCHHCCC | 66.15 | - | |
| 3641 (in isoform 4) | Ubiquitination | - | 13.91 | - | |
| 3670 | Phosphorylation | DLWMFIFSDTMLLNI HHHHHHHCCCHHHCC | 27.62 | 27067055 | |
| 3738 | Ubiquitination | DAEGLPKKFVDIFQQ CCCCCCHHHHHHHHC | 48.99 | - | |
| 3787 (in isoform 4) | Ubiquitination | - | 3.04 | - | |
| 3799 | Ubiquitination | WSCTRKLKAASEAPE HHHHHHHHHHHCCCH | 44.96 | - | |
| 3848 (in isoform 4) | Ubiquitination | - | 17.13 | - | |
| 3874 | Phosphorylation | TEMLTRNTLKPSPQA HHHHHHCCCCCCHHH | 32.63 | 20873877 | |
| 3876 | Ubiquitination | MLTRNTLKPSPQAWL HHHHCCCCCCHHHHH | 41.22 | - | |
| 3925 (in isoform 4) | Ubiquitination | - | 15.48 | - | |
| 3957 | Ubiquitination | EHVFLLDKCLRENSD HHHHHHHHHHHCCCC | 34.83 | - | |
| 3966 | Ubiquitination | LRENSDVKTHGPFEA HHCCCCCCCCCHHHH | 39.53 | - | |
| 3982 | Ubiquitination | MRTLCECKETASKTL HHHHHHCHHHHCHHH | 35.49 | - | |
| 3987 | Ubiquitination | ECKETASKTLSRFGI HCHHHHCHHHHHHCC | 51.53 | - | |
| 4005 | Ubiquitination | SICLGDAKDPVCLPC CEEECCCCCCEEEEC | 68.27 | - | |
| 4006 (in isoform 4) | Ubiquitination | - | 42.45 | - | |
| 4015 (in isoform 4) | Ubiquitination | - | 1.86 | - | |
| 4031 (in isoform 4) | Ubiquitination | - | 1.82 | - | |
| 4034 | Phosphorylation | SEQMICPYCLTALPD CCCCCCHHHHHHCCC | 8.83 | 20090780 | |
| 4036 (in isoform 4) | Ubiquitination | - | 2.31 | - | |
| 4054 (in isoform 4) | Ubiquitination | - | 18.39 | - | |
| 4115 | Ubiquitination | QRHCEHTKSLSPFND HHHCHHCCCCCCCCC | 51.84 | - | |
| 4116 | Phosphorylation | RHCEHTKSLSPFNDV HHCHHCCCCCCCCCC | 34.92 | 27067055 | |
| 4118 | Phosphorylation | CEHTKSLSPFNDVVD CHHCCCCCCCCCCCC | 34.24 | 28857561 | |
| 4126 | Ubiquitination | PFNDVVDKTPVIRSV CCCCCCCCCHHHHHH | 43.02 | - | |
| 4132 | Phosphorylation | DKTPVIRSVILKLLL CCCHHHHHHHHHHHH | 11.46 | - | |
| 4141 | Phosphorylation | ILKLLLKYSFHDVKD HHHHHHHCCCCCHHH | 19.28 | 17924679 | |
| 4158 | Ubiquitination | QEYLTLLKKKAFITE HHHHHHHHHCCCCCC | 56.17 | - | |
| 4159 | Ubiquitination | EYLTLLKKKAFITED HHHHHHHHCCCCCCC | 49.67 | - | |
| 4160 | Ubiquitination | YLTLLKKKAFITEDK HHHHHHHCCCCCCCC | 47.11 | - | |
| 4164 | Phosphorylation | LKKKAFITEDKTELY HHHCCCCCCCCHHHH | 31.51 | 26074081 | |
| 4164 (in isoform 4) | Ubiquitination | - | 31.51 | - | |
| 4168 | Phosphorylation | AFITEDKTELYMLFI CCCCCCCHHHHHHHH | 43.47 | 26074081 | |
| 4171 | Phosphorylation | TEDKTELYMLFINCL CCCCHHHHHHHHHHH | 5.87 | 26074081 | |
| 4175 (in isoform 4) | Ubiquitination | - | 2.91 | - | |
| 4181 | Phosphorylation | FINCLEDSILEKTSA HHHHHHHHHHHHCCC | 21.50 | 24719451 | |
| 4206 | Ubiquitination | EEEGRFLKAYSPASR HHCCCHHHHCCCCCC | 42.43 | - | |
| 4225 | Phosphorylation | ANEASVEYLQEVARI CCHHHHHHHHHHHHH | 16.13 | 20090780 | |
| 4252 | Sulfoxidation | EPEGGPEMAKEKQCY CCCCCHHHHHHHHHH | 7.90 | 21406390 | |
