PKHG5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PKHG5_HUMAN
• UniProt AC: O94827
• Protein Name: Pleckstrin homology domain-containing family G member 5
• Gene Name: PLEKHG5
• Organism: Homo sapiens (Human).
• Sequence Length: 1062
• Subcellular Localization: Cytoplasm . Cytoplasm, perinuclear region . Cell membrane . Cell junction . Cell projection, lamellipodium . Predominantly cytoplasmic, however when endothelial cells are stimulated with lysophosphatidic acid, PLEKHG5 is found in perinuclear regions
• Protein Description: Guanine nucleotide exchange factor that activates RHOA and maybe the NF-kappa-B signaling pathway. Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis..
• Protein Sequence: MDDQSPAEKKGLRCQNPACMDKGRAAKVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MDDQSPAEKK -----CCCCCHHHHC	63.82	27642862
17 (in isoform 2)	Phosphorylation	-	10.85	22210691
20 (in isoform 2)	Phosphorylation	-	6.92	22210691
26 (in isoform 2)	Phosphorylation	-	11.94	22210691
116	Phosphorylation	KSTGLKLSKKKARRR HHHCCCCCHHHHHHH	40.62	27251275
125	Phosphorylation	KKARRRHTDDPSKEC HHHHHHCCCCCCCCC	40.04	24719451
139	Phosphorylation	CFTLKFDLNVDIETE CEEEEEEEECCCCCC	8.29	27251275
146	Phosphorylation	LNVDIETEIVPAMKK EECCCCCCCHHHHCC	29.24	24719451
177	Phosphorylation	ALGKVDIYLDQSNTP EEEEEEEEECCCCCC	10.36	-
192	Phosphorylation	LSLTFEAYRFGGHYL EEEEEEEEEECCEEE	10.16	-
198	Phosphorylation	AYRFGGHYLRVKAPA EEEECCEEEEEECCC	10.24	-
222	Phosphorylation	QGMKDSKSLSLPILR HCCCCCCCCCCCEEC	27.43	28188228
224	Phosphorylation	MKDSKSLSLPILRPA CCCCCCCCCCEECCC	38.91	23403867
233	Phosphorylation	PILRPAGTGPPALER CEECCCCCCCCHHHH	48.93	23403867
245	Phosphorylation	LERVDAQSRRESLDI HHHCCHHHHHHHCCC	34.72	24719451
247	Phosphorylation	RVDAQSRRESLDILA HCCHHHHHHHCCCCC	43.00	27251275
249	Phosphorylation	DAQSRRESLDILAPG CHHHHHHHCCCCCCC	29.54	23403867
263	Phosphorylation	GRRRKNMSEFLGEAS CCCCCCHHHHHCCCC	34.29	26074081
270	Phosphorylation	SEFLGEASIPGQEPP HHHHCCCCCCCCCCC	25.64	24719451
272	Phosphorylation	FLGEASIPGQEPPTP HHCCCCCCCCCCCCC	35.60	27251275
335	Phosphorylation	QLEGKLHTYSLFGLP HHCCCCEEHHHHCCC	25.83	28348404
337	Phosphorylation	EGKLHTYSLFGLPRL CCCCEEHHHHCCCCC	20.55	28348404
482	Ubiquitination	GDFLKGFKMFGSLFK CCHHHHHHHHHHHHH	41.82	-
486	Phosphorylation	KGFKMFGSLFKPYIR HHHHHHHHHHHHHHH	21.26	24719451
489	Ubiquitination	KMFGSLFKPYIRYCM HHHHHHHHHHHHHHH	42.05	-
504	Phosphorylation	EEEGCMEYMRGLLRD HHCCHHHHHHHHHCC	2.52	-
604	Phosphorylation	VVSRIDAYEVVESSS HHHHCHHHHHHHCCH	12.90	-
609	Phosphorylation	DAYEVVESSSDEVDK HHHHHHHCCHHHHHH	24.43	-
610	Phosphorylation	AYEVVESSSDEVDKL HHHHHHCCHHHHHHH	28.44	-
611	Phosphorylation	YEVVESSSDEVDKLL HHHHHCCHHHHHHHH	47.25	-
646	Phosphorylation	RQLLLEGSLRMKEGK HHHHHHHHHHCCCCC	11.92	23684312
729	Phosphorylation	ASGQALCRGWVDTIY CCCCHHHHHHHHHHH	42.74	-
734	Phosphorylation	LCRGWVDTIYNAQNQ HHHHHHHHHHHHHHH	18.75	-
785	Phosphorylation	EEGEDSGTSAASSPT HCCCCCCCCCCCCCC	21.10	-
790	Phosphorylation	SGTSAASSPTIMRKS CCCCCCCCCCEECCC	22.72	-
851	Phosphorylation	SLSTTASSATPTSEL CCCCCCCCCCCCHHH	33.43	-
868	Phosphorylation	LGPVDGRSCSMDSAY CCCCCCCCCCCCCCC	18.97	28348404
870	Phosphorylation	PVDGRSCSMDSAYGT CCCCCCCCCCCCCCC	27.20	28348404
873	Phosphorylation	GRSCSMDSAYGTLSP CCCCCCCCCCCCCCC	18.10	28348404
