| UniProt ID | RND2_HUMAN | |
|---|---|---|
| UniProt AC | P52198 | |
| Protein Name | Rho-related GTP-binding protein RhoN | |
| Gene Name | RND2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 227 | |
| Subcellular Localization |
Cytoplasmic vesicle, secretory vesicle, acrosome membrane Lipid-anchor Cytoplasmic side . Colocalizes with RACGAP1 in Golgi-derived proacrosomal vesicles and the acrosome. |
|
| Protein Description | May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity).. | |
| Protein Sequence | MEGQSGRCKIVVVGDAECGKTALLQVFAKDAYPGSYVPTVFENYTASFEIDKRRIELNMWDTSGSSYYDNVRPLAYPDSDAVLICFDISRPETLDSVLKKWQGETQEFCPNAKVVLVGCKLDMRTDLATLRELSKQRLIPVTHEQGTVLAKQVGAVSYVECSSRSSERSVRDVFHVATVASLGRGHRQLRRTDSRRGMQRSAQLSGRPDRGNEGEIHKDRAKSCNLM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 184 | Methylation | ATVASLGRGHRQLRR HHHHHCCCCCHHHHC | 42.93 | 115491361 | |
| 194 | Phosphorylation | RQLRRTDSRRGMQRS HHHHCCCCCCCHHHH | 24.22 | 24719451 | |
| 205 | Phosphorylation | MQRSAQLSGRPDRGN HHHHHHHCCCCCCCC | 22.22 | - | |
| 224 | Methylation | HKDRAKSCNLM---- CHHHHHHCCCC---- | 4.46 | - | |
| 224 | Geranylgeranylation | HKDRAKSCNLM---- CHHHHHHCCCC---- | 4.46 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RND2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RND2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RND2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RHG05_HUMAN | ARHGAP5 | physical | 12842009 | |
| UBX11_HUMAN | UBXN11 | physical | 11940653 | |
| PKHG5_HUMAN | PLEKHG5 | physical | 22807448 | |
| PLXB1_HUMAN | PLXNB1 | physical | 22807448 | |
| RGS14_HUMAN | RGS14 | physical | 22807448 | |
| RHG35_HUMAN | ARHGAP35 | physical | 22807448 | |
| UBP47_HUMAN | USP47 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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