| 4254 | Acetylation | EGGPEMAKEKQCYLQ CCCHHHHHHHHHHHH | 65.22 | 25953088 | |
| 4254 | Ubiquitination | EGGPEMAKEKQCYLQ CCCHHHHHHHHHHHH | 65.22 | - | |
| 4255 (in isoform 4) | Ubiquitination | - | 38.53 | - | |
| 4256 | Ubiquitination | GPEMAKEKQCYLQQV CHHHHHHHHHHHHHH | 44.99 | - | |
| 4264 | Acetylation | QCYLQQVKQFCIRVE HHHHHHHHHHHHEEC | 33.06 | 25953088 | |
| 4264 | Ubiquitination | QCYLQQVKQFCIRVE HHHHHHHHHHHHEEC | 33.06 | - | |
| 4297 | Ubiquitination | EFVQGLSKPGRPHQW HHHHCCCCCCCCCCE | 57.44 | - | |
| 4305 (in isoform 4) | Ubiquitination | - | 4.78 | - | |
| 4308 | Ubiquitination | PHQWVFPKDVVKQQG CCCEECCHHHHHHCC | 52.25 | - | |
| 4312 | Ubiquitination | VFPKDVVKQQGLRQD ECCHHHHHHCCCCCC | 36.43 | - | |
| 4313 (in isoform 4) | Ubiquitination | - | 30.85 | - | |
| 4335 | Ubiquitination | LVYGDEYKALRDAVA EEECHHHHHHHHHHH | 38.61 | - | |
| 4343 | Ubiquitination | ALRDAVAKAVLECKP HHHHHHHHHHHHCCC | 32.22 | - | |
| 4346 (in isoform 4) | Ubiquitination | - | 8.37 | - | |
| 4349 | Acetylation | AKAVLECKPLGIKTA HHHHHHCCCCCHHHH | 33.62 | 25953088 | |
| 4349 | Ubiquitination | AKAVLECKPLGIKTA HHHHHHCCCCCHHHH | 33.62 | - | |
| 4354 | Acetylation | ECKPLGIKTALKACK HCCCCCHHHHHHHCC | 26.41 | 25953088 | |
| 4354 | Ubiquitination | ECKPLGIKTALKACK HCCCCCHHHHHHHCC | 26.41 | - | |
| 4361 (in isoform 4) | Ubiquitination | - | 69.01 | - | |
| 4384 (in isoform 4) | Ubiquitination | - | 28.17 | - | |
| 4392 (in isoform 4) | Ubiquitination | - | 55.75 | - | |
| 4398 (in isoform 4) | Ubiquitination | - | 52.37 | - | |
| 4402 | Ubiquitination | EQCEAVSKFIGECKI HHHHHHHHHHHCCCC | 34.11 | - | |
| 4403 (in isoform 4) | Ubiquitination | - | 7.26 | - | |
| 4408 | Ubiquitination | SKFIGECKILSPPDI HHHHHCCCCCCCCCH | 42.24 | - | |
| 4411 | Phosphorylation | IGECKILSPPDISRF HHCCCCCCCCCHHHH | 37.55 | 27067055 | |
| 4420 | Phosphorylation | PDISRFATSLVDNSV CCHHHHHHHHCCCCC | 21.63 | 28857561 | |
| 4421 | Phosphorylation | DISRFATSLVDNSVP CHHHHHHHHCCCCCC | 23.98 | 28857561 | |
| 4451 (in isoform 4) | Ubiquitination | - | 5.50 | - | |
| 4457 (in isoform 4) | Ubiquitination | - | 33.06 | - | |
| 4495 | Ubiquitination | LAQARRWKGLERVHW HHHHHHHCCCCEEEE | 52.38 | - | |
| 4538 | Ubiquitination | PIGGIDHKPRDGFHL CCCCCCCCCCCCEEE | 37.69 | - | |
| 4544 (in isoform 4) | Ubiquitination | - | 34.93 | - | |
| 4547 | Ubiquitination | RDGFHLVKDKADRTQ CCCEEEEECCCCCCC | 60.93 | - | |
| 4586 | Phosphorylation | FLLIRLLTHLALLLG HHHHHHHHHHHHHHC | 21.31 | - | |
| 4595 | Phosphorylation | LALLLGASQSSQALI HHHHHCCCCCHHHHH | 28.88 | 30622161 | |
| 4596 (in isoform 4) | Ubiquitination | - | 46.71 | - | |
| 4597 | Phosphorylation | LLLGASQSSQALINI HHHCCCCCHHHHHHH | 23.17 | 30622161 | |
| 4598 | Phosphorylation | LLGASQSSQALINII HHCCCCCHHHHHHHH | 16.31 | 30622161 | |
| 4622 | Ubiquitination | FLQQHILKDLEQLAK HHHHHHHHHHHHHHH | 60.71 | - | |
| 4671 | Ubiquitination | FDTELSTKEMRNNWE CCHHCCHHHHHHCHH | 46.25 | - | |
| 4679 | Ubiquitination | EMRNNWEKEIAAVIS HHHHCHHHHHHHHHC | 46.14 | - | |
| 4686 | Phosphorylation | KEIAAVISPELEHLD HHHHHHHCHHHHHHH | 13.01 | 27067055 | |
| 4694 | Ubiquitination | PELEHLDKTLPTMNN HHHHHHHHHCHHHHH | 59.32 | - | |
| 4695 | Phosphorylation | ELEHLDKTLPTMNNL HHHHHHHHCHHHHHH | 37.32 | 29978859 | |
| 4698 | Phosphorylation | HLDKTLPTMNNLISQ HHHHHCHHHHHHHCC | 35.33 | 29978859 | |
| 4704 | Phosphorylation | PTMNNLISQDKRISS HHHHHHHCCCCCCCC | 35.18 | 29978859 | |
| 4707 | Ubiquitination | NNLISQDKRISSNPV HHHHCCCCCCCCCCC | 43.95 | - | |
| 4716 | Ubiquitination | ISSNPVAKIIYGDPV CCCCCCEEEECCCCC | 29.85 | - | |
| 4719 | Phosphorylation | NPVAKIIYGDPVTFL CCCEEEECCCCCCCC | 20.96 | 20090780 | |
| 4720 (in isoform 4) | Ubiquitination | - | 23.49 | - | |
| 4728 (in isoform 4) | Ubiquitination | - | 51.08 | - | |
| 4732 | Ubiquitination | FLPHLPRKSVVHCSK CCCCCCCCCEEEEHH | 45.74 | - | |
| 4739 | Ubiquitination | KSVVHCSKIWSCRKR CCEEEEHHHHCCCCC | 54.30 | - | |
| 4743 (in isoform 4) | Ubiquitination | - | 3.41 | - | |
| 4751 | Phosphorylation | RKRITVEYLQHIVEQ CCCCHHHHHHHHHHH | 13.81 | 20090780 | |
| 4756 (in isoform 4) | Ubiquitination | - | 6.30 | - | |
| 4759 | Ubiquitination | LQHIVEQKNGKERVP HHHHHHHHCCCCCCC | 54.91 | - | |
| 4765 (in isoform 4) | Ubiquitination | - | 3.47 | - | |
| 4774 | Ubiquitination | ILWHFLQKEAELRLV CHHHHHHHHHHHHHH | 62.12 | - | |
| 4782 | Ubiquitination | EAELRLVKFLPEILA HHHHHHHHHHHHHHH | 45.86 | - | |
| 4796 | Ubiquitination | ALQRDLVKQFQNVQQ HHCHHHHHHHCCCCE | 53.33 | - | |
| 4814 | Phosphorylation | SSIRGFLSKHSSDGL HHHHHHHHHCCCHHH | 26.51 | 27251275 | |
| 4815 | Ubiquitination | SIRGFLSKHSSDGLR HHHHHHHHCCCHHHH | 50.05 | - | |
| 4817 | Phosphorylation | RGFLSKHSSDGLRQL HHHHHHCCCHHHHHH | 33.58 | 27251275 | |
| 4818 | Phosphorylation | GFLSKHSSDGLRQLL HHHHHCCCHHHHHHH | 35.10 | 27251275 | |
| 4823 (in isoform 4) | Ubiquitination | - | 54.11 | - | |
| 4831 (in isoform 4) | Ubiquitination | - | 4.17 | - | |
| 4835 | O-linked_Glycosylation | RITVFLSTWNKLRRS HHHHHHHHHHHHHHH | 34.89 | 30379171 | |
| 4845 (in isoform 4) | Ubiquitination | - | 54.54 | - | |
| 4864 (in isoform 4) | Ubiquitination | - | 50.28 | - | |
| 4896 | Phosphorylation | RLHNEIVYAVEKLSK HHHHHHHHHHHHHHC | 15.59 | 20090780 | |
| 4900 | Acetylation | EIVYAVEKLSKENNS HHHHHHHHHHCCCCC | 52.00 | 25953088 | |
| 4949 (in isoform 4) | Ubiquitination | - | 53.73 | - | |
| 4952 (in isoform 4) | Ubiquitination | - | 53.84 | - | |
| 4955 | Ubiquitination | VQEFDLEKIQRQIVS HHHCCHHHHHHHHHH | 51.98 | - | |
| 4968 | Methylation | VSRFLQGKPRLSLKG HHHHHCCCCCCEECC | 17.63 | - | |
| 4968 | Ubiquitination | VSRFLQGKPRLSLKG HHHHHCCCCCCEECC | 17.63 | - | |