875	Phosphorylation	SCSMDSAYGTLSPTS CCCCCCCCCCCCCCC	18.00	28348404
876	Phosphorylation	CSMDSAYGTLSPTSL CCCCCCCCCCCCCCH	21.64	-
877	Phosphorylation	SMDSAYGTLSPTSLQ CCCCCCCCCCCCCHH	16.04	28348404
879	Phosphorylation	DSAYGTLSPTSLQDF CCCCCCCCCCCHHHH	26.43	28348404
881	Phosphorylation	AYGTLSPTSLQDFVA CCCCCCCCCHHHHCC	38.40	-
902	Phosphorylation	LVPRAPESPRVPSPP HCCCCCCCCCCCCCC	19.56	28355574
903	Phosphorylation	VPRAPESPRVPSPPP CCCCCCCCCCCCCCC	39.36	32142685
907	Phosphorylation	PESPRVPSPPPSPRL CCCCCCCCCCCCCCC	47.37	23927012
911	Phosphorylation	RVPSPPPSPRLRRRT CCCCCCCCCCCCCCC	28.55	28355574
918	Phosphorylation	SPRLRRRTPVQLLSC CCCCCCCCCCHHHCC	26.46	23312004
924	Phosphorylation	RTPVQLLSCPPHLLK CCCCHHHCCCHHHHC	32.92	23312004
928	Phosphorylation	QLLSCPPHLLKSKSE HHHCCCHHHHCCCCH	29.01	24719451
930	Phosphorylation	LSCPPHLLKSKSEAS HCCCHHHHCCCCHHH	5.53	27251275
932	Phosphorylation	CPPHLLKSKSEASLL CCHHHHCCCCHHHHH	41.19	23927012
934	Phosphorylation	PHLLKSKSEASLLQL HHHHCCCCHHHHHHH	45.55	23927012
937	Phosphorylation	LKSKSEASLLQLLAG HCCCCHHHHHHHHHC	26.09	23403867
939	Phosphorylation	SKSEASLLQLLAGAG CCCHHHHHHHHHCCC	2.90	24719451
941	Phosphorylation	SEASLLQLLAGAGTH CHHHHHHHHHCCCCC	3.41	27251275
947	Phosphorylation	QLLAGAGTHGTPSAP HHHHCCCCCCCCCCC	19.32	23403867
950	Phosphorylation	AGAGTHGTPSAPSRS HCCCCCCCCCCCCCC	13.38	23403867
952	Phosphorylation	AGTHGTPSAPSRSLS CCCCCCCCCCCCCHH	53.28	23403867
953	Phosphorylation	GTHGTPSAPSRSLSE CCCCCCCCCCCCHHH	13.80	24719451
955	Phosphorylation	HGTPSAPSRSLSELC CCCCCCCCCCHHHHH	33.93	23403867
957	Phosphorylation	TPSAPSRSLSELCLA CCCCCCCCHHHHHHH	40.35	28122231
959	Phosphorylation	SAPSRSLSELCLAVP CCCCCCHHHHHHHCC	29.75	28348404
972	Phosphorylation	VPAPGIRTQGSPQEA CCCCCCCCCCCCCCC	35.05	32142685
975	Phosphorylation	PGIRTQGSPQEAGPS CCCCCCCCCCCCCCC	17.37	28985074
980	Phosphorylation	QGSPQEAGPSWDCRG CCCCCCCCCCCCCCC	18.93	24719451
982	Phosphorylation	SPQEAGPSWDCRGAP CCCCCCCCCCCCCCC	34.33	27251275
990	Phosphorylation	WDCRGAPSPGSGPGL CCCCCCCCCCCCCCC	41.16	28348404
993	Phosphorylation	RGAPSPGSGPGLVGC CCCCCCCCCCCCHHH	45.24	24719451
996	Phosphorylation	PSPGSGPGLVGCLAG CCCCCCCCCHHHHCC	36.20	24719451
998	Phosphorylation	PGSGPGLVGCLAGEP CCCCCCCHHHHCCCC	6.70	27251275
1008	Phosphorylation	LAGEPAGSHRKRCGD HCCCCCCCCCCCCCC	23.40	30257219
1014	Phosphorylation	GSHRKRCGDLPSGAS CCCCCCCCCCCCCCC	43.45	24719451
1021	Phosphorylation	GDLPSGASPRVQPEP CCCCCCCCCCCCCCC	19.43	22210691
1033	Phosphorylation	PEPPPGVSAQHRKLT CCCCCCCCHHHHHHH	28.29	30257219

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PKHG5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PKHG5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PKHG5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FBW1A_HUMAN	BTRC	physical	28514442
FBW1B_HUMAN	FBXW11	physical	28514442
1433E_HUMAN	YWHAE	physical	28514442
1433Z_HUMAN	YWHAZ	physical	28514442
1433G_HUMAN	YWHAG	physical	28514442
PDP1_HUMAN	PDP1	physical	28514442
GBB4_HUMAN	GNB4	physical	28514442
1433F_HUMAN	YWHAH	physical	28514442
1433T_HUMAN	YWHAQ	physical	28514442
UBP7_HUMAN	USP7	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 611067: Distal spinal muscular atrophy, autosomal recessive, 4 (DSMA4)
• 615376: Charcot-Marie-Tooth disease, recessive, intermediate type, C (CMTRIC)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.