PDE7A_HUMAN - dbPTM
PDE7A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PDE7A_HUMAN
UniProt AC Q13946
Protein Name High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Gene Name PDE7A
Organism Homo sapiens (Human).
Sequence Length 482
Subcellular Localization Isoform PDE7A1: Cytoplasm, cytosol. PDE7A1 (57 kDa) is located mostly to soluble cellular fractions.
Isoform PDE7A2: Cytoplasm. PDE7A2 (50 kDa) is located to particulate cellular fractions.
Protein Description Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction..
Protein Sequence MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
24MethylationPQHVLSRRGAISFSS
CHHHHHCCCCEEECC		35.20115386437
28PhosphorylationLSRRGAISFSSSSAL
HHCCCCEEECCCHHH		20.6727080861
45PhosphorylationCPNPRQLSQRRGAIS
CCCHHHHHHHCCCEE		17.1924706070
48MethylationPRQLSQRRGAISYDS
HHHHHHHCCCEECCC		31.12115386441
52PhosphorylationSQRRGAISYDSSDQT
HHHCCCEECCCCHHH		23.5028450419
53PhosphorylationQRRGAISYDSSDQTA
HHCCCEECCCCHHHH		17.4628450419
55PhosphorylationRGAISYDSSDQTALY
CCCEECCCCHHHHEH		27.8128450419
56PhosphorylationGAISYDSSDQTALYI
CCEECCCCHHHHEHH		30.7328450419
58PhosphorylationISYDSSDQTALYIRM
EECCCCHHHHEHHHH		30.5332142685
59PhosphorylationSYDSSDQTALYIRML
ECCCCHHHHEHHHHH		24.5028450419
62PhosphorylationSSDQTALYIRMLGDV
CCHHHHEHHHHHCCE		5.5228450419
79PhosphorylationRSRAGFESERRGSHP
HHCCCCCCCCCCCCC		33.8624719451
84PhosphorylationFESERRGSHPYIDFR
CCCCCCCCCCEEEEE		21.3423401153
87PhosphorylationERRGSHPYIDFRIFH
CCCCCCCEEEEEEEE		14.0130266825
113PhosphorylationRNIRRLLSFQRYLRS
HHHHHHHHHHHHHHC		24.7523401153
145UbiquitinationDDYNGQAKCMLEKVG
CCCCCCEEEHHEECC		16.58-
306PhosphorylationFSHLPLESRQQMETQ
CCCCCHHHHHHHHHH		42.97-
312PhosphorylationESRQQMETQIGALIL
HHHHHHHHHHHHHHH		21.8324043423
321PhosphorylationIGALILATDISRQNE
HHHHHHHHCHHHHHH		30.3524043423
324PhosphorylationLILATDISRQNEYLS
HHHHHCHHHHHHHHH		30.5324043423
331PhosphorylationSRQNEYLSLFRSHLD
HHHHHHHHHHHHHCC		25.2624719451
348UbiquitinationDLCLEDTRHRHLVLQ
CCCCCCCCHHHHHHH		36.8429967540
359UbiquitinationLVLQMALKCADICNP
HHHHHHHHHHHHCCH		20.17-
366UbiquitinationKCADICNPCRTWELS
HHHHHCCHHHHHHHH		12.4529967540
374UbiquitinationCRTWELSKQWSEKVT
HHHHHHHHHHHHHHH		69.3029967540
379UbiquitinationLSKQWSEKVTEEFFH
HHHHHHHHHHHHHHH		49.28-
392UbiquitinationFHQGDIEKKYHLGVS
HHHCCHHHHEECCCC		59.9929967540
393UbiquitinationHQGDIEKKYHLGVSP
HHCCHHHHEECCCCC		25.72-
399PhosphorylationKKYHLGVSPLCDRHT
HHEECCCCCCCCCCC		15.4522985185
426UbiquitinationYLVEPLFTEWARFSN
HHHHHHHHHHHHCCC		38.0029967540
448UbiquitinationLGHVGLNKASWKGLQ
HHCCCCCHHHHHCCH		49.17-
450PhosphorylationHVGLNKASWKGLQRE
CCCCCHHHHHCCHHC		30.8124719451
452UbiquitinationGLNKASWKGLQREQS
CCCHHHHHCCHHCCC		47.4529967540
459PhosphorylationKGLQREQSSSEDTDA
HCCHHCCCCCCCCHH		30.9527251275
460PhosphorylationGLQREQSSSEDTDAA
CCHHCCCCCCCCHHH		37.1228348404
461PhosphorylationLQREQSSSEDTDAAF
CHHCCCCCCCCHHHH		44.7528348404
464PhosphorylationEQSSSEDTDAAFELN
CCCCCCCCHHHHHHH		24.4027251275
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PDE7A_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PDE7A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PDE7A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VP13A_HUMANVPS13Aphysical
26186194
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00201Caffeine
DB00651Dyphylline
DB00920Ketotifen
Regulatory Network of PDE7A_HUMAN

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Related Literatures of Post-Translational Modification

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