| 4974 | Methylation | GKPRLSLKGIPTLVY CCCCCEECCCCEEEE | 51.96 | - | |
| 4974 | Ubiquitination | GKPRLSLKGIPTLVY CCCCCEECCCCEEEE | 51.96 | - | |
| 4981 | Phosphorylation | KGIPTLVYRHDWNYE CCCCEEEECCCCCHH | 12.82 | 20090780 | |
| 4995 | Ubiquitination | EHLFMDIKNKMAQDS HHEEHHHHHHHHHCC | 46.37 | - | |
| 5004 (in isoform 4) | Ubiquitination | - | 28.63 | - | |
| 5017 (in isoform 4) | Ubiquitination | - | 34.89 | - | |
| 5023 (in isoform 4) | Ubiquitination | - | 48.49 | - | |
| 5046 (in isoform 4) | Ubiquitination | - | 3.05 | - | |
| 5095 | Ubiquitination | EQLLRLHKEPFGEIS HHHHHHHCCCCCHHC | 72.22 | - | |
| 5102 | Phosphorylation | KEPFGEISSRYKADL CCCCCHHCHHHCCCC | 12.40 | 27080861 | |
| 5103 | Phosphorylation | EPFGEISSRYKADLS CCCCHHCHHHCCCCC | 45.34 | 27080861 | |
| 5106 | Ubiquitination | GEISSRYKADLSPEN CHHCHHHCCCCCHHH | 34.02 | - | |
| 5110 | Phosphorylation | SRYKADLSPENAKLL HHHCCCCCHHHHHHH | 30.62 | 28674419 | |
| 5142 | Ubiquitination | EMIILKLKNPQTQTE HHHHHHCCCCCCCCC | 66.06 | - | |
| 5144 (in isoform 4) | Ubiquitination | - | 36.69 | - | |
| 5155 (in isoform 4) | Ubiquitination | - | 37.83 | - | |
| 5157 | Phosphorylation | ERFRPQWSLRDTLVS HHHCCCCCHHHHHHH | 14.31 | 24719451 | |
| 5191 (in isoform 4) | Ubiquitination | - | 4.85 | - | |
| 5201 | Ubiquitination | WKTAAVLKWNREMR- HHHHHHHHHHHHCC- | 35.50 | - | |
| 5250 (in isoform 4) | Ubiquitination | - | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RN213_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RN213_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
| 1188 | Phosphorylation | 1195 (7) | V ⇒ M | rs10782008 |
| 29273593 |
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RN213_HUMAN | RNF213 | physical | 24658080 | |
| UBX11_HUMAN | UBXN11 | physical | 25416956 | |
| K1C40_HUMAN | KRT40 | physical | 25416956 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 607151 | Moyamoya disease 2 (MYMY2) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Acetylation | |
| Reference | PubMed |
| "Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1223, AND MASS SPECTROMETRY. | |
| Phosphorylation | |
| Reference | PubMed |
| "Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1258, AND MASSSPECTROMETRY. | |
| "Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1258, AND MASSSPECTROMETRY. | |
| "Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography."; Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.; Proteomics 8:1346-1361(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1258, AND MASSSPECTROMETRY. | |
| "A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1258, AND MASSSPECTROMETRY. | |
| "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1188, AND MASSSPECTROMETRY. | |
| "Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-4141, AND MASSSPECTROMETRY. | |
