UBX11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBX11_HUMAN
• UniProt AC: Q5T124
• Protein Name: UBX domain-containing protein 11
• Gene Name: UBXN11
• Organism: Homo sapiens (Human).
• Sequence Length: 520
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 AND RND3. Promotes RHOA activation mediated by GNA12 and GNA13 (By similarity)..
• Protein Sequence: MSSPLASLSKTRKVPLPSEPMNPGRRGIRIYGDEDEVDMLSDGCGSEEKISVPSCYGGIGAPVSRQVPASHDSELMAFMTRKLWDLEQQVKAQTDEILSKDQKIAALEDLVQTLRPHPAEATLQRQEELETMCVQLQRQVREMERFLSDYGLQWVGEPMDQEDSESKTVSEHGERDWMTAKKFWKPGDSLAPPEVDFDRLLASLQDLSELVVEGDTQVTPVPGGARLRTLEPIPLKLYRNGIMMFDGPFQPFYDPSTQRCLRDILDGFFPSELQRLYPNGVPFKVSDLRNQVYLEDGLDPFPGEGRVVGRQLMHKALDRVEEHPGSRMTAEKFLNRLPKFVIRQGEVIDIRGPIRDTLQNCCPLPARIQEIVVETPTLAAERERSQESPNTPAPPLSMLRIKSENGEQAFLLMMQPDNTIGDVRALLAQARVMDASAFEIFSTFPPTLYQDDTLTLQAAGLVPKAALLLRARRAPKSSLKFSPGPCPGPGPGPSPGPGPGPSPGPGPGPSPCPGPSPSPQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSPLASLS ------CCCCCHHCC	40.43	18691976
3	Phosphorylation	-----MSSPLASLSK -----CCCCCHHCCC	23.72	18691976
7	Phosphorylation	-MSSPLASLSKTRKV -CCCCCHHCCCCCCC	40.64	23025827
9	Phosphorylation	SSPLASLSKTRKVPL CCCCHHCCCCCCCCC	29.50	23025827
11	Phosphorylation	PLASLSKTRKVPLPS CCHHCCCCCCCCCCC	32.14	29083192
13	Ubiquitination	ASLSKTRKVPLPSEP HHCCCCCCCCCCCCC	54.13	-
41	Phosphorylation	EDEVDMLSDGCGSEE HHHHEECCCCCCCCC	25.89	30622161
46	Phosphorylation	MLSDGCGSEEKISVP ECCCCCCCCCCCCCC	46.81	30622161
70	Phosphorylation	VSRQVPASHDSELMA CCCCCCCCCCHHHHH	23.04	-
73	Phosphorylation	QVPASHDSELMAFMT CCCCCCCHHHHHHHH	27.49	-
80	Phosphorylation	SELMAFMTRKLWDLE HHHHHHHHHHHHCHH	20.42	-
100	Ubiquitination	QTDEILSKDQKIAAL HHHHHCCHHHHHHHH	61.81	-
179	Phosphorylation	HGERDWMTAKKFWKP HCCCCCEECHHHCCC	30.94	29083192
182	Ubiquitination	RDWMTAKKFWKPGDS CCCEECHHHCCCCCC	54.73	-
203	Phosphorylation	DFDRLLASLQDLSEL CHHHHHHHHHHHHHH	26.91	30622161
208	Phosphorylation	LASLQDLSELVVEGD HHHHHHHHHHHHCCC	36.85	-
236	Ubiquitination	TLEPIPLKLYRNGIM CCCCCEEEEEECCEE	37.81	-
284	Ubiquitination	YPNGVPFKVSDLRNQ CCCCCCEEHHHHCCC	34.46	-
402	Ubiquitination	PLSMLRIKSENGEQA CCHHEEEECCCCCEE	45.33	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBX11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBX11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBX11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CF206_HUMAN	C6orf165	physical	16189514
RND1_HUMAN	RND1	physical	11940653
RND2_HUMAN	RND2	physical	11940653
RND3_HUMAN	RND3	physical	11940653
TERA_HUMAN	VCP	physical	18775313
NPL4_HUMAN	NPLOC4	physical	18775313
PPB1_HUMAN	ALPP	physical	18775313
VCIP1_HUMAN	VCPIP1	physical	18775313
CF206_HUMAN	C6orf165	physical	25416956
NCKP1_HUMAN	NCKAP1	physical	26186194
GT252_HUMAN	COLGALT2	physical	26186194
CYFP2_HUMAN	CYFIP2	physical	26186194
CYFP1_HUMAN	CYFIP1	physical	26186194
RTEL1_HUMAN	RTEL1	physical	26186194
CO1A1_HUMAN	COL1A1	physical	26186194
WASF1_HUMAN	WASF1	physical	26186194
TR61B_HUMAN	TRMT61B	physical	26186194
PDE7A_HUMAN	PDE7A	physical	26186194
ABI2_HUMAN	ABI2	physical	26186194
ABI1_HUMAN	ABI1	physical	26186194
IF4E2_HUMAN	EIF4E2	physical	21516116
WASF1_HUMAN	WASF1	physical	28514442
PDE7A_HUMAN	PDE7A	physical	28514442
ABI2_HUMAN	ABI2	physical	28514442
ABI1_HUMAN	ABI1	physical	28514442
CO1A1_HUMAN	COL1A1	physical	28514442
RTEL1_HUMAN	RTEL1	physical	28514442
NCKP1_HUMAN	NCKAP1